Oscar Marin

Summary

Country: Spain

Publications

  1. doi request reprint Cellular and molecular mechanisms controlling the migration of neocortical interneurons
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas, Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Eur J Neurosci 38:2019-29. 2013
  2. doi request reprint A new beginning for a broken mind: balancing neuregulin 1 reverses synaptic dysfunction
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain Electronic address
    Neuron 78:577-9. 2013
  3. doi request reprint Human cortical interneurons take their time
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Cell Stem Cell 12:497-9. 2013
  4. doi request reprint Interneuron dysfunction in psychiatric disorders
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Nat Rev Neurosci 13:107-20. 2012
  5. ncbi request reprint Cell migration in the forebrain
    Oscar Marin
    Unidad de Neurobiologia del Desarrollo, Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, 03550 San Juan de Alicante, Spain
    Annu Rev Neurosci 26:441-83. 2003
  6. ncbi request reprint [Origin of cortical interneurons: basic concepts and clinical implications]
    O Marin
    Division of Neurobiología del Desarrollo, Instituto de Neurociencias, CSIC, Universidad Miguel Hernandez, San Juan de Alicate, Alicate, Espana
    Rev Neurol 35:743-51. 2002
  7. pmc Guiding neuronal cell migrations
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Cold Spring Harb Perspect Biol 2:a001834. 2010
  8. ncbi request reprint Neurons in motion: same principles for different shapes?
    Oscar Marin
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Trends Neurosci 29:655-61. 2006
  9. doi request reprint A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
    Diego Gelman
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    J Neurosci 31:16570-80. 2011
  10. doi request reprint The embryonic preoptic area is a novel source of cortical GABAergic interneurons
    Diego M Gelman
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 29:9380-9. 2009

