J Martin

Summary

Country: Spain

Publications

  1. ncbi request reprint Complete characterization of the DQB1 first exon polymorphism
    M Pascual
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Eur J Immunogenet 29:447-8. 2002
  2. pmc Genetic markers of cardiovascular disease in rheumatoid arthritis
    Luis Rodríguez-Rodríguez
    Department of Rheumatology, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040 Madrid, Spain
    Mediators Inflamm 2012:574817. 2012
  3. doi request reprint Genetic component of giant cell arteritis
    F David Carmona
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Parque Tecnologico Ciencias de la Salud, Avenida del Conocimiento s n, 18100 Armilla, Granada, Spain
    Rheumatology (Oxford) 53:6-18. 2014
  4. pmc Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition
    Maria Carmen Cénit
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN, CSIC, Parque Tecnologico Ciencias de la Salud, Avenida del Conocimiento, 18100 Armilla, Granada, Spain
    BMC Med Genet 14:52. 2013
  5. pmc Genetics of scleroderma: implications for personalized medicine?
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    BMC Med 11:9. 2013
  6. pmc A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis
    Lara Bossini-Castillo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avenida del Conocimiento s n, Granada, 18100, Spain
    Arthritis Res Ther 14:R85. 2012
  7. pmc Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
    María Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avda, del Conocimiento s n, 18010, Granada, SpainArmilla Granada, Spain
    Arthritis Res Ther 14:R154. 2012
  8. pmc The lp13.3 genomic region -rs599839- is associated with endothelial dysfunction in patients with rheumatoid arthritis
    Raquel López-Mejías
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Arthritis Res Ther 14:R42. 2012
  9. pmc PTPN22 splice forms: a new role in rheumatoid arthritis
    Lina Marcela Diaz-Gallo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC IPBLN CSIC, Parque Tecnologico Ciencias de la Salud, Avenida del Conocimiento s n 18100, Armilla, Granada, Spain
    Genome Med 4:13. 2012
  10. doi request reprint NPSR1 gene is associated with reduced risk of rheumatoid arthritis
    Gema Robledo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    J Rheumatol 39:1166-70. 2012

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint Complete characterization of the DQB1 first exon polymorphism
    M Pascual
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Eur J Immunogenet 29:447-8. 2002
    ..Six different variants, including a novel polymorphic site, were detected among the DBQ1 haplotypes...
  2. pmc Genetic markers of cardiovascular disease in rheumatoid arthritis
    Luis Rodríguez-Rodríguez
    Department of Rheumatology, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, 28040 Madrid, Spain
    Mediators Inflamm 2012:574817. 2012
    ..Despite considerable effort to decipher the genetic basis of CV disease in RA, further studies are required to better establish the genetic influence in the increased risk of CV events observed in patients with RA...
  3. doi request reprint Genetic component of giant cell arteritis
    F David Carmona
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Parque Tecnologico Ciencias de la Salud, Avenida del Conocimiento s n, 18100 Armilla, Granada, Spain
    Rheumatology (Oxford) 53:6-18. 2014
    ..Considering that no literature review has been published so far about the genetic component of this vasculitis, we aimed to summarize here the current knowledge on the genetics underlying GCA predisposition and severity. ..
  4. pmc Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition
    Maria Carmen Cénit
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN, CSIC, Parque Tecnologico Ciencias de la Salud, Avenida del Conocimiento, 18100 Armilla, Granada, Spain
    BMC Med Genet 14:52. 2013
    ..We aimed to investigate for the first time the potential influence of the IL2/IL21, IL2RA and IL2RB most associated polymorphisms with autoimmunity on the endogenous non-anterior uveitis genetic predisposition...
  5. pmc Genetics of scleroderma: implications for personalized medicine?
    Shervin Assassi
    Division of Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    BMC Med 11:9. 2013
    ..Future genetic studies in well-characterized systemic sclerosis cohorts paired with advanced analytic approaches can lead to development of genetic biomarkers for targeted diagnostic and therapeutic interventions in systemic sclerosis...
  6. pmc A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis
    Lara Bossini-Castillo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avenida del Conocimiento s n, Granada, 18100, Spain
    Arthritis Res Ther 14:R85. 2012
    ..The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population...
  7. pmc Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
    María Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avda, del Conocimiento s n, 18010, Granada, SpainArmilla Granada, Spain
    Arthritis Res Ther 14:R154. 2012
    ..The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc)...
  8. pmc The lp13.3 genomic region -rs599839- is associated with endothelial dysfunction in patients with rheumatoid arthritis
    Raquel López-Mejías
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Arthritis Res Ther 14:R42. 2012
    ....
