Research Topics
Genomes and Genes | J M LuqueSummaryCountry: Spain Publications
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Publications
Whole-mount confocal immunofluorescence of mammalian CNSJ M Luque
Instituto de Neurociencias, CSIC, Universidad Miguel Hernandez, Campus de San Juan, E 03550 San Juan de Alicante, Spain
Brain Res Brain Res Protoc 6:129-33. 2001..Examples are shown of preparations in which colocalization can be observed in nerve cells of cytoskeletal and calcium-binding proteins...
Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical developmentJuan M Luque
Instituto de Neurociencias, Universidad Miguel Hernandez, CSIC, Campus de San Juan, E 03550, San Juan de Alicante, Spain
Brain Res Dev Brain Res 140:195-203. 2003..They are also consistent with a working model of reelin action, according to which reelin signaling on the newborn neuron-inherited radial process regulates perikaryal translocation and positioning...
Neural stem cells and the quest for restorative neurologyJ M Luque
Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, San Juan de Alicante, Spain
Histol Histopathol 19:271-80. 2004..A brief survey of current stem cell-based experimental literature tries to provide a realistic picture of how far we have gone in the quest to establish a restorative neurology...
Integrin and the Reelin-Dab1 pathway: a sticky affair?Juan M Luque
Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Campus de San Juan s n, E 03550 San Juan de Alicante, Alicante, Spain
Brain Res Dev Brain Res 152:269-71. 2004..This proposal however is hardly compatible with time-lapse anatomical investigations and genetic studies on integrin or with recent works which indicate direct reelin signalling to radial fibers...
Puzzling out the reeler brainteaser: does reelin signal to unique neural lineages?Juan M Luque
Instituto de Neurociencias, UMH CSIC, San Juan de Alicante, Spain
Brain Res 1140:41-50. 2007..I hereby submit a personal glimpse of reeler morphogenesis which embodies a testable hypothesis; namely, that reelin signals to unique neural lineages to regulate migration...
Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's diseaseJavier Saez-Valero
Instituto de Neurociencias, UMH CSIC, Campus de San Juan, San Juan, Alicante, Spain
J Neurosci Res 72:132-6. 2003..7 +/- 6.7 arbitrary units; a.u.) and AD (151.4 +/- 3.8 a.u.) compared with control individuals (141.4 +/- 1.2 a.u., P < 0.05). Our results strongly suggest the involvement of reelin signaling in neurodegenerative pathologies...
Reelin signaling directly affects radial glia morphology and biochemical maturationEva Hartfuss
Max Planck Institute of Neurobiology, Neuronal Specification, Am Klopferspitz 18a, D 82152 Martinsried, Germany
Development 130:4597-609. 2003..Taken together, these results unravel a novel role of reelin signaling to radial glial cells that is crucial for the regulation of their Blbp content and characteristic morphology in a region-specific manner...
