Santiago Lamas

Summary

Country: Spain

Publications

  1. doi request reprint Endothelial control of vasomotor tone: the kidney perspective
    Santiago Lamas
    Centro de Biología Molecular Severo Ochoa and Laboratorio Mixto Consejo Superior de Investigaciones Científicas CSIC Fundación Renal Iñigo Alvarez de Toledo FRIAT, Madrid, Spain
    Semin Nephrol 32:156-66. 2012
  2. doi request reprint Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide
    Mariano Redondo-Horcajo
    Departamento Medicina Celular y Molecular, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Cardiovasc Res 87:356-65. 2010
  3. doi request reprint Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase
    David Lagares
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    Am J Respir Cell Mol Biol 47:834-42. 2012
  4. doi request reprint A "fluorescence switch" technique increases the sensitivity of proteomic detection and identification of S-nitrosylated proteins
    Daniel Tello
    Servicio de Inmunologia, Hospital de la Princesa, Madrid, Spain
    Proteomics 9:5359-70. 2009
  5. doi request reprint Hydrogen peroxide signaling mediator in the activation of p38 MAPK in vascular endothelial cells
    Rosa Bretón-Romero
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    Methods Enzymol 528:49-59. 2013
  6. pmc Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability
    Fernando Rodriguez-Pascual
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain
    Mol Cell Biol 28:7139-55. 2008
  7. ncbi request reprint Transforming growth factor-beta receptor requirements for the induction of the endothelin-1 gene
    Cristina Castañares
    Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biologicas, C S I C, Instituto Reina Sofía de Investigaciones Nefrológicas, Ramiro de Maeztu 9, E 28040, Madrid, Spain
    Exp Biol Med (Maywood) 231:700-3. 2006
  8. ncbi request reprint Mitochondrial dysfunction in human pathologies
    Maria Monsalve
    Centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040, Madrid, Spain
    Front Biosci 12:1131-53. 2007
  9. doi request reprint Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis
    David Lagares
    Laboratorio Mixto Fundación Renal Iñigo Alvárez de Toledo, FRIAT CSIC, Madrid, Spain
    Arthritis Rheum 62:878-89. 2010
  10. ncbi request reprint High-sensitivity analysis of specific peptides in complex samples by selected MS/MS ion monitoring and linear ion trap mass spectrometry: application to biological studies
    Inmaculada Jorge
    Protein Chemistry and Proteomics Laboratory, Centro de Biologia Molecular Severo Ochoa, CSIC, Madrid, Spain
    J Mass Spectrom 42:1391-403. 2007