  9. pmc PTPN22 splice forms: a new role in rheumatoid arthritis
    Lina Marcela Diaz-Gallo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC IPBLN CSIC, Parque Tecnologico Ciencias de la Salud, Avenida del Conocimiento s n 18100, Armilla, Granada, Spain
    Genome Med 4:13. 2012
    ..This study provides new insights into the role of PTPN22 in autoimmune diseases...
  10. doi request reprint NPSR1 gene is associated with reduced risk of rheumatoid arthritis
    Gema Robledo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    J Rheumatol 39:1166-70. 2012
    ..We investigated the possible contribution of several polymorphisms in the intronic region of NPSR1 to rheumatoid arthritis (RA)...
  11. pmc CD209 in inflammatory bowel disease: a case-control study in the Spanish population
    Concepcion Nunez
    Servicio de Inmunología Clínica, Hospital Clinico San Carlos, Madrid, Spain
    BMC Med Genet 8:75. 2007
    ..Our aim was to study the potential involvement of this CD209 variant in IBD susceptibility...
  12. pmc Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus
    Elena Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    BMC Med Genet 7:48. 2006
    ..The aim of this study was to evaluate the relevance of functional genetic variations of RANTES, IL-8, IL-1alpha, and MCP-1 for systemic lupus erythematosus...
  13. pmc Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients
    María Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avd, del Conocimiento s n, 18010, Granada, Spain
    Arthritis Res Ther 13:R116. 2011
    ....
  14. pmc CCR5Δ32 variant and cardiovascular disease in patients with rheumatoid arthritis: a cohort study
    Luis Rodríguez-Rodríguez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, C S I C, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s n Armilla, Granada E 18100, Spain
    Arthritis Res Ther 13:R133. 2011
    ..The aim of our study was to analyze the influence of the CCR5Δ32 polymorphism in the risk of cardiovascular (CV) events and subclinical atherosclerosis among patients with rheumatoid arthritis (RA)...
  15. pmc Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis
    Ann W Morgan
    Leeds Institute for Molecular Medicine, University of Leeds, Leeds, UK
    Arthritis Res Ther 8:R109. 2006
    ..These findings may ultimately provide new insights into disease pathogenesis...
  16. pmc Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor
    Alejandro Balsa
    Servicio de Reumatologia, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid, 28046, Spain
    Arthritis Res Ther 12:R62. 2010
    ..The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF)...
  17. pmc A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis
    Rogelio Palomino-Morales
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s n Armilla, Granada 18100, Spain
    Arthritis Res Ther 12:R71. 2010
    ....
  18. pmc Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis
    Rogelio J Palomino-Morales
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s n Armilla, Granada 18100, Spain
    Arthritis Res Ther 12:R51. 2010
    ..The objective was to investigate the potential implication of the IL18 gene promoter polymorphisms in the susceptibility to giant-cell arteritis (GCA)...
  19. doi request reprint The genetics of scleroderma
    Javier Martin
    CSIC, Instituto de Parasitologia y Biomedicina Lopez Neyra, Avenida Conocimiento s n 18100 Armilla, Granada, Spain
    Curr Rheumatol Rep 13:13-20. 2011
    ..The challenge that lies ahead is to confirm these associations and to find markers or pathways that are unique to scleroderma and that may define its distinctive phenotype...
  20. ncbi request reprint The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease
    M C Martin
    Servicio de Inmunologia, Hospital Clinico San Carlos, Madrid, Spain
    Tissue Antigens 66:314-7. 2005
    ..These results indicate that the PTPN22 1858C-->T polymorphism does not appear to play a major role in IBD predisposition in our population...
  21. ncbi request reprint Distribution of HERV-LTR elements in the 5'-flanking region of HLA-DQB1 and association with autoimmunity
    M Pascual
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, C Ventanilla No 11, 18001 Granada, Spain
    Immunogenetics 53:114-8. 2001
    ..Our results shed new light on the phylogeny of the HLA region and the possible contribution of DQB1 to susceptibility to autoimmunity...
  22. ncbi request reprint No primary association of MICA polymorphism with systemic lupus erythematosus
    E Sanchez
    Instituto de Biomedicina, CSIC, Hospital Virgen de las Nieves, Granada, Spain
    Rheumatology (Oxford) 45:1096-100. 2006
    ..To replicate the described association between MHC class I chain-related A (MICA) gene polymorphism and susceptibility to systemic lupus erythematosus (SLE)...
  23. ncbi request reprint Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Genes Immun 7:433-6. 2006
    ..001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173(*)C allele and CATT(7)-MIF -173(*)C haplotype, confer susceptibility to SLE in our population...
