J Navarro-González

Summary

Affiliation: Las Palmas de Gran Canaria
Country: Spain

Publications

  1. ncbi request reprint Beneficial effects of selective vitamin d receptor activation by paricalcitol in chronic kidney disease
    Javier Donate-Correa
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Curr Drug Targets 15:703-9. 2014
  2. ncbi request reprint Selective vitamin d receptor activation as anti-inflammatory target in chronic kidney disease
    J Donate-Correa
    Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain GEENDIAB Grupo Español para el Estudio de la Nefropatía Diabética and REDINREN RD12 0021 0019, Spain
    Mediators Inflamm 2014:670475. 2014
  3. doi request reprint Anti-inflammatory profile of paricalcitol in hemodialysis patients: a prospective, open-label, pilot study
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    J Clin Pharmacol 53:421-6. 2013
  4. doi request reprint Relationship between inflammation and microalbuminuria in prehypertension
    J F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    J Hum Hypertens 27:119-25. 2013
  5. pmc Should we adjust erythropoiesis-stimulating agent dosage to postdialysis hemoglobin levels? A pilot study
    Nieves Castillo
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    BMC Nephrol 13:60. 2012
  6. pmc Baseline characteristics of patients with chronic kidney disease stage 3 and stage 4 in Spain: the MERENA observational cohort study
    Alberto Martinez-Castelao
    Nephrology Unit, Hospital Universitario Bellvitge, L Hospitalet de Llobregat, Barcelona, Spain
    BMC Nephrol 12:53. 2011
  7. pmc Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients
    Juan F Navarro-González
    Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Clin J Am Soc Nephrol 6:2272-9. 2011
  8. doi request reprint Inflammatory pathways
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    Contrib Nephrol 170:113-23. 2011
  9. doi request reprint Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Carretera del Rosario, 145, 38010 Santa Cruz de Tenerife, Spain
    Nat Rev Nephrol 7:327-40. 2011
  10. doi request reprint Pentoxifylline for renoprotection in diabetic nephropathy: the PREDIAN study. Rationale and basal results
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    J Diabetes Complications 25:314-9. 2011

Collaborators

  • Juan F Navarro
  • Antonio Rivero
  • J Donate-Correa
  • Javier Donate-Correa
  • Nieves Castillo
  • Alberto Martinez-Castelao
  • Carmen Mora-Fernández
  • Virginia Domínguez-Pimentel
  • E Martín-Núñez
  • M Muros-de-Fuentes
  • Ernesto Martín-Nunez
  • V Cazaña-Pérez
  • V Domínguez-Pimentel
  • C Mora-Fernandez
  • Mercedes Muros-de-Fuentes
  • M L Méndez-Pérez
  • Violeta Cazaña-Pérez
  • Manuel Macia
  • Patricia García-García
  • Alejandro Jimenez-Sosa
  • María Luisa Méndez
  • Javier Garcia-Perez
  • María Adela Getino
  • Rafael Montes
  • Daniel Batlle
  • José Luño
  • Aleix Cases
  • Fernando de Alvaro
  • Juan J de la Cruz-Troca
  • Aparna Natarajan
  • Jose L Gorriz
  • José M Portolés

