Eugenia Negredo

Summary

Affiliation: Lluita contra la SIDA Foundation
Country: Spain

Publications

  1. ncbi Time of progression to osteopenia/osteoporosis in chronically HIV-infected patients: screening DXA scan
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 7:e46031. 2012
  2. ncbi Ezetimibe, a promising lipid-lowering agent for the treatment of dyslipidaemia in HIV-infected patients with poor response to statins
    Eugenia Negredo
    Lluita contra la SIDA, Germans Trias i Pujol Hospital, Universitat Autonoma de Barcelona, Ctra de Canyet s n, 08916 Badalona, Barcelona, Spain
    AIDS 20:2159-64. 2006
  3. ncbi Four-year safety with polyacrylamide hydrogel to correct antiretroviral-related facial lipoatrophy
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 25:451-5. 2009
  4. ncbi Partial immunological and mitochondrial recovery after reducing didanosine doses in patients on didanosine and tenofovir-based regimens
    Eugenia Negredo
    Germans Trias i Pujol University Hospital, Lluita contra la SIDA and IrsiCaixa Foundations, University of Barcelona, 08916 Badalona, Barcelona, Spain
    Antivir Ther 13:231-40. 2008
  5. ncbi Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications
    Eugenia Negredo
    Lluita contra Sida Foundation, Institut de Recerca en Ciències de Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Barcelona, Spain
    Clin Infect Dis 50:1300-8. 2010
  6. ncbi Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with Nevirapine and Kaletra (MULTINEKA)
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Barcelona, Spain
    Clin Infect Dis 49:892-900. 2009
  7. ncbi Benefits and concerns of simplification strategies in HIV-infected patients
    Eugenia Negredo
    Lluita contra la SIDA Foundation, HIV Unit, Universitat Autonoma de Barcelona, Hospital Universitari Germans Trias i Pujol Barcelona, Spain
    J Antimicrob Chemother 58:235-42. 2006
  8. ncbi Treatment simplification to once daily darunavir/ritonavir guided by the darunavir inhibitory quotient in heavily pretreated HIV-infected patients
    Jose Molto
    Lluita contra Sida Foundation, HIV Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Antivir Ther 15:219-25. 2010
  9. ncbi High prevalence of and progression to low bone mineral density in HIV-infected patients: a longitudinal cohort study
    Anna Bonjoch
    Lluita contra la SIDA Foundation, University Hospital Germans Trias, Barcelona, Spain
    AIDS 24:2827-33. 2010
  10. ncbi The effect of atorvastatin treatment on HIV-1-infected patients interrupting antiretroviral therapy
    Eugenia Negredo
    Lluita contra la SIDA, Germans Trias i Pujol University Hospital, Universitat Autonoma de Barcelona, Badalona, Barcelona, Spain
    AIDS 20:619-21. 2006

Detail Information

Publications61

  1. ncbi Time of progression to osteopenia/osteoporosis in chronically HIV-infected patients: screening DXA scan
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 7:e46031. 2012
    ..Our objective was to assess how often a dual-energy x-ray absorptiometry (DXA) scan should be performed by assessing time of progression to osteopenia/osteoporosis...
  2. ncbi Ezetimibe, a promising lipid-lowering agent for the treatment of dyslipidaemia in HIV-infected patients with poor response to statins
    Eugenia Negredo
    Lluita contra la SIDA, Germans Trias i Pujol Hospital, Universitat Autonoma de Barcelona, Ctra de Canyet s n, 08916 Badalona, Barcelona, Spain
    AIDS 20:2159-64. 2006
    ..To assess the efficacy, safety, and pharmacokinetic interactions of ezetimibe in HIV-infected patients with poorly controlled antiretroviral-associated dyslipidaemia while taking pravastatin alone...
  3. ncbi Four-year safety with polyacrylamide hydrogel to correct antiretroviral-related facial lipoatrophy
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 25:451-5. 2009
    ..However, prolonged follow-up of these patients is recommended to detect unexpected long-term adverse reactions...