  24. ncbi request reprint A functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population
    C Nunez
    Servicio de Inmunología Clínica, Hospital Clinico San Carlos, Madrid 28040, Spain
    World J Gastroenterol 12:4397-400. 2006
    ..Recently, a functional variant in the promoter of the CD209 gene (-336A/G) has been shown to affect the transcriptional CD209 activity in vitro and it has been associated with a higher susceptibility to/or severity of infection...
  25. ncbi request reprint Association study of ghrelin receptor gene polymorphisms in rheumatoid arthritis
    G Robledo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Clin Exp Rheumatol 28:25-9. 2010
    ..In this study we investigated the possible contribution of several polymorphisms in the functional Ghrelin receptor to RA susceptibility...
  26. ncbi request reprint Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis
    R Palomino-Morales
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
    Clin Exp Rheumatol 28:695-701. 2010
    ....
  27. ncbi request reprint CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Granada, Spain
    Hum Immunol 66:321-5. 2005
    ..Therefore, our results suggest that the CTLA4/CT60 polymorphism does not play a major role in inflammatory intestinal disorders...
  28. ncbi request reprint Inducible and endothelial nitric oxide synthase genes polymorphism in inflammatory bowel disease
    J Oliver
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Tissue Antigens 67:326-30. 2006
    ..There was not association between NOS2A and NOS3 genotypes, alleles or haplotypes frequencies with UC, CD and controls. Our data suggest that NOS2A and NOS3 polymorphisms do not play a major role in IBD predisposition...
  29. pmc Asporin repeat polymorphism in rheumatoid arthritis
    B Torres
    Servicio de Inmunologia, Hospital Universitario Virgen del Rocio, Sevilla, Spain
    Ann Rheum Dis 66:118-20. 2007
    ..Asporin belongs to a family of proteins associated with the cartilage matrix...
  30. ncbi request reprint Lack of association between macrophage migration inhibitory factor-173 gene polymorphism with disease susceptibility and cardiovascular risk in rheumatoid arthritis patients from northwestern Spain
    R Palomino-Morales
    Instituto de Parasitologia y Biomedicina, Lopez Neyra, Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
    Clin Exp Rheumatol 28:68-72. 2010
    ....
  31. ncbi request reprint Influence of MHCIITA rs3087456 and rs4774 polymorphisms in the susceptibility to cardiovascular disease of patients with rheumatoid arthritis
    M Garcia-Bermudez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, C S I C, Granada, Spain
    Clin Exp Rheumatol 30:51-7. 2012
    ..In this study we investigated the potential association of two MHCIITA gene polymorphisms with cardiovascular (CV) risk in patients with RA...
  32. ncbi request reprint Caspase 7 influences susceptibility to rheumatoid arthritis
    J R Garcia-Lozano
    Servicio de Inmunologia, Hospital Universitario Virgen del Rocio, Avda Manuel Siurot s n, 41013 Sevilla, Spain
    Rheumatology (Oxford) 46:1243-7. 2007
    ..The aim of this study was to investigate the possible role of the caspase 7 (CASP7) in susceptibility to rheumatoid arthritis (RA)...
  33. ncbi request reprint Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population
    L M Gomez
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia, and Instituto de Parasitología y Biomedicina Lopez Neyra, CSIC, Grenada, Spain
    Tissue Antigens 70:28-33. 2007
    ..07-2.52) in a dominant pattern. No allele in the MIF-794 CATT microsatellite was associated with risk of TB. These results indicate that MIF gene influences the risk of developing TB in the studied population...
  34. ncbi request reprint Study of a functional polymorphism in the p53 gene in systemic lupus erythematosus: lack of replication in a Spanish population
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Lupus 15:658-61. 2006
    ..In conclusion, the p53 codon 72 polymorphism associated with SLE in a Korean population does not appear to play a major role in the susceptibility or severity of SLE in the Spanish population...
  35. pmc Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus
    G Orozco
    Instituto de Parasitologia y Biomedicina, CSIC, Granada, Spain
    Ann Rheum Dis 65:791-5. 2006
    ..Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin-like modifier 4 (SUMO4) genes have been shown to be associated with several autoimmune diseases...
  36. doi request reprint The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Ann Rheum Dis 68:253-6. 2009
    ..The aim of the current study was to investigate the possible implication of the IL23R gene in SSc susceptibility and/or clinical phenotype...
  37. doi request reprint The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra CSIC, Granada, Spain
    Hum Mol Genet 18:2071-7. 2009
    ..36-1.74; P < 0.0001). Our data show a strong and reproducible association of the STAT4 gene with the genetic predisposition to lcSSc suggesting that this gene seems to be one of the genetic markers influencing SSc phenotype...
