- DNA double-strand breaks: a potential causative factor for mammalian aging?Han Li
Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
Mech Ageing Dev 129:416-24. 2008..Based on these comparisons we believe the basic mechanisms responsible for their aging phenotypes are fundamentally different demonstrating the complex and pleiotropic nature of this process...
- SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53Cian J Lynch
YCR p53 Research Unit, Department of Biology, University of York, York, United Kingdom
PLoS ONE 5:e13502. 2010..Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, precisely how SIRT1 integrates such diverse processes remains to be elucidated...
- Ku80-deleted cells are defective at base excision repairHan Li
The Department of Molecular Medicine, The University of Texas Health Science Center, San Antonio, TX 78245 3207, USA
Mutat Res 745:16-25. 2013..Ku80 deletion also impaired BER at the initial lesion recognition/strand scission step; thus, involvement of a DSB is unlikely. Therefore, our data suggests that Ku80 deletion impairs BER via a mechanism that does not repair DSBs...
- Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repairLavinia C Dumitrache
Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245 3207, USA
Genetics 188:787-97. 2011..These unexpected data suggest Trex2 does not enable DSB repair and prompt a new model that posits Trex2 suppresses the formation of broken chromosomes...
- Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repairYong Jun Choi
Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
PLoS ONE 9:e86358. 2014..In addition, free Ku70 and free Ku80 bound to AP sites and in the case of Ku70 inhibited APE1 activity. These observations support a novel role for free Ku70 and free Ku80 in altering BER. ..
- Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancerHan Li
Department of Molecular Medicine and Institute of Biotechnology, The University of Texas Health Science Center, San Antonio, Texas 78245, USA
Mol Cell Biol 27:8205-14. 2007..Thus, our observations suggest that the Ku heterodimer is important for longevity assurance in mice since divergent genetic backgrounds and/or environments likely account for these previously reported differences...
- Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitorMariana Yaneva
Lexicon Genetics Inc The Woodlands, TX 77381 4287, USA
Nucleic Acids Res 33:5320-30. 2005....