Francisco Leyva-Cobian

Summary

Affiliation: Hospital Universitario "Marques de Valdecilla"
Location: Santander, Spain
Summary:
Head, Department of Immunology and Director of the Unit of Histocompatibility, Hospital Universitario "Marques de Valdecilla", Servicio Cantabro de Salud, Santander, Spain
Grants:
Inmunobiología del macrófago en el melanoma experimental B16 (Proyect FDC 12-159-1978), Inmunobiología del macrófago alveolar humano en condiciones normales y patológicas (Proyect FIS 1981-236), Nefropatía experimental por depósitos de IgM asociada a síndrome nefrótico (Proyect FIS 1981-237), Caracterización morfológica y funcional de los macrófagos de la leche humana (Heinz-Koch Foundation, 1983), Análisis de las alteraciones en macrófagos por Listeria monocytogenes (Proyect FIS 1989-0156), Procesamiento y presentación de antígenos por macrófagos (Proyect CICYT PM1989-0157), Biología celular de la interacción de Listeria monocytogenes con los macrófagos. Part I (Proyect FIS 1992-0158), Biología celular de la interacción de Listeria monocytogenes con los macrófagos. Part II (Proyect FIS 1994-0933), Trisomía 21 (síndrome de Down). Estudios neurobiológicos e inmunológicos en un modelo murino, la trisomía 16 parcial (Proyect DGICYT PB1994-1063), Estructura y patrones de enfermedad genéticos en la población pasiega. Estimación del papel de la inmunogenética en la susceptibilidad a la diabetes mellitus dependiente de insulin (Proyect FMV, 1997), Estructura y patrones de enfermedad genéticos en la población cántabra. I. Patrones epidemiológicos y genéticos de susceptibilidad a la diabetes mellitus dependiente de insulina en poblaciones cerradas pero geográficamente próximas (Proyect FIS 1997-1119), Estructura y patrones de enfermedad genéticos en la población pasiega. II. Búsqueda de mutaciones en apolipoproteína A-I que favorezcan ventajas selectivas frente a la diabetes mellitus y aterogenesis (Proyect FMV 16-1999), Estructura y patrones de enfermedad genéticos en la población cántabra (Proyect Parliament of Cantabria, 2001), Expresión de genes del herpesvirus asociado al sarcoma de Kaposi (herpesvirus humano-8) en el tejido sinovial de pacientes con artritis reumatoide (Proyect FMV A26-2001), Herpesvirus humano-8, proteínas de choque térmico y metaloproteasas de la matriz extracelular en pacientes con artritis reumatoide (Proyect Pharmacia Spain, S.A., 2002), Análisis funcional del transcriptoma de células eucarióticas infectadas por el herpesvirus asociado al sarcoma de Kaposi (Proyect FMV A22-03), Inmunologia del transplante: nuevas vias de tolerancia y control del rechazo y perspectivas para el empleo de tratamientos inmunosupresores especificos (Proyect FIS RED TEM G2003-104), Polimorfismos genéticos (TLR, CD14 & citocinas) en relación con infección por herpesvirus oncogénicos y rechazo de transplantes alogénicos (Proyect FIS PI2005-0503).
Publications:
Leyva Covián F.Eosinófilos. I. Morfología y estructura [Eosinophils: I. Morphology and structure]. Rev Clin Esp. 1975 Aug 31;138(4):293-300.
PMID: 1178978

Leyva Covián F. Eosinófilos. II. Quimiotaxis [Eosinophils. II. Chemotaxis]. Rev Clin Esp. 1976 Jun 15;141(5):403-410.
PMID: 948664

Toupin J, Leyva F, Lamoureux G. Transformation blastique par la PHA des coelomocytes de Lumbricus terrestris [PHA transformation of coelomocytes of Lubricus terrestris]. Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):29-32.
PMID: 848888

Lamoureux G, Toupin J, Leyva F. Un modèle de maladie à déficiences immunes spécifiques multiples: la sclérose en plaques [Multiple sclerosis: a multi-specific immune deficiency disease]. Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):531-536.
PMID: 848902

Leyva Covián F. Eosinófilos. III. Fagocitosis [Eosinophils. III. Phagocytosis]. Rev Clin Esp. 1977 Feb 15;144(3):167-171.
PMID: 320634

