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Genomes and GenesSpecies | Alex IranzoSummaryCountry: Spain Publications
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Publications
Prevalence and clinical importance of sleep apnea in the first night after cerebral infarctionA Iranzo
Services of Neurology, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain
Neurology 58:911-6. 2002..To determine the prevalence of sleep apnea (SA) during the first night after hemispheric ischemic stroke and its influence on clinical presentation, course, and functional outcome at 6 months...- Persistent sleepiness in CPAP treated obstructive sleep apnea patients: evaluation and treatmentJoan Santamaria
Neurology Service, Multidisciplinary Sleep Disorders Unit, Hospital Clinic de Barcelona, Faculty of Medicine, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
Sleep Med Rev 11:195-207. 2007..Modafinil has been shown to reduce subjective sleepiness after CPAP in OSAS patients. Further studies are warranted to clarify the way in which CPAP modifies sleepiness... 
Longitudinal assessment of olfactory function in idiopathic REM sleep behavior disorderAlex Iranzo
Neurology Service, Hospital Clinic, Barcelona, Spain Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Barcelona, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain Electronic address
Parkinsonism Relat Disord 19:600-4. 2013..We evaluated whether olfactory function deteriorates with time in IRBD. Progressive smell loss could be a useful way in which to monitor the effect of disease-modifying interventions in subjects with IRBD...- Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort studyAlex Iranzo
Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, Barcelona, Spain Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Barcelona, Spain Electronic address
Lancet Neurol 12:443-53. 2013.... - Sleep disorders in Parkinson diseaseAlex Iranzo de Riquer
Neurology Service, Hospital Clinic, Barcelona, Spain
Neurologist 17:S38-42. 2011..Finally, the most effective treatments will be proposed... - Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PDA Iranzo
Neurology Service, ospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer, Barcelona, Spain
Neurology 65:247-52. 2005..To compare the clinical and video-polysomnographic (VPSG) characteristics of idiopathic REM sleep behavior disorder (RBD) vs the RBD seen in multiple system atrophy (MSA) and Parkinson disease (PD)... - Severe obstructive sleep apnea/hypopnea mimicking REM sleep behavior disorderAlex Iranzo
Neurology Service, Hospital Clinic and Institut d Investigacions Biomèndiques August Pi i Sunyer, Barcelona, Spain
Sleep 28:203-6. 2005..To describe the clinical and video-polysomnographic (VPSG) features of a group of subjects with severe obstructive sleep apnea/hypopnea (OSAH) mimicking the symptoms of REM sleep behavior disorder (RBD)... - Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitisAlex Iranzo
Neurology Service, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer, C Villaroel 170, 08036 Barcelona, Spain
Ann Neurol 59:178-81. 2006..In addition, these observations suggest that impairment of the limbic system may play a role in the pathogenesis of RBD... - [Breathing disorders during sleep and the circadian rhythm of strokes]A Iranzo-de Riquer
Servicio de Neurologia, Unidad Multidisciplinaria de los Trastornos delSueño, Hospital Clinic de Barcelona, Espana
Rev Neurol 41:S17-9. 2005..These findings suggest that apneas, likely associated with other risk factors, can worsen or precipitate an ischemic stroke... - Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive studyAlex Iranzo
Neurology Service, Hospital Clínic de Barcelona and Institut D Investigació Biomèdiques August Pi i Sunyer, Barcelona, Spain
Lancet Neurol 5:572-7. 2006..We sought to determine the frequency and nature of neurological disorders developing in patients diagnosed with idiopathic RBD at our sleep centre... 
