Ma Isabel Lucena

Summary

Country: Spain

Publications

  1. ncbi request reprint Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period
    Raul J Andrade
    Unidad de Hepatología y Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos, Coordinating Centre, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos s n, Malaga, Spain
    Gastroenterology 129:512-21. 2005
  2. ncbi request reprint Comparison of two clinical scales for causality assessment in hepatotoxicity
    M I Lucena
    Servicio de Farmacologia Clinica, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos s n, Malaga, Spain
    Hepatology 33:123-30. 2001
  3. doi request reprint Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis
    M I Lucena
    Servicio de Farmacologia Clinica, Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos, Co ordinating Centre, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos s n, Malaga, Spain
    J Hepatol 55:820-7. 2011
  4. doi request reprint Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex
    M Isabel Lucena
    Clincal Pharmacology Service, School of Medicine, University Hospital Virgen de la Victoria, Malaga, Spain
    Hepatology 49:2001-9. 2009
  5. doi request reprint Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury
    M Isabel Lucena
    Servicio de Farmacologia Clinica, Clinical Pharmacology Service, Liver Unit University Hospital School of Medicine, Malaga, Spain
    Hepatology 48:588-96. 2008
  6. doi request reprint Assessment of drug-induced liver injury in clinical practice
    Ma Isabel Lucena
    Servicio de Farmacologia Clinica, Hospital Universitario Virgen de Victoria, School of Medicine, Malaga, Spain
    Fundam Clin Pharmacol 22:141-58. 2008
  7. ncbi request reprint Determinants of the clinical expression of amoxicillin-clavulanate hepatotoxicity: a prospective series from Spain
    M Isabel Lucena
    Servicio de Farmacologia Clinica, Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos, Coordinating Centre, Hospital Universitario Virgen de la Victoria, Malaga, Spain
    Hepatology 44:850-6. 2006
  8. ncbi request reprint Prolonged cholestasis after raloxifene and fenofibrate interaction: A case report
    M Isabel Lucena
    Department of Clinical Pharmacology, Facultad de Medicina, E 29071 Malaga, Spain
    World J Gastroenterol 12:5244-6. 2006
  9. ncbi request reprint The administration of N-acetylcysteine causes a decrease in prothrombin time in patients with paracetamol overdose but without evidence of liver impairment
    M Isabel Lucena
    Clinical Pharmacology Service, Hospital Universitario, School of Medicine, University of Malaga, Malaga, Spain
    Eur J Gastroenterol Hepatol 17:59-63. 2005
  10. doi request reprint [Hepatotoxicity, a global problem with local features: toward the creation of a Pan-American Hepatotoxicity Network]
    Maria Isabel Lucena
    Servicio de Farmacología Clínica y Unidad de Hepatología, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Universidad de Malaga, Malaga, Espana
    Gastroenterol Hepatol 34:361-8. 2011