Leyva-Cobián F, Moneo I, Mampaso F, Sánchez-Bayle M, Ecija JL, Bootello A. Familial C1q deficiency associated with renal and cutaneous disease. Clin Exp Immunol. 1981 Apr;44(1):173-180.
PMID: 6790209

Mampaso F, Leyva-Cobián F, Martínez-Montero JC, Gonzalo A, Bellas C, Moneo I, Junquera E. Mesangial proliferative glomerulonephritis with unusual intramembranous granular dense deposits. Clin Nephrol. 1983 Feb;19(2):92-98.
PMID: 6188567

Leyva-Cobián F, Clerici N. Analysis of chemotactic factor generation in C1q-deficient sera. Int Arch Allergy Appl Immunol. 1983;71(2):151-155.
PMID: 6601627

Leyva-Cobián F, Clemente J. Phenotypic characterization and functional activity of human milk macrophages. Immunol Lett. 1984;8(5):249-256.
PMID: 6596292

Méndez E, Fernández-Luna JL, Grubb A, Leyva-Cobián F. Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis. Proc Natl Acad Sci USA. 1986 Mar;83(5):1472-1475.
PMID: 2419908

Ibañez MD, Leyva Cobián F, Díaz Gómez ML. Generación del factor quimiotáctico de los eosinófilos de la anafilaxia en pacientes con urticaria a frigore y estudio de la desactivación quimiotáctica in vitro [Generation of eosinophil chemotactic factor of anaphylaxis in patients with cold urticaria and study of its in vitro chemotactic deactivation]. Med Clin (Barc). 1986 May 17;86(19):794-797.
PMID: 3736185

Clemente J, Clerici N, Espinosa MA, Leyva-Cobián F. Defective chemotactic response of human alveolar and colostral macrophages. Immunol Lett. 1986 Jun;12(5-6):271-276.
PMID: 3733158

Clerici N, Leyva-Cobián F, Reboiras S, Lázaro de Mercado P. Functional characteristics of human alveolar macrophages in lung cancer. Lung. 1986;164(6):355-364.
PMID: 3100876

Clemente J, Leyva-Cobián F, Hernández M, García-Alonso A. Intracellular immunoglobulins in human milk macrophages. Ultrastructural localization and factors affecting the kinetics of immunoglobulin release. Int Arch Allergy Appl Immunol. 1986;80(3):291-299.
PMID: 3522436

Fierro C, Valverde D, Leyva-Cobián F, Mampaso F. A simple method for detecting anti-tubular membrane antibodies in rat lymphoid cell cultures. J Clin Lab Immunol. 1987 Apr;22(4):201-203.
PMID: 3612756

Roy G, Rojo N, Leyva-Cobián F. Phenotypic changes in monocytes and alveolar macrophages in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC). J Clin Lab Immunol. 1987 Jul;23(3):135-141.
PMID: 3118038

Giménez A, Leyva-Cobián F, Fierro C, Rio M, Bricio T, Mampaso F. Effect of cyclosporin A on autoimmune tubulointerstitial nephritis in the brown Norway rat. Clin Exp Immunol. 1987 Sep;69(3):550-556.
PMID: 3311496

Leyva-Cobián F, Flores R. A double staining method for the detection of a macrophage surface marker and nonspecific esterase activity. J Immunol Methods. 1988 Jun 28;111(1):147-151.
PMID: 2455751

Roy G, Pardo A, Leyva-Cobián F. Phenotypic and functional abnormalities in monocytes from patients with haemophilia A treated with factor VIII concentrates. Acta Haematol. 1988;79(1):26-32.
PMID: 2829491

Fernández-Luna JL, Leyva-Cobián F, Méndez E. Measurement of protein HC (alpha 1 microglobulin) and protein HC-IgA complex in different body fluids. J Clin Pathol. 1988 Nov;41(11):1176-1179.
PMID: 2463270

Carrasco-Marín E, Álvarez-Domínguez C, Leyva-Cobián F. Wortmannin, an inhibitor of phospholipase D activation, selectively blocks major histocompatibility complex class II-restricted antigen presentation. Eur J Immunol. 1994 Sep;24(9):2031-2039.
PMID: 8088323

Leyva-Cobián F, Carrasco-Marín E. Participation of intracellular oxidative pathways in antigen processing by dendritic cells, B cells and macrophages. Immunol Lett. 1994 Dec;43(1-2):29-37.
PMID: 7737687