  4. ncbi Partial immunological and mitochondrial recovery after reducing didanosine doses in patients on didanosine and tenofovir-based regimens
    Eugenia Negredo
    Germans Trias i Pujol University Hospital, Lluita contra la SIDA and IrsiCaixa Foundations, University of Barcelona, 08916 Badalona, Barcelona, Spain
    Antivir Ther 13:231-40. 2008
    ..We assessed whether a simple reduction of the ddl dose in patients receiving ddl (400 mg/day) and TDF could revert this side effect...
  5. ncbi Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications
    Eugenia Negredo
    Lluita contra Sida Foundation, Institut de Recerca en Ciències de Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Barcelona, Spain
    Clin Infect Dis 50:1300-8. 2010
    ..Although antiretroviral therapy improves immune response, some human immunodeficiency virus-infected patients present unsatisfactory CD4 T cell recovery despite achieving viral suppression, resulting in increased morbidity and mortality...
  6. ncbi Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with Nevirapine and Kaletra (MULTINEKA)
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Barcelona, Spain
    Clin Infect Dis 49:892-900. 2009
    ..This study aimed to evaluate in vivo the effects of NRTI withdrawal on mitochondrial parameters and body fat distribution...
  7. ncbi Benefits and concerns of simplification strategies in HIV-infected patients
    Eugenia Negredo
    Lluita contra la SIDA Foundation, HIV Unit, Universitat Autonoma de Barcelona, Hospital Universitari Germans Trias i Pujol Barcelona, Spain
    J Antimicrob Chemother 58:235-42. 2006
    ..An accurate analysis of each patient's history will be necessary in each case to determine whether a simplification strategy is appropriate...
  8. ncbi Treatment simplification to once daily darunavir/ritonavir guided by the darunavir inhibitory quotient in heavily pretreated HIV-infected patients
    Jose Molto
    Lluita contra Sida Foundation, HIV Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Antivir Ther 15:219-25. 2010
    ..We explored a treatment simplification strategy to darunavir/ritonavir 900/100 mg once daily guided by the darunavir virtual inhibitory quotient (vIQ) in patients receiving salvage therapy with darunavir/ritonavir 600/100 mg twice daily...
  9. ncbi High prevalence of and progression to low bone mineral density in HIV-infected patients: a longitudinal cohort study
    Anna Bonjoch
    Lluita contra la SIDA Foundation, University Hospital Germans Trias, Barcelona, Spain
    AIDS 24:2827-33. 2010
    ..Low bone mineral density (BMD) is an emerging metabolic condition in HIV-infected patients; however, data on progression of this disease are scarce...
  10. ncbi The effect of atorvastatin treatment on HIV-1-infected patients interrupting antiretroviral therapy
    Eugenia Negredo
    Lluita contra la SIDA, Germans Trias i Pujol University Hospital, Universitat Autonoma de Barcelona, Badalona, Barcelona, Spain
    AIDS 20:619-21. 2006
    ..Statin groups showed lower serum cholesterol but similar viral loads and CD4 T-cell counts to the control group at weeks 4 and 12. Paradoxically, baseline serum cholesterol, but not atorvastatin, influenced viral rebound at week 4...
  11. ncbi Increased antiretroviral potency by the addition of enfuvirtide to a four-drug regimen in antiretroviral-naive, HIV-infected patients
    Jose Molto
    Lluita contra la SIDA Foundation, HIV Unit, Germans Trias i Pujol Hospital, Badalona, Spain
    Antivir Ther 11:47-51. 2006
    ..To assess if enfuvirtide (ENF) increases antiviral activity of a highly active four-drug antiretroviral (ARV) regimen containing lopinavir/ritonavir, efavirenz, lamivudine and tenofovir in ARV-naive, HIV-infected patients...
