Marta Izquierdo

Summary

Country: Spain

Publications

  1. ncbi request reprint [Gene therapy in neuro-oncology]
    M Izquierdo
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
    Rev Neurol 43:613-7. 2006
  2. ncbi request reprint Short interfering RNAs as a tool for cancer gene therapy
    Marta Izquierdo
    Department of Molecular Biology, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Madrid, Spain
    Cancer Gene Ther 12:217-27. 2005
  3. ncbi request reprint Cyclin E1 knockdown induces apoptosis in cancer cells
    Esteban N Gurzov
    Departament of Molecular Biology, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Cantoblanco, Madrid 28049, Spain
    Neurol Res 28:493-9. 2006
  4. pmc An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells
    Jon Gil-Ranedo
    Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Instituto Sanitario Ramón y Cajal, Madrid, Spain
    PLoS ONE 6:e28753. 2011
  5. doi request reprint Combination of KIT gene silencing and tocopherol succinate may offer improved therapeutic approaches for human mastocytosis
    Irene Ruano
    Centro de Biología Molecular Severo Ochoa CSIC, Departamento de Biología Molecular Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
    Br J Haematol 148:59-68. 2010
  6. pmc Selective RNAi-mediated inhibition of mutated c-kit
    Irene Ruano
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Departamento de Biologia Molecular, C Nicolás Cabrera, 1 Campus de Cantoblanco, Madrid, Spain
    J RNAi Gene Silencing 5:339-44. 2009
  7. ncbi request reprint Construction and characterization of pentacistronic retrovirus vectors
    Pablo de Felipe
    Departamento de Bioquímica y Biología Molecular Centro de Biología Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Cantoblanco, 28049 Madrid, Spain
    J Gen Virol 84:1281-5. 2003
  8. ncbi request reprint Cyanide bystander effect of the linamarase/linamarin killer-suicide gene therapy system
    Maria Luisa Cortés
    Departamento de Biología Molecular Centro de Biología Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Cantoblanco 28049 Madrid, Spain
    J Gene Med 4:407-14. 2002
  9. ncbi request reprint RNA interference against Hec1 inhibits tumor growth in vivo
    E N Gurzov
    Department of Molecular Biology, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Cantoblanco, Madrid, Spain
    Gene Ther 13:1-7. 2006
  10. ncbi request reprint Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy
    P de Felipe
    Departamento de Bioquimica y Biologia Molecular, Universidad Autonoma de Madrid, Facultad de Ciencias, Spain
    Gene Ther 6:198-208. 1999

Collaborators

  • Esteban N Gurzov
  • Irene Ruano
  • Jon Gil-Ranedo
  • Pablo de Felipe
  • Maria Luisa Cortés
  • Mercedes Garcia-Villanueva
  • Marina Mendiburu-Eliçabe
  • Marta del Alamo
  • Diego Medina
  • Ricardo Gargini
  • P de Felipe
  • Vega García-Escudero
  • Monica Hughes
  • M L Cortés
  • M Ryan
  • V Martin

Detail Information

Publications10

  1. ncbi request reprint [Gene therapy in neuro-oncology]
    M Izquierdo
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
    Rev Neurol 43:613-7. 2006
    ..Among the most popular and successful gene therapies against cancer we find the immunotherapy, the antiangiogenic strategies, the killer-suicide genes and RNA interference against specific oncogenes...
  2. ncbi request reprint Short interfering RNAs as a tool for cancer gene therapy
    Marta Izquierdo
    Department of Molecular Biology, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Madrid, Spain
    Cancer Gene Ther 12:217-27. 2005
    ..RNAi against multidrug resistance genes or chemoresistance targets may also provide useful cancer treatments. Studies investigating these approaches in preclinical models are also reviewed...
  3. ncbi request reprint Cyclin E1 knockdown induces apoptosis in cancer cells
    Esteban N Gurzov
    Departament of Molecular Biology, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Cantoblanco, Madrid 28049, Spain
    Neurol Res 28:493-9. 2006
    ..Abnormally high levels of cyclin E1 expression have frequently been found in cancer cells. Here, we investigate the effect of cyclin E1 knockdown on cancer cells...
  4. pmc An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells
    Jon Gil-Ranedo
    Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Instituto Sanitario Ramón y Cajal, Madrid, Spain
    PLoS ONE 6:e28753. 2011
    ..The use of this shRNA may contribute to develop new therapeutic approaches for this incurable type of brain tumor...
  5. doi request reprint Combination of KIT gene silencing and tocopherol succinate may offer improved therapeutic approaches for human mastocytosis
    Irene Ruano
    Centro de Biología Molecular Severo Ochoa CSIC, Departamento de Biología Molecular Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
    Br J Haematol 148:59-68. 2010
    ..Targeting kit in the presence of alpha-TOS represents a new approach against proliferation of human mast leukaemia cell lines...
  6. pmc Selective RNAi-mediated inhibition of mutated c-kit
    Irene Ruano
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Departamento de Biologia Molecular, C Nicolás Cabrera, 1 Campus de Cantoblanco, Madrid, Spain
    J RNAi Gene Silencing 5:339-44. 2009
    ..2 cells which are resistant to the Kit tyrosine kinase inhibitor, imatinib mesylate...
  7. ncbi request reprint Construction and characterization of pentacistronic retrovirus vectors
    Pablo de Felipe
    Departamento de Bioquímica y Biología Molecular Centro de Biología Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Cantoblanco, 28049 Madrid, Spain
    J Gen Virol 84:1281-5. 2003
    ..9 kb) were comparable to those of vector systems with shorter genomes. Other vectors constructed that exceeded the genome length of the wild-type virus suffered frequent deletions...
  8. ncbi request reprint Cyanide bystander effect of the linamarase/linamarin killer-suicide gene therapy system
    Maria Luisa Cortés
    Departamento de Biología Molecular Centro de Biología Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Cantoblanco 28049 Madrid, Spain
    J Gene Med 4:407-14. 2002
    ..We have studied the bystander effect associated with this new system mediated by the production of the cyanide ion that diffuses freely across membranes...
  9. ncbi request reprint RNA interference against Hec1 inhibits tumor growth in vivo
    E N Gurzov
    Department of Molecular Biology, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Cantoblanco, Madrid, Spain
    Gene Ther 13:1-7. 2006
    ..These results indicate that depletion of Hec1 could be used as a new strategy to block the dividing cell, and therefore against cancer...
  10. ncbi request reprint Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy
    P de Felipe
    Departamento de Bioquimica y Biologia Molecular, Universidad Autonoma de Madrid, Facultad de Ciencias, Spain
    Gene Ther 6:198-208. 1999
    ..Transcription and translation gives rise to a bicistronic mRNA and two independent protein products. The system offers advantages to other alternative ways to create polycistronic mRNAs and can be used in gene therapy delivery vectors...