Jose Mg Izarzugaza

Summary

Country: Spain

Publications

  1. pmc Interpretation of the consequences of mutations in protein kinases: combined use of bioinformatics and text mining
    Jose M G Izarzugaza
    Structural Computational Biology Group, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre Madrid, Spain
    Front Physiol 3:323. 2012
  2. pmc Prioritization of pathogenic mutations in the protein kinase superfamily
    Jose M G Izarzugaza
    Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    BMC Genomics 13:S3. 2012
  3. pmc Characterization of pathogenic germline mutations in human protein kinases
    Jose M G Izarzugaza
    Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre CNIO, C Melchor Fernandez Almagro 3, E28029 Madrid, Spain
    BMC Bioinformatics 12:S1. 2011
  4. pmc Enhancing the prediction of protein pairings between interacting families using orthology information
    Jose M G Izarzugaza
    Structural Bioinformatics Group, Spanish National Cancer Research Centre CNIO, C Melchor Fernández Almagro, 3 28029, Madrid, Spain
    BMC Bioinformatics 9:35. 2008
  5. pmc An integrated approach to the interpretation of single amino acid polymorphisms within the framework of CATH and Gene3D
    Jose M G Izarzugaza
    Institute of Structural and Molecular Biology, University College London, UK
    BMC Bioinformatics 10:S5. 2009
  6. pmc Extraction of human kinase mutations from literature, databases and genotyping studies
    Martin Krallinger
    Spanish National Cancer Research Centre, Madrid, Spain
    BMC Bioinformatics 10:S1. 2009
  7. pmc wKinMut: An integrated tool for the analysis and interpretation of mutations in human protein kinases
    Jose Mg Izarzugaza
    Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre CNIO, C Melchor Fernández Almagro, 3, E 28029 Madrid, Spain
    BMC Bioinformatics 14:345. 2013

Detail Information

Publications7

  1. pmc Interpretation of the consequences of mutations in protein kinases: combined use of bioinformatics and text mining
    Jose M G Izarzugaza
    Structural Computational Biology Group, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre Madrid, Spain
    Front Physiol 3:323. 2012
    ..Finally, we will discuss how text mining approaches constitute a powerful tool for the interpretation of the consequences of mutations in the context of disease genome analysis with particular focus on cancer...
  2. pmc Prioritization of pathogenic mutations in the protein kinase superfamily
    Jose M G Izarzugaza
    Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    BMC Genomics 13:S3. 2012
    ..Still, current high-throughput sequencing efforts and the concomitant need for massive interpretation of protein sequence variants will demand for more efficient and/or accurate computational methods in the forthcoming years...
  3. pmc Characterization of pathogenic germline mutations in human protein kinases
    Jose M G Izarzugaza
    Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre CNIO, C Melchor Fernandez Almagro 3, E28029 Madrid, Spain
    BMC Bioinformatics 12:S1. 2011
    ....
  4. pmc Enhancing the prediction of protein pairings between interacting families using orthology information
    Jose M G Izarzugaza
    Structural Bioinformatics Group, Spanish National Cancer Research Centre CNIO, C Melchor Fernández Almagro, 3 28029, Madrid, Spain
    BMC Bioinformatics 9:35. 2008
    ....
  5. pmc An integrated approach to the interpretation of single amino acid polymorphisms within the framework of CATH and Gene3D
    Jose M G Izarzugaza
    Institute of Structural and Molecular Biology, University College London, UK
    BMC Bioinformatics 10:S5. 2009
    ..Although many mutations occur within domains whose structure has been solved, many more occur within genes whose protein products have not been structurally characterized...
  6. pmc Extraction of human kinase mutations from literature, databases and genotyping studies
    Martin Krallinger
    Spanish National Cancer Research Centre, Madrid, Spain
    BMC Bioinformatics 10:S1. 2009
    ..Previously published mutation extraction approaches did not sufficiently distinguish between two fundamentally different variation origin categories, namely natural occurring and induced mutations generated through in vitro experiments...
  7. pmc wKinMut: An integrated tool for the analysis and interpretation of mutations in human protein kinases
    Jose Mg Izarzugaza
    Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre CNIO, C Melchor Fernández Almagro, 3, E 28029 Madrid, Spain
    BMC Bioinformatics 14:345. 2013
    ..Unfortunately, the exploration of the consequences on the phenotypes of each individual mutation remains a considerable challenge...