Ocejo-Vinyals JG, Leyva-Cobián F, Fernández-Luna JL. A mutation unique in serine protease inhibitors (serpins) identified in a family with type II hereditary angioneurotic edema. Mol Med. 1995 Sep;1(6):700-705.
PMID: 8529136

Carrasco-Marín E, Alvarez-Domínguez C, López-Mato P, Martínez-Palencia R, Leyva-Cobián F. Iron salts and iron-containing porphyrins block presentation of protein antigens by macrophages to MHC class II-restricted T cells. Cell Immunol. 1996 Aug 1;171(2):173-85.
PMID: 8806786

Álvarez-Domínguez C, Vázquez-Boland JA, Carrasco-Marín E, López-Mato P, Leyva-Cobián F. Host cell heparan sulfate proteoglycans mediate attachment and entry of Listeria monocytogenes, and the listerial surface protein ActA is involved in heparan sulfate receptor recognition. Infect Immun. 1997 Jan;65(1):78-88.
PMID: 8975895

González-Fernández M, Carrasco-Marín E, Álvarez-Domínguez C, Outschoorn IM, Leyva-Cobián F. Inhibitory effects of thymus-independent type 2 antigens on MHC class II-restricted antigen presentation: comparative analysis of carbohydrate structures and the antigen presenting cell. Cell Immunol. 1997 Feb 25;176(1):1-13.
PMID: 9070312

Leyva-Cobián F, Outschoorn IM, Carrasco-Marín E, Álvarez-Domínguez C. The consequences of the intracellular retention of pathogen-derived T-cell-independent antigens on protein presentation to T cells. Clin Immunol Immunopathol. 1997 Oct;85(1):1-15.
PMID: 9325063

Combarros O, Escribano J, Sánchez-Velasco P, Leyva-Cobián F, Oterino A, Leno C, Berciano J. Association of the HLA-A2 allele with an earlier age of onset of Alzheimers disease. Acta Neurol Scand. 1998 Aug;98(2):140-141.
PMID: 9724015

Carrasco-Marín E, Paz-Miguel JE, López-Mato P, Álvarez-Domínguez C, Leyva-Cobián F. Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells. Immunology. 1998 Nov;95(3):314-321.
PMID: 9824492

Sánchez-Velasco P, Escribano de Diego J, Paz-Miguel JE, Ocejo-Vinyals G, Leyva-Cobián F. HLA-DR, DQ nucleotide sequence polymorphisms in the Pasiegos (Pas valleys, Northern Spain) and comparison of the allelic and haplotypic frequencies with those of other European populations. Tissue Antigens. 1999 Jan;53(1):65-73.
PMID:

Segundo C, Medina F, Rodríguez C, Martínez-Palencia R, Leyva-Cobián F, Brieva JA. Surface molecule loss and bleb formation by human germinal center B cells undergoing apoptosis: role of apoptotic blebs in monocyte chemotaxis. Blood. 1999 Aug 1;94(3):1012-1020.
PMID:

Escribano-de-Diego J, Sánchez-Velasco P, Luzuriaga C, Ocejo-Vinyals JG, Paz-Miguel JE, Leyva-Cobián F. HLA class II immunogenetics and incidence of insulin-dependent diabetes mellitus in the population of Cantabria (Northern Spain). Hum Immunol. 1999 Oct;60(10):990-1000.
PMID:

Paz-Miguel JE, Flores R, Sánchez-Velasco P, Ocejo-Vinyals G, Escribano de Diego J, López de Rego J, Leyva-Cobián F. Reactive oxygen intermediates during programmed cell death induced in the thymus of the Ts(1716)65Dn mouse, a murine model for human Downs syndrome. J Immunol. 1999 Nov 15;163(10):5399-5410.
PMID:

Gómez-Román JJ, Ocejo-Vinyals JG, Sánchez-Velasco P, Leyva-Cobián F, Val-Bernal JF. Presence of human herpesvirus 8 DNA sequences in renal transplantation-associated pleural Kaposi sarcoma. Arch Pathol Lab Med. 1999 Dec;123(12):1269-1273.
PMID:

Sánchez-Velasco P, Mendizabal L, Antón EM, Ocejo-Vinyals G, Jerez J, Leyva-Cobián F. Association of hypersensitivity to the nematode Anisakis simplex with HLA class II DRB1*1502-DQB1*0601 haplotype. Hum Immunol. 2000 Mar;61(3):314-319.
PMID:

