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Genomes and GenesSpecies | Las Palmas de Gran CanariaSummaryOrganization: Las Palmas de Gran Canaria Country: Spain Top Publications
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Publications
Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosisJose A Caminero
Servicio de Neumologia, Hospital General de Gran Canaria, Las Palmas, Canary Islands, Spain
Lancet Infect Dis 10:621-9. 2010..Drugs in group five should be used in the following order: clofazimine, amoxicillin with clavulanate, linezolid, carbapenems, thioacetazone, then clarithromycin...
[Epidemiological features of invasive pneumococcal disease before and after the introduction of pneumococcal conjugate vaccine in Gran Canaria (Canary Islands)]Fernando Artiles
Servicio de Microbiologia, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Espana
Enferm Infecc Microbiol Clin 27:14-21. 2009..The introduction of pneumococcal conjugate vaccine (PCV-7) has modified the epidemiology of invasive pneumococcal disease (IPD). Our aim was to investigate the epidemiological features of IPD before and after implementing the use of PCV-7...
Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: a new role in the treatment of leukaemia for these agentsSilvia De la Iglesia Iñigo
Servicio de Hematologia, Hospital de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Espana, Spain
Leuk Res 33:810-6. 2009..These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line of treatment for some acute myeloid leukemias and a new area of clinical research...
[Antibiotic use in the pediatric population: factors to consider]V Olmo Quintana
Gobierno de Canarias, Farmaceutico, Grupo Urano Uso Racional de los Antibiotico Orales, Farmaceutico de Atencion Primaria, Canarias, Spain
Rev Esp Quimioter 20:409-20. 2007..Prescribing practices in Las Palmas are based on scientific data, probably because of the continuing education courses on antibiotherapy that began in 2003...
[Characteristics and prognosis of patients with very long stay in an Intensive Care Unit]L Santana Cabrera
Servicio de Medicina Intensiva, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Espana
Med Intensiva 32:157-62. 2008..To describe the characteristics and prognostic factors of elderly patients hospitalized for > or = 30 days in an Intensive Care Unit (ICU)...
Time to desaturation in the 6-min walking distance test predicts 24-hour oximetry in COPD patients with a PO2 between 60 and 70mmHgIgnacio Garcia-Talavera
Pulmonary Department, Respiratory Research Unit, NS Candelaria University Hospital, Carretera del Rosario 145, 38010 Santa Cruz de Tenerife, Tenerife, Spain
Respir Med 102:1026-32. 2008..The 6-min walking distance (6MWD) test is a useful tool for assessing patients with chronic obstructive pulmonary disease (COPD), but little is known about the changes in oxygen saturation that occur during the test...
[Prognostic factors in community acquired pneumonia. Prospective multicenter study in internal medical departments]R Apolinario Hidalgo
Servicio de Medicina Interna, Hospital Universitario Insular de Gran Canaria
An Med Interna 24:467-72. 2007....
What is the diagnostic value of ultrasonography compared to physical evaluation in patients with idiopathic carpal tunnel syndrome?A Naranjo
Department of Rheumatology, Hospital de Gran Canaria Dr Negrin, University of Las Palmas de Gran Canaria, Spain
Clin Exp Rheumatol 25:853-9. 2007..Our hypothesis is that sonography performed by the rheumatologist in patients with suspected carpal tunnel syndrome (CTS) has higher diagnostic value compared to physical evaluation...
Influence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor-alpha and interleukin-6 in type 2 diabetic patientsJuan F Navarro
Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
Nephrol Dial Transplant 23:919-26. 2008..We investigated the influence of renal damage on serum, urinary and PBMCs expression behavior of TNF-alpha and IL-6 in these patients...
[The old battle between the human species and Koch's bacillae. Can one dream of eradicating tuberculosis?]Ja Caminero
Servicio de Neumologia, Hospital General de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, 35010, Spain
An Sist Sanit Navar 30:163-80. 2007..Therefore, the dream of eradicating TB is a very old dream, but one that unfortunately remains very distant...
Paraneoplastic pemphigus associated with Castleman's disease: usefulness of the laboratory of autoimmunity in the diagnosis of this diseaseI Alarcón-Torres
Clinical Biochemistry Department, Laboratory of Autoimmunity, University Hospital of Gran Canaria Doctor Negrín, Barranco de la Ballena s n 35010, Las Palmas de Gran Canaria, Spain
Ann N Y Acad Sci 1107:231-8. 2007..This case illustrates the importance of the laboratory of autoimmunity in the diagnosis of this type of pemphigus...