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period
    Raul J Andrade
    Unidad de Hepatología y Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos, Coordinating Centre, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos s n, Malaga, Spain
    Gastroenterology 129:512-21. 2005
    ..Progress in the understanding of susceptibility factors to drug-induced liver injury (DILI) and outcome predictability are hampered by the lack of systematic programs to detect bona fide cases...
  2. ncbi request reprint Comparison of two clinical scales for causality assessment in hepatotoxicity
    M I Lucena
    Servicio de Farmacologia Clinica, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos s n, Malaga, Spain
    Hepatology 33:123-30. 2001
    ..The performance of the M&V scale was poor in reactions with long latency periods (i.e., amoxycillin/clavulanic acid), evolution to chronicity after withdrawal (cholestatic pattern), or death...
  3. doi request reprint Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis
    M I Lucena
    Servicio de Farmacologia Clinica, Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos, Co ordinating Centre, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos s n, Malaga, Spain
    J Hepatol 55:820-7. 2011
    ..We have sought evidence of the frequency and characteristics of patients who have experienced two DILI episodes due to different drugs...
  4. doi request reprint Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex
    M Isabel Lucena
    Clincal Pharmacology Service, School of Medicine, University Hospital Virgen de la Victoria, Malaga, Spain
    Hepatology 49:2001-9. 2009
    ..Women distinctly exhibit the worst outcome. Knowledge of these phenotypic associations could guide differential diagnosis and attribution of causality in DILI...
  5. doi request reprint Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury
    M Isabel Lucena
    Servicio de Farmacologia Clinica, Clinical Pharmacology Service, Liver Unit University Hospital School of Medicine, Malaga, Spain
    Hepatology 48:588-96. 2008
    ..001). CONCLUSION: The double-null genotype for GSTT1 and GSTM1 might play a role in determining the susceptibility to develop DILI, as a general mechanism that occurs regardless of the type of drug involved, and predominantly in women...
  6. doi request reprint Assessment of drug-induced liver injury in clinical practice
    Ma Isabel Lucena
    Servicio de Farmacologia Clinica, Hospital Universitario Virgen de Victoria, School of Medicine, Malaga, Spain
    Fundam Clin Pharmacol 22:141-58. 2008
    ..The CIOMS/RUCAM instrument is considered at present the best method for assessing causality in DILI, although it could be improved through the use of large database of bona fide DILI cases for validation criteria...
  7. ncbi request reprint Determinants of the clinical expression of amoxicillin-clavulanate hepatotoxicity: a prospective series from Spain
    M Isabel Lucena
    Servicio de Farmacologia Clinica, Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos, Coordinating Centre, Hospital Universitario Virgen de la Victoria, Malaga, Spain
    Hepatology 44:850-6. 2006
    ....
  8. ncbi request reprint Prolonged cholestasis after raloxifene and fenofibrate interaction: A case report
    M Isabel Lucena
    Department of Clinical Pharmacology, Facultad de Medicina, E 29071 Malaga, Spain
    World J Gastroenterol 12:5244-6. 2006
    ..The findings of an overexpression of vascular endothelial growth factor in the liver biopsy suggest that angiogenesis might play a role in the persistence of toxic cholestasis...
  9. ncbi request reprint The administration of N-acetylcysteine causes a decrease in prothrombin time in patients with paracetamol overdose but without evidence of liver impairment
    M Isabel Lucena
    Clinical Pharmacology Service, Hospital Universitario, School of Medicine, University of Malaga, Malaga, Spain
    Eur J Gastroenterol Hepatol 17:59-63. 2005
    ..To explore the effect of intravenous N-acetylcysteine (NAC) on the prothrombin time (PT) in patients with paracetamol overdose and persistent normal liver profile...
  10. doi request reprint [Hepatotoxicity, a global problem with local features: toward the creation of a Pan-American Hepatotoxicity Network]
    Maria Isabel Lucena
    Servicio de Farmacología Clínica y Unidad de Hepatología, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Universidad de Malaga, Malaga, Espana
    Gastroenterol Hepatol 34:361-8. 2011
    ..Hopefully, Latin American registries will be incorporated into existing initiatives, which will stimulate research and improve understanding of the complex mechanisms involved in this adverse reaction...
  11. ncbi request reprint Effects of silymarin MZ-80 on oxidative stress in patients with alcoholic cirrhosis. Results of a randomized, double-blind, placebo-controlled clinical study
    M I Lucena
    Clinical Pharmacology Service, University Hospital, School of Medicine, Malaga, Spain
    Int J Clin Pharmacol Ther 40:2-8. 2002
    ..The role of silymarin in the treatment of liver cirrhosis is controversial...
  12. ncbi request reprint Multicenter hospital study on prescribing patterns for prophylaxis and treatment of complications of cirrhosis
    M Isabel Lucena
    Clinical Pharmacology Service, Hospital Universitario, School of Medicine, University of Malaga, 29071 Malaga, Spain