Gómez-Román JJ, Ocejo-Vinyals G, Sánchez-Velasco P, Nieto EH, Leyva-Cobián F, Val-Bernal JF. Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor). Lab Invest. 2000 Jul;80(7):1121-1126.
PMID:

Ocejo-Vinyals JG, Lozano MJ, Sánchez-Velasco P, Escribano de Diego J, Paz-Miguel JE, Leyva-Cobián F. An unusual concurrence of graft versus host disease caused by engraftment of maternal lymphocytes with DiGeorge anomaly. Arch Dis Child. 2000 Aug;83(2):165-169.
PMID:

Álvarez-Domínguez C, Carrasco-Marín E, López-Mato P, Leyva-Cobián F. The contribution of both oxygen and nitrogen intermediates to the intracellular killing mechanisms of C1q-opsonized Listeria monocytogenes by the macrophage-like IC-21 cell line. Immunology. 2000 Sep;101(1):83-89.
PMID:

Sánchez-Velasco P, Ocejo-Vinyals JG, Flores R, Gómez-Román JJ, Lozano MJ, Leyva-Cobián F. Simultaneous multiorgan presence of human herpesvirus 8 and restricted lymphotropism of Epstein-Barr virus DNA sequences in a human immunodeficiency virus-negative immunodeficient infant. J Infect Dis. 2001 Jan 15;183(2):338-342.
PMID:

Paz-Miguel JE, Pardo-Manuel de Villena F, Sánchez-Velasco P, Leyva-Cobián F. H2-haplotype-dependent unequal transmission of the 1716 translocation chromosome from Ts65Dn females. Mamm Genome. 2001 Jan;12(1):83-85.
PMID:

Gómez-Román JJ, Sánchez-Velasco P, Ocejo-Vinyals G, Hernández-Nieto E, Leyva-Cobián F, Val-Bernal JF. Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). Am J Surg Pathol. 2001 May;25(5):624-629.
PMID:

Sánchez-Velasco P, Karadsheh NS, García-Martín A, Ruíz de Alegria C, Leyva-Cobián F. Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations. Hum Immunol. 2001 Sep;62(9):901-909.
PMID:

Sánchez-Velasco P, Leyva-Cobián F. The HLA class I and class II allele frequencies studied at the DNA level in the Svanetian population (Upper Caucasus) and their relationships to Western European populations. Tissue Antigens. 2001 Oct;58(4):223-233.
PMID:

Martín M, Echevarria S, Leyva-Cobián F, Pereda I, López-Hoyos M. Limited immune reconstitution at intermediate stages of HIV-1 infection during one year of highly active antiretroviral therapy in antiretroviral-naive versus non-naive adults. Eur J Clin Microbiol Infect Dis. 2001 Dec;20(12):871-879.
PMID:

Ding Y, Saylors RL, Brown H, Parham DM, Gómez-Román JJ, Sánchez-Velasco P, Ocejo-Vinyals G, Leyva-Cobián F, Val-Bernal JF. Pulmonary inflammatory pseudotumor with HHV-8.
Am J Surg Pathol. 2002 Aug;26(8):1089-91; author reply 1091-2. Comment on: Am J Surg Pathol. 2001 May;25(5):624-629.
PMID:

Miñambres E, Cemborain A, Sánchez-Velasco P, Gandarillas M, Díaz-Regañón G, Sánchez-González U, Leyva-Cobián F. Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury. Crit Care Med. 2003 Mar;31(3):933-938.
PMID:

Sánchez-Velasco P, Gomez-Casado E, Martínez-Laso J, Moscoso J, Zamora J, Lowy E, Silvera C, Cemborain A, Leyva-Cobián F, Arnáiz-Villena A. HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians. Tissue Antigens. 2003 May;61(5):384-392.
PMID:

Maca-Meyer N, Sánchez-Velasco P, Flores C, Larruga JM, González AM, Oterino A, Leyva-Cobián F. Y chromosome and mitochondrial DNA characterization of Pasiegos, a human isolate from Cantabria (Spain). Ann Hum Genet. 2003 Jul;67(Pt 4):329-339.
PMID:

Zarrabeitia MT, Riancho JA, Lareu MV, Leyva-Cobián F, Carracedo A. Significance of micro-geographical population structure in forensic cases: a bayesian exploration. Int J Legal Med. 2003 Oct;117(5):302-305.
PMID:

