B Laffon

Summary

Country: Spain

Publications

  1. ncbi request reprint Cytogenetic and molecular biomonitoring of a Portuguese population exposed to pesticides
    Carla Costa
    National Institute of Health, Centre of Environmental and Occupational Health Praça Coronel Pacheco, 15, 4050 453 Porto Portugal, Portugal
    Mutagenesis 21:343-50. 2006
  2. ncbi request reprint Genotoxicity associated to exposure to Prestige oil during autopsies and cleaning of oil-contaminated birds
    Blanca Laffon
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus de Elviña s n, 15071 A Coruna, Spain
    Food Chem Toxicol 44:1714-23. 2006
  3. doi request reprint The organic selenium compound selenomethionine modulates bleomycin-induced DNA damage and repair in human leukocytes
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071, A Coruna, Spain
    Biol Trace Elem Res 133:12-9. 2010
  4. doi request reprint Follow-up study of genotoxic effects in individuals exposed to oil from the tanker Prestige, seven years after the accident
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain Electronic address
    Mutat Res 760:10-6. 2014
  5. doi request reprint Endocrine and immunological parameters in individuals involved in Prestige spill cleanup tasks seven years after the exposure
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Environ Int 59:103-11. 2013
  6. pmc Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    BMC Genomics 13:46. 2012
  7. ncbi request reprint Assessment of occupational genotoxic risk in the production of rubber tyres
    Blanca Laffon
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Ann Occup Hyg 50:583-92. 2006
  8. ncbi request reprint Monitoring of the impact of Prestige oil spill on Mytilus galloprovincialis from Galician coast
    Blanca Laffon
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Environ Int 32:342-8. 2006
  9. ncbi request reprint Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes
    B Laffon
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus de Elviña s n, A Coruna, Spain
    Am J Ind Med 48:128-36. 2005
  10. doi request reprint Relationship between blood concentrations of heavy metals and cytogenetic and endocrine parameters among subjects involved in cleaning coastal areas affected by the 'Prestige' tanker oil spill
    Beatriz Pérez-Cadahía
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, E 15071 A Coruna, Spain
    Chemosphere 71:447-55. 2008

