Salvador Resino

Summary

Affiliation: Instituto de Salud Carlos III
Country: Spain

Publications

  1. ncbi request reprint Coinfection by human immunodeficiency virus and hepatitis C virus: noninvasive assessment and staging of fibrosis
    Salvador Resino
    Unit of HIV Hepatitis Coinfection, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Curr Opin Infect Dis 25:564-9. 2012
  2. doi request reprint Immunological recovery and metabolic disorders in severe immunodeficiency HIV type 1-infected children on highly active antiretroviral therapy
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    AIDS Res Hum Retroviruses 24:1477-84. 2008
  3. ncbi request reprint Diagnosis of advanced fibrosis in HIV and hepatitis C virus-coinfected patients via a new noninvasive index: the HGM-3 index
    S Resino
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    HIV Med 11:64-73. 2010
  4. doi request reprint An artificial neural network improves the non-invasive diagnosis of significant fibrosis in HIV/HCV coinfected patients
    Salvador Resino
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Carretera Majadahonda Pozuelo, Km 2 2, Majadahonda, Madrid, Spain
    J Infect 62:77-86. 2011
  5. doi request reprint Adipokine profiles and lipodystrophy in HIV-infected children during the first 4 years on highly active antiretroviral therapy
    S Resino
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    HIV Med 12:54-60. 2011
  6. pmc Can serum hyaluronic acid replace simple non-invasive indexes to predict liver fibrosis in HIV/Hepatitis C coinfected patients?
    Salvador Resino
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    BMC Infect Dis 10:244. 2010
  7. doi request reprint Analysis of IL28B alleles with virologic response patterns and plasma cytokine levels in HIV/HCV-coinfected patients
    Amanda Fernandez-Rodriguez
    Unidad de coinfección HIV hepatitis, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    AIDS 27:163-73. 2013
  8. ncbi request reprint Immunological changes after highly active antiretroviral therapy with lopinavir-ritonavir in heavily pretreated HIV-infected children
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    AIDS Res Hum Retroviruses 21:398-406. 2005
  9. ncbi request reprint Extensive implementation of highly active antiretroviral therapy shows great effect on survival and surrogate markers in vertically HIV-infected children
    Salvador Resino
    Laboratorio de Inmunobiologia of Hospital Gregorio Maranon, Madrid, Spain
    Clin Infect Dis 38:1605-12. 2004
  10. ncbi request reprint HLA-E variants are associated with sustained virological response in HIV/hepatitis C virus-coinfected patients on hepatitis C virus therapy
    María Guzmán-Fulgencio
    Unidad de coinfección HIV hepatitis, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda
    AIDS 27:1231-8. 2013

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Coinfection by human immunodeficiency virus and hepatitis C virus: noninvasive assessment and staging of fibrosis
    Salvador Resino
    Unit of HIV Hepatitis Coinfection, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Curr Opin Infect Dis 25:564-9. 2012
    ..This review presents recent findings on noninvasive alternatives for the diagnosis of fibrosis and cirrhosis in patients who are coinfected with HIV and hepatitis C virus (HCV)...
  2. doi request reprint Immunological recovery and metabolic disorders in severe immunodeficiency HIV type 1-infected children on highly active antiretroviral therapy
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    AIDS Res Hum Retroviruses 24:1477-84. 2008
    ..006). Overall, having a low nadir of CD4(+) hindered immune reconstitution; however, children with rapid immunologic recovery showed a higher prevalence of the lipodystrophy syndrome...
  3. ncbi request reprint Diagnosis of advanced fibrosis in HIV and hepatitis C virus-coinfected patients via a new noninvasive index: the HGM-3 index
    S Resino
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    HIV Med 11:64-73. 2010
    ..Noninvasive tests are increasingly being used for the assessment of liver fibrosis. We aimed to develop a serum index for the identification of advanced fibrosis (F>or=3) in HIV/hepatitis C virus (HCV)-coinfected patients...
  4. doi request reprint An artificial neural network improves the non-invasive diagnosis of significant fibrosis in HIV/HCV coinfected patients
    Salvador Resino
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Carretera Majadahonda Pozuelo, Km 2 2, Majadahonda, Madrid, Spain
    J Infect 62:77-86. 2011
    ..To develop an artificial neural network to predict significant fibrosis (F≥2) (ANN-SF) in HIV/Hepatitis C (HCV) coinfected patients using clinical data derived from peripheral blood...