  38. ncbi request reprint Lack of association of NAMPT rs9770242 and rs59744560 polymorphisms with disease susceptibility and cardiovascular risk in patients with rheumatoid arthritis
    M Garcia-Bermudez
    Instituto de Parasitología y Biomedicina López Neyra, C S I C, Granada, Spain
    Clin Exp Rheumatol 29:681-8. 2011
    ..In this study we assessed the potential association of two NAMPT gene polymorphisms with disease susceptibility and cardiovascular (CV) risk in patients with rheumatoid arthritis (RA)...
  39. doi request reprint Association of the methionine sulfoxide reductase A rs10903323 gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis
    M Garcia-Bermudez
    Institute of Parasitology and Biomedicine of the Spanish National Research Council, Granada, Spain
    Scand J Rheumatol 41:350-3. 2012
    ..The aim of the present study was to determine whether the MSRA gene is implicated in susceptibility to cardiovascular (CV) disease in RA patients...
  40. ncbi request reprint Involvement of macrophage migration inhibitory factor gene in celiac disease susceptibility
    C Nunez
    Servicio de Inmunología Clínica, Hospital Clinico San Carlos, Madrid, Spain
    Genes Immun 8:168-70. 2007
    ..33 (1.00-1.76); P=0.04). Our data evidence for first time the role of the MIF gene increasing predisposition to CD. A common effect of MIF variants seems to underlie the etiology of these complex conditions...
  41. ncbi request reprint Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis
    G Orozco
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Rheumatology (Oxford) 47:138-41. 2008
    ....
  42. ncbi request reprint A poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis
    M Pascual
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Arthritis Rheum 48:638-41. 2003
    ..To investigate the association of the poly(ADP-ribose) polymerase 1 (PARP-1) gene promoter polymorphism with rheumatoid arthritis (RA) predisposition...
  43. ncbi request reprint Investigation of CD69 as a new candidate gene for rheumatoid arthritis
    B Rueda
    Consejo Superior de Investigaciones Cientificas, Instituto de Parasitologia y Biomedicina Lopez Neyra, Granada, Spain
    Tissue Antigens 72:206-10. 2008
    ..In summary, our results do not support a major role for the CD69 gene polymorphisms in RA genetic predisposition in our population...
  44. doi request reprint No evidence for genetic association of interferon regulatory factor 3 in systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Lupus 18:230-4. 2009
    ..Our data suggest that the IRF3 polymorphisms do not appear to play a major role in the susceptibility or severity of SLE in a Spanish population...
  45. ncbi request reprint Lack of association between IL-6-174G/C gene polymorphism and Chagas disease
    O A Torres
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Tissue Antigens 76:131-4. 2010
    ..Our results do not support an evidence for a major role contribution of this IL-6 gene polymorphism in the susceptibility to or clinical manifestations of Chagas disease in these studied cohorts...
  46. doi request reprint Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach
    R J Palomino-Morales
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Genes Immun 10:356-64. 2009
    ..014, pooled OR=1.13). In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC...
  47. ncbi request reprint Poly (ADP-ribose) polymerase-1 haplotypes are associated with coeliac disease
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra CSIC, Parque Tecnológico de Ciencias de la Salud, Avda del Conocimiento, S N, 18100 Armilla, Granada, Spain
    Int J Immunogenet 32:245-8. 2005
    ..007, OR 1.79 95%CI 1.14-2.82). Our results provide the first evidence that PARP-1 haplotypes are related with coeliac disease susceptibility...
  48. ncbi request reprint Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition
    M Pascual
    Instituto de Parasitología y López Neyra, Biomedicina, CSIC, Granada, Spain
    Arthritis Rheum 44:307-14. 2001
    ....
  49. ncbi request reprint Association of MICA-A5.1 allele with susceptibility to celiac disease in a family study
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Am J Gastroenterol 98:359-62. 2003
    ..The aim of this study was to analyze the role of the major histocompatibility complex class I chain-related gene A (MICA) transmembrane polymorphism in celiac disease (CD) susceptibility...
  50. doi request reprint The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Ann Rheum Dis 67:1451-4. 2008
    ..The aim of the current study was to investigate, for the first time, the possible involvement of the IL23R gene in genetic susceptibility to ankylosing spondylitis (AS)...
  51. ncbi request reprint CA microsatellite polymorphism of the nuclear factor kappa B1 gene in celiac disease
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Eur J Immunogenet 31:129-32. 2004
    ..These results suggest that the NFKB1 CAn microsatellite does not play a major role in CD susceptibility. In addition, a more detailed molecular characterization of the CA microsatellite is described...
