Francisco J López de Saro
- The beta sliding clamp binds to multiple sites within MutL and MutSFrancisco J López de Saro
The Rockefeller University, New York, New York 10021, USA
J Biol Chem 281:14340-9. 2006..In light of these results, we propose roles for the beta clamp in orchestrating the sequence of events that lead to mismatch repair in the cell...
- Competitive processivity-clamp usage by DNA polymerases during DNA replication and repairFrancisco J López de Saro
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
EMBO J 22:6408-18. 2003..Given the limited amounts of clamps in the cell, these results suggest that clamp binding may be competitive and regulated, and that the different polymerases may use the same clamp sequentially during replication and repair...
- A peptide switch regulates DNA polymerase processivityFrancisco J López de Saro
Howard Hughes Medical Institute and Laboratory of DNA Replication, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
Proc Natl Acad Sci U S A 100:14689-94. 2003..Therefore, DNA sensing by tau switches the polymerase peptide tail on and off the clamp and coordinates the dynamic turnover of polymerase during lagging strand synthesis...