B Lopez-Corcuera

Summary

Country: Spain

Publications

  1. ncbi request reprint Regulation of glycine transporters
    B Lopez-Corcuera
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    Biochem Soc Trans 29:742-5. 2001
  2. ncbi request reprint Characterization of the interactions between the glycine transporters GLYT1 and GLYT2 and the SNARE protein syntaxin 1A
    A Geerlings
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, 28049, Madrid, Spain
    FEBS Lett 470:51-4. 2000
  3. ncbi request reprint The role of N-glycosylation in transport to the plasma membrane and sorting of the neuronal glycine transporter GLYT2
    R Martinez-Maza
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    J Biol Chem 276:2168-73. 2001
  4. ncbi request reprint Group-selective reagent modification of the sodium- and chloride-coupled glycine transporter under native and reconstituted conditions
    R Alcantara
    Departamento de Biologia Molecular, Centro de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma, Madrid, Spain
    Biochim Biophys Acta 1067:64-70. 1991
  5. pmc Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters
    E Nunez
    Departamento de Biología Molecular Centro de Biología Molecular Severo Ochoa Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Br J Pharmacol 129:200-6. 2000
  6. ncbi request reprint Glycine neurotransmitter transporters: an update
    B Lopez-Corcuera
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Mol Membr Biol 18:13-20. 2001
  7. ncbi request reprint Substrate-induced conformational changes of extracellular loop 1 in the glycine transporter GLYT2
    B Lopez-Corcuera
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    J Biol Chem 276:43463-70. 2001
  8. ncbi request reprint Calcium- and syntaxin 1-mediated trafficking of the neuronal glycine transporter GLYT2
    A Geerlings
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, , Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    J Biol Chem 276:17584-90. 2001
  9. ncbi request reprint [Molecular bases of hereditary hyperekplexia]
    C Gimenez
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Madrid, Espana
    Rev Neurol 47:648-52. 2008

Collaborators

  • C Gimenez
  • F Zafra
  • A Geerlings
  • C Aragon
  • R Martinez-Maza
  • E Nunez
  • E N úñez
  • I Poyatos
  • J Vazquez
  • R Alcantara

Detail Information

Publications9

  1. ncbi request reprint Regulation of glycine transporters
    B Lopez-Corcuera
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    Biochem Soc Trans 29:742-5. 2001
    ..We are trying to find signal sequences responsible for this differential localization...
  2. ncbi request reprint Characterization of the interactions between the glycine transporters GLYT1 and GLYT2 and the SNARE protein syntaxin 1A
    A Geerlings
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, 28049, Madrid, Spain
    FEBS Lett 470:51-4. 2000
    ..Finally, we conclude that this physical interaction resulted in a partial removal of the glycine transporters from the plasma membrane as demonstrated by biotinylation studies...
  3. ncbi request reprint The role of N-glycosylation in transport to the plasma membrane and sorting of the neuronal glycine transporter GLYT2
    R Martinez-Maza
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    J Biol Chem 276:2168-73. 2001
    ..However, a partially unglycosylated mutant (triple mutant) was distributed in a nonpolarized manner in MDCK cells. The apical localization of GLYT2 occurred by a glycolipid rafts independent pathway...
  4. ncbi request reprint Group-selective reagent modification of the sodium- and chloride-coupled glycine transporter under native and reconstituted conditions
    R Alcantara
    Departamento de Biologia Molecular, Centro de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma, Madrid, Spain
    Biochim Biophys Acta 1067:64-70. 1991
    ..It is concluded that SH groups are involved in the glycine transporter function and that these critical residues are mostly located in a relatively hydrophilic environment of the protein...
  5. pmc Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters
    E Nunez
    Departamento de Biología Molecular Centro de Biología Molecular Severo Ochoa Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Br J Pharmacol 129:200-6. 2000
    ..Additionally, the inhibition of the glycine uptake by GLYT2 is suggested to have some role in the sedative and psychomotor side effects of amoxapine. British Journal of Pharmacology (2000) 129, 200 - 206..
  6. ncbi request reprint Glycine neurotransmitter transporters: an update
    B Lopez-Corcuera
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Mol Membr Biol 18:13-20. 2001
    ..This article reviews recent progress on the study of the molecular heterogeneity, localization, function, structure, regulation and pharmacology of the glycine transporter proteins...
  7. ncbi request reprint Substrate-induced conformational changes of extracellular loop 1 in the glycine transporter GLYT2
    B Lopez-Corcuera
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    J Biol Chem 276:43463-70. 2001
    ..We conclude that EL1 acts as a fluctuating hinge undergoing sequential conformational changes during the transport cycle...
  8. ncbi request reprint Calcium- and syntaxin 1-mediated trafficking of the neuronal glycine transporter GLYT2
    A Geerlings
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, , Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    J Biol Chem 276:17584-90. 2001
    ..GLYT2-containing vesicles may represent neurotransmitter transporter that is being trafficked. The results of our work suggest a close correlation between exocytosis of neurotransmitter and its reuptake by transporters...
  9. ncbi request reprint [Molecular bases of hereditary hyperekplexia]
    C Gimenez
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Madrid, Espana
    Rev Neurol 47:648-52. 2008
    ..Typically it is accompanied by a temporally but complete muscular rigidly, and usually it manifests shortly after birth. Some affected infants die suddenly from lapses in cardiorespiratory function. Mental development usually is normal...