  52. ncbi request reprint Interleukin-6 gene -174 promoter polymorphism is associated with endothelial dysfunction but not with disease susceptibility in patients with rheumatoid arthritis
    R Palomino-Morales
    Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
    Clin Exp Rheumatol 27:964-70. 2009
    ..To determine whether the interleukin (IL)6 -174 gene polymorphism may influence the development of subclinical atherosclerosis manifested by the presence of endothelial dysfunction in RA patients...
  53. pmc Epistatic interaction between FCRL3 and NFkappaB1 genes in Spanish patients with rheumatoid arthritis
    A Martinez
    Immunology Department, Hospital Clinico San Carlos, C Martín Lagos, S N, 28040 Madrid, Spain
    Ann Rheum Dis 65:1188-91. 2006
    ..A Japanese study has described a strong association between rheumatoid arthritis and several polymorphisms located in the Fc receptor-like 3 (FCRL3) gene, a member of a family of genes related to Fc receptors located on chromosome 1q21-23...
  54. ncbi request reprint Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus
    E Sanchez
    Biología Celular e Inmunología, Consejo Superior de Investigaciones Cientificas, Technological Park of the Health Sciences, Avenida del Conocimiento s n, 18100 Armilla, Granada, Spain
    Tissue Antigens 70:233-7. 2007
    ..These results suggest that IL23R polymorphisms do not appear to play an important role in the susceptibility or severity of SLE in the Spanish population...
  55. ncbi request reprint HLA haplotypes and susceptibility to rheumatoid arthritis. More than class II genes
    M Pascual
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Scand J Rheumatol 31:275-8. 2002
    ..The present results along with data from others prove the existence of a second predisposing locus located inside the MHC region, and suggest that might be located within the TNFa-HLA-B region...
  56. ncbi request reprint Analysis of the functional NFKB1 promoter polymorphism in rheumatoid arthritis and systemic lupus erythematosus
    G Orozco
    Instituto de Parasitologia y Biomedicina, Granada, Spain
    Tissue Antigens 65:183-6. 2005
    ..From these results, it seems that the -94ins/delATTG and the (CA)(n) repeat of NFKB1 gene may not play a relevant role in RA and/or SLE in our population...
  57. doi request reprint STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians
    R J Palomino-Morales
    Instituto de Biomedicina López Neyra, Consejo Superior de Investigaciones Cientificas, Granada, Spain
    Genes Immun 9:379-82. 2008
    ..Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases...
  58. ncbi request reprint Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy
    J E Calzada
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, C Ventanilla 11, 18001 Granada, Spain
    Tissue Antigens 58:154-8. 2001
    ..02; OR=0.35, 95% CI 0.12-0.96). Our data suggest that the CCR5 59029 promoter polymorphism may be involved in a differential susceptibility to chagasic cardiomyopathy...
  59. ncbi request reprint Lack of association between LEP rs2167270 (19 G>A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis
    M Garcia-Bermudez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, C S I C, Granada, Spain
    Clin Exp Rheumatol 29:293-8. 2011
    ..To assess the potential association between LEP rs2167270 (19 G>A) gene polymorphism and disease susceptibility and cardiovascular disease (CV) in patients with rheumatoid arthritis (RA)...
  60. ncbi request reprint Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC Parque Tecnológico de Ciencias de la Salud, Armilla Granada, Spain
    Rheumatology (Oxford) 44:1136-9. 2005
    ..In addition, we have undertaken a systematic search for genetic variants of interleukin 23 (IL23A)...
  61. ncbi request reprint HLA class I and class II allele distribution in the Peruvian population
    R de Pablo
    Servicio de Inmunologia, Clinica Puerta de Hierro, Madrid, Spain
    Tissue Antigens 56:507-14. 2000
    ....
  62. ncbi request reprint The inducible nitric oxide synthase promoter polymorphism does not confer susceptibility to systemic lupus erythematosus
    M A Lopez-Nevot
    Servicio de Inmunologia, Hospital Virgen de las Nieves, CSIC, Granada, Spain
    Rheumatology (Oxford) 42:113-6. 2003
    ..We studied the possible contribution of (CCTTT)(n) microsatellite polymorphism in the NOS2 promoter region to susceptibility to SLE and the clinical outcome of the disease...
  63. ncbi request reprint Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis
    B Rueda
    Instituto de Parasitologia y Biomedicina, 18100 Armilla, Granada, Spain
    Tissue Antigens 65:544-8. 2005
    ..Our data suggest that -607 A/C (rs1946518) and -137 G/C (rs187238) polymorphisms within the IL-18-promoter region do not play a major role in RA predisposition...