Absence of alterations in serum sex hormone levels in idiopathic REM sleep behavior disorderAlex Iranzo
Neurology Service, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
Sleep 30:803-6. 2007..The aim of our study was to determine the serum sex hormone levels in consecutive idiopathic RBD male patients who presented to our sleep center...- REM sleep behavior disorder and other sleep disturbances in Disney animated filmsAlex Iranzo
Neurology Service, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, C Villarroel 170, Barcelona 08036, Spain
Sleep Med 8:531-6. 2007..These sleep disorders were inserted as comic elements. The inclusion of a broad range of accurately depicted sleep disorders in these films indicates that the Disney screenwriters were astute observers of sleep and its disorders... - Restless legs syndrome in Parkinson's disease and other neurodegenerative diseases of the central nervous systemAlex Iranzo
Neurology Service, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
Mov Disord 22:S424-30. 2007.... - Excessive muscle activity increases over time in idiopathic REM sleep behavior disorderAlex Iranzo
Neurology Service, Hospital Clinic, Barcelona, Spain
Sleep 32:1149-53. 2009..It is unknown if the excessive EMG activity in REM sleep changes over time in patients with idiopathic RBD... - The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseasesAlex Iranzo
Neurology Service, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Barcelona, Spain
Sleep Med Rev 13:385-401. 2009..RBD is mediated neither by direct abnormal alpha-synuclein inclusions nor by striatonigral dopaminergic deficiency alone... - Sleep and breathing in multiple system atrophyAlex Iranzo
Alex Iranzo, MD Neurology Service, Hospital Clinic de Barcelona, C Villarroel 170, Barcelona 08036, Spain
Curr Treat Options Neurol 9:347-53. 2007..Long-term treatment with continuous positive airway pressure (CPAP) eliminates nocturnal stridor. Tracheostomy is advised when CPAP is not tolerated and stridor occurs during wakefulness... - REM sleep behavior disorder and vocal cord paralysis in Machado-Joseph diseaseAlex Iranzo
Neurology Service, Institut Clinic Malalties del Sistema Nervios, Hospital Clinic Universitari de Barcelona, Spain
Mov Disord 18:1179-83. 2003..RBD and VCAP are two potentially injurious conditions that should be considered part of the clinical spectrum of MJD... - Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]Alex Iranzo
Department of Neurology, University Hospital Clinic, Networked Biomedical Research Centre for Neurodegenerative Diseases, The August Pi i Sunyer Biomedical Research Institute, Spain
Lancet Neurol 9:1070-7. 2010..We postulated that these neuroimaging changes could occur in a proportion of IRBD individuals who might then be at increased risk for development of a neurodegenerative disorder associated with substantia nigra dysfunction... - Sleep symptoms and polysomnographic architecture in advanced Parkinson's disease after chronic bilateral subthalamic stimulationA Iranzo
Service of Neurology, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain
J Neurol Neurosurg Psychiatry 72:661-4. 2002..To evaluate the sleep symptoms and polysomnographic architecture in advanced Parkinson's disease after chronic bilateral subthalamic stimulation (STN-DBS)... - Brainstem proton magnetic resonance spectroscopy in idopathic REM sleep behavior disorderAlex Iranzo
Neurology Service, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain
Sleep 25:867-70. 2002..The aim of our study was to investigate whether 1H-MRS can detect brainstem abnormalities in patients with idiopathic RBD... - Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective studyAlex Iranzo
Neurology Service, Hospital Clinic, Barcelona, Spain
Lancet Neurol 10:797-805. 2011.... - Sleep-wake changes in the premotor stage of Parkinson diseaseAlex Iranzo
Neurology Service, Hospital Clinic, Barcelona, Spain
J Neurol Sci 310:283-5. 2011.... - Long-term effect of CPAP in the treatment of nocturnal stridor in multiple system atrophyA Iranzo
Neurology Service, Hospital Clínic and Instisut d Investigació Biomèdiques August Pi i Sunyer, Barcelona, Spain
Neurology 63:930-2. 2004..This study shows that in MSA, CPAP is an effective noninvasive long-term therapy for nocturnal stridor... - Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson's disease dementiaYaroslau Compta
Movement Disorders Unit, ICN, IDIBAPS, CIBERNED, Hospital Clinic, C Villarroel 170, 08036, Barcelona, Spain
Brain 132:3308-17. 2009..Alternatively, mechanisms other than hypocretin cells dysfunction may be responsible for excessive daytime sleepiness and the sleep architecture alterations seen in these patients... - Lack of effects of pramipexole on REM sleep behavior disorder in Parkinson diseaseHatice Kumru
Neurology Service, Hospital Clinic, Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
Sleep 31:1418-21. 2008..Dopaminergic mechanisms are thought to play a role in RBD pathogenesis. To further asses such a role, we have evaluated the effect of pramipexole, a dopamine receptor agonist, on RBD features in PD patients... - [Comparative analysis of patients with narcolepsy-cataplexy, narcolepsy without cataplexy and idiopathic hypersomnia]Jose E Martinez Rodriguez
