José M Izquierdo

Summary

Country: Spain

Publications

  1. doi request reprint Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition
    José M Izquierdo
    Departamento de Biología Molecular and the Centro de Biología Molecular Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco 28049, Madrid, Spain
    J Biol Chem 283:19077-84. 2008
  2. ncbi request reprint Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression
    Isabel Carrascoso
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid CSIC UAM, c Nicolas Cabrera 1, Cantoblanco, DP 28049 Madrid, Spain
    Mol Cancer 13:90. 2014
  3. ncbi request reprint Cell-specific regulation of Fas exon 6 splicing mediated by Hu antigen R
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Lab 107, C Nicolás Cabrera, 1, Cantoblanco, 28049 Madrid, Spain
    Biochem Biophys Res Commun 402:324-8. 2010
  4. pmc Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T-cell intracellular antigen-1-related/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, c Nicolas Cabrera 1, Lab 107, Cantoblanco, 28049 Madrid, Spain
    Nucleic Acids Res 38:8001-14. 2010
  5. doi request reprint Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growth
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, c Nicolas Cabrera 1, Cantoblanco, 28049 Madrid, Spain
    Biochem J 435:337-44. 2011
  6. pmc Fas splicing regulation during early apoptosis is linked to caspase-mediated cleavage of U2AF65
    José M Izquierdo
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, DP 28049, Madrid, Spain
    Mol Biol Cell 19:3299-307. 2008
  7. ncbi request reprint Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein
    José M Izquierdo
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 282:19410-7. 2007
  8. pmc Poliovirus 2A protease triggers a selective nucleo-cytoplasmic redistribution of splicing factors to regulate alternative pre-mRNA splicing
    Enrique Alvarez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid CSIC UAM, Madrid, Spain
    PLoS ONE 8:e73723. 2013
  9. doi request reprint Alternative splicing, a new target to block cellular gene expression by poliovirus 2A protease
    Enrique Alvarez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Nicolás Cabrera, 1 Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Biochem Biophys Res Commun 414:142-7. 2011
  10. ncbi request reprint Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma de Madrid UAM CSIC, Facultad de Ciencias, Módulo C V, Lab 230, Cantoblanco, DP 28049, Madrid, Spain
    Biochem Biophys Res Commun 348:703-11. 2006