  64. ncbi request reprint Genetic polymorphisms in Spanish rheumatoid arthritis patients: an association and linkage study
    A Martinez
    Servico de Immunologiá Clinica, Hospital Universitario San Carlos, Madrid, Spain
    Genes Immun 4:117-21. 2003
    ..No other allele in the present study is found to be associated to RA. Our data suggest that most of the loci studied play no major role in the susceptibility to RA, the IL-10 gene being the sole exception...
  65. ncbi request reprint Systemic lupus erythematosus in southern Spain: a comparative clinical and genetic study between Caucasian and Gypsy patients
    L M Ramal
    Servicio de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
    Lupus 13:934-40. 2004
    ..008, Pc = 0.032). In conclusion, we found some clinical differences between WCM and Gypsy patients with SLE. Furthermore, HLA associations between HLA-DRB1-DQB1 and SLE were different for Gypsy people...
  66. ncbi request reprint Cytotoxic T-lymphocyte antigen-4-CT60 polymorphism in rheumatoid arthritis
    G Orozco
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Tissue Antigens 64:667-70. 2004
    ....
  67. ncbi request reprint Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Clin Exp Rheumatol 27:267-71. 2009
    ..The aim of this study was to evaluate the relevance of genetic variants of TLR5 (rs5744168) and TLR7 (rs179008) gene in systemic lupus erythematosus (SLE) in a Spanish population...
  68. doi request reprint Vascular endothelial growth factor A and cardiovascular disease in rheumatoid arthritis patients
    L Rodriguez-Rodriguez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Armilla, Granada, Spain
    Tissue Antigens 77:291-7. 2011
    ..VEGFA polymorphisms do not seem to exert a significant influence on the risk of CV disease in patients with RA...
  69. doi request reprint Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis
    R López-Mejías
    Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain
    Tissue Antigens 78:438-41. 2011
    ..In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA...
  70. pmc Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis
    A Serrano
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Ann Rheum Dis 72:1882-6. 2013
    ..To analyse the role of the PTPN22 and CSK genes, previously associated with autoimmunity, in the predisposition and clinical phenotypes of giant cell arteritis (GCA)...
  71. ncbi request reprint Prevalence and intensity of haemogregarinid blood parasites in a population of the Iberian rock lizard, Lacerta monticola
    L Amo
    Departamento de Ecologia Evolutiva, Museo Nacional de Ciencias Naturales, CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    Parasitol Res 94:290-3. 2004
    ..The parasite load had a negative effect on the body condition during the reproductive season. The results suggest that the interactions between parasites and hosts are not stable in this lizard population...
  72. ncbi request reprint Genetic determinants of rheumatoid arthritis: the inducible nitric oxide synthase (NOS2) gene promoter polymorphism
    M Pascual
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Genes Immun 3:299-301. 2002
    ..After evaluating for the first time the influence of NOS2 promoter polymorphism in RA, it seems to have no major effect on disease susceptibility and/or outcome...
  73. pmc Association study of functional genetic variants of innate immunity related genes in celiac disease
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    BMC Med Genet 6:29. 2005
    ..In this work for the first time we have assessed the relevance of different proinflammatory mediators typically related to innate immunity in CD predisposition...
  74. doi request reprint Lack of association of ACP1 gene with inflammatory bowel disease: a case-control study
    M Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Armilla, Granada, Spain
    Tissue Antigens 80:61-4. 2012
    ..After the analysis, no evidence of association of the ACP1 genetic variants was found with CD or UC. Therefore, our results suggest that the ACP1 gene may not play a relevant role in the development of IBD...
  75. doi request reprint Association of Toll-like receptor 10 and susceptibility to Crohn's disease independent of NOD2
    C Abad
    Servicio de Inmunologia, Instituto de Biomedicina, Hospital Universitario Virgen del Rocio, Sevilla, Spain
    Genes Immun 12:635-42. 2011
    ..36%), indicating redundancy or independent effects. Our results support association of the TLR10 gene with CD susceptibility. The effect of TLR10 would be independent of NOD2, suggesting different signaling pathways for both genes...
  76. ncbi request reprint Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to Henoch-Schönlein purpura
    G Orozco
    The Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
    Clin Exp Rheumatol 25:750-3. 2007
    ..To assess the possible association between the PTPN22 gene 1858C-->T polymorphism and the susceptibility to Henoch-Schönlein purpura (HSP) and determine if this polymorphism is implicated in the severity of this systemic vasculitis...
