Research Topics
Genomes and GenesSpecies | Marta IzquierdoSummaryCountry: Spain Publications
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Detail Information
Publications
[Gene therapy in neuro-oncology]M Izquierdo
Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
Rev Neurol 43:613-7. 2006..At present, the majority of these procedures are in clinical phases but none as yet is considered a therapeutic option...
Short interfering RNAs as a tool for cancer gene therapyMarta Izquierdo
Department of Molecular Biology, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Facultad de Ciencias, Madrid, Spain
Cancer Gene Ther 12:217-27. 2005..RNAi against multidrug resistance genes or chemoresistance targets may also provide useful cancer treatments. Studies investigating these approaches in preclinical models are also reviewed...
Cyclin E1 knockdown induces apoptosis in cancer cellsEsteban N Gurzov
Departament of Molecular Biology, , , Facultad de Ciencias, Cantoblanco, Madrid 28049, Spain
Neurol Res 28:493-9. 2006..DISCUSSION: Our results indicate that retrovirus carrying the DNA to be transcribed into a short hairpin RNA (shRNA) against cyclin E1 could be used as a therapeutic agent for cancer therapy...
An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cellsJon Gil-Ranedo
Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Instituto Sanitario Ramón y Cajal, Madrid, Spain
PLoS ONE 6:e28753. 2011..The use of this shRNA may contribute to develop new therapeutic approaches for this incurable type of brain tumor...
Combination of KIT gene silencing and tocopherol succinate may offer improved therapeutic approaches for human mastocytosisIrene Ruano
Centro de Biología Molecular Severo Ochoa CSIC, Departamento de Biología Molecular Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
Br J Haematol 148:59-68. 2010..Targeting kit in the presence of alpha-TOS represents a new approach against proliferation of human mast leukaemia cell lines...
Selective RNAi-mediated inhibition of mutated c-kitIrene Ruano
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Departamento de Biologia Molecular, C Nicolás Cabrera, 1 Campus de Cantoblanco, Madrid, Spain
J RNAi Gene Silencing 5:339-44. 2009..2 cells which are resistant to the Kit tyrosine kinase inhibitor, imatinib mesylate...
Construction and characterization of pentacistronic retrovirus vectorsPablo de Felipe
, , Facultad de Ciencias, Cantoblanco, 28049 Madrid, Spain
J Gen Virol 84:1281-5. 2003..9 kb) were comparable to those of vector systems with shorter genomes. Other vectors constructed that exceeded the genome length of the wild-type virus suffered frequent deletions...
RNA interference against Hec1 inhibits tumor growth in vivoE N Gurzov
Department of Molecular Biology, , , Facultad de Ciencias, Cantoblanco, Madrid, Spain
Gene Ther 13:1-7. 2006..These results indicate that depletion of Hec1 could be used as a new strategy to block the dividing cell, and therefore against cancer...
Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapyP de Felipe
Departamento de Bioquimica y Biologia Molecular, Universidad Autonoma de Madrid, Facultad de Ciencias, Spain
Gene Ther 6:198-208. 1999..Transcription and translation gives rise to a bicistronic mRNA and two independent protein products. The system offers advantages to other alternative ways to create polycistronic mRNAs and can be used in gene therapy delivery vectors...