Servicio de Neurologia, Hospital Clinic, Universitat de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Espana
Med Clin (Barc) 128:361-4. 2007.... - Different profiles of Alzheimer's disease cerebrospinal fluid biomarkers in controls and subjects with subjective memory complaintsAnna Antonell
Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, C Villarroel, 170, 08036, Barcelona, Spain
J Neural Transm 118:259-62. 2011..3%). Group 2 could represent an earlier phase of preclinical AD than group 3, and group 4 an unknown etiology... - Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorderAlex Iranzo
Neurology Service, Multidisciplinary Sleep Unit, Hospital Clinic de Barcelona, Institut D Investigació Biomèdiques August Pi i Sunyer, CIBERNED, Barcelona, Spain
Sleep Med 11:534-9. 2010..We hypothesized that those IRBD patients who later developed MCI had pronounced cortical EEG slowing at presentation... - Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutationsHatice Kumru
Neurology Service, Hospital Clínic de Barcelona and Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
Ann Neurol 56:599-603. 2004..In all instances, RBD followed the onset of motor symptoms by several years. Our study shows that RBD is frequent in Park2, suggesting that mechanisms other than synuclein deposition can cause RBD in neurodegenerative disorders... - Subclinical nigrostriatal dopaminergic denervation in the cerebellar subtype of multiple system atrophy (MSA-C)Esteban Muñoz
Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències ICN, Hospital Clinic i Universitari, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Villarroel 170, 08036, Barcelona, Catalunya, Spain
J Neurol 258:2248-53. 2011..123)I]FP-CIT SPECT shows that most but not all MSA-C patients without parkinsonism have subclinical nigrostriatal dopaminergic denervation which is not related to disease duration, cerebellar dysfunction, or pontine atrophy... - Obstructive sleep apnea in narcolepsyGemma Sansa
Neurology Service, Hospital Clinic, Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Barcelona, Spain
Sleep Med 11:93-5. 2010..The presence of obstructive sleep apnea (OSA) in a narcoleptic patient may interfere with the diagnosis of narcolepsy. The aim of the study was to determine the prevalence of OSA in narcolepsy... - Usefulness of the SINBAR electromyographic montage to detect the motor and vocal manifestations occurring in REM sleep behavior disorderAlex Iranzo
Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain
Sleep Med 12:284-8. 2011..As a next step, in the present study we evaluated the usefulness of the SINBAR EMG montage to detect the movements and vocalizations occurring in RBD... - Relation between subtype of Parkinson's disease and REM sleep behavior disorderHatice Kumru
Neurology Service, Hospital Clinic of Barcelona, Barcelona, Spain
Sleep Med 8:779-83. 2007..Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently found in Parkinson's disease (PD). PD has been classified in different subtypes and it is unknown if RBD occurs more often in one particular subtype... - Evaluation of hypothalamic-specific autoimmunity in patients with narcolepsyJose E Martinez-Rodriguez
Neurology Service, Hospital Clínic de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
Sleep 30:27-8. 2007..The screening of the hypothalmic library detected some reactive clones but not a common reactivity. Our study did not find any evidence of hypothalamic-specific autoimmunity in narcolepsy... - Changes in dreaming induced by CPAP in severe obstructive sleep apnea syndrome patientsEva Carrasco
Neurology Service, Neuroscience Institute, , Barcelona, Spain
J Sleep Res 15:430-6. 2006..Violent/highly anxious dreams disappeared with treatment. A dream recall decrease with CPAP is associated with normalization of sleep in OSAS patients... - REM sleep behavior disorder and narcoleptic features in anti-Ma2-associated encephalitisYaroslau Compta
Neurology Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
Sleep 30:767-9. 2007.... - Cerebrospinal fluid biomarkers and memory present distinct associations along the continuum from healthy subjects to AD patientsLorena Rami
Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Barcelona, Spain
J Alzheimers Dis 23:319-26. 2011..This suggests that in the continuum from healthy aging to AD, memory performance is first related with Aβ(1-42) levels and then with t-tau or p-tau, before becoming independent of biomarker levels in the dementia stage... - Restless abdomen: a phenotypic variant of restless legs syndromeHernando Pérez-Díaz
Neurology Service, Hospital Clinic de Barcelona, C Villarroel 170, Barcelona 08036, Spain
Neurology 77:1283-6. 2011..We describe 3 patients who presented with sensorimotor symptoms confined to the abdominal wall and, with the exception of not involving the legs, satisfied the primary and secondary diagnostic criteria for RLS... - Cerebrospinal fluid hypocretin-1 levels in multiple system atrophyJose Enrique Martinez Rodriguez
Neurology Service, Hospital Clínic de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, University of Barcelona Medical School, Barcelona, Spain
Mov Disord 22:1822-4. 2007..All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease... - Decreased hypocretin-1 (Orexin-A) levels in the cerebrospinal fluid of patients with myotonic dystrophy and excessive daytime sleepinessJose E Martinez-Rodriguez