Spinal cord stimulation in the treatment of post-stroke patients: current state and future directionsF Robaina
Stereotactic and Functional Neurosurgery and Chronic Pain Unit and Research Unit, Las Palmas de Gran Canaria, Canary Islands, Spain
Acta Neurochir Suppl 97:277-82. 2007..Its potential role in the management of stroke and low-perfusion syndromes is further investigated by experimental studies and reports describing clinical experience. Appropriate clinical trials are warranted...
Breast cancer, Poland's syndrome, and sentinel lymph node involvementJon Uña
Servicio de Medicina Nuclear, Hospital Universitario Insular de Gran Canaria, Islas Canarias, Spain
Clin Nucl Med 32:613-5. 2007..Our experience with the present case suggests that the sentinel lymph node biopsy is feasible in patients with Poland's syndrome and breast cancer...
[Utility of diuretic renography in the detection of an enteroureteral fistula]E Martínez Gimeno
Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada
Rev Esp Med Nucl 26:221-5. 2007..Both isotopic renograms evidenced the presence of uretero-sigmoid fistula, an uncommon postsurgical that was not detected by cystography, ultrasonography or RMN. The patient subsequently underwent surgery for fistula repair...
Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer's diseaseJulio Lopez-Bastida
Evaluation and Planning Unit, Canary Islands Health Service, Spain
J Alzheimers Dis 16:399-407. 2009..Incremental cost-effectiveness ratios vary according to the selected perspective. For the baseline scenario, donepezil treatment is cost-effective with a probability of 95% for a threshold efficiency of 25,000 euro/QALY...
[Burnout syndrome among nurses and nurses' aides in an intensive care unit and admission wards]Luciano Santana Cabrera
Servicio de Medicina Intensiva, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Espana
Enferm Clin 19:31-4. 2009..To compare the degree of severity of burnout syndrome among the healthcare personnel of an intensive care unit (ICU) and admission wards...
Tumor necrosis factor-alpha as a therapeutic target for diabetic nephropathyJuan F Navarro-González
Nephrology Service, Univeristy Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Cytokine Growth Factor Rev 20:165-73. 2009..Overall, these studies indicate that inhibition of TNF-alpha might be an efficacious treatment for renal disease secondary to diabetes mellitus...
Decision aids for patients facing health treatment decisions in Spain: preliminary resultsLilisbeth Perestelo-Perez
Evaluation Unit of the Canary Islands Health Care SESCS, Tenerife, Spain
Patient Educ Couns 80:364-71. 2010..This study presents ongoing research aimed at understanding the suitability and impact of various decision aids (DAs) on patients with different chronic conditions in the Spanish National Health System...
[Variability in the sensitivity to tigecycline against Acinetobacter baumannii in different culture media]A Tenorio-Abreu
Servicio de Microbiologia, Hospital Clinico Universitario de Valladolid, Avda Ramón y Cajal 3, 47005 Valladolid, Spain
Rev Esp Quimioter 23:76-80. 2010..Therefore, our objective was to verify this variability, and propose the culture medium that comes closest to the standard method...
[Etanercept in pregnancy and breast-feeding]L Borrego
Servicio de Dermatologia, Hospital Universitario Insular, Las Palmas de Gran Canaria, Espana
Actas Dermosifiliogr 101:97-101. 2010....
Spanish recommendations on economic evaluation of health technologiesJulio Lopez-Bastida
Evaluation and Planning Unit, Canary Islands Health Services, CIBER Epidemiologia y Salud Pública CIBERESP, Spain, C Pérez de Rozas 5, 4th Floor, 38004 Santa Cruz de Tenerife, Spain
Eur J Health Econ 11:513-20. 2010....
Multidrug-resistant tuberculosis: epidemiology, risk factors and case findingJ A Caminero
Department of Pulmonary Medicine, Hospital de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria University, Las Palmas de Gran Canaria, Spain
Int J Tuberc Lung Dis 14:382-90. 2010..Patients previously treated for TB and the other risk factors analysed in this article should be prioritised in case finding...
The challenge of colorectal cancer prevention in SpainJulio Lopez-Bastida
Evaluation and Planning Service, Canary Islands Health Service, Canary Islands, Spain
Eur J Health Econ 10:S75-83. 2010..Overall, Spain is aware of the issues raised by CRC oncology management and has acted to improve patient outcomes, adding screening to its arsenal will further impact survival rates...