Collaborators

Detail Information

Publications26

  1. doi request reprint Endothelial control of vasomotor tone: the kidney perspective
    Santiago Lamas
    Centro de Biología Molecular Severo Ochoa and Laboratorio Mixto Consejo Superior de Investigaciones Científicas CSIC Fundación Renal Iñigo Alvarez de Toledo FRIAT, Madrid, Spain
    Semin Nephrol 32:156-66. 2012
    ..Ultimately, renal circulation and tubular function have a profound influence in systemic blood pressure as a result of the overall regulation of volume homeostasis...
  2. doi request reprint Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide
    Mariano Redondo-Horcajo
    Departamento Medicina Celular y Molecular, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Cardiovasc Res 87:356-65. 2010
    ..We have now studied the subcellular origin of superoxide formation in endothelial cells treated with CsA and the biochemical consequences for the function of mitochondrial enzymes...
  3. doi request reprint Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase
    David Lagares
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    Am J Respir Cell Mol Biol 47:834-42. 2012
    ..Our data suggest that the ET-1/FAK axis may contribute importantly to the pathogenesis of fibrotic disorders, and highlight FAK as a potential therapeutic target in these devastating diseases...
  4. doi request reprint A "fluorescence switch" technique increases the sensitivity of proteomic detection and identification of S-nitrosylated proteins
    Daniel Tello
    Servicio de Inmunologia, Hospital de la Princesa, Madrid, Spain
    Proteomics 9:5359-70. 2009
    ..7 (murine macrophage) cells. We believe that this method represents an improvement in order to approach the identification of S-nitrosylated proteins in physiological conditions...
  5. doi request reprint Hydrogen peroxide signaling mediator in the activation of p38 MAPK in vascular endothelial cells
    Rosa Bretón-Romero
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    Methods Enzymol 528:49-59. 2013
    ..We describe p38 MAPK as an early redox sensor in LSS. Our studies show that it is essential for the activation of endothelial nitric oxide synthase, the subsequent nitric oxide generation, and the protection of endothelial function. ..
  6. pmc Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability
    Fernando Rodriguez-Pascual
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain
    Mol Cell Biol 28:7139-55. 2008
    ..Taken together, these results describe a novel, redox-based mechanism regulating mRNA stability and add a new facet to the panoply of GAPDH cellular homeostatic actions...
  7. ncbi request reprint Transforming growth factor-beta receptor requirements for the induction of the endothelin-1 gene
    Cristina Castañares
    Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biologicas, C S I C, Instituto Reina Sofía de Investigaciones Nefrológicas, Ramiro de Maeztu 9, E 28040, Madrid, Spain
    Exp Biol Med (Maywood) 231:700-3. 2006
    ....
  8. ncbi request reprint Mitochondrial dysfunction in human pathologies
    Maria Monsalve
    Centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040, Madrid, Spain
    Front Biosci 12:1131-53. 2007
    ..We will also consider recent advances in our understanding of the molecular mechanisms involved in mitochondrial ROS detoxification...
  9. doi request reprint Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis
    David Lagares
    Laboratorio Mixto Fundación Renal Iñigo Alvárez de Toledo, FRIAT CSIC, Madrid, Spain
    Arthritis Rheum 62:878-89. 2010
    ....
  10. ncbi request reprint High-sensitivity analysis of specific peptides in complex samples by selected MS/MS ion monitoring and linear ion trap mass spectrometry: application to biological studies
    Inmaculada Jorge
    Protein Chemistry and Proteomics Laboratory, Centro de Biologia Molecular Severo Ochoa, CSIC, Madrid, Spain
    J Mass Spectrom 42:1391-403. 2007
    ....
  11. ncbi request reprint Nitric oxide down-regulates caveolin-3 levels through the interaction with myogenin, its transcription factor
    Mónica Martínez-Moreno
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, 28040, Madrid, Spain
    J Biol Chem 282:23044-54. 2007
    ....
  12. ncbi request reprint Transforming growth factor-beta induces endothelin-1 expression through activation of the Smad signaling pathway
    Fernando Rodriguez-Pascual
    Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biologicas, C S I C, Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain
    J Cardiovasc Pharmacol 44:S39-42. 2004
    ..These results demonstrate that transforming growth factor-beta induces endothelin-1 expression by a functional cooperation between Smads and activator protein-1 through activation of the Smad signaling pathway...
  13. pmc Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells
    Laura Genís
    Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    Blood 110:2916-23. 2007
    ..MT1-MMP thus appears to be a key molecular effector of NO during the EC migration and angiogenic processes, and is a potential therapeutic target for NO-associated vascular disorders...
  14. doi request reprint Nitric oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair
    Tania R Lizarbe
    Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    FASEB J 22:3207-15. 2008
    ..Collectively, our data reveal a new pathway through which NO modulates wound repair: nitration of MMP-13 promotes its release from endothelial cells, where it accelerates angiogenesis and wound healing...
  15. pmc Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation
    David Lagares
    Centro de Biologia Molecular Severo Ochoa, CSIC and Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain
    Arthritis Rheum 64:1653-64. 2012
    ..This study was undertaken to characterize the contribution of FAK to the development of pulmonary fibrosis both in vivo and in vitro...
  16. doi request reprint Nitric oxide signaling: classical, less classical, and nonclassical mechanisms
    Antonio Martínez-Ruiz
    Servicio de Inmunologia, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid, Spain
    Free Radic Biol Med 51:17-29. 2011
    ..Cross talk trespassing these necessarily artificial conceptual boundaries is progressively being identified and hence an integrated systems biology approach to the comprehension of NO function will probably emerge in the near future...
  17. doi request reprint Role of endothelin in the cardiovascular system
    Fernando Rodriguez-Pascual
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas C S I C Universidad Autónoma de Madrid U A M, Madrid, Spain
    Pharmacol Res 63:463-72. 2011
    ....
  18. ncbi request reprint Proteomic identification of S-nitrosylated proteins in endothelial cells
    Antonio Martínez-Ruiz
    Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain
    Methods Mol Biol 357:215-23. 2007
    ....
  19. ncbi request reprint Cellular mechanisms of vascular injury mediated by calcineurin inhibitors
    Santiago Lamas
    Centro de Investigaciones Biologicas and Instituto Reina Sofia de Investigaciones Nefrologicas, Consejo Superior de Investigaciones Cientificas, and Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    Kidney Int 68:898-907. 2005
  20. ncbi request reprint PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells
    Inmaculada Valle
    Centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu, Madrid, Spain
    Cardiovasc Res 66:562-73. 2005
    ....
  21. pmc Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage
    Jesus Loureiro
    Unidad de Biología Molecular and Servicio de Nefrología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid, Spain
    J Am Soc Nephrol 22:1682-95. 2011
    ..Taken together, these results demonstrate that TGF-β1 drives the peritoneal deterioration induced by dialysis fluid and highlights a role of TGF-β1-mediated MMT in the pathophysiology of peritoneal-membrane dysfunction...
  22. pmc Specificity in S-nitrosylation: a short-range mechanism for NO signaling?
    Antonio Martínez-Ruiz
    1 Servicio de Inmunología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid, Spain
    Antioxid Redox Signal 19:1220-35. 2013
    ..S-Nitrosylation, a covalent post-translational modification of protein cysteines, has emerged as a paradigm of nonclassical NO signaling...
  23. pmc SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex
    Yolanda Olmos
    1 Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain
    Antioxid Redox Signal 19:1507-21. 2013
    ..The transcription factor FoxO3a and the transcriptional coactivator peroxisome proliferator activated receptor γ-coactivator 1α (PGC-1α) have been shown to induce the expression of antioxidant genes and to be deacetylated by SirT1...
  24. ncbi request reprint Nitrosylation of thiols in vascular homeostasis and disease
    Antonio Martínez-Ruiz
    Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Sinesio Delgado, 4, E 28029, Madrid, Spain
    Curr Atheroscler Rep 7:213-8. 2005
    ..New functional consequences of the modification of individual proteins are also summarized...
  25. pmc Endothelin-1 expression is strongly repressed by AU-rich elements in the 3'-untranslated region of the gene
    Francisco M Reimunde
    Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biologicas, C S I C, Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain
    Biochem J 387:763-72. 2005
    ....
  26. ncbi request reprint Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells
    Carlos Zaragoza
    Centro de Investigaciones Biologicas, Instituto Reina Sofía de Investigaciones Nefrológicas, Consejo Superior de Investigaciones Cientificas, and Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain
    Mol Pharmacol 62:927-35. 2002
    ..Thus, we propose that the NO-cGMP-PKG pathway enhances MMP-13 expression by the activation of ERK 1,2. This effect of NO may be important in the context of pathophysiological conditions such as inflammation or atherogenesis [corrected]...