  5. doi request reprint Adipokine profiles and lipodystrophy in HIV-infected children during the first 4 years on highly active antiretroviral therapy
    S Resino
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    HIV Med 12:54-60. 2011
    ..The aim of the study was to evaluate the evolution of plasma adipokines and lipodystrophy in protease inhibitor-naıve vertically HIV-infected children on highly active antiretroviral therapy(HAART)...
  6. pmc Can serum hyaluronic acid replace simple non-invasive indexes to predict liver fibrosis in HIV/Hepatitis C coinfected patients?
    Salvador Resino
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    BMC Infect Dis 10:244. 2010
    ....
  7. doi request reprint Analysis of IL28B alleles with virologic response patterns and plasma cytokine levels in HIV/HCV-coinfected patients
    Amanda Fernandez-Rodriguez
    Unidad de coinfección HIV hepatitis, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    AIDS 27:163-73. 2013
    ..We also explore the behavior of plasma cytokine levels...
  8. ncbi request reprint Immunological changes after highly active antiretroviral therapy with lopinavir-ritonavir in heavily pretreated HIV-infected children
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    AIDS Res Hum Retroviruses 21:398-406. 2005
    ..Our data indicate an immune system reconstitution in heavily pretreated HIV-infected children in response to salvage therapy with LPV/r as a consequence of a decrease in immune system activation and an increase in thymic function...
  9. ncbi request reprint Extensive implementation of highly active antiretroviral therapy shows great effect on survival and surrogate markers in vertically HIV-infected children
    Salvador Resino
    Laboratorio de Inmunobiologia of Hospital Gregorio Maranon, Madrid, Spain
    Clin Infect Dis 38:1605-12. 2004
    ..HAART is effective at the population level at decreasing VL, increasing CD4+ T cells, and increasing the survival in a higher percentage of HIV-infected children...
  10. ncbi request reprint HLA-E variants are associated with sustained virological response in HIV/hepatitis C virus-coinfected patients on hepatitis C virus therapy
    María Guzmán-Fulgencio
    Unidad de coinfección HIV hepatitis, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda
    AIDS 27:1231-8. 2013
    ..To analyze whether human leukocyte antigen (HLA)-E allelic variants are associated with and may predict response to peg-interferon (IFN) alpha and ribavirin treatment in HIV/hepatitis C virus (HCV)-coinfected patients...
  11. doi request reprint High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
    Juan Berenguer
    Infectious Diseases HIV Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Cytokine 57:25-9. 2012
    ..The aim of our study was to analyze the relationship among virological, immunological, and clinical characteristics with plasma CXCL10 levels in human immunodeficiency virus (HIV)/HCV-coinfected patients...
  12. doi request reprint IL28B polymorphisms are associated with severity of liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus
    María Guzmán-Fulgencio
    Unit of HIV Hepatitis Coinfection, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Infect 66:170-8. 2013
    ..To evaluate the association of IL28B polymorphisms and severity of liver disease among human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients...
  13. ncbi request reprint Positive virological outcome after lopinavir/ritonavir salvage therapy in protease inhibitor-experienced HIV-1-infected children: a prospective cohort study
    Salvador Resino
    Laboratory of Immuno Molecular Biology, Hospital Gregorio Maranon, Madrid, Spain
    J Antimicrob Chemother 54:921-31. 2004
    ..Lopinavir/ritonavir has demonstrated antiviral activity in the HIV-infected patient...
  14. pmc Effects of highly active antiretroviral therapy with nelfinavir in vertically HIV-1 infected children: 3 years of follow-up. Long-term response to nelfinavir in children
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    BMC Infect Dis 6:107. 2006
    ..We studied during a 3-year follow-up period the effects of highly active antiretroviral therapy with nelfinavir in vertically HIV-1 infected children...