Factors involved in the progress of preclinical atherosclerosis associated with systemic lupus erythematosus: a 2-year longitudinal studyI Rua-Figueroa
Rheumatology Division, Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas, Spain
Ann Rheum Dis 69:1136-9. 2010..To assess the changes in carotid intima-media thickness (IMT) and the associated risks factors in patients with low severity systemic lupus erythematosus (SLE)...
Patient involvement in health research: a contribution to a systematic review on the effectiveness of treatments for degenerative ataxiasP Serrano-Aguilar
Planning and Evaluation Unit, Canary Islands Health Authority, Santa Cruz de Tenerife, Canary Islands, CIBERESP, Spain
Soc Sci Med 69:920-5. 2009..Effective participation of patients can extend the value of systematic reviews to ensure they respond to both clinicians' information needs and patients' expectations...
Screening for tuberculosis infection in spanish healthcare workers: Comparison of the QuantiFERON-TB gold in-tube test with the tuberculin skin testEva Elisa Alvarez-León
Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas, Gran Canaria, Spain
Infect Control Hosp Epidemiol 30:876-83. 2009..The purpose of our study was to compare the TST and the QFT-G test in Spanish HCWs in order to improve procedures for the detection of LTBI...
A synergistic association of ACE I/D and eNOS G894T gene variants with the progression of immunoglobulin A nephropathy - a pilot studyJose C Rodriguez-Perez
Nephrology, Pathology and Research Unit, Hospital Universitario de Gran Canaria Dr Negrin, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
Am J Nephrol 30:303-9. 2009..We investigated whether single nucleotide polymorphisms (SNPs) involved in the non-immunologic progression of renal disease are related with disease progression...
[Nurse activities for communicating with the families of patients admitted to an intensive care unit]Luciano Santana Cabrera
Servicio de Medicina Intensiva, Hospital de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Espana
Enferm Clin 19:335-9. 2009..To study nurses' perceptions of the quality of communication with the families of patients admitted to an intensive care unit (ICU)...
[Role of decompressive craniectomy in brain injury patient]S Lubillo
Unidad de Medicina Intensiva, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Espana
Med Intensiva 33:74-83. 2009..2% or PtiO(2) < 10 mmHg maintained from the moment of admission...
[Analysis of the current situation and outlook of thoracic surgery]Jordi Freixinet
Servicio de Cirugía Torácica, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Espana
Arch Bronconeumol 45:107-10. 2009....
[Microbiological diagnosis of upper respiratory tract infections]Oscar Díez
Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Espana
Enferm Infecc Microbiol Clin 25:387-93. 2007..All the information included in this article is contained in the Standard Operating Procedures for Clinical Microbiology (http://www.seimc.org/protocolos/microbiologia/)...
Outbreak of Achromobacter xylosoxidans pseudobacteremia in a neonatal care unit related to contaminated chlorhexidine solutionJ Molina-Cabrillana
Department of Preventive Medicine, Complejo Hospitalario Universitario Insular-Materno Infantil, , 35016, Las Palmas de Gran Canaria, Spain
Eur J Clin Microbiol Infect Dis 26:435-7. 2007
[Changes in the surgical treatment of bronchogenic cancer]J Freixinet
, , Las Palmas de Gran Canaria, Las Palmas,
Arch Bronconeumol 41:177-9. 2005
Alternating weekly administration of paclitaxel and gemcitabine: a phase II study in patients with advanced non-small-cell lung cancerDavid Aguiar
Servicio de Oncologia Medica, Hospital de Gran Canaria Dr Negrin, C Barranco de la Ballena s n, 35020, Las Palmas de Gran Canaria, Spain
Cancer Chemother Pharmacol 55:152-8. 2005..We sought to evaluate toxicity and efficacy of an alternating week schedule of paclitaxel and gemcitabine in patients with advanced non-small-cell lung cancer (NSCLC)...
Leptin and altitude in the cardiovascular diseasesAntonio Cabrera de León
Hospital de la Candelaria, Unidad de Investigación Santa Cruz de Tenerife 38010, Spain
Obes Res 12:1492-8. 2004..Leptin has been proposed as a cardiovascular risk factor. We investigated whether leptin varies according to the altitude at which people live...
Prevalence and associated factors of anterior atlantoaxial luxation in a nation-wide sample of rheumatoid arthritis patientsA Naranjo
Rheumatology Department, Hospital Dr Negrin, Las Palmas, Spain
Clin Exp Rheumatol 22:427-32. 2004..To estimate the prevalence of anterior atlantoaxial subluxation (AAS) in patients with rheumatoid arthritis (RA), and to analyse its association with disease markers...
