J Lerma

Summary

Country: Spain

Publications

  1. ncbi Kainate receptors: an interplay between excitatory and inhibitory synapses
    J Lerma
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    FEBS Lett 430:100-4. 1998
  2. ncbi Molecular physiology of kainate receptors
    J Lerma
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Physiol Rev 81:971-98. 2001
  3. ncbi Roles and rules of kainate receptors in synaptic transmission
    Juan Lerma
    Instituto Cajal, , Av. Doctor Arce 37, 28002 Madrid, Spain
    Nat Rev Neurosci 4:481-95. 2003
  4. ncbi [Synaptic physiology of the kainate receptors and its influence in epileptogenesis]
    J Lerma
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid
    Neurologia 19:106-16. 2004
  5. ncbi GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors
    A V Paternain
    Department of Neural Plasticity, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 20:196-205. 2000
  6. ncbi Intersubunit cooperativity in the NMDA receptor
    M P Regalado
    Instituto Cajal, , 28002, Madrid, Spain
    Neuron 32:1085-96. 2001
  7. ncbi Dual signaling by mGluR5a results in bi-directional modulation of N-type Ca2+ channels
    J Sanchez-Prieto
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    FEBS Lett 576:428-32. 2004
  8. ncbi Block of kainate receptor desensitization uncovers a key trafficking checkpoint
    Avi Priel
    The Institute of Basic Dental Sciences, The Hebrew University-Hadassah Dental School, 91120 Jerusalem, Israel
    Neuron 52:1037-46. 2006
  9. ncbi Kainate receptor physiology
    Juan Lerma
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, 03550, San Juan de Alicante, Spain
    Curr Opin Pharmacol 6:89-97. 2006
  10. ncbi Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors
    André R Gomes
    Centre for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, Largo Marques de Pombal, 3004 517 Coimbra, Portugal
    Mol Cell Neurosci 37:323-34. 2008

Collaborators

Detail Information

Publications18

  1. ncbi Kainate receptors: an interplay between excitatory and inhibitory synapses
    J Lerma
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    FEBS Lett 430:100-4. 1998
    ..Thus, kainate receptors may have a role in the etiology of epilepsy and could become a target for antiepileptic drugs...
  2. ncbi Molecular physiology of kainate receptors
    J Lerma
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Physiol Rev 81:971-98. 2001
    ....
  3. ncbi Roles and rules of kainate receptors in synaptic transmission
    Juan Lerma
    Instituto Cajal, , Av. Doctor Arce 37, 28002 Madrid, Spain
    Nat Rev Neurosci 4:481-95. 2003
  4. ncbi [Synaptic physiology of the kainate receptors and its influence in epileptogenesis]
    J Lerma
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid
    Neurologia 19:106-16. 2004
    ....
  5. ncbi GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors
    A V Paternain
    Department of Neural Plasticity, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 20:196-205. 2000
    ....
  6. ncbi Intersubunit cooperativity in the NMDA receptor
    M P Regalado
    Instituto Cajal, , 28002, Madrid, Spain
    Neuron 32:1085-96. 2001
    ..Thus, these segments mediate negative allosteric coupling between the two subunit types that form the NMDA receptor...
  7. ncbi Dual signaling by mGluR5a results in bi-directional modulation of N-type Ca2+ channels
    J Sanchez-Prieto
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    FEBS Lett 576:428-32. 2004
    ..These results show that mGluR5a exerts a bi-directional influence on Ca2+ channels, which may explain how group I mGluRs facilitate and inhibit glutamate release at central synapses...
  8. ncbi Block of kainate receptor desensitization uncovers a key trafficking checkpoint
    Avi Priel
    The Institute of Basic Dental Sciences, The Hebrew University-Hadassah Dental School, 91120 Jerusalem, Israel
    Neuron 52:1037-46. 2006
    ..Therefore, in addition to its role at the synapse, we now propose an intracellular role for desensitization in controlling maturation and trafficking of glutamate receptors...
  9. ncbi Kainate receptor physiology
    Juan Lerma
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, 03550, San Juan de Alicante, Spain
    Curr Opin Pharmacol 6:89-97. 2006
    ..However, the role of kainate receptors in other brain pathologies remains obscure...
  10. ncbi Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors
    André R Gomes
    Centre for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, Largo Marques de Pombal, 3004 517 Coimbra, Portugal
    Mol Cell Neurosci 37:323-34. 2008
    ..The existence of truncated AMPA receptor subunits may constitute an intrinsic neuroprotective mechanism...
  11. ncbi A role for extracellular Na+ in the channel gating of native and recombinant kainate receptors
    Ana V Paternain
    Instituto Cajal, , 28002 Madrid, Spain
    J Neurosci 23:8641-8. 2003
    ..Thus, these results show the existence of a specific kainate receptor gating mechanism that requires external Na+ to be operative...
  12. ncbi Molecular mechanism of AMPA receptor noncompetitive antagonism
    Victoria Balannik
    The Institute of Basic Dental Sciences, The Hebrew University-Hadassah Dental School, 91120 Jerusalem, Israel
    Neuron 48:279-88. 2005
    ..These results provide evidence for substantial conformational changes in the S1-M1 and S2-M4 linkers following agonist binding and channel opening, offering a conceptual frame to account for noncompetitive antagonism of AMPA receptors...
  13. ncbi Noncanonical signaling by ionotropic kainate receptors
    José Luis Rozas
    Instituto Cajal, CSIC, 28002 Madrid, Spain
    Neuron 39:543-53. 2003
    ..Thus, such a system represents a noncanonical signaling route of ion channel-forming receptors...
  14. ncbi A meeting to remember: meeting on memory and related disorders
    Gregory P Gasic
    Harvard Medical School and Massachussets General Hospital, Boston, Massachusetts 02115, USA
    EMBO Rep 7:768-73. 2006
  15. ncbi Pharmacological intervention at ionotropic glutamate receptor complexes
    Rosa Planells-Cases
    , FVIB, 46012 Valencia, Spain
    Curr Pharm Des 12:3583-96. 2006
    ..As a consequence, an enormous effort is being carried out to identify and develop safe and potent antagonists for the clinics. In this review, we will describe progress in this important arena of human health...
  16. ncbi The synaptic hypothesis of schizophrenia
    W Gordon Frankle
    Department of Psychiatry, Columbia College of Physicians and Surgeons, New York, NY 10032, USA
    Neuron 39:205-16. 2003
  17. ncbi PKC-dependent autoregulation of membrane kainate receptors
    Rocio Rivera
    Cellular and Systems Neurobiology, Instituto de Neurociencias de Alicante, CSIC UMH, San Juan de Alicante, Spain
    EMBO J 26:4359-67. 2007
    ..Such a mechanism represents an active way to limit overactivation of the KAR system, by regulating the number of KARs in the cell membrane...
  18. ncbi A mosaic of functional kainate receptors in hippocampal interneurons
    Jeppe K Christensen
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 24:8986-93. 2004
    ....