  15. doi request reprint Association between lipodystrophy and leptin in human immunodeficiency virus-1-infected children receiving lopinavir/ritonavir-based therapy
    Salvador Resino
    Laboratorio de Epidemiología Molecular de Enfermedades Infecciosas, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Pediatr Infect Dis J 29:774-7. 2010
    ..Increase in plasma leptin levels and leptin/adiponectin ratio was associated with LD. These adipokines may be surrogate markers of LD...
  16. ncbi request reprint Long-term response to highly active antiretroviral therapy with lopinavir/ritonavir in pre-treated vertically HIV-infected children
    Beatriz Larru
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Antimicrob Chemother 61:183-90. 2008
    ..Our study aimed at evaluating the long-term use of lopinavir/ritonavir among children in a clinical setting...
  17. ncbi request reprint Long-term effects of highly active antiretroviral therapy in pretreated, vertically HIV type 1-infected children: 6 years of follow-up
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin Infect Dis 42:862-9. 2006
    ..The aim of this study was to define the long-term impact of HAART on CD4+ cell percentage and viral load according to CD4+ cell percentages before HAART was initiated...
  18. ncbi request reprint Slow progression of human immunodeficiency virus and hepatitis C virus disease in a cohort of coinfected children
    Dariela Micheloud
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Pediatr Infect Dis J 26:846-9. 2007
    ..05). HIV-1/HCV children had a good evolution in relation to CD4 and HIV-RNA viral load. They presented higher CD8 counts than HIV-1 children during long periods, and slower progression of HCV liver disease...
  19. ncbi request reprint Plasma IL-6 and IL-9 predict the failure of interferon-α plus ribavirin therapy in HIV/HCV-coinfected patients
    María Guzmán-Fulgencio
    Laboratorio de Epidemiología Molecular de Enfermedades Infecciosas, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Antimicrob Chemother 67:1238-45. 2012
    ..The aim of this study was to evaluate which cytokines affect the response to interferon-α (IFN-α) and ribavirin therapy and how these cytokines change 72 weeks after starting anti-HCV therapy in HIV/HCV-coinfected patients...
  20. doi request reprint Association between exposure to nevirapine and reduced liver fibrosis progression in patients with HIV and hepatitis C virus coinfection
    Juan Berenguer
    HIV Infectious Diseases Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin Infect Dis 46:137-43. 2008
    ....
  21. doi request reprint European mitochondrial DNA haplogroups and metabolic disorders in HIV/HCV-coinfected patients on highly active antiretroviral therapy
    Dariela Micheloud
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Acquir Immune Defic Syndr 58:371-8. 2011
    ..Mitochondrial DNA (mtDNA) haplogroups play an important role in susceptibility to metabolic disorders and cardiovascular disease...
  22. doi request reprint Sustained virological response to interferon-α plus ribavirin decreases inflammation and endothelial dysfunction markers in HIV/HCV co-infected patients
    María Guzmán-Fulgencio
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Antimicrob Chemother 66:645-9. 2011
    ..The aim was to evaluate the effect of HCV eradication on serum markers of inflammation and endothelial dysfunction markers in HIV/HCV co-infected patients...
  23. ncbi request reprint Negative influence of age on CD4+ cell recovery after highly active antiretroviral therapy in naive HIV-1-infected patients with severe immunodeficiency
    Dariela Micheloud
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Infect 56:130-6. 2008
    ..To study the effect of age on several outcomes among 187 antiretroviral-naive infected patients who started highly active antiretroviral therapy (HAART) with <or=200 CD4(+)/microl...
  24. pmc Immunological predictors of CD4+ T cell decline in antiretroviral treatment interruptions
    Elena Seoane
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    BMC Infect Dis 8:20. 2008
    ..The aim was to identify predictive markers of CD4+ cell count declines to < 350/microL in CD4-guided antiretroviral treatment interruptions...
  25. ncbi request reprint Clinical outcomes improve with highly active antiretroviral therapy in vertically HIV type-1-infected children
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin Infect Dis 43:243-52. 2006
    ..Conclusions. We observed that HAART produces a decrease in adverse clinical outcomes (i.e., hospital admission, AIDS, and death) in children with vertical HIV-1 infection in Madrid, Spain...
  26. ncbi request reprint Long-term response to highly active antiretroviral therapy in human immunodeficiency virus and hepatitis C virus coinfected children: 6 years of follow-up
    Dariela Micheloud
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Pediatr Infect Dis J 26:1061-4. 2007
    ....