  12. ncbi Safety and efficacy of once-daily didanosine, tenofovir and nevirapine as a simplification antiretroviral approach
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Germans Trias i Pujol Hospital, Badalona, Spain
    Antivir Ther 9:335-42. 2004
    ..To assess the efficacy and safety of a once-daily antiretroviral regimen in HAART-experienced subjects with long-lasting viral suppression...
  13. ncbi Longitudinal study on mitochondrial effects of didanosine-tenofovir combination
    Sonia Lopez
    Mitochondrial Research Laboratory, Muscle Research Unit, Internal Medicine Department, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain
    AIDS Res Hum Retroviruses 22:33-9. 2006
    ..The particular relevance of either ddI, TDF, or any interaction between them in such a mitochondrial dysfunction remains to be established...
  14. ncbi Efficacy and safety of ritonavir dose reduction based on the tipranavir inhibitory quotient in HIV-infected patients on salvage antiretroviral therapy with tipranavir/ritonavir
    Jose Molto
    Lluita contra la SIDA Foundation, HIV Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    AIDS Res Hum Retroviruses 26:1191-6. 2010
    ....
  15. ncbi Interruptions of antiretroviral therapy in human immunodeficiency virus infection: are they detrimental to neurocognitive functioning?
    Jose A Muñoz-Moreno
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Badalona, Barcelona, Catalonia, Spain
    J Neurovirol 16:208-18. 2010
    ..Additionally, neurocognitive functioning was observed to be more impaired in the same individuals. Further studies should examine the potential negative effects of antiretroviral therapy interruptions on neurocognitive functioning...
  16. ncbi Effect of nevirapine on the steady-state trough concentrations of atazanavir in HIV-infected patients receiving atazanavir/ritonavir
    Jose Molto
    Lluita contra la SIDA Foundation, HIV Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Ther Drug Monit 32:93-6. 2010
    ..Atazanavir Ctroughs were compared between Days 0 and 28. Atazanavir and nevirapine Ctroughs at Day 28 were compared with historical controls receiving either 400 mg atazanavir once daily or 200 mg nevirapine twice daily...
  17. ncbi Lopinavir/ritonavir plus nevirapine as a nucleoside-sparing approach in antiretroviral-experienced patients (NEKA study)
    Eugenia Negredo
    Department of Internal Medicine, Lluita contra la SIDA and IrsiCaixa Foundations, Germans Trias i Pujol Hospital, Badalona, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 38:47-52. 2005
    ..To compare the efficacy and safety of a nucleoside-sparing approach with a conventional highly active antiretroviral therapy (HAART) regimen in antiretroviral-experienced patients with prolonged viral suppression...
  18. ncbi Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil fumarate and didanosine in the TORO studies
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Badalona, Spain
    Clin Infect Dis 41:901-5. 2005
    ..Individuals receiving both agents showed little additional increase in CD4+ cell count after week 8 of therapy, whereas those receiving 1 or neither of the agents had continuous increases over a 48-week period...
  19. ncbi Mild improvement in mitochondrial function after a 3-year antiretroviral treatment interruption despite persistent impairment of mitochondrial DNA content
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Germans Trias i Pujol Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Curr HIV Res 8:379-85. 2010
    ..The ability of a prolonged antiretroviral treatment interruption to reverse mitochondrial toxicity was evaluated in a sub-study of TIBET, a prospective trial examining antiretroviral treatment interruption guided by CD4+ cell count...
  20. ncbi Long-term neuropsychiatric disorders on efavirenz-based approaches: quality of life, psychologic issues, and adherence
    Carmina R Fumaz
    Lluita contra la SIDA Foundation, HIV Unit Germans Trias i Pujol Hospital, Autonomous University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 38:560-5. 2005
    ..Efavirenz has been associated with neuropsychiatric disorders, although little is known about its long-term toxicity...
  21. ncbi Influence of prior structured treatment interruptions on the length of time without antiretroviral treatment in chronically HIV-infected subjects
    Jose Molto
    HIV Clinical Unit Lluita Contra Ia Sida Foundation, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain
    AIDS Res Hum Retroviruses 20:1283-8. 2004
    ..Previous STIs do not influence time off therapy when HAART is definitively discontinued in chronically HIV-infected subjects. CD4 nadir is an important factor in the treatment discontinuation decision...