Oterino A, Valle N, Bravo Y, Muñoz P, Sánchez-Velasco P, Ruíz-Alegría C, Castillo J, Leyva-Cobián F, Vadillo A, Pascual J. MTHFR T677 homozygosis influences the presence of aura in migraineurs. Cephalalgia. 2004 Jun;24(6):491-494.
PMID:

Prada-Delgado A, Carrasco-Marín E, Pena-Macarro C, Del Cerro-Vadillo E, Fresno-Escudero M, Leyva-Cobián F, Álvarez-Domínguez C. Inhibition of Rab5a exchange activity is a key step for Listeria monocytogenes survival. Traffic. 2005 Mar;6(3):252-265.
PMID:

Sánchez-Velasco P, Antón E, Muñoz D, Martínez-Quesada J, Ruíz de Alegria C, López-Hoyos M, García-Martín A, Jiménez I, Alonso ST, Duque S, Suárez A, Jerez J, Leyva-Cobián F. Sensitivity to bee venom antigen phospholipase A2: association with specific HLA class I and class II alleles and haplotypes in beekeepers and allergic patients. Hum Immunol. 2005 Jul;66(7):818-825.
PMID:

Oterino A, Valle N, Pascual J, Bravo Y, Muñoz P, Castillo J, Ruíz-Alegria C, Sánchez-Velasco P, Leyva-Cobián F, Cid C. Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele. Mol Brain Res. 2005 Sep 13;139(1):163-168.
PMID:

Oterino A, Pascual J, Ruíz de Alegria C, Valle N, Castillo J, Bravo Y, González F, Sánchez-Velasco P, Cayón A, Leyva-Cobián F, Alonso-Arranz A, Muñoz P. Association of migraine and ESR1 G325C polymorphism. Neuroreport. 2006 Jan 23;17(1):61-64.
PMID:

del Cerro-Vadillo E, Madrazo-Toca F, Carrasco-Marín E, Fernández-Prieto L, Beck C, Leyva-Cobián F, Saftig P, Álvarez-Domínguez C. Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth. J Immunol. 2006 Feb 1;176(3):1321-1325.
PMID:

García-Astudillo LA, Leyva-Cobián F. Human herpesvirus-8 infection and Kaposis sarcoma after liver and kidney transplantation in different geographical areas of Spain. Transpl Immunol. 2006 Dec;17(1):65-69.
PMID:

Mata I, Crespo-Facorro B, Pérez-Iglesias R, Carrasco-Marín E, Arranz MJ, Pelayo-Terán JM, Leyva-Cobián F, Vázquez-Barquero JL. Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment. Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141(8):939-943.
PMID:

Rodrigo E, Sánchez-Velasco P, Ruíz JC, Fernández-Fresnedo G, López-Hoyos M, Piñera C, Palomar R, Gómez-Alamillo C, González-Cotorruelo J, Leyba-Cobián F, Arias M. Cytokine polymorphisms and risk of infection after kidney transplantation. Transplant Proc. 2007 Sep;39(7):2219-2221.
PMID:

Sánchez-Velasco P, Rodrigo E, Valero R, Ruíz JC, Fernández-Fresnedo G, López-Hoyos M, Piñera C, Palomar R, Leyva-Cobián F, Arias M. Intracellular ATP concentrations of CD4 cells in kidney transplant patients with and without infection. Clin Transplant. 2008 Jan-Feb;22(1):55-60.
PMID:

Roiz-Santiáñez R, Crespo-Facorro B, Pérez-Iglesias R, Pelayo-Terán JM, Carrasco-Marín E, Mata I, Sánchez E, Leyva-Cobián F, Vázquez-Barquero JL. Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis. Psychiatry Res. 2008 Feb 28;162(2):167-171.
PMID:

Álvarez-Domínguez C, Madrazo-Toca F, Fernández-Prieto L, Vandekerckhove J, Pareja E, Tobes R, Gómez-López MT, Del Cerro-Vadillo E, Fresno M, Leyva-Cobián F, Carrasco-Marín E. Characterization of a Listeria monocytogenes protein interfering with Rab5a. Traffic. 2008 Mar;9(3):325-337.
PMID:

