Abelardo Lopez Rivas
Serrano Saenz S, Palacios C, Delgado Bellido D, López Jiménez L, García Díaz A, Soto Serrano Y, et al
. PIM kinases mediate resistance of glioblastoma cells to TRAIL by a p62/SQSTM1-dependent mechanism. Cell Death Dis. 2019;10:51 pubmed publisher
Palacios C, Yerbes R, Sanchez Perez T, Martín Pérez R, Cano González A, Lopez Rivas A. The long and winding road to cancer treatment: the TRAIL system. Curr Pharm Des. 2014;20:2819-33 pubmed
Cano González A, Lopez Rivas A. Opposing roles of TGF-? and EGF in the regulation of TRAIL-induced apoptosis in human breast epithelial cells. Biochim Biophys Acta. 2016;1863:2104-14 pubmed publisher
..Together, the data reveal a fine regulation by EGF and TGF-? of sensitivity of human breast epithelial cells to TRAIL which may be relevant during morphogenesis. ..
Cano González A, Mauro Lizcano M, Iglesias Serret D, Gil J, Lopez Rivas A. Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells. Cell Death Dis. 2018;9:134 pubmed publisher
..Overall, our data show that ER stress induces cell death through a pleiotropic mechanism in TNBC cells and suggest that targeting FLIP expression may be an effective approach to sensitize these tumor cells to ER stress-inducing agents. ..
Mauro Lizcano M, LÃ³pez Rivas A. Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells. Cell Death Dis. 2018;9:205 pubmed publisher
..Overall, our findings suggest that targeting the glutamine addiction phenotype of TNBC can be regarded as a potential antitumoral target in combination with agonists of proapoptotic TRAIL receptors. ..