  22. ncbi Quality of life, emotional status, and adherence of HIV-1-infected patients treated with efavirenz versus protease inhibitor-containing regimens
    Carmina R Fumaz
    HIV Unit, Fundació Lluita SIDA and IrsiCaixa Retrovirology Laboratory, Germans Trias i Pujol University Hospital, Badalona, Catalonia, Spain
    J Acquir Immune Defic Syndr 29:244-53. 2002
    ....
  23. ncbi Association between HIV replication and cholesterol in peripheral blood mononuclear cells in HIV-infected patients interrupting HAART
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Institut de Recerca en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, 08916 Badalona, Barcelona, Spain
    J Antimicrob Chemother 61:400-4. 2008
    ..Cellular cholesterol is essential for HIV replication and may control HIV spread. HIV, in turn, appears to control cholesterol metabolism...
  24. ncbi Monitoring atazanavir concentrations with boosted or unboosted regimens in HIV-infected patients in routine clinical practice
    Jose Molto
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Ther Drug Monit 29:648-51. 2007
    ..Therapeutic drug monitoring may be useful in this setting...
  25. ncbi Role of structured treatment interruption before a 5-drug salvage antiretroviral regimen: the Retrogene Study
    Lidia Ruiz
    Retrovirology Laboratory, IrsiCaixa Foundation and Lluita contra la SIDA Foundation, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Infect Dis 188:977-85. 2003
    ..66; 95% confidence interval, 0.47-0.93; P=.021). A prior STI seems to confer no additional benefit to subsequent virological or immunological outcomes of a salvage regimen...
  26. ncbi Lopinavir/ritonavir monotherapy as a simplification strategy in routine clinical practice
    Jose Molto
    Lluita contra la SIDA Foundation, Germans Trias i Pujol Hospital, Badalona, and Universidad Autonoma de Barcelona, Spain
    J Antimicrob Chemother 60:436-9. 2007
    ..The objective of this study was to assess the effectiveness and safety of monotherapy with lopinavir/ritonavir as a treatment simplification strategy in HIV-infected patients with viral suppression outside a clinical trial setting...
  27. ncbi Simultaneous population pharmacokinetic model for lopinavir and ritonavir in HIV-infected adults
    Jose Molto
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Clin Pharmacokinet 47:681-92. 2008
    ..It is coformulated with low doses of ritonavir in order to enhance its pharmacokinetic profile. After oral administration, plasma concentrations of lopinavir can vary widely between different HIV-infected patients...
  28. ncbi Alternation of antiretroviral drug regimens for HIV infection. Efficacy, safety and tolerability at week 96 of the Swatch Study
    Eugenia Negredo
    Department of Internal Medicine, Lluita contra la SIDA and IrsiCaixa Foundations, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
    Antivir Ther 9:889-93. 2004
    ..Alternation of antiretroviral drug regimens has been proposed as a novel treatment strategy for HIV infection. However, some concerns persist regarding antiviral efficacy, adherence, toxicity and resistance evolution in the long term...
  29. ncbi Genetic and functional mitochondrial assessment of HIV-infected patients developing HAART-related hyperlactatemia
    Gloria Garrabou
    Mitochondrial Research Laboratory, Internal Medicine Department, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona and CIBER de Enfermedades Raras, CIBERER, Barcelona, Spain
    J Acquir Immune Defic Syndr 52:443-51. 2009
    ....
  30. ncbi Low levels of adherence to antiretroviral therapy in HIV-1-infected women with menstrual disorders
    Carmina R Fumaz
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain
    AIDS Patient Care STDS 23:463-8. 2009
    ..The subjective attribution of these irregularities to antiretrovirals seems to affect medication intake, possibly favoring negative clinical consequences...