Crespo-Facorro B, Carrasco-Marín E, Pérez-Iglesias R, Pelayo-Terán JM, Fernández-Prieto L, Leyva-Cobián F, Vázquez-Barquero JL. Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: effects of antipsychotic drugs. Psychiatry Res. 2008 Mar 15;158(2):206-216.
PMID:

Pelayo-Terán JM, Crespo-Facorro B, Carrasco-Marín E, Pérez-Iglesias R, Mata I, Arranz MJ, Leyva-Cobián F, Vázquez-Barquero JL. Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosis. Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):550-556.
PMID:

Sánchez-Castañón M, Baquero IC, Sánchez-Velasco P, Fariñas M-C, Ausín F, Leyva-Cobián F, Ocejo-Vinyals J-G. Polymorphisms in CCL5 promoter are associated with pulmonary tuberculosis in Northern Spain. Int J Tuberc Lung Dis 2009 Apr; 13 (4): 480-485.
PMID:

Sánchez-Velasco P, Rodrigo E, Fernández-Fresnedo G, Ocejo-Vinyals JG, Ruiz JC, Arnau A, Leyva-Cobián F, Arias M. Influence of interleukin-6 promoter polymorphism -174 g/c on kidney graft outcome. Transplant Proc. 2010 Oct;42(8):2854-2855.
PMID:

Publications

  1. doi Influence of interleukin-6 promoter polymorphism -174 g/c on kidney graft outcome
    P Sanchez-Velasco
    Service of Immunology, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
    Transplant Proc 42:2854-5. 2010
  2. ncbi HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians
    P Sanchez-Velasco
    Department of Immunology and Molecular Biology, Hosp 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 61:384-92. 2003
  3. ncbi Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury
    Eduardo Minambres
    Departamento de Medicina Intensiva, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Crit Care Med 31:933-8. 2003
  4. ncbi Pulmonary inflammatory pseudotumor with HHV-8
    Yiling Ding
    Am J Surg Pathol 26:1089-91; author reply 1091-2. 2002
  5. ncbi Limited immune reconstitution at intermediate stages of HIV-1 infection during one year of highly active antiretroviral therapy in antiretroviral-naive versus non-naive adults
    M Martin
    Immunology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Eur J Clin Microbiol Infect Dis 20:871-9. 2001
  6. ncbi The HLA class I and class II allele frequencies studied at the DNA level in the Svanetian population (Upper Caucasus) and their relationships to Western European populations
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Tissue Antigens 58:223-33. 2001
  7. ncbi Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Hum Immunol 62:901-9. 2001
  8. ncbi Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor)
    J J Gómez-Roman
    Departamento de Anatomia Patologica, Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Am J Surg Pathol 25:624-9. 2001
  9. ncbi Simultaneous multiorgan presence of human herpesvirus 8 and restricted lymphotropism of Epstein-Barr virus DNA sequences in a human immunodeficiency virus-negative immunodeficient infant
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    J Infect Dis 183:338-342. 2001
  10. ncbi Association of hypersensitivity to the nematode Anisakis simplex with HLA class II DRB1*1502-DQB1*0601 haplotype
    P Sanchez-Velasco
    Servicios de Inmunologia, Santander, Spain
    Hum Immunol 61:314-9. 2000