  27. ncbi request reprint Salvage lopinavir-ritonavir therapy in human immunodeficiency virus-infected children
    Salvador Resino
    Laboratory of Immuno Molecular Biology, Department of Pediatrics, Hospital Carlos III, and Abbott Laboratories, Madrid, Spain
    Pediatr Infect Dis J 23:923-30. 2004
    ..To study the control of viral replication in human immunodeficiency virus (HIV)-infected children on different salvage therapies...
  28. doi request reprint Insulin resistance impairs response to interferon plus ribavirin in patients coinfected with HIV and hepatitis C virus
    Pablo Ryan
    Department of Microbiology, Hospital Gregorio Maranon, Madrid, Spain
    J Acquir Immune Defic Syndr 55:176-81. 2010
    ..We evaluated the effect of IR on sustained virologic response (SVR) in HIV/hepatitis C virus (HCV)-coinfected patients treated with interferon plus ribavirin...
  29. doi request reprint European mitochondrial haplogroups are associated with CD4+ T cell recovery in HIV-infected patients on combination antiretroviral therapy
    María Guzmán-Fulgencio
    Unit of HIV Hepatitis Coinfection, National Centre of Microbiology Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Antimicrob Chemother 68:2349-57. 2013
    ..The aim of our study was to determine whether mitochondrial DNA (mtDNA) haplogroups are associated with recovery of CD4+ in HIV-infected patients on cART...
  30. ncbi request reprint Impact of highly active antiretroviral therapy on CD4+ T cells and viral load of children with AIDS: a population-based study
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, 28007 Madrid, Spain
    AIDS Res Hum Retroviruses 20:927-31. 2004
    ..In conclusion, our study shows that the generalized use of HAART has permitted improvement in immunological and virological status of HIV-infected children without AIDS, and more importantly in children with AIDS...
  31. doi request reprint Lipid and apoprotein profile in HIV-1-infected patients after CD4-guided treatment interruption
    Elena Seoane
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Acquir Immune Defic Syndr 48:455-9. 2008
    ..The aims of the present study were to determine if metabolic abnormalities and cytokine derangements are modified in HIV-1-infected patients after 12 months on treatment interruption (TI)...
  32. doi request reprint European mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients
    Mónica García-Álvarez
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Spain
    AIDS 25:1619-926. 2011
    ..The aim of this study was to investigate whether mtDNA haplogroups had any influence on liver fibrosis progression in HIV/HCV coinfected patients...
  33. doi request reprint Hepatitis C virus infection is associated with endothelial dysfunction in HIV/hepatitis C virus coinfected patients
    Isabel Fernandez de Castro
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    AIDS 24:2059-67. 2010
    ....
  34. ncbi request reprint Low immunologic response to highly active antiretroviral therapy in naive vertically human immunodeficiency virus type 1-infected children with severe immunodeficiency
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Pediatr Infect Dis J 25:365-8. 2006
    ..We conclude that starting HAART after severe immunosuppression of naive HIV-infected children may not be effective for recovery of normal %CD4...
  35. ncbi request reprint Characterizing the immune system after long-term undetectable viral load in HIV-1-infected children
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Clin Immunol 23:279-89. 2003
    ..HIV-infected-children who respond to HAART had TRECs reconstitution, decreased immune activation, and lower effector CD8+ T cells. Moreover, successful HAART allow the increment of activated CD4+ T cells...
  36. pmc Different profiles of immune reconstitution in children and adults with HIV-infection after highly active antiretroviral therapy
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    BMC Infect Dis 6:112. 2006
    ..The aim of this study was to investigate differences in immune reconstitution profiles after highly active antiretroviral therapy (HAART) between HIV-children and adults...
  37. doi request reprint High plasma fractalkine (CX3CL1) levels are associated with severe liver disease in HIV/HCV co-infected patients with HCV genotype 1
    Mónica García-Álvarez
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Cytokine 54:244-8. 2011
    ....
  38. ncbi request reprint Short communication: Immune reconstitution after autologous peripheral blood stem cell transplantation in HIV-infected patients: might be better than expected?