    Eur J Clin Pharmacol 58:435-40. 2002
    ..To describe the prescribing patterns for liver disease management...
  13. ncbi request reprint [Committees on Ethics and Clinical Research over 10 years: risks of complacency]
    M Isabel Lucena
    Servicio de Farmacología Clínica Hospital Universitario Facultad de Medicina Málaga España
    Med Clin (Barc) 120:257-60. 2003
  14. ncbi request reprint Drug use for non-hepatic associated conditions in patients with liver cirrhosis
    M Isabel Lucena
    Clinical Pharmacology Service and Liver Unit, Hospital Universitario, School of Medicine, University of Malaga, 29071 Malaga, Spain
    Eur J Clin Pharmacol 59:71-6. 2003
    ..To study the prescribing patterns of practising physicians for the most frequent non-hepatic associated conditions in patients with liver cirrhosis...
  15. ncbi request reprint Pharmacogenomics in drug induced liver injury
    Raul J Andrade
    Hepatology Unit, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Malaga, Spain
    Curr Drug Metab 10:956-70. 2009
    ..We identify potential sources of heterogeneity in studies carried out so far as well as new genetic targets which require further investigation...
  16. doi request reprint Analysis of IL-10, IL-4 and TNF-alpha polymorphisms in drug-induced liver injury (DILI) and its outcome
    Ketevan Pachkoria
    Servicio de Farmacologia Clinica, Facultad de Medicina, Departmento de Farmacologia, Boulevard Louis Pasteur, 32, Campus de Teatinos s n, 29071 Malaga, Spain
    J Hepatol 49:107-14. 2008
    ....
  17. ncbi request reprint Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry
    Raul J Andrade
    Unidad de Hepatologia, Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos, Co ordinating Centre, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos s n, Malaga, Spain
    Hepatology 44:1581-8. 2006
    ..Cardiovascular and central nervous system drugs are the main groups leading to chronic liver damage...
  18. ncbi request reprint HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease
    Raul J Andrade
    Unidad de Hepatologia, Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos, Coordinating Center, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos, Malaga, Spain
    Hepatology 39:1603-12. 2004
    ....
  19. doi request reprint Drug-induced liver injury: insights from genetic studies
    Raul J Andrade
    Unidad de Hepatologia, Departamento de Medicina, Facultad de Medicina, Boulevard Louis Pasteur 32, 29071 Malaga, Spain
    Pharmacogenomics 10:1467-87. 2009
    ....
  20. ncbi request reprint Cholestatic hepatitis related to use of irbesartan: a case report and a literature review of angiotensin II antagonist-associated hepatotoxicity
    Raul J Andrade
    Liver Unit, Department of Gastroenterology, University Hospital Virgin de la Victoria, School of Medicine, Malaga, Spain
    Eur J Gastroenterol Hepatol 14:887-90. 2002
    ..There have been seven prior cases of angiotensin II antagonist-induced hepatotoxicity reported in the literature. A class warning for hepatotoxicity for these compounds should probably be considered...
  21. ncbi request reprint Vascular ophthalmological side effects associated with antiviral therapy for chronic hepatitis C are related to vascular endothelial growth factor levels
    Raul J Andrade
    Liver Unit, University Hospital and School of Medicine, Malaga, Spain
    Antivir Ther 11:491-8. 2006
    ..In 3 out of 13 patients visual acuity was affected and 2 had residual lesions in the follow-up. In this exploratory study, antiviral therapy of CHC frequently induces VOSE, apparently through an activation of angiogenesis...
  22. ncbi request reprint Causality assessment in drug-induced hepatotoxicity
    Raul J Andrade
    Unidad de Hepatologia, Departamento de Medicina, Facultad de Medicina, Virgen de la Victoria University Hospital, Campus de Teatinos s n, 29071 Malaga, Spain
    Expert Opin Drug Saf 3:329-44. 2004
    ....
  23. ncbi request reprint Genetic and molecular factors in drug-induced liver injury: a review
    Ketevan Pachkoria
    Clinical Pharmacology Service, University Hospital Virgen de la Victoria, School of Medicine, Malaga, Spain
    Curr Drug Saf 2:97-112. 2007
    ..Knowledge regarding these operational mechanisms could provide further insight for the prospective identification of susceptible patients at risk of developing drug-induced hepatotoxicity...
  24. ncbi request reprint Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?
    Carmen Verge
    Clinical Pharmacology Service, Virgen de la Victoria University Hospital, Malaga, Spain
    World J Gastroenterol 12:5078-80. 2006
    ..A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed...
  25. doi request reprint Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury
    M Isabel Lucena
    Servicio de Farmacología Clínica y Grupo de Estudio para las Hepatopatias Asociadas a Medicamentos, Coordinating Centre, Facultad de Medicina, Hospital Universitario Virgen de la Victoria, Campus Universitario s n, Malaga, Spain
    Hepatology 52:303-12. 2010
    ..0; 95%CI = 1.7-5.5; Pc = 0.0008) and S-oxides, diazines, nitroanion radicals, or iminium ions (OR = 16.0; 95%CI = 1.8-146.1; Pc = 0.009)...
  26. ncbi request reprint Severe toxic hepatitis related to chlormethiazole
    Eva Gallardo-Caballero
    J Hepatol 39:1092-3. 2003