  31. ncbi Reconstructive treatment for antiretroviral-associated facial lipoatrophy: a prospective study comparing autologous fat and synthetic substances
    Eugenia Negredo
    HIV Unit, Fundació de la Lluita contra la SIDA, Germans Trias i Pujol University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    AIDS Patient Care STDS 20:829-37. 2006
    ..Similar results were observed for all degrees of severity and between genders. Polyacrylamide gel provided the longest lasting benefits...
  32. ncbi Antiretroviral simplification with darunavir/ritonavir monotherapy in routine clinical practice: safety, effectiveness, and impact on lipid profile
    Jose R Santos
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
    PLoS ONE 7:e37442. 2012
    ....
  33. ncbi Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
    Elena Ferrer
    HIV Unit, Service of Infectious Diseases, Hospital Universitari de Bellvitge, L Hospitalet de Llobregat, Barcelona, Spain
    AIDS Res Hum Retroviruses 27:1061-5. 2011
    ..008) and subcutaneous fat (42%, p = 0.008). These data suggest that switching from LPV/r to ATV/r is associated with increased trunk fat, both subcutaneous and visceral...
  34. ncbi Low-density lipoprotein size and lipoprotein-associated phospholipase A2 in HIV-infected patients switching to abacavir or tenofovir
    Maria Saumoy
    Infectious Disease Service, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
    Antivir Ther 16:459-68. 2011
    ....
  35. ncbi Neuropsychiatric symptoms associated with efavirenz: prevalence, correlates, and management. A neurobehavioral review
    Jose A Muñoz-Moreno
    Lluita Contra la SIDA Foundation Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain
    AIDS Rev 11:103-9. 2009
    ..Different recommendations on the assessment of efavirenz-related adverse events are also provided...
  36. ncbi Saquinavir/ritonavir monotherapy as a new nucleoside-sparing maintenance strategy in long-term virologically suppressed HIV-infected patients
    Echeverria Patricia
    Germans Trias i Pujol University Hospital, Barcelona, Spain
    Curr HIV Res 8:467-70. 2010
    ..The high antiviral potency and low toxicity of saquinavir/ritonavir (SQV/r) prompted us to assess a viable strategy in chronic virologically suppressed HIV-infected patients...
  37. ncbi Viral failure in HIV-infected patients with long-lasting viral suppression who discontinued enfuvirtide
    Anna Bonjoch
    Lluita contra la SIDA Foundation, AIDS Care Unit, Hospital Universitari Germans Trias i Pujol, , Badalona, Spain
    AIDS 20:1896-8. 2006
    ..5%) and in no patients, respectively, (P = 0.007). The CD4 cell decrease in failure patients was 5% (P = ns). These results suggest that enfuvirtide should be maintained until new active drugs became available...
  38. ncbi Herb-drug interaction between Echinacea purpurea and darunavir-ritonavir in HIV-infected patients
    Jose Molto
    Lluita contra la SIDA Foundation, HIV Clinic, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
    Antimicrob Agents Chemother 55:326-30. 2011
    ..Although no dose adjustment is required, monitoring darunavir concentrations on an individual basis may give reassurance in this setting...
  39. ncbi Saquinavir exposure in HIV-infected patients with chronic viral hepatitis
    Jose Molto
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    J Antimicrob Chemother 63:992-7. 2009
    ....
  40. ncbi Once- or twice-daily dosing of nevirapine in HIV-infected adults: a population pharmacokinetics approach
    Jose Molto
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    J Antimicrob Chemother 62:784-92. 2008
    ....
  41. ncbi Alternation of antiretroviral drug regimens for HIV infection. A randomized, controlled trial
    Javier Martinez-Picado
    IrsiCaixa Foundation, Hospital Germans Trias i Pujol, Carretera de Canyet s n, 08916 Badalona, Spain
    Ann Intern Med 139:81-9. 2003
    ..Mathematical modeling has suggested that alternating antiretroviral regimens while patients' viral load remains suppressed would minimize HIV resistance mutations...
  42. ncbi Evaluation of the anti-HIV activity of statins
    Gemma Moncunill
    Retrovirology Laboratory IrsiCaixa and HIV Unit, Hospital Universitari Germans Trias i Pujol, , 08916 Badalona, Spain
    AIDS 19:1697-700. 2005
    ..No anti-HIV activity was detected at subtoxic concentrations and simvastatin did not induce a significant change in the mean viral load or CD4 cell count in study patients. We caution on the use of statins as antiretroviral agents...
  43. ncbi Nadir CD4 cell count predicts neurocognitive impairment in HIV-infected patients
    Jose A Muñoz-Moreno
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Badalona, Barcelona, Catalonia, Spain
    AIDS Res Hum Retroviruses 24:1301-7. 2008
    ..We found differences in neurocognitive functioning in relation to nadir CD4 count in HIV-infected patients. Attention should be given to this value in the management of neurocognitive protection in HIV infection...
  44. ncbi Lopinavir/ritonavir pharmacokinetics in HIV and hepatitis C virus co-infected patients without liver function impairment: influence of liver fibrosis
    Jose Molto
    Fundació Lluita contra la Sida, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Clin Pharmacokinet 46:85-92. 2007
    ..To assess the influence of hepatitis C virus (HCV) co-infection and the extent of liver fibrosis on lopinavir/ritonavir pharmacokinetics in HIV-infected patients without liver function impairment...
  45. ncbi Reversal of HIV-1-associated osteoporosis with once-weekly alendronate
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain
    AIDS 19:343-5. 2005
    ..Improvements in trochanter BMD were obtained after 2 years. Once-weekly oral alendronate may be an effective and safe treatment for HIV-1-associated osteoporosis...
  46. ncbi High rate of reversibility of renal damage in a cohort of HIV-infected patients receiving tenofovir-containing antiretroviral therapy
    Anna Bonjoch
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Autonomous University, Barcelona, Spain
    Antiviral Res 96:65-9. 2012
    ....
  47. ncbi Effect of milk thistle on the pharmacokinetics of darunavir-ritonavir in HIV-infected patients
    Jose Molto
    Lluita contra la SIDA Foundation, HIV Clinic, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Antimicrob Agents Chemother 56:2837-41. 2012
    ..19) for the concentration at the end of the dosing interval. In summary, coadministration of silymarin with darunavir-ritonavir seems to be safe in HIV-infected patients; no dose adjustment for darunavir-ritonavir seems to be necessary...
  48. ncbi Assessing self-reported adherence to HIV therapy by questionnaire: the SERAD (Self-Reported Adherence) Study
    Jose A Muñoz-Moreno
    Lluita contra la SIDA Foundation, Badalona, Barcelona, Catalonia, Spain
    AIDS Res Hum Retroviruses 23:1166-75. 2007
    ....
  49. ncbi Validation of estimated renal function measurements compared with the isotopic glomerular filtration rate in an HIV-infected cohort
    Anna Bonjoch
    University Hospital Germans Trias, Barcelona, Spain
    Antiviral Res 88:347-54. 2010
    ....
  50. ncbi HIV-1 infection in subjects older than 70: a multicenter cross-sectional assessment in Catalonia, Spain
    Beatriz Mothe
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Catalonia, Spain
    Curr HIV Res 7:597-600. 2009
    ..Based on our findings, we suggest some recommendations regarding the management of this growing population...
  51. ncbi Herb-drug interaction between Echinacea purpurea and etravirine in HIV-infected patients
    Jose Molto
    Lluita contra la SIDA Foundation, HIV Clinic, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Antimicrob Agents Chemother 56:5328-31. 2012
    ..In conclusion, the coadministration of E. purpurea with etravirine was safe and well tolerated in HIV-infected patients; our data suggest that no dose adjustment for etravirine is necessary...
  52. ncbi The changing face of HIV/AIDS in treated patients
    Josep M Llibre
    Lluita contra la SIDA Foundation, University Hospital Germans Trias, Barcelona 08916, Spain
    Curr HIV Res 7:365-77. 2009
    ..The present review focuses on these twelve areas of increasing interest for physicians currently facing successfully treated HIV+ patients...
  53. ncbi Reversal of atherogenic lipoprotein profile in HIV-1 infected patients with lipodystrophy after replacing protease inhibitors by nevirapine
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, , Badalona, Spain
    AIDS 16:1383-9. 2002
    ..These changes are expected to reduce the risk of cardiovascular disease in HIV-1-infected patients on highly active antiretroviral therapy...
  54. ncbi Safety of Switching Nevirapine Twice Daily to Nevirapine Once Daily in Virologically Suppressed Patients
    Daniel Podzamczer
    Hospital Universitari de Bellvitge, L Hospitalet, Barcelona, Spain
    J Acquir Immune Defic Syndr 50:390-6. 2009
    ..The strategy of switching nevirapine (NVP) twice daily to once daily was evaluated...
  55. ncbi CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART
    Marta Massanella
    Fundació irsiCaixa HIVACAT, Institut de Recerca en Ciències de la Salut Germans Trias i Pujol IGTP, Hospital Germans Trias, Universitat Autonoma de Barcelona, Spain
    AIDS 24:959-68. 2010
    ..However, the relative contribution of these factors is still unclear, strongly limiting the definition of appropriate therapeutic strategies for these patients...
  56. ncbi Switching to raltegravir in virologically suppressed in HIV-1-infected patients: a retrospective, multicenter, descriptive study
    Daniel Podzamczer
    Infectious Disease Service, Hospital Universitari de Belvitge, L Hospitalet de Llobregat, Barcelona, Spain
    Curr HIV Res 10:673-8. 2012
    ..To describe the efficacy and tolerability of switching to raltegravir (RAL) in virologically suppressed HIV-1-infected patients during routine clinical practice...
  57. ncbi HIV protease inhibitors and dyslipidemia
    Bonaventura Clotet
    HIV Unit and Retrovirology Laboratory, IrsiCaixa Foundation, Hospital Universitari, Germans Trias i Pujol, Carretera del Canyet s n Badalona, Barcelona, Spain
    AIDS Rev 5:19-24. 2003
    ..The need for lipid reduction therapy may be minimized with the use of new PIs that are comparable in efficacy to current PIs but do not negatively affect lipid levels...
  58. ncbi Impact of nevirapine on lipid metabolism
    Bonaventura Clotet
    Germans Trias i Pujol University Hospital, Barcelona, Spain
    J Acquir Immune Defic Syndr 34:S79-84. 2003
    ..These favorable lipid profiles may be of clinical benefit in reducing the risk for coronary artery disease in HIV-1 infected patients who are receiving long-term antiretroviral therapy...
  59. ncbi [Contribution of human papillomavirus second-generation hybrid capture test for the diagnosis of cervical pathology in HIV-infected outpatients]
    Guillem Sirera
    Unidad VIH, Servicio de Medicina, Hospital Universitario Germans Trias i Pujol, Universitat Autonoma de Barcelona, Ctra de Canyet s n, 08916 Badalona, Barcelona, Spain
    Med Clin (Barc) 125:127-31. 2005
    ....
  60. ncbi Virological, immunological, and clinical impact of switching from protease inhibitors to nevirapine or to efavirenz in patients with human immunodeficiency virus infection and long-lasting viral suppression
    Eugenia Negredo
    Fundació Lluita contra la Sida, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
    Clin Infect Dis 34:504-10. 2002
    ..Quality of life significantly improved for groups A and B. In patients receiving effective PI-based therapy, the replacement of the PI with either nevirapine or efavirenz is safe and virologically effective...
  61. ncbi [A 50-year-old male with AIDS and retroperitoneal mass]
    Eugenia Negredo
    Fundació de la Lluita contra la SIDA, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Espana
    Med Clin (Barc) 129:70-6. 2007