Collaborators

Detail Information

Publications62

  1. doi Influence of interleukin-6 promoter polymorphism -174 g/c on kidney graft outcome
    P Sanchez-Velasco
    Service of Immunology, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
    Transplant Proc 42:2854-5. 2010
    ..The relationship between IL-6 polymorphisms and graft survival, cardiovascular events, and new-onset diabetes mellitus after kidney transplantation is controversial...
  2. ncbi HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians
    P Sanchez-Velasco
    Department of Immunology and Molecular Biology, Hosp 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 61:384-92. 2003
    ..These populations have been compared with neighbouring ones and other Mediterraneans by using neighbour-joining dendrograms and plane genetic distances...
  3. ncbi Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury
    Eduardo Minambres
    Departamento de Medicina Intensiva, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Crit Care Med 31:933-8. 2003
    ....
  4. ncbi Pulmonary inflammatory pseudotumor with HHV-8
    Yiling Ding
    Am J Surg Pathol 26:1089-91; author reply 1091-2. 2002
  5. ncbi Limited immune reconstitution at intermediate stages of HIV-1 infection during one year of highly active antiretroviral therapy in antiretroviral-naive versus non-naive adults
    M Martin
    Immunology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Eur J Clin Microbiol Infect Dis 20:871-9. 2001
    ..This finding indicates a need for longer HIV suppression in order to achieve effective recovery of the immune system...
  6. ncbi The HLA class I and class II allele frequencies studied at the DNA level in the Svanetian population (Upper Caucasus) and their relationships to Western European populations
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Tissue Antigens 58:223-33. 2001
    ..These observations suggest a mixture of alleles in Svans from geographically distinct areas, and probably do not support a common ancestor for these Caucasian inhabitants and people from Northern Spain...
  7. ncbi Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Hum Immunol 62:901-9. 2001
    ....
  8. ncbi Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor)
    J J Gómez-Roman
    Departamento de Anatomia Patologica, Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Am J Surg Pathol 25:624-9. 2001
    ..These differences may be related to either cell-specific or immunologic host factors...
  9. ncbi Simultaneous multiorgan presence of human herpesvirus 8 and restricted lymphotropism of Epstein-Barr virus DNA sequences in a human immunodeficiency virus-negative immunodeficient infant
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    J Infect Dis 183:338-342. 2001
    ..This report is believed to be the first of multiorgan dissemination of HHV-8 in a primary immunodeficiency...
  10. ncbi Association of hypersensitivity to the nematode Anisakis simplex with HLA class II DRB1*1502-DQB1*0601 haplotype
    P Sanchez-Velasco
    Servicios de Inmunologia, Santander, Spain
    Hum Immunol 61:314-9. 2000
    ..The data suggest that this haplotype can be considered to be a susceptibility factor for hypersensitivity to A. simplex antigens...
  11. ncbi Significance of micro-geographical population structure in forensic cases: a bayesian exploration
    Maria T Zarrabeitia
    Unit of Legal Medicine, Faculty of Medicine, University of Cantabria, 39011, Santander, Spain
    Int J Legal Med 117:302-5. 2003
    ..A bayesian analysis revealed that this had a significant impact on the estimation of the probability of identity in scenarios of low "a priori" odds of suspicion...
  12. ncbi Y chromosome and mitochondrial DNA characterization of Pasiegos, a human isolate from Cantabria (Spain)
    N Maca-Meyer
    Departamento de Genetica, Facultad de Biologia, Universidad de La Laguna, Tenerife, Spain
    Ann Hum Genet 67:329-39. 2003
    ..However, this does not discount a conjoint recolonization...
  13. ncbi MTHFR T677 homozygosis influences the presence of aura in migraineurs
    A Oterino
    Service of Neurology, University Hospital Marques de Valdecilla, Santander, Spain
    Cephalalgia 24:491-4. 2004
    ..Overall, however, there was no association between migraine and the C677T MTHFR polymorphism...
  14. ncbi Polymorphisms in CCL5 promoter are associated with pulmonary tuberculosis in northern Spain
    M Sánchez-Castañón
    Immunology Service, Department of Internal Medicine, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Int J Tuberc Lung Dis 13:480-5. 2009
    ....
  15. doi Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: effects of antipsychotic drugs
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 158:206-16. 2008
    ..Thus, patients with a first episode of psychosis have inflammatory-like immunological function during early phases of the illness that it is independent of the antipsychotic treatment used...
  16. doi Intracellular ATP concentrations of CD4 cells in kidney transplant patients with and without infection
    Pablo Sánchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Servico Cántabro de Salud, Santander, Spain
    Clin Transplant 22:55-60. 2008
    ..This assay identifies transplant patients at risk for infection or rejection, providing information which can guide immunosuppressive therapy...
  17. doi Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis
    Roberto Roiz-Santiáñez