Detail Information

Publications27

  1. ncbi request reprint Cytogenetic and molecular biomonitoring of a Portuguese population exposed to pesticides
    Carla Costa
    National Institute of Health, Centre of Environmental and Occupational Health Praça Coronel Pacheco, 15, 4050 453 Porto Portugal, Portugal
    Mutagenesis 21:343-50. 2006
    ..Despite the low number of subjects, results suggest that low mEH (microsomal epoxide hydrolase) activity as well as GSTT1 positive genotype are associated with increased cytogenetic damage...
  2. ncbi request reprint Genotoxicity associated to exposure to Prestige oil during autopsies and cleaning of oil-contaminated birds
    Blanca Laffon
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus de Elviña s n, 15071 A Coruna, Spain
    Food Chem Toxicol 44:1714-23. 2006
    ..No effect of the DNA repair genetic polymorphisms analysed was observed in the MN test...
  3. doi request reprint The organic selenium compound selenomethionine modulates bleomycin-induced DNA damage and repair in human leukocytes
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071, A Coruna, Spain
    Biol Trace Elem Res 133:12-9. 2010
    ..Our results showed antigenotoxic effect of SeMet on BLM-induced DNA and also on repair and persistence of this damage when applied before and simultaneously with BLM...
  4. doi request reprint Follow-up study of genotoxic effects in individuals exposed to oil from the tanker Prestige, seven years after the accident
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain Electronic address
    Mutat Res 760:10-6. 2014
    ..Nevertheless, the need to plan biomonitoring studies on people participating in clean-up activities in case a new oil spill occurs should be established. ..
  5. doi request reprint Endocrine and immunological parameters in individuals involved in Prestige spill cleanup tasks seven years after the exposure
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Environ Int 59:103-11. 2013
    ..Surveillance of the exposed individuals for early detection of possible health problems related to the endocrine or immunological systems is recommended. ..
  6. pmc Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    BMC Genomics 13:46. 2012
    ....
  7. ncbi request reprint Assessment of occupational genotoxic risk in the production of rubber tyres
    Blanca Laffon
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Ann Occup Hyg 50:583-92. 2006
    ..No effect of CYP2E1 or GSTM1 variants was obtained in the biomarkers analysed...
  8. ncbi request reprint Monitoring of the impact of Prestige oil spill on Mytilus galloprovincialis from Galician coast
    Blanca Laffon
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Environ Int 32:342-8. 2006
    ....
  9. ncbi request reprint Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes
    B Laffon
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus de Elviña s n, A Coruna, Spain
    Am J Ind Med 48:128-36. 2005
    ..Concern about the genotoxic risk associated with chronic handling of antineoplastic drugs has increased, and usual safety practices may not avoid exposure...
  10. doi request reprint Relationship between blood concentrations of heavy metals and cytogenetic and endocrine parameters among subjects involved in cleaning coastal areas affected by the 'Prestige' tanker oil spill
    Beatriz Pérez-Cadahía
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, E 15071 A Coruna, Spain
    Chemosphere 71:447-55. 2008
    ..Plasma levels of cortisol deserve further evaluation as a potentially relevant biomarker to assess the effects of exposure to heavy metals...
  11. doi request reprint Cytogenetic effects induced by Prestige oil on human populations: the role of polymorphisms in genes involved in metabolism and DNA repair
    Beatriz Pérez-Cadahía
    Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Mutat Res 653:117-23. 2008
    ....
  12. ncbi request reprint Evaluation of genotoxic effects in a group of workers exposed to low levels of styrene
    Blanca Laffon
    Dpto Biología Celular y Molecular, Facultad de Ciencias, Universidade da Coruna, Campus A Zapateira s n, 15071, La Coruna, Spain
    Toxicology 171:175-86. 2002
    ....
  13. ncbi request reprint Genetic damage induced by accidental environmental pollutants
    Beatriz Pérez-Cadahía
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña, Coruna, Spain
    ScientificWorldJournal 6:1221-37. 2006
    ..Sex, age and tobacco consumption have shown to influence the level of genetic damage, while the effect of using protective devices was less noticeable than expected, perhaps because the kind used was not the most adequate...
  14. ncbi request reprint DNA damage and repair in human leukocytes exposed to styrene-7,8-oxide measured by the comet assay
    Blanca Laffon
    Dept de Biologia Celular y Molecular, Facultad de Ciencias, Universidade da Coruna, Campus A Zapateira s n, 15071, La Coruna, Spain
    Toxicol Lett 126:61-8. 2002
    ..Our results show that SO induces DNA damage at concentrations higher than 50 microM in a dose-dependent manner, and that the lesions produced by SO are efficiently removed within a few hours after the end of treatment...
  15. doi request reprint Assessment of okadaic acid effects on cytotoxicity, DNA damage and DNA repair in human cells
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Mutat Res 689:74-9. 2010
    ..Furthermore, we found that OA can induce modulations in DNA repair processes when exposure was performed prior to BLM treatment, in co-exposure, or during the subsequent DNA repair process...
  16. ncbi request reprint Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypes
    Blanca Laffon
    Departmento Biología Celular y Molecular, Facultad de Ciencias, Universidade da Coruna, Campus A Zapateira s n, 15071, A, Coruna, Spain
    Toxicology 186:131-41. 2003
    ..The results obtained suggest that CYP1A1 m1, m2 and m4, CYP2E1 Dra I and GSTP1 (exons 5 and 6) polymorphisms may affect styrene induction of DNA damage in human leukocytes...
  17. ncbi request reprint Initial study on the effects of Prestige oil on human health
    Beatriz Pérez-Cadahía
    Toxicology Unit, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Environ Int 33:176-85. 2007
    ..In addition, data obtained point to the importance of using protective devices in preventing the effects related to the exposure...
  18. ncbi request reprint Effects of styrene-7,8-oxide over p53, p21, bcl-2 and bax expression in human lymphocyte cultures
    B Laffon
    , , Campus da Zapateira s/n, 15071, , Spain
    Mutagenesis 16:127-32. 2001
    ....
  19. ncbi request reprint Genetic polymorphism in cytochrome P450 1B1 in a Spanish population
    Beatriz Pérez-Cadahía
    Toxicology Unit, University of A Coruna, Spain
    Basic Clin Pharmacol Toxicol 101:70-2. 2007
  20. doi request reprint Genotoxic effects of lead: an updated review
    Julia García-Lestón
    Department Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, A Coruna, Spain
    Environ Int 36:623-36. 2010
    ..This article reviews the works listed in the literature that use different parameters to evaluate the genotoxic effects of lead in vitro, in vivo and in epidemiological studies...
  21. doi request reprint Okadaic acid induces morphological changes, apoptosis and cell cycle alterations in different human cell types
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    J Environ Monit 13:1831-40. 2011
    ..Nevertheless, in the presence of S9 fraction no apoptosis was detected, indicating a metabolic detoxifying activity, although necrosis was observed in neuroblastoma cells...
  22. doi request reprint In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: a review
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Arch Toxicol 84:337-51. 2010
    ..Results from these studies provide a better knowledge on the selenium activity and help to elucidate the reasons underlying its duality in order to regulate its correct use in nutrition and clinic...
  23. ncbi request reprint Evaluation of genotoxicity in a group of workers from a petroleum refinery aromatics plant
    Joana Roma-Torres
    National Institute of Health, Environmental Health and Toxicology Department, Largo 1 Dezembro, 4000 Porto, Portugal
    Mutat Res 604:19-27. 2006
    ..05). No association was found between tobacco smoking and the effect biomarkers analysed. A positive association was found between CA and MN with age in the control group (p<0.05)...
  24. ncbi request reprint The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo
    Micheline Kirsch-Volders
    Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 15:1038-42. 2006
    ..79). This study confirms that pooled analyses, by increasing the statistical power, are adequate for assessing the involvement of genetic variants on genome stability and for resolving discrepancies among individual studies...
  25. ncbi request reprint Evaluation of PAH bioaccumulation and DNA damage in mussels (Mytilus galloprovincialis) exposed to spilled Prestige crude oil
    Beatriz Pérez-Cadahía
    Unidad de Toxicología, Universidade da Coruna, Spain
    Comp Biochem Physiol C Toxicol Pharmacol 138:453-60. 2004
    ..In the view of our results, the importance of the evaluation of biodisponibility, bioaccumulation and DNA damage in the assessment of the effects of xenobiotic pollutants to marine environments could be highlighted...
  26. ncbi request reprint Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1
    João P Teixeira
    National Institute of Health, Environmental Health and Toxicology Department, Largo 1 de Dezembro, 4000 Porto, Portugal
    Toxicology 195:231-42. 2004
    ....
  27. ncbi request reprint Effect of epoxide hydrolase and glutathione S-tranferase genotypes on the induction of micronuclei and DNA damage by styrene-7,8-oxide in vitro
    Blanca Laffon
    Dpto Biologi a Celular y Molecular, Facultad de Ciencias, Universidade da Coruna, Campus da Zapateira s n, 15071 A, Coruna, Spain
    Mutat Res 536:49-59. 2003
    ..The present in vitro findings using human leukocytes suggest that polymorphisms in EH, and, to a lesser extent, in GSTP1, may influence induction of cytogenetic and DNA damage by SO...