Collaborators

Detail Information

Publications20

  1. doi request reprint Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition
    José M Izquierdo
    Departamento de Biología Molecular and the Centro de Biología Molecular Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco 28049, Madrid, Spain
    J Biol Chem 283:19077-84. 2008
    ..Taken together, these results support a functional link between HuR as repressor of alternative Fas splicing and the molecular mechanisms modulating programmed cell death...
  2. ncbi request reprint Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression
    Isabel Carrascoso
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid CSIC UAM, c Nicolas Cabrera 1, Cantoblanco, DP 28049 Madrid, Spain
    Mol Cancer 13:90. 2014
    ..The permanent down-regulated expression of T-cell intracellular antigen (TIA) proteins in HeLa cells improves cytoskeleton-mediated functions such as cell proliferation and tumor growth...
  3. ncbi request reprint Cell-specific regulation of Fas exon 6 splicing mediated by Hu antigen R
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Lab 107, C Nicolás Cabrera, 1, Cantoblanco, 28049 Madrid, Spain
    Biochem Biophys Res Commun 402:324-8. 2010
    ..Thus, overexpression and knockdown of HuR led to Fas exon 6 skipping and inclusion, respectively. These results suggest that the TIA and HuR cellular ratio influences cell-type specific Fas exon 6 splicing pattern...
  4. pmc Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T-cell intracellular antigen-1-related/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, c Nicolas Cabrera 1, Lab 107, Cantoblanco, 28049 Madrid, Spain
    Nucleic Acids Res 38:8001-14. 2010
    ..This effect was reversed by splice-site strengthening and is linked to its basic leucine zipper-like motif. These results suggest that hnRNP C1/C2 acts as a bridge between HuR and TIAR to modulate alternative Fas splicing...
  5. doi request reprint Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growth
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, c Nicolas Cabrera 1, Cantoblanco, 28049 Madrid, Spain
    Biochem J 435:337-44. 2011
    ..Taken together, these results are consistent with a role for TIA proteins as growth/tumour-suppressor genes...
  6. pmc Fas splicing regulation during early apoptosis is linked to caspase-mediated cleavage of U2AF65
    José M Izquierdo
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, DP 28049, Madrid, Spain
    Mol Biol Cell 19:3299-307. 2008
    ..Thus, these results support a functional link among apoptosis induction, U2AF65 cleavage, and the regulation of Fas alternative splicing...
  7. ncbi request reprint Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein
    José M Izquierdo
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 282:19410-7. 2007
    ..Taken together, the results reveal distinct functional properties of TIA-1 isoforms and the existence of a regulatory network that controls isoform expression...
  8. pmc Poliovirus 2A protease triggers a selective nucleo-cytoplasmic redistribution of splicing factors to regulate alternative pre-mRNA splicing
    Enrique Alvarez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid CSIC UAM, Madrid, Spain
    PLoS ONE 8:e73723. 2013
    ..Therefore, poliovirus 2A(pro) can target alternative pre-mRNA splicing by regulating protein shuttling between the nucleus and the cytoplasm. ..
  9. doi request reprint Alternative splicing, a new target to block cellular gene expression by poliovirus 2A protease
    Enrique Alvarez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Nicolás Cabrera, 1 Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Biochem Biophys Res Commun 414:142-7. 2011
    ..These findings reveal that the mechanism of action of 2A(pro) on splicing is to selectively block the second catalytic step...
  10. ncbi request reprint Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma de Madrid UAM CSIC, Facultad de Ciencias, Módulo C V, Lab 230, Cantoblanco, DP 28049, Madrid, Spain
    Biochem Biophys Res Commun 348:703-11. 2006
    ....
  11. pmc Identification of a set of miRNAs differentially expressed in transiently TIA-depleted HeLa cells by genome-wide profiling
    Carmen Sánchez-Jiménez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid CSIC UAM, c Nicolas Cabrera 1, Cantoblanco, Madrid 28049, Spain
    BMC Mol Biol 14:4. 2013
    ..Herein we identified a micro(mi)RNA signature associated to transiently TIA-depleted HeLa cells and analyzed the potential role of miRNAs combining genome-wide analysis data on mRNA and miRNA profiles...
  12. pmc Depletion of T-cell intracellular antigen proteins promotes cell proliferation
    Raquel Reyes
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, c Nicolas Cabrera 1, Lab 107, Cantoblanco DP 28049, Madrid, Spain
    Genome Biol 10:R87. 2009
    ..Despite the biological relevance of these regulators, there are no genome-wide studies assessing global transcriptomic and phenotypic impacts after changes in the expression and/or function of these proteins...
  13. ncbi request reprint Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells
    Isabel Carrascoso
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid CSIC UAM, c Nicolas Cabrera 1, Cantoblanco, DP 28049 Madrid, Spain
    Biochem J 461:43-50. 2014
    ..Our data support the hypothesis that a concerted activation of both global and selective translational rates leads to the transition to a more proliferative status in TIA-knockdown HeLa cells. ..
  14. pmc Assembly of the ribonucleoprotein complex containing the mRNA of the beta-subunit of the mitochondrial H+-ATP synthase requires the participation of two distal cis-acting elements and a complex set of cellular trans-acting proteins
    Javier Ricart
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma de Madrid Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Biochem J 365:417-28. 2002
    ..The present study illustrates the existence of an intramolecular RNA cross-talking required for the association of the mRNA with the translational machinery...
  15. ncbi request reprint Half pint couples transcription and splicing of eIF4E-1,2 gene during fly development
    Raquel Reyes
    Centro de Biologia Molecular Severo Ochoa, UAM CSIC, c Nicolas Cabrera 1, Cantoblanco, 28049 Madrid, Spain
    Biochem Biophys Res Commun 374:758-62. 2008
    ..Thus, these results suggest that the eIF4E-1,2 gene is regulated by Hfp through a mechanism linked to transcription control and 3' splice site selection, which determines the pattern and translation efficiency of eIF4E-1,2 mRNAs...
  16. ncbi request reprint The RNA-binding protein PTB exerts translational control on 3'-untranslated region of the mRNA for the ATP synthase beta-subunit
    Raquel Reyes
    Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid UAM CSIC, Facultad de Ciencias, Módulo C V, Lab 230, Cantoblanco DP 28049, Madrid, Spain
    Biochem Biophys Res Commun 357:1107-12. 2007
    ..Taken together, these results suggest that PTB regulates post-transcriptional expression of the beta-F1-ATPase mRNA at the translational level...
  17. ncbi request reprint Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing
    José M Izquierdo
    Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid CBMSO UAM, Cantoblanco 28049 Madrid, Spain
    J Biol Chem 282:1539-43. 2007
    ..Taken together, the results connect Fas signaling with the activity of splicing factors that modulate Fas alternative splicing, suggesting the existence of an autoregulatory loop that could serve to amplify Fas responses...
  18. pmc T-cell intracellular antigen (TIA)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy
    Carmen Sánchez-Jiménez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid CSIC UAM, Madrid, Spain
    PLoS ONE 8:e75127. 2013
    ..TIA1/TIAR might function as cell sensors to maintain homeostasis and promote adaptation/survival responses to developmental stress. ..
  19. ncbi request reprint Epigenetic regulation of the binding activity of translation inhibitory proteins that bind the 3' untranslated region of beta-F1-ATPase mRNA by adenine nucleotides and the redox state
    José M Izquierdo
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, C S I C U A M, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Arch Biochem Biophys 433:481-6. 2005
    ....
  20. ncbi request reprint RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage
    Alfredo Castello
    Centro de Biologia Molecular, Severo Ochoa CSIC UAM, C Nicolás Cabrera, 1 Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Cell Sci 122:3799-809. 2009
    ..Taken together, these results are consistent with a specific proteolysis of Nup98 by 2A protease to prevent de novo mRNA traffic in poliovirus-infected cells...