  77. ncbi request reprint PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases
    L M Gomez
    Cellular Biology and Immunogenetics Unit CBIU, Corporación para Investigaciones Biológicas CIB and Universidad de Antioquia, Medellin, Colombia, CSIC, Granada, Spain
    Genes Immun 6:628-31. 2005
    ..26). These results confirm the influence of PTPN22 in autoimmunity and indicate that autoimmune phenotypes could represent pleiotropic outcomes of nonspecific disease genes that underlie similar immunogenetic mechanisms...
  78. ncbi request reprint Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection
    G Robledo
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Tissue Antigens 69:261-4. 2007
    ..Our findings suggest that the PTPN22 polymorphism analyzed does not play a major role in the development of Chagas' disease in the Colombian and Peruvian populations...
  79. ncbi request reprint No evidence for association of the inducible nitric oxide synthase promoter polymorphism with Trypanosoma cruzi infection
    J E Calzada
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Tissue Antigens 59:316-9. 2002
    ..Our data suggest that the NOS2 promoter pentanucleotide microsatellite polymorphisms analyzed do not play a major role in the pathogenesis of chronic T. cruzi infection in this Peruvian sample...
  80. ncbi request reprint Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Tissue Antigens 63:54-7. 2004
    ....
  81. doi request reprint Lack of association between ADIPOQ rs266729 and ADIPOQ rs1501299 polymorphisms and cardiovascular disease in rheumatoid arthritis patients
    L Rodriguez-Rodriguez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, C S I C, Granada, Spain
    Tissue Antigens 77:74-8. 2011
    ..Therefore, ADIPOQ rs266729 and rs1501299 polymorphisms do not seem to be associated with cardiovascular disease in RA...
  82. ncbi request reprint A functional variant of IFNgamma gene is associated with coeliac disease
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Genes Immun 5:517-9. 2004
    ..This fact might be due to parent-of-origin effect in the IFNgamma CA polymorphism. Our data suggest a possible role of IFNgamma CA polymorphism in CD susceptibility...
  83. ncbi request reprint Genetic basis of rheumatoid arthritis
    G Orozco
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s n 18100 Armilla, Granada, Spain
    Biomed Pharmacother 60:656-62. 2006
    ..In this work we review the progress made in the field of RA genetics, focusing mainly on the contribution of candidate gene association studies to the dissection of RA genetic risk factors...
  84. ncbi request reprint Prevalence and intensity of haemogregarine blood parasites and their mite vectors in the common wall lizard, Podarcis muralis
    L Amo
    Departamento de Ecologia Evolutiva, Museo Nacional de Ciencias Naturales, CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    Parasitol Res 96:378-81. 2005
    ..Parasite load was higher in lizards with better body condition, which could be reflecting the mortality of infected lizards with poor condition...
  85. ncbi request reprint Interleukin 4, interleukin 4 receptor-α and interleukin 10 gene polymorphisms in Chagas disease
    O Flórez
    Grupo de Inmunología y Epidemiología Molecular, GIEM, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia Instituto de Parasitología y Biomedicina López Neyra, CSIC, Granada, Spain
    Parasite Immunol 33:506-11. 2011
    ..Our experimental evidence suggests that the IL4RA +148 AA genotype has a weak association with the development of chagasic cardiomyopathy in the population under study...
  86. doi request reprint PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection
    M A Montes-Cano
    Servicio de Inmunologia, Hospital Universitario Virgen del Rocio, Sevilla, Spain
    Viral Immunol 21:491-4. 2008
    ..8%; p = 0.5), and the NSR with the SR group (11.5% versus 14.6%; p = 0.4). Our results do not support a major role of this polymorphism of the PTPN22 gene in the outcome of chronic hepatitis C virus infection in the Spanish population...
  87. pmc A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype
    B Rueda
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Parque Tecnologico Ciencias de la Salud, Avenida del Conocimiento s n 18100 Armilla, Granada, Spain
    Ann Rheum Dis 68:1618-20. 2009
    ..To conduct a replication study to investigate whether the -945 CTGF genetic variant is associated with systemic sclerosis (SSc) susceptibility or specific SSc phenotype...
  88. ncbi request reprint Lack of association between NRAMP1 gene polymorphisms and Trypanosoma cruzi infection
    J E Calzada
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Tissue Antigens 57:353-7. 2001
    ..Our data suggest that the NRAMP1 genetic polymorphism analysed do not play a major role in the pathogenesis of T. cruzi infection in this Peruvian sample...
  89. doi request reprint In-vitro radiosensitivity in patients with systemic lupus erythematosus
    P L Carrillo-Alascio
    Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, Spain
    Lupus 18:645-9. 2009
    ..According to these results, and with the caution of being a limited laboratory study, the use of radiotherapy should not be avoided in patients with SLE when it is clinically needed...
