Ana Losada

Summary

Country: Spain

Publications

  1. doi request reprint Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts
    Teresa Rivera
    Spanish National Cancer Research Centre, Madrid, Spain
    Chromosoma 118:223-33. 2009
  2. ncbi request reprint Cohesin regulation: fashionable ways to wear a ring
    Ana Losada
    Spanish National Cancer Research Center, Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Chromosoma 116:321-9. 2007
  3. doi request reprint The regulation of sister chromatid cohesion
    Ana Losada
    Chromosome Dynamics Group, Spanish National Cancer Research Centre, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Biochim Biophys Acta 1786:41-8. 2008
  4. pmc New clues to understand how CENP-A maintains centromere identity
    Patricia Sanchez
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid, E 28029, Spain
    Cell Div 6:11. 2011
  5. doi request reprint The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development
    Ana Cuadrado
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain
    Cell Cycle 11:2233-8. 2012
  6. doi request reprint Cohesin, a chromatin engagement ring
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Curr Opin Cell Biol 25:63-71. 2013
  7. pmc Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex
    Teresa Rivera
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 31:1467-79. 2012
  8. pmc Xenopus HJURP and condensin II are required for CENP-A assembly
    Rafael Bernad
    Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    J Cell Biol 192:569-82. 2011
  9. doi request reprint Cohesin in development and disease
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Development 140:3715-8. 2013
  10. pmc Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 31:2076-89. 2012

Collaborators

  • Tatsuya Hirano
  • Juan Mendez
  • Ana Cuadrado
  • Hironori Funabiki
  • Genevieve Almouzni
  • William C Drosopoulos
  • Satoru Mochida
  • Maria A Blasco
  • Silvia Remeseiro
  • Teresa Rivera
  • María Carretero
  • Miriam Rodríguez-Corsino
  • Patricia Sanchez
  • Rafael Bernad
  • Emmanuelle Guillou
  • Angel Serrano
  • Takao Ono
  • David E MacCallum
  • David E Anderson
  • Isabel Barthelemy
  • Miguel Ruiz-Torres
  • Arthur D Lander
  • Anne L Calof
  • Shimako Kawauchi
  • Paula Martinez
  • Cristina Ghenoiu
  • Carl L Schildkraut
  • Gonzalo Gomez-Lopez
  • David G Pisano
  • Marta Canamero
  • Alexei Arnaoutov
  • Dominique Ray-Gallet
  • Isabelle Vassias
  • Ekaterina Boyarchuk
  • Mary Dasso
  • Etienne Schwob
  • Vincent Coulon
  • Daniel Rico
  • Juan Casado-Vela
  • Arkaitz Ibarra
  • Ignacio Casal
  • Michael P Myers
  • Andrew F Neuwald
  • Michiko Hirano
  • Harold P Erickson
  • Ryuji Kobayashi