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, C Doctor Esquerdo 46, 28007 Madrid, Spain
    AIDS Res Hum Retroviruses 23:543-8. 2007
    ..Overall, HIV+Ly+ patients showed an appropriate immune reconstitution 12 months after ASCT, and, interestingly, they had an amount of DNA-HIV copies similar to HIV+Ly- control patients in their CD4+ cells...
  39. ncbi request reprint Incidence of liver cirrhosis in HIV-infected patients with chronic hepatitis B or C in the era of highly active antiretroviral therapy
    Paula Tuma
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Antivir Ther 15:881-6. 2010
    ..Herein, we examine the incidence of cirrhosis, using TE assessment, in HIV-infected individuals with chronic hepatitis B or C receiving highly active antiretroviral therapy (HAART)...
  40. ncbi request reprint [Evolution of HIV and HCV coinfected children receiving long-term lopinavir/ritonavir-based antiretroviral therapy]
    Beatriz Larru
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Enferm Infecc Microbiol Clin 26:426-9. 2008
    ..There are few studies investigating the effect of HCV coinfection on HIV-related disease among children...
  41. ncbi request reprint ACSM4 polymorphisms are associated with rapid AIDS progression in HIV-infected patients
    María Guzmán-Fulgencio
    Unidad de coinfección HIV hepatitis, Centro Nacional de Microbiologia, Hospital Carlos III, Madrid, Spain Plataforma de Laboratorio, Hospital General Universitario Gregorio Maranon, Madrid, Spain Fundación para la Investigación Biomédica, Hospital General Universitario Gregorio Maranon, Madrid, Spain Servicio de Enfermedades Infecciosas, Hospital Carlos III, Madrid, Spain Servicio Microbiología, Hospital General Universitario Gregorio Maranon, Madrid, Spain Servicio de Enfermedades Infecciosas, Hospital General Universitario Reina Sofia, Madrid, Spain Servicio de Enfermedades Infecciosas, Hospital Virgen del Rocio, Seville, Spain Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain Instituto de Investigación Sanitaria del Gregorio Marañón, Madrid, Spain and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine CIBER BBN, Madrid, Spain
    J Acquir Immune Defic Syndr 65:27-32. 2014
    ..85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression. ..
  42. doi request reprint Prediction of hepatic fibrosis in patients coinfected with HIV and hepatitis C virus based on genetic markers
    Amanda Fernandez-Rodriguez
    Viral Infection and Immunity Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain Infectious Diseases and HIV Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón IiSGM, Madrid, Spain and Departments of Internal Medicine Pathology, Hospital General Universitario, Gregorio Maranon, Madrid, Spain
    J Acquir Immune Defic Syndr 64:434-42. 2013
    ..To assess the ability of the cirrhosis risk score (CRS) to predict liver fibrosis progression in HIV/hepatitis C virus (HCV)-coinfected patients...
  43. ncbi request reprint Low blood CD8+ T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children
    Silvia Sánchez-Ramón
    Unit of Neuroimmunology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Pediatrics 111:E168-75. 2003
    ....
  44. ncbi request reprint Mutations at codons 54 and 82 of HIV protease predict virological response of HIV-infected children on salvage lopinavir/ritonavir therapy
    José Luis Jiménez
    Laboratory of Immunobiología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Antimicrob Chemother 56:1081-6. 2005
    ..Lopinavir/ritonavir is a protease inhibitor (PI) that has shown great effectiveness as salvage therapy in PI-experienced HIV-infected children...
  45. pmc Impact of long-term viral suppression in CD4+ recovery of HIV-children on Highly Active Antiretroviral Therapy
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    BMC Infect Dis 6:10. 2006
    ..A major aim of our study was to determine CD4+ evolution associated with long-term VL control during 4 years of observation on HAART...
  46. ncbi request reprint CD4(+) T-cell immunodeficiency is more dependent on immune activation than viral load in HIV-infected children on highly active antiretroviral therapy
    Salvador Resino
    Laboratorio de Inmuno Biología Molecular, Hospital Universitario Virgen de Rocío, Sevilla, Spain
    J Acquir Immune Defic Syndr 42:269-76. 2006
    ..The aim of this study was to analyze the association between CD4(+) depletion and immune activation in HIV-1-infected children on highly active antiretroviral therapy (HAART)...