Neurology Service, Hospital Clinic i Provincial de Barcelona and Institut d lnvestigació Biomédica August Pi i Sunyer IDIBAPS, Barcelona, Spain
Sleep 26:287-90. 2003..Since narcolepsy is characterized by a dysfunction of the hypothalamic hypocretin system, we investigated whether patients with myotonic dystrophy type 1 with excessive daytime sleepiness have abnormalities in the hypocretin system... - Usefulness of uvulopalatopharyngoplasty with genioglossus and hyoid advancement in the treatment of obstructive sleep apneaIsabel Vilaseca
Otorhinolaryngology Service, Hospital Clinic de Barcelona, C Villarroel 170, Barcelona 08036, Spain
Arch Otolaryngol Head Neck Surg 128:435-40. 2002..To evaluate the usefulness of uvulopalatopharyngoplasty plus mandibular osteotomy with genioglossus and hyoid advancement in the treatment of obstructive sleep apnea syndrome (OSAS)... - Development of restless legs syndrome after dopaminergic treatment in a patient with periodic leg movements in sleepJoan Santamaria
Neurology Service, Hospital Clinic of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, C Villarroel 170, 08036, Barcelona, Spain
Sleep Med 4:153-5. 2003..Discontinuation of dopaminergic drugs in patients with isolated PLMS who develop RLS during the course of the treatment would be a reasonable recommendation... - [Sleep disorders in multiple system atrophy]J Santamaria
Servicio de Neurologia, Hospital Clinic de Barcelona, Barcelona
Neurologia 19:307-11. 2004..Nocturnal stridor is associated with decreased survival and its treatment is based on continuous positive air pressure (CPAP) when it occurs only during sleep or tracheostomy when it worsens and becomes also diurnal... - Sleep and sleep disorders in Don QuixoteAlex Iranzo
Service of Neurology, , Hospital Clinic de Barcelona, C/Villaroel 170, 08036 Barcelona, Spain
Sleep Med 5:97-100. 2004..His concept of sleep was shared by his contemporary, Shakespeare, and could have been influenced by the reading of the classical Spanish book of psychiatry Examen de Ingenios (1575)... - Refractory nonconvulsive status epilepticus in Creutzfeldt-Jakob diseaseMaria Aiguabella
Neurology Department, Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
Epileptic Disord 12:239-42. 2010..The final diagnosis was CJD. Continuous video-EEG monitoring revealed the ictal pattern of nonconvulsive SE to be periodic sharp wave complexes characteristic of CJD. [Published with video sequences]... - Sleep-disordered breathing in neurodegenerative diseasesCarles Gaig
Neurology Service, Multidisciplinary Sleep Unit, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain
Curr Neurol Neurosci Rep 12:205-17. 2012..Recognition of SDB in neurodegenerative disease is important because they are associated with significant morbidity and potential effective treatments are available... - Prevalence of restless legs syndrome and REM sleep behavior disorder in multiple sclerosisM J Gómez Choco
Service of Neurology, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
Mult Scler 13:805-8. 2007..Our study shows that RLS in MS is not more frequent than in the general population, and that RBD, although uncommon, may occur in the setting of this neurological disease... - Pathological description of a non-motor variant of multiple system atrophyC Gaig
Neurology Service, Hospital Clinic de Barcelona, C Villarroel 170, Barcelona 08036, Spain
J Neurol Neurosurg Psychiatry 79:1399-400. 2008..This case illustrates that MSA may present clinically without its cardinal motor symptoms, and that stridor and RBD may be clues to recognise the disease in a patient with autonomic failure... - Nocturnal problems occurring in Parkinson's diseaseF Grandas
Department of Neurology, Hospital General Universitario Gregorio Maranon, C Doctor Esquerdo 46, 28007 Madrid, Spain
Neurology 63:S8-11. 2004..This article reviews the clinical characteristics of some nocturnal motor problems that often induce sleep disruption in PD patients... - Hyperkalemic periodic paralysis associated with multiple sleep onset REM periodsA Iranzo
Neurology Service, Hospital Clinic de Barcelona, Spain
Sleep 22:1123-4. 1999..Furthermore, the present case suggests that SOREMPs may be explained by an increased extracellular potassium conductance related to HPP... - Management of sleep-disordered breathing in multiple system atrophyAlex Iranzo
Sleep Med 6:297-300. 2005 - Age-related metabolic changes in the upper brainstem tegmentum by MR spectroscopyAngel Moreno-Torres
Research Department, Centre Diagnostic Pedralbes, 08950, Esplugues de Llobregat, Spain
Neurobiol Aging 26:1051-9. 2005..Our findings provided evidence of regional differences and suggest different effects of age on the two studied brainstem segments, hitherto undescribed... - Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorderBirgit Frauscher
Innsbruck Medical University, Department of Neurology, Innsbruck, Austria
Sleep 31:724-31. 2008.... - A genetic risk factor for periodic limb movements in sleepHreinn Stefansson
deCODE Genetics, Reykjavik, Iceland
N Engl J Med 357:639-47. 2007..It is a major cause of sleep disruption. Periodic limb movements in sleep are detectable in most patients with RLS and represent an objective physiological metric...