Detail Information

Publications22

  1. ncbi request reprint Beneficial effects of selective vitamin d receptor activation by paricalcitol in chronic kidney disease
    Javier Donate-Correa
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Curr Drug Targets 15:703-9. 2014
    ....
  2. ncbi request reprint Selective vitamin d receptor activation as anti-inflammatory target in chronic kidney disease
    J Donate-Correa
    Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain GEENDIAB Grupo Español para el Estudio de la Nefropatía Diabética and REDINREN RD12 0021 0019, Spain
    Mediators Inflamm 2014:670475. 2014
    ..8% (P = 0.01) and 35.4% (P = 0.01), respectively. In conclusion, selective VDR activation is an effective target to modulate inflammation in CKD. ..
  3. doi request reprint Anti-inflammatory profile of paricalcitol in hemodialysis patients: a prospective, open-label, pilot study
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    J Clin Pharmacol 53:421-6. 2013
    ..This effect may contribute to the survival benefits of paricalcitol observed in clinical studies...
  4. doi request reprint Relationship between inflammation and microalbuminuria in prehypertension
    J F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    J Hum Hypertens 27:119-25. 2013
    ..Inflammatory parameters are significantly and independently associated with UAE in prehypertensive subjects, suggesting that inflammation may be a pathogenic factor for the early vascular or TOD in these individuals...
  5. pmc Should we adjust erythropoiesis-stimulating agent dosage to postdialysis hemoglobin levels? A pilot study
    Nieves Castillo
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    BMC Nephrol 13:60. 2012
    ..We tested whether predialysis Hb is a reliable predictor of the postdialysis level to better control ESA dosage, and evaluated the relation between ESA, Hb and cardiovascular events (CVE)...
  6. pmc Baseline characteristics of patients with chronic kidney disease stage 3 and stage 4 in Spain: the MERENA observational cohort study
    Alberto Martinez-Castelao
    Nephrology Unit, Hospital Universitario Bellvitge, L Hospitalet de Llobregat, Barcelona, Spain
    BMC Nephrol 12:53. 2011
    ....
  7. pmc Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients
    Juan F Navarro-González
    Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Clin J Am Soc Nephrol 6:2272-9. 2011
    ..We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and sCD14 levels in HD patients...
  8. doi request reprint Inflammatory pathways
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    Contrib Nephrol 170:113-23. 2011
    ....
  9. doi request reprint Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Carretera del Rosario, 145, 38010 Santa Cruz de Tenerife, Spain
    Nat Rev Nephrol 7:327-40. 2011
    ..In the next few years, promising new therapeutic strategies based on anti-inflammatory effects could be successfully translated into clinical treatments for diabetic complications, including diabetic nephropathy...
  10. doi request reprint Pentoxifylline for renoprotection in diabetic nephropathy: the PREDIAN study. Rationale and basal results
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    J Diabetes Complications 25:314-9. 2011
    ..Here we report the study design and the baseline patient characteristics...
  11. ncbi request reprint Serum and gene expression profile of tumor necrosis factor-alpha and interleukin-6 in hypertensive diabetic patients: effect of amlodipine administration
    J Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    Int J Immunopathol Pharmacol 23:51-9. 2010
    ..These modulatory effects of amlodipine on proinflammatory cytokine level and expression may be related to its suggested anti-atherosclerotic actions...
  12. pmc Mineral metabolism and inflammation in chronic kidney disease patients: a cross-sectional study
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Spain
    Clin J Am Soc Nephrol 4:1646-54. 2009
    ..Mineral metabolism abnormalities and inflammation are concerns in chronic kidney disease (CKD). Interrelationships among these parameters have not been analyzed. DESIGN, SETTING, PARTICIPANTS, and..
  13. ncbi request reprint Additive antiproteinuric effect of pentoxifylline in patients with type 2 diabetes under angiotensin II receptor blockade: a short-term, randomized, controlled trial
    Juan F Navarro
    Servicio de Nefrologia, Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Tenerife 38010, Spain
    J Am Soc Nephrol 16:2119-26. 2005
    ..In conclusion, administration of PTF to patients who have type 2 diabetes and are under long-term treatment with an ARB produces a significant additive antiproteinuric effect associated with a reduction of urinary TNF-alpha excretion...
  14. ncbi request reprint Diabetes, inflammation, proinflammatory cytokines, and diabetic nephropathy
    Juan F Navarro
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    ScientificWorldJournal 6:908-17. 2006
    ..This new pathogenic perspective may lead to important new therapeutic considerations and new therapeutic goals for the treatment of diabetic nephropathy...
  15. ncbi request reprint Urinary tumour necrosis factor-alpha excretion independently correlates with clinical markers of glomerular and tubulointerstitial injury in type 2 diabetic patients
    Juan F Navarro
    Nephrology Service, Hospital Nuestra Señora de Candelaria, Carretera del Rosario, 145, 38010 Santa Cruz de Tenerife, Tenerife, Spain
    Nephrol Dial Transplant 21:3428-34. 2006
    ....
  16. ncbi request reprint The role of TNF-alpha in diabetic nephropathy: pathogenic and therapeutic implications
    Juan F Navarro
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Ctra del Rosario 145, 38010 Santa Cruz de Tenerife, Spain
    Cytokine Growth Factor Rev 17:441-50. 2006
    ..This review discusses the role of TNF-alpha as a pathogenic factor in renal injury, focusing on diabetic nephropathy, and describes potential treatment strategies based on modulation of TNF-alpha activity...
  17. ncbi request reprint Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotensin-converting enzyme inhibition and pentoxifylline administration
    Juan F Navarro
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    Am J Nephrol 26:562-70. 2006
    ..In addition, we also investigated the effect of angiotensin-converting enzyme inhibition and pentoxifylline (PTF) administration on these parameters...
  18. ncbi request reprint Influence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor-alpha and interleukin-6 in type 2 diabetic patients
    Juan F Navarro
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    Nephrol Dial Transplant 23:919-26. 2008
    ..We investigated the influence of renal damage on serum, urinary and PBMCs expression behavior of TNF-alpha and IL-6 in these patients...
  19. doi request reprint The role of inflammatory cytokines in diabetic nephropathy
    Juan F Navarro-González
    Servicio de Nefrologia, Hospital Universitario Nuestra Senora de Candelaria, Carretera del Rosario, 145, 38010 Santa Cruz de Tenerife, Spain
    J Am Soc Nephrol 19:433-42. 2008
    ..Finally, the recognition of these molecules as significant pathogenic mediators in diabetic nephropathy leaves open the possibility of new potential therapeutic targets...
  20. ncbi request reprint Clinical implications of disordered magnesium homeostasis in chronic renal failure and dialysis
    Juan F Navarro-González
    Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
    Semin Dial 22:37-44. 2009
    ..In addition, low Mg has been also linked to carotid intima-media thickness, a marker of atherosclerotic vascular disease and a predictor of vascular events...
  21. doi request reprint Tumor necrosis factor-alpha as a therapeutic target for diabetic nephropathy
    Juan F Navarro-González
    Nephrology Service, Univeristy Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Cytokine Growth Factor Rev 20:165-73. 2009
    ..Overall, these studies indicate that inhibition of TNF-alpha might be an efficacious treatment for renal disease secondary to diabetes mellitus...
  22. ncbi request reprint Effects of pentoxifylline administration on urinary N-acetyl-beta-glucosaminidase excretion in type 2 diabetic patients: a short-term, prospective, randomized study
    Juan F Navarro
    Nephrology and Biochemistry Services, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Tenerife, Spain
    Am J Kidney Dis 42:264-70. 2003
    ....