  47. doi request reprint Mitochondrial haplogroups are associated with clinical pattern of AIDS progression in HIV-infected patients
    María Guzmán-Fulgencio
    Unidad de coinfección HIV hepatitis, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Acquir Immune Defic Syndr 63:178-83. 2013
    ..049) in an ordinal logistic regression adjusted by gender, age at HIV infection, intravenous drug users, and hepatitis C virus infection. These data suggest that mitochondrial haplogroups might play a significant role in AIDS progression...
  48. doi request reprint Bacterial DNA translocation and liver disease severity among HIV-infected patients with chronic hepatitis C
    Mónica García-Álvarez
    HIV and Hepatitis Coinfection Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Acquir Immune Defic Syndr 61:552-6. 2012
    ..05). Our data show that bacterial translocation is associated with severe liver disease among human immunodeficiency virus-infected patients with chronic hepatitis C...
  49. doi request reprint Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV
    Jose Medrano
    Department of Infectious Diseases, Hospital Carlos III, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Clin Infect Dis 51:1209-16. 2010
    ..Given that therapy is poorly tolerated and rates of response are lower in patients coinfected with HCV and human immunodeficiency virus (HIV), the recognition of predictors of response is a high priority in this population...
  50. ncbi request reprint Association between plasma levels of eotaxin (CCL-11) and treatment response to interferon-alpha and ribavirin in HIV/HCV co-infected patients
    Ana Vargas
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Antimicrob Chemother 65:303-6. 2010
    ..To analyse the association between plasma chemokine levels at baseline and virological response to interferon-alpha (IFN-alpha) + ribavirin in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infected patients...
  51. ncbi request reprint SLC30A8 rs13266634 polymorphism is related to a favorable cardiometabolic lipid profile in HIV/hepatitis C virus-coinfected patients
    Daniel Pineda-Tenor
    aUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda bServicio de Medicina Interna cUnidad de Enfermedades Infecciosas VIH, Hospital General Universitario Gregorio Marañón dInstituto de Investigación Sanitaria Gregorio Marañón IiSGM eFundación para la Investigación Biomédica, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    AIDS 28:1325-32. 2014
    ..To analyze the relationship of SLC30A8 rs13266634 polymorphism with insulin resistance and dyslipidemia in HIV/hepatitis C virus (HCV)-coinfected patients...
  52. doi request reprint Soluble markers of inflammation are associated with Framingham scores in HIV-infected patients on suppressive antiretroviral therapy
    María Guzmán-Fulgencio
    Laboratory of Molecular Epidemiology of Infectious Diseases, Centro Nacional de Microbiologia, Instituto de Salud Carlos III Campus Majadahonda, Carretera Majadahonda Pozuelo, Km 2 2, 28220 Majadahonda, Madrid, Spain
    J Infect 63:382-90. 2011
    ....
  53. pmc Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C
    María A Jiménez-Sousa
    Unit of HIV Hepatitis Coinfection, National Center for Microbiology, Health Institute Carlos III ISCIII, 28220 Majadahonda, Madrid, Spain
    BMC Med 11:6. 2013
    ..Because this large amount of data includes some inconsistencies, we consider assessment of the global estimate for each SNP to be essential...
  54. pmc Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study
    Ma Angeles Jimenez-Sousa
    Unidad de Epidemiología Molecular de Enfermedades Infecciosas, Centro Nacional de Microbiologia, Instituto de Salud Carlos III Campus Majadahonda, Carretera Majadahonda Pozuelo Km 2, 2, Majadahonda, Madrid, Spain
    BMC Med Genet 13:58. 2012
    ..Chronic kidney disease progression has been linked to pro-inflammatory cytokines and markers of inflammation. These markers are also elevated in end-stage renal disease (ESRD), which constitutes a serious public health problem...
  55. ncbi request reprint [Changes in CD4+ and CD8+ T-cell subsets in HIV-infected children differently correlate with viral replication and thymic function]
    Salvador Resino
    Laboratorio de Inmunobiologia Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Med Clin (Barc) 123:527-31. 2004
    ..We intended to study the relationship between T-cell subsets with plasmatic detectable viral load (VL) and T-receptor excision circles (TREC)...