Collaborators

Detail Information

Publications35

  1. doi request reprint Cellular and molecular mechanisms controlling the migration of neocortical interneurons
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas, Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Eur J Neurosci 38:2019-29. 2013
    ....
  2. doi request reprint A new beginning for a broken mind: balancing neuregulin 1 reverses synaptic dysfunction
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain Electronic address
    Neuron 78:577-9. 2013
    ..These abnormalities can be reverted by restoring normal levels of Neuregulin 1, opening possibilities for the treatment of mental disease...
  3. doi request reprint Human cortical interneurons take their time
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Cell Stem Cell 12:497-9. 2013
    ..Functional maturation of these neurons occurs over a protracted period, which resembles normal human development, and suggests these cells may be useful for modeling brain development and disease...
  4. doi request reprint Interneuron dysfunction in psychiatric disorders
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Nat Rev Neurosci 13:107-20. 2012
    ..These insights are leading to a better understanding of the causes of schizophrenia, autism and intellectual disabilities, and may contribute to the development of more-effective therapeutic interventions...
  5. ncbi request reprint Cell migration in the forebrain
    Oscar Marin
    Unidad de Neurobiologia del Desarrollo, Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, 03550 San Juan de Alicante, Spain
    Annu Rev Neurosci 26:441-83. 2003
    ....
  6. ncbi request reprint [Origin of cortical interneurons: basic concepts and clinical implications]
    O Marin
    Division of Neurobiología del Desarrollo, Instituto de Neurociencias, CSIC, Universidad Miguel Hernandez, San Juan de Alicate, Alicate, Espana
    Rev Neurol 35:743-51. 2002
    ..Aims. In this review I have summarized our current knowledge of the factors that control the specification of cortical interneurons, as well as the mechanisms that direct their migration to the cortex...
  7. pmc Guiding neuronal cell migrations
    Oscar Marin
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Cold Spring Harb Perspect Biol 2:a001834. 2010
    ..Perhaps more surprisingly, the cellular mechanisms underlying the response of the leading process of migrating cells to guidance cues might be different to those involved in growth cone steering, at least for some neuronal populations...
  8. ncbi request reprint Neurons in motion: same principles for different shapes?
    Oscar Marin
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Trends Neurosci 29:655-61. 2006
    ..According to this idea, the same basic molecular mechanisms found in other cell types, such as fibroblasts, might have been adapted to the special morphological needs of migrating neurons in different regions of the developing brain...
  9. doi request reprint A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
    Diego Gelman
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    J Neurosci 31:16570-80. 2011
    ..Together with earlier findings, our results also suggest that the POA generates nearly 10% of the GABAergic interneurons in the cerebral cortex of the mouse...
  10. doi request reprint The embryonic preoptic area is a novel source of cortical GABAergic interneurons
    Diego M Gelman
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 29:9380-9. 2009
    ....
  11. doi request reprint Slit/Robo signaling modulates the proliferation of central nervous system progenitors
    Victor Borrell
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Neuron 76:338-52. 2012
    ..At the molecular level, the role of Slit/Robo in progenitor cells involves transcriptional activation of the Notch effector Hes1. These findings demonstrate that Robo signaling modulates progenitor cell dynamics in the developing brain...
  12. doi request reprint Origin and molecular specification of globus pallidus neurons
    Sandrina Nóbrega-Pereira
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, Sant Joan d Alacant, Spain
    J Neurosci 30:2824-34. 2010
    ....
  13. pmc Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation
    Guillermina López-Bendito
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Cell 125:127-42. 2006
    ..These results show that neuronal tangential migration constitutes a novel mechanism to control the timely arrangement of guidance cues required for axonal tract formation in the mammalian brain...
  14. doi request reprint Chemokine signaling controls intracortical migration and final distribution of GABAergic interneurons
    Guillermina López-Bendito
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 28:1613-24. 2008
    ....
  15. doi request reprint Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes
    Isabel del Pino
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Neuron 79:1152-68. 2013
    ..Our results reinforce the view that dysfunction of cortical fast-spiking interneurons might be central to the pathophysiology of schizophrenia. ..
  16. doi request reprint Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling
    Pietro Fazzari
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Nature 464:1376-80. 2010
    ....
  17. ncbi request reprint Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling
    Victor Borrell
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Nat Neurosci 9:1284-93. 2006
    ..Thus, the meningeal membranes are fundamental in the development of Cajal-Retzius cells and, hence, in the normal development of the cerebral cortex...
  18. doi request reprint Lineage-specific laminar organization of cortical GABAergic interneurons
    Gabriele Ciceri
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant, Spain
    Nat Neurosci 16:1199-210. 2013
    ..Thus, specific lineages of cortical interneurons seem to be produced to primarily mirror the laminar structure of the cerebral cortex, rather than its columnar organization. ..
  19. pmc Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors
    Sandrina Nóbrega-Pereira
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Neuron 59:733-45. 2008
    ..Our results demonstrate a role for the cell-fate determinant Nkx2-1 in regulating neuronal migration by direct transcriptional regulation of guidance receptors in postmitotic cells...
  20. ncbi request reprint Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain
    Guillermina López-Bendito
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 27:3395-407. 2007
    ..Our results demonstrate that Robo1 and Robo2 mostly cooperate to mediate the function of Slit proteins in guiding the major forebrain projections...
  21. doi request reprint Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration
    Francisco J Martini
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Development 136:41-50. 2009
    ..These results reveal a novel guidance mechanism during neuronal migration that might be extensively used in brain development...
  22. ncbi request reprint Layer acquisition by cortical GABAergic interneurons is independent of Reelin signaling
    Ramón Pla
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 26:6924-34. 2006
    ....
  23. doi request reprint Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26
    Manuel Valiente
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 31:11678-91. 2011
    ..These results indicate that FAK plays a fundamental role in the dynamic regulation of Gap-mediated adhesions during glial-guided neuronal migration in the mouse...
  24. ncbi request reprint Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 27:9682-95. 2007
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains...
  25. pmc Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells
    Verona Villar-Cerviño
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Neuron 77:457-71. 2013
    ..At the molecular level, we found that contact repulsion is mediated by Eph/ephrin interactions. Our observations reveal a mechanism that controls the even distribution of neurons in the developing brain...
  26. doi request reprint Cxcr7 controls neuronal migration by regulating chemokine responsiveness
    Juan Antonio Sánchez-Alcañiz
    Instituto de Neurociencias, Consejo Superior Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Neuron 69:77-90. 2011
    ..This demonstrates that a chemokine receptor modulates the function of another chemokine receptor by controlling the amount of protein that is made available for signaling at the cell surface...
  27. doi request reprint Integration of GABAergic interneurons into cortical cell assemblies: lessons from embryos and adults
    Giorgia Bartolini
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Neuron 79:849-64. 2013
    ..To this end, we analyze similarities and differences between the integration of GABAergic interneurons in the developing cerebral cortex and in the postnatal brain, using the neocortex and the olfactory bulb as model systems. ..
  28. ncbi request reprint Developmental mechanisms underlying the generation of cortical interneuron diversity
    Nuria Flames
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Campus de San Juan, 03550 San Joan d Alacant, Spain
    Neuron 46:377-81. 2005
    ..Here, we review recent data on how the large variety of distinct classes of cortical interneurons may arise during development...
  29. doi request reprint Neuregulin signaling, cortical circuitry development and schizophrenia
    Beatriz Rico
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Curr Opin Genet Dev 21:262-70. 2011
    ..We will also discuss how this basic knowledge may help us to understand the etiology of schizophrenia, and eventually lead to the development of novel therapies for treating the disorder...
  30. doi request reprint Transcriptional control of neuronal migration in the developing mouse brain
    Sandrina Nóbrega-Pereira
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Cereb Cortex 19:i107-13. 2009
    ..In this review, we will describe recent progress made in understanding the contribution of transcription factors in controlling neuronal migration in the developing mouse brain, with a special focus on the developing telencephalon...
  31. doi request reprint Generation of interneuron diversity in the mouse cerebral cortex
    Diego M Gelman
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Eur J Neurosci 31:2136-41. 2010
    ..In this review, we summarize recent progress on this process, progress which holds the promise of providing a rational framework for their classification, as well as means to understand their role in cortical processing...
  32. ncbi request reprint Thalamocortical topography reloaded: it's not where you go, but how you get there
    Oscar Marin
    Developmental Neurobiology Unit, Institute of Neurosciences, University Miguel Hernández and CSIC, 03550 San Juan de Alicante, Spain
    Neuron 39:388-91. 2003
  33. doi request reprint Neuronal migration mechanisms in development and disease
    Manuel Valiente
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Curr Opin Neurobiol 20:68-78. 2010
    ..We will also review how this basic knowledge is contributing to a better understanding of the etiology and pathophysiology of multiple neurological syndromes in which neuronal migration is disrupted...
  34. ncbi request reprint Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 San Joan d Alacant, Spain
    Neuron 44:251-61. 2004
    ..These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system...
  35. ncbi request reprint Differential expression of Eph receptors and ephrins correlates with the formation of topographic projections in primary and secondary visual circuits of the embryonic chick forebrain
    O Marin
    Instituto Cajal, CSIC, Doctor Arce 37, Madrid, 28002, Spain
    Dev Biol 234:289-303. 2001
    ..These results suggest a conserved function for EphA receptors and their ligands in the elaboration of topographic maps at multiple levels of the visual pathway...