    University Hospital Marques de Valdecilla, Department of Psychiatry School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 162:167-71. 2008
    ..We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness...
  18. ncbi Characterization of a Listeria monocytogenes protein interfering with Rab5a
    Carmen Alvarez-Dominguez
    Servicio de Inmunología and Instituto de Formación e Investigación Marqués de Valdecilla IFIMAV, Hospital Universitario Marques de Valdecilla, 39008 Santander, Spain
    Traffic 9:325-37. 2008
    ..Listeria GAPDH might be the first intracellular gram-positive enzyme targeted to Rab proteins with ADP-ribosylating ability and a putative novel virulence factor...
  19. ncbi Cytokine polymorphisms and risk of infection after kidney transplantation
    E Rodrigo
    Service of Nephrology, Hospital Valdecilla University of Cantabria, Santander, Spain
    Transplant Proc 39:2219-21. 2007
    ..Genetic background has an influence on the incidence of infection. The aim of our study was to analyze the relationship between cytokine polymorphisms and infection in our kidney transplant recipients...
  20. ncbi Human herpesvirus-8 infection and Kaposi's sarcoma after liver and kidney transplantation in different geographical areas of Spain
    Luis Alfonso García-Astudillo
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Transpl Immunol 17:65-9. 2006
    ..Time of KS diagnosis after transplant is significantly higher in kidney transplant patients (33.7 months) than in liver transplant recipients (10.4 months), indicating that the latter have a higher risk of developing KS...
  21. ncbi Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment
    Ignacio Mata
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Am J Med Genet B Neuropsychiatr Genet 141:939-43. 2006
    ..These results suggest that the VNTR polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs...
  22. ncbi Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth
    Elida Del Cerro-Vadillo
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
    J Immunol 176:1321-5. 2006
    ..Based on infection experiments with mutant bacteria, in vitro degradation, and immunoprecipitation experiments, we suggest that a major target of cathepsin D is the main virulence factor listeriolysin O...
  23. ncbi Association of migraine and ESR1 G325C polymorphism
    Agustin Oterino
    Services of Neurology, Universitary Hospital Marques de Valdecilla, Santander, Spain
    Neuroreport 17:61-4. 2006
    ..Women carrying the C352C genotype were over 3 times more likely to suffer from migraine than those carrying the G325G genotype. Therefore, we conclude that ESR1 G325C polymorphism is associated with migraine in our population...
  24. ncbi Sensitivity to bee venom antigen phospholipase A2: association with specific HLA class I and class II alleles and haplotypes in beekeepers and allergic patients
    Pablo Sánchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Hum Immunol 66:818-25. 2005
    ..02) were significantly increased in the former. These observations emphasize the importance of the DRB1*0103-DQA1*0101-DQB1*0501 haplotype as a strong candidate for susceptibility to vbPLA2 hypersensitivity, at least in our region...
  25. ncbi Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele
    Agustin Oterino
    Services of Neurology, University Hospital Marqués de Valdecilla UC, Santander 39008, Spain
    Brain Res Mol Brain Res 139:163-8. 2005
    ..08; 95% CI = 1.3-7.4). We conclude that the pathogenetic role of the MTHFR T677 allele in migraine is modulated by functional polymorphisms of TS and MTHFD1...
  26. ncbi Inhibition of Rab5a exchange activity is a key step for Listeria monocytogenes survival
    Amaya Prada-Delgado
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, 39008 Santander, Spain
    Traffic 6:252-65. 2005
    ..We cotransfected functional Rab5a GEF into this dominant negative mutant and restored normal LM intraphagosomal viability, Rab5a exchange and listericidal action of cathepsin-D...
  27. ncbi Phenotypic changes in monocytes and alveolar macrophages in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC)
    G Roy
    Department of Immunology, , Madrid, Spain
    J Clin Lab Immunol 23:135-41. 1987
    ..5 +/- 10.9%, p less than 0.005) patients in comparison with controls (87.4 +/- 8.7%). Only alveolar M phi from one AIDS patient could be studied for LFA-1 antigen and this was into the normal range.(ABSTRACT TRUNCATED AT 250 WORDS)..
  28. pmc Measurement of protein HC (alpha 1 microglobulin) and protein HC-IgA complex in different body fluids
    J L Fernandez-Luna
    Servicio de Endocrinologia, Centro Ramon y Cajal, Madrid, Spain
    J Clin Pathol 41:1176-9. 1988
    ..On the other hand, the concentrations of HC-IgA complex were raised only in those patients with pulmonary alveolar proteinosis or rheumatoid arthritis...
  29. pmc Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis
    E Mendez
    Proc Natl Acad Sci U S A 83:1472-5. 1986
    ..These results suggest that protein HC and its IgA complex play physiological roles in the regulation of the inflammatory response...
  30. pmc A mutation unique in serine protease inhibitors (serpins) identified in a family with type II hereditary angioneurotic edema
    J G Ocejo-Vinyals
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Mol Med 1:700-5. 1995
    ..Most of the dysfunctional proteins result from mutations involving the Arg-444 (the P-1 site of the reactive center) or amino acids NH2-terminal to the reactive center...