  56. ncbi request reprint Association of adiponectin (ADIPOQ) rs2241766 polymorphism and dyslipidemia in HIV/HCV-coinfected patients
    Daniel Pineda-Tenor
    Viral Infection and Immunity Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain
    Eur J Clin Invest 44:453-62. 2014
    ..The aim of this study was to evaluate the association of the ADIPOQ rs2241766 polymorphism with serum dyslipidemia and insulin resistance (IR) in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients...
  57. ncbi request reprint Virological phenotype switches under salvage therapy with lopinavir-ritonavir in heavily pretreated HIV-1 vertically infected children
    Isabel Galan
    Laboratorio de Inmuno Biología Molecular and Servicio de Pediatría, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    AIDS 18:247-55. 2004
    ..To investigate the effects of salvage therapy with lopinavir-ritonavir on HIV-1 phenotype in heavily antiretroviral experienced HIV-infected children...
  58. ncbi request reprint Increased interleukin-7 plasma levels are associated with recovery of CD4+ T cells in HIV-infected children
    Rafael Correa
    Department of Immunology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Clin Immunol 23:401-6. 2003
    ..The increase in the thymic production of new T cells recovers the CD4 population, and leads to a normalization of IL-7 levels...
  59. ncbi request reprint CD38 expression in CD8+ T cells predicts virological failure in HIV type 1-infected children receiving antiretroviral therapy
    Salvador Resino
    Laboratorio de Inmunobiologia Molecular, Hospital Gregorio Maranon, Madrid, Spain
    Clin Infect Dis 38:412-7. 2004
    ..In conclusion, we demonstrate for the first time that CD8(+)CD38(+) T cell count is a good prognostic marker of therapeutic failure in HIV-1-infected children...
  60. doi request reprint Vitamin D deficiency is associated with severity of liver disease in HIV/HCV coinfected patients
    María Guzmán-Fulgencio
    Unit of Viral Infection and Immunity, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Infect 68:176-84. 2014
    ....
  61. ncbi request reprint Viral load and CD4+ T lymphocyte response to highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children: an observational study
    Salvador Resino
    Laboratory of Immuno Molecular Biology, Hospital Gregorio Maranon, Madrid, Spain
    Clin Infect Dis 37:1216-25. 2003
    ..A CD4+ T lymphocyte percentage of >25% was directly associated with undetectable VL during the follow-up period. In conclusion, first-line HAART induces beneficial virological and immunological outcome responses in children...
  62. pmc Rate of candidiasis among HIV-infected children in Spain in the era of highly active antiretroviral therapy (1997-2008)
    Alejandro Alvaro-Meca
    Unidad de Medicina Preventiva y Salud Publica, Universidad Rey JuanCarlos, Alcorcon, Madrid, Spain
    BMC Infect Dis 13:115. 2013
    ..The aim of our study was to estimate the candidiasis rate and evaluate its trend in HIV-infected children in Spain during the era of highly active antiretroviral therapy (HAART) compared to HIV-uninfected children...
  63. ncbi request reprint Neuroprotective effects of early antiretrovirals in vertical HIV infection
    Silvia Sánchez-Ramón
    Unit of Neuroimmunology, Laboratory of Immuno Molecular Biology, Madrid, Spain
    Pediatr Neurol 29:218-21. 2003
    ..Our findings clearly indicate that antiretroviral therapy before the onset of neurologic symptoms delayed presentation of progressive HIV-1-associated encephalopathy, with an additional beneficial effect on survival...
  64. ncbi request reprint Immunity in HIV-1-infected adults with a previous state of moderate-severe immune-suppression and more than 500 CD4+ T cell after highly active antiretroviral therapy
    Salvador Resino
    Laboratorio de Immuno Biología Molecular, Hospital General Universitario Gregorio Maranon, C Doctor Esquerdo 46, 28007 Madrid, Spain
    J Clin Immunol 24:379-88. 2004
    ..Long-term consequences of this subclinical immune deficiency remain to be determined...
  65. ncbi request reprint Epidemiologic trends of cancer diagnoses among HIV-infected children in Spain from 1997 to 2008
    Alejandro Alvaro-Meca
    Unidad de Medicