Han Li

Summary

Country: Spain

Publications

  1. pmc DNA double-strand breaks: a potential causative factor for mammalian aging?
    Han Li
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    Mech Ageing Dev 129:416-24. 2008
  2. pmc SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53
    Cian J Lynch
    YCR p53 Research Unit, Department of Biology, University of York, York, United Kingdom
    PLoS ONE 5:e13502. 2010
  3. pmc Ku80-deleted cells are defective at base excision repair
    Han Li
    The Department of Molecular Medicine, The University of Texas Health Science Center, San Antonio, TX 78245 3207, USA
    Mutat Res 745:16-25. 2013
  4. pmc Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair
    Lavinia C Dumitrache
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245 3207, USA
    Genetics 188:787-97. 2011
  5. pmc Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer
    Han Li
    Department of Molecular Medicine and Institute of Biotechnology, The University of Texas Health Science Center, San Antonio, Texas 78245, USA
    Mol Cell Biol 27:8205-14. 2007
  6. pmc Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor
    Mariana Yaneva
    Lexicon Genetics Inc The Woodlands, TX 77381 4287, USA
    Nucleic Acids Res 33:5320-30. 2005

Collaborators

Detail Information

Publications6

  1. pmc DNA double-strand breaks: a potential causative factor for mammalian aging?
    Han Li
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    Mech Ageing Dev 129:416-24. 2008
    ..Based on these comparisons we believe the basic mechanisms responsible for their aging phenotypes are fundamentally different demonstrating the complex and pleiotropic nature of this process...
  2. pmc SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53
    Cian J Lynch
    YCR p53 Research Unit, Department of Biology, University of York, York, United Kingdom
    PLoS ONE 5:e13502. 2010
    ..Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, precisely how SIRT1 integrates such diverse processes remains to be elucidated...
  3. pmc Ku80-deleted cells are defective at base excision repair
    Han Li
    The Department of Molecular Medicine, The University of Texas Health Science Center, San Antonio, TX 78245 3207, USA
    Mutat Res 745:16-25. 2013
    ..Ku80 deletion also impaired BER at the initial lesion recognition/strand scission step; thus, involvement of a DSB is unlikely. Therefore, our data suggests that Ku80 deletion impairs BER via a mechanism that does not repair DSBs...
  4. pmc Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair
    Lavinia C Dumitrache
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245 3207, USA
    Genetics 188:787-97. 2011
    ..These unexpected data suggest Trex2 does not enable DSB repair and prompt a new model that posits Trex2 suppresses the formation of broken chromosomes...
  5. pmc Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer
    Han Li
    Department of Molecular Medicine and Institute of Biotechnology, The University of Texas Health Science Center, San Antonio, Texas 78245, USA
    Mol Cell Biol 27:8205-14. 2007
    ..Thus, our observations suggest that the Ku heterodimer is important for longevity assurance in mice since divergent genetic backgrounds and/or environments likely account for these previously reported differences...
  6. pmc Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor
    Mariana Yaneva
    Lexicon Genetics Inc The Woodlands, TX 77381 4287, USA
    Nucleic Acids Res 33:5320-30. 2005
    ....