Consuegra Fernández M, Julia M, Martínez Florensa M, Aranda F, Català C, Armiger Borràs N, et al
. Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis. Cell Mol Immunol. 2018;15:898-906 pubmed publisher
..Taken together, these results provide new supportive evidence of the contribution of the CD6 lymphocyte receptor in psoriasis at both experimental and clinical levels. ..
Aibar J, MartÃnez Florensa M, Castro P, Carrasco E, Escoda Ferran C, FernÃ¡ndez S, et al
. Pattern of soluble CD5 and CD6 lymphocyte receptors in critically ill patients with septic syndromes. J Crit Care. 2015;30:914-9 pubmed publisher
..Levels of sCD6 are associated with an increased risk of mortality in these patients. ..
Consuegra Fernández M, Lin F, Fox D, Lozano F. Clinical and experimental evidence for targeting CD6 in immune-based disorders. Autoimmun Rev. 2018;17:493-503 pubmed publisher
..Here we review current knowledge about CD6 and its ligands, and consider its potential value as a therapeutic target in a range of immune-mediated disorders. ..
MartÃnez Florensa M, Consuegra FernÃ¡ndez M, Aranda F, Armiger BorrÃ s N, Di Scala M, Carrasco E, et al
. Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis. Antimicrob Agents Chemother. 2017;61: pubmed publisher
..Taken together, the data support the conserved antibacterial effects of human and mouse sCD6 and their use as adjunctive therapy in experimental models of complex and severe polymicrobial sepsis. ..
Escoda Ferran C, Carrasco E, Caballero Baños M, Miró Julià C, Martínez Florensa M, Consuegra Fernández M, et al
. Modulation of CD6 function through interaction with Galectin-1 and -3. FEBS Lett. 2014;588:2805-13 pubmed publisher
..The results suggest that interaction of Galectin-1 and -3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology. ..
Sarukhan A, Martínez Florensa M, Escoda Ferran C, Carrasco E, Carreras E, Lozano F. Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor. Curr Drug Targets. 2016;17:640-50 pubmed
..Importantly, microbe recognition by CD6 may also have functional consequences on T cell activation and differentiation, which remain to be explored. ..
Orta Mascaró M, Consuegra Fernández M, Carreras E, Roncagalli R, Carreras Sureda A, Alvarez P, et al
. CD6 modulates thymocyte selection and peripheral T cell homeostasis. J Exp Med. 2016;213:1387-97 pubmed publisher
..Collectively, these data indicate that CD6 modulates the threshold for thymocyte selection and the generation and/or function of several peripheral T cell subpopulations, including T reg cells. ..
Retamozo S, Flores Chavez A, Consuegra Fernández M, Lozano F, Ramos Casals M, Brito Zeron P. Cytokines as therapeutic targets in primary Sjögren syndrome. Pharmacol Ther. 2018;184:81-97 pubmed publisher
..This review summarizes the potential pharmacotherapeutic options targeting the main cytokine families involved in the etiopathogenesis of primary SjS and analyzes potential insights for developing new therapies. ..