Detail Information

Publications24

  1. doi request reprint Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts
    Teresa Rivera
    Spanish National Cancer Research Centre, Madrid, Spain
    Chromosoma 118:223-33. 2009
    ..We propose that Sgo drives relocalization of PP2A from arms to centromeres and, in this way, coordinates release of arm cohesin with protection of centromeric cohesin in mitosis...
  2. ncbi request reprint Cohesin regulation: fashionable ways to wear a ring
    Ana Losada
    Spanish National Cancer Research Center, Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Chromosoma 116:321-9. 2007
    ..In this review, I briefly summarize these studies and discuss their implications for current and future models of cohesin behavior...
  3. doi request reprint The regulation of sister chromatid cohesion
    Ana Losada
    Chromosome Dynamics Group, Spanish National Cancer Research Centre, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Biochim Biophys Acta 1786:41-8. 2008
    ..In this review I summarize recent advances in our understanding of cohesin function and regulation in mitosis, and discuss the consequences of impairing the cohesion process at the level of the whole organism...
  4. pmc New clues to understand how CENP-A maintains centromere identity
    Patricia Sanchez
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid, E 28029, Spain
    Cell Div 6:11. 2011
    ..Here, we discuss our results together with other recent advances in our understanding of the mechanisms that mediate centromere inheritance...
  5. doi request reprint The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development
    Ana Cuadrado
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain
    Cell Cycle 11:2233-8. 2012
    ..These results point out a prominent role of cohesin-SA1 in transcriptional regulation, with clear implications in the etiology of CdLS...
  6. doi request reprint Cohesin, a chromatin engagement ring
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Curr Opin Cell Biol 25:63-71. 2013
    ..Given all its essential functions, it is not surprising that mutations in cohesin and its interacting factors have been associated to cancer and developmental syndromes known as cohesinopathies...
  7. pmc Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex
    Teresa Rivera
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 31:1467-79. 2012
    ..Our results further suggest that this functional specificity could rely on the association of XSgo1 and XSgo2 with different regulatory subunits of the PP2A complex...
  8. pmc Xenopus HJURP and condensin II are required for CENP-A assembly
    Rafael Bernad
    Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    J Cell Biol 192:569-82. 2011
    ..We propose that the chromatin structure imposed by condensin II at centromeres enables CENP-A incorporation initiated by xHJURP...
  9. doi request reprint Cohesin in development and disease
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Development 140:3715-8. 2013
    ..Here, we provide an overview of how cohesin functions, highlighting its role both in development and in disease. ..
  10. pmc Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 31:2076-89. 2012
    ..We propose a novel mechanism for aneuploidy generation that involves impaired telomere replication upon loss of cohesin-SA1, with clear implications in tumourigenesis...
  11. pmc Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres
    María Carretero
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 32:2938-49. 2013
    ..Our work supports a model in which the composition and function of cohesin complexes differs between different chromosomal regions. ..
  12. pmc A unique role of cohesin-SA1 in gene regulation and development
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 31:2090-102. 2012
    ..Lack of SA1 also alters cohesin-binding pattern along some gene clusters and leads to dysregulation of genes within. We hypothesize that impaired cohesin-SA1 function in gene expression underlies the molecular aetiology of CdLS...
  13. ncbi request reprint Shugoshin and PP2A, shared duties at the centromere
    Teresa Rivera
    Chromosome Dynamics Group, Spanish National Cancer Center CNIO, Madrid, Spain
    Bioessays 28:775-9. 2006
    ..Additional evidence, however, suggests that this is only part of the story, and that Sgo has also a role independent of PP2A...
  14. pmc Cohesin organizes chromatin loops at DNA replication factories
    Emmanuelle Guillou
    DNA replication Group, Spanish National Cancer Research Centre CNIO, E 28029 Madrid, Spain
    Genes Dev 24:2812-22. 2010
    ..These results give a new dimension to the role of cohesin in the architectural organization of interphase chromatin, by showing its participation in DNA replication...
  15. doi request reprint Cohesin ties up the genome
    María Carretero
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Curr Opin Cell Biol 22:781-7. 2010
    ..Our current knowledge of the molecular mechanisms underlying cohesin behavior should now be considered from the perspective of its novel functions, which promise to be as relevant for cell viability as cohesion...
  16. doi request reprint Epigenetic specification of centromeres by CENP-A
    Rafael Bernad
    Molecular Oncology Programme, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Exp Cell Res 315:3233-41. 2009
    ..Here we review some of the highlights of this research...
  17. pmc Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells
    Angel Serrano
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS ONE 4:e5118. 2009
    ..However, depletion of HP1gamma leads to defects in mitotic progression...
  18. pmc Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Biochim Biophys Acta 1832:2097-102. 2013
    ..These results provide further support for the idea that developmental defects in CdLS are caused by deregulated transcription and not by malfunction of cohesion-related processes. ..
  19. pmc Condensin and cohesin display different arm conformations with characteristic hinge angles
    David E Anderson
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 156:419-24. 2002
    ..We propose that the "closed" conformation of condensin and the "open" conformation of cohesin are important structural properties that contribute to their specialized biochemical and physiological functions...
  20. pmc Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis
    Ana Losada
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 16:3004-16. 2002
    ..More importantly, our results strongly suggest that cohesin release at the onset of mitosis is essential for sister chromatid resolution but not for condensin-mediated compaction...
  21. pmc ISWI remodeling complexes in Xenopus egg extracts: identification as major chromosomal components that are regulated by INCENP-aurora B
    David E MacCallum
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA
    Mol Biol Cell 13:25-39. 2002
    ..Apparently contradictory to the generally accepted model, we find that neither chromosome condensation nor chromosomal targeting of condensin is compromised when H3 phosphorylation is drastically reduced by depletion of INCENP-aurora B...
  22. ncbi request reprint Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts
    Ana Losada
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    J Cell Sci 118:2133-41. 2005
    ..This idea would explain why cells lacking Pds5 function display rather complex and diverse phenotypes in different organisms...
  23. ncbi request reprint Dynamic molecular linkers of the genome: the first decade of SMC proteins
    Ana Losada
    Spanish National Cancer Center CNIO, Madrid
    Genes Dev 19:1269-87. 2005
    ..Dissecting this class of chromosomal ATPases is likely to be central to our understanding of the structural basis of genome organization, stability, and evolution...
  24. ncbi request reprint Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells
    Takao Ono
    Cold Spring Harbor Laboratory, One Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA
    Cell 115:109-21. 2003
    ..We propose that the two condensin complexes make distinct mechanistic contributions to mitotic chromosome architecture in vertebrate cells...