The economic costs of traffic accidents in SpainJulio López Bastida
Servicio de Evaluación y Planificación, Servicio Canario de Salud, Canary Islands, Spain
J Trauma 56:883-8; discussion 888-9. 2004..This study aimed to evaluate the economic impact of traffic accidents in Spain during 1997...
Toxic epidermal necrolysis in patients receiving anticonvulsants and cranial irradiation: a risk to considerDavid Aguiar
Servicio de Oncologia Medica, Hospital Universitario Son Dureta, Palma de Mallorca, Islas Baleares, Spain
J Neurooncol 66:345-50. 2004..Clinical considerations about diagnosis of SJS and TEN are presented. The use of prophylactic anticonvulsants is also discussed as well as a review of the literature...
De novo insertion of an Alu sequence in the coding region of the CLCN5 gene results in Dent's diseaseFelix Claverie-Martin
Research Unit, Nuestra Señora de Candelaria University Hospital, Carretera del Rosario s n, 38010 Santa Cruz de Tenerife, Spain
Hum Genet 113:480-5. 2003..However, this is the first report of a retrotransposon insertion in the CLCN5 gene associated with Dent's disease...
[Epidemic outbreak of meningitis due to Echovirus type 13 on the island of Gran Canaria (Spain)]Carmen Perez
Servicio de Microbiología Hospital General de Gran Canaria Dr Negrín Las Palmas de Gran Canaria Spain
Enferm Infecc Microbiol Clin 21:340-5. 2003..In Spain the most frequently isolated echoviruses are serotypes 30, 9, 6 and 4.Objectives. Determine the clinical-epidemiological characteristics of a meningitis outbreak due to echovirus type 13...
Nontraditional nutrition education interventions: the radio ECCA methodL M Bello Luján
Dirección General de Salud Pública del Gobierno de Canarias, Spain
Eur J Clin Nutr 57:S86-9. 2003..To evaluate a nutrition education intervention using a radio programme in the Canary Islands...
[External ventricular drainage in complete infarction of the medial cerebral artery]Y Aladro
Servicio de Neurologia, Hospital de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Espana
Rev Neurol 36:526-9. 2003..Some authors have reported good outcome after performing decompressive hemicraniectomy in this condition. The potential clinical benefit of intracranial pressure reduction by means of an external ventriculostomy in such cases is unknown...
Latex-fruit syndromeCarlos Blanco
Servicio de Alergia, Hospital Universitario Dr Negrin, c Barrenco de la Ballena s n, 35012 Las Palmas de Gran Canaria, Spain
Curr Allergy Asthma Rep 3:47-53. 2003..This review focuses on our current understanding of the latex-fruit syndrome...
Prevalence, awareness, treatment and control of hypertension in a Canarian population. Relationship with glucose tolerance categories. The Guía StudyPedro de Pablos-Velasco
Endocrinology Department, Hospital General de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain
J Hypertens 20:1965-71. 2002..To estimate the prevalence, awareness, treatment and control of hypertension in a Canarian population; and their relationship with the glucose tolerance categories...
Cord blood levels of cytokines as predictors of early neonatal sepsisC Santana
Department of Pediatrics, Hospital Universitario Materno Infantil de Canarias, Las Palmas de Gran Canaria, Spain
Acta Paediatr 90:1176-81. 2001....
[Routine preoperative screening of asymptomatic patients: beliefs and attitudes of anesthesiologists in the Canary Islands, Spain]P Serrano-Aguilar
Servicio de Evaluación y Planificación, Servicio Canario de Salud, Santa Cruz de Tenerife
Rev Esp Anestesiol Reanim 52:193-9. 2005..To identify factors that explain anesthesiologists' inappropriate use of preoperative tests in asymptomatic patients scheduled for elective surgery...
Long-term inhaled nitric oxide plus dipyridamole for pulmonary arterial hypertensionGregorio Perez-Peñate
Pneumology Unit, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
Respiration 72:419-22. 2005..This is the first study reporting 2-year iNO therapy in 2 patients with primary and secondary pulmonary hypertension. The combination of dipyridamole with iNO augments the pulmonary vasodilatation and may be useful in managing PAH...
A 6-month regimen for EPTB with intermittent treatment in the continuation phase: a study of 679 casesJ A Caminero
International Union Against Tuberculosis and Lung Disease, Paris, France
Int J Tuberc Lung Dis 9:890-5. 2005..No large studies have demonstrated the effectiveness of a 6-month regimen for all forms of extra-pulmonary tuberculosis (EPTB)...
Blood pressure, antihypertensive treatment and factors associated with good blood pressure control in hypertensive diabetics: the Tarmidas studyP de Pablos-Velasco
Department of Endocrinology, Hospital General de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain
J Hum Hypertens 21:664-72. 2007..Better application of therapeutic guidelines and the prevention and treatment of compounding factors could improve the response rate to BP control measures in poorly controlled patients...
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breastDavid Aguiar Bujanda
Servicio de Oncologia Medica, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
Breast J 13:189-91. 2007..A brief review of the literature and possible mechanisms of this infrequent condition are also commented...
Osteonecrosis of the jaws in patients with bone metastasis receiving intravenous bisphosphonates. A rising concernD Aguiar Bujanda
Servicio de Oncologia Medica, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
Clin Transl Oncol 8:919-21. 2006..We report 2 additional cases of ONJ in women with breast cancer after long-term exposure to BP, discussing some considerations about the presentation and management of this rare and new complication...
The role of TNF-alpha in diabetic nephropathy: pathogenic and therapeutic implicationsJuan F Navarro
Nephrology Service, University Hospital Nuestra Senora de Candelaria, Ctra del Rosario 145, 38010 Santa Cruz de Tenerife, Spain
Cytokine Growth Factor Rev 17:441-50. 2006..This review discusses the role of TNF-alpha as a pathogenic factor in renal injury, focusing on diabetic nephropathy, and describes potential treatment strategies based on modulation of TNF-alpha activity...
Steroids and bone density in patients with functioning kidney allograftsR Gallego
Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
Transplant Proc 38:2434-7. 2006..We studied the prevalence of low bone density (LBD) according to WHO criteria...
Leptin, estrogens and cancerMaría del Carmen Maeso Fortuny
Unidad de Investigacion, Hospital de la Candelaria, Santa Cruz de Tenerife, Spain
Mini Rev Med Chem 6:897-907. 2006..These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways...
Diabetes, inflammation, proinflammatory cytokines, and diabetic nephropathyJuan F Navarro
Nephrology Service, University Hospital Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
ScientificWorldJournal 6:908-17. 2006..This new pathogenic perspective may lead to important new therapeutic considerations and new therapeutic goals for the treatment of diabetic nephropathy...
[Incidence of nosocomial infections at a neonatal intensive care unit: a six-year surveillance study]Jesús Molina-Cabrillana
Servicio de Medicina Preventiva, Hospital Universitario Materno Infantil, Las Palmas de Gran Canaria, Espana
Enferm Infecc Microbiol Clin 24:307-12. 2006..Nosocomial infection is a frequent complication in neonatal intensive care units (NICUs) attending patients who require lengthy hospitalization and frequent invasive techniques...
[Implementation and evaluation of critical hazards and check points analysis (CHCPA) in gofio-producing industries from Tenerife]J M Caballero Mesa
Area de Toxicología de la Universidad de La Laguna, Espana
Nutr Hosp 21:189-98. 2006..To satisfactorily implement the critical hazards and check points analysis...
[Klippel-Trenaunay syndrome and bone scintigraphy. A case report]E Martínez Gimeno
Servicio de Medicina Nuclear, Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife
Rev Esp Med Nucl 25:26-30. 2006..Secondly, to dismiss a reflex sympathetic dystrophy in the affected lower limb and finally, due to knee pain. Magnetic resonance of pelvis and knee and biopsy of iliac spine were performed too...
Relevance of renin expression by real-time PCR in acute myeloid leukemiaSilvia de la Iglesia Iñigo
Department of Hematology, Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Spain
Leuk Lymphoma 47:409-16. 2006..5 +/- 8.8% for renin-negative patients), no significant differences were found. It is believed that further studies should aim to validate whether such a difference exists, using a much larger and homogeneus group of patients...
High prevalence of asthma symptoms in the Canary Islands: climatic influence?G Juliá Serdá
Servicio de Neumologia, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain
J Asthma 42:507-11. 2005..We hypothesize that climatic conditions play an important role in the prevalence of asthma symptoms...
[Preoperative testing routines for healthy, asymptomatic patients in the Canary Islands (Spain)]P Serrano Aguilar
Servicio del Plan de Salud, Investigación y Evaluación de Tecnologías Sanitarias, Servicio Canario de Salud, Spain
Rev Esp Anestesiol Reanim 48:307-13. 2001..To analyze patterns of routine testing before elective/scheduled surgery in healthy/asymptomatic patients classified as ASA I or II according to the American Society of Anesthesiologists...