  90. pmc Chemoreception, symmetry and mate choice in lizards
    J Martin
    Departamento de Ecologia Evolutiva, Museo Nacional de Ciencias Naturales, CSIC, Madrid, Spain
    Proc Biol Sci 267:1265-9. 2000
    ..We suggest that the quality and/or amount of male pheromones could communicate the heritable genetic quality of a male to the female and thereby serve as the basis for adaptive female choice in lizards...
  91. ncbi request reprint Hindlimb asymmetry reduces escape performance in the lizard Psammodromus algirus
    J Martin
    Departamento de Ecologia Evolutiva, Museo Nacional de Ciencias Naturales, Consejo Superior de Investigaciones Cientificas CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    Physiol Biochem Zool 74:619-24. 2001
    ..We discuss the possible basis of these alterations of locomotion, the relevance of reduced performance for the ecology of this species, and how individuals may compensate for the costs of asymmetry...
  92. ncbi request reprint Prevalence and intensity of blood and intestinal parasites in a field population of a Mediterranean lizard, Lacerta lepida
    L Amo
    Departamento de Ecologia Evolutiva, Museo Nacional de Ciencias Naturales, CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    Parasitol Res 96:413-7. 2005
    ..However, neither the intensity of haemogregarine's infection nor the prevalence of intestinal parasites was related to the lizards' body condition...
  93. pmc BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians
    B Rueda
    Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, University of Milan corrected
    Ann Rheum Dis 69:700-5. 2010
    ..To investigate the possible association of the BANK1 gene with genetic susceptibility to systemic sclerosis (SSc) and its subphenotypes...
  94. ncbi request reprint TAP1 and TAP2 polymorphism in Spanish patients with ankylosing spondylitis
    A Fraile
    Instituto de Parasitologia y Biomedicina Lopez Neyra, C S I C, Granada, Spain
    Exp Clin Immunogenet 17:199-204. 2000
    ..We studied the influence of polymorphism in the transporter associated with antigen processing (TAP) genes, including point mutations not previously analyzed...
  95. ncbi request reprint The -174/-597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis
    M Fedetz
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Calle Ventanilla 11, 18001, Granada, Spain
    J Neurol Sci 190:69-72. 2001
    ..Future studies focusing on complex transcriptional interactions between the IL-6pr and 3' flanking region polymorphic sites will be necessary to determine the IL-6 haplotype influence on susceptibility to MS...
  96. ncbi request reprint A new HLA-Cw*15 allele, Cw*1508, identified in the Peruvian population
    L Sanz
    Servicio de Inmunologia, Clinica Puerto de Hierro, Madrid, Spain
    Tissue Antigens 53:391-3. 1999
    ..The nucleotide sequence of Cw*1508 only differs from that of Cw*1502 at position 539; this change determines the replacement of Leu by Arg 156 in Cw*1508...
  97. ncbi request reprint Comparison of genotypic and phenotypic techniques for assessing the variability of the fungus Epicoccum nigrum
    F Arenal
    Centro de Investigación Basica Merck Sharp and Dohme de España S A, Madrid, Spain
    J Appl Microbiol 93:36-45. 2002
    ..In addition, the abilities of phenotypic and genotypic techniques for the differentiation of a set of isolates are compared...
  98. ncbi request reprint Lack of association between interleukin-6 promoter polymorphism at position -174 and Henoch-Schönlein pur pura
    M M Amoli
    The Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Rheumatol 25:S6-9. 2007
    ..A further objective was to determine if any relationship existed with severe systemic complications of HSP, in particular with severe renal and gastrointestinal involvement...
  99. ncbi request reprint A new large CFTR rearrangement illustrates the importance of searching for complex alleles
    F Niel
    Service de Biochimie Génétique, Hôpital Henri Mondor AP HP, Creteil, France
    Hum Mutat 27:716-7. 2006
    ..Val754Met with CF. We thus suggest looking for a possible complex allele whenever p.Val754Met is detected and considering it neutral regarding genetic counseling when found in isolation...
  100. ncbi request reprint The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci
    E Zanelli
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, The Netherlands
    Hum Immunol 62:75-84. 2001
    ..We conclude that the telomeric part of the HLA region contains a locus conferring predisposition to RA independently of HLA class II...
  101. ncbi request reprint Lack of association between macrophage migration inhibitory factor gene (-173 G/C) polymorphism and cutaneous vasculitis
    M M Amoli
    The Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Rheumatol 24:576-9. 2006
    ..A further objective was to determine if any relationship existed with severe systemic complications of HSP, in particular with severe renal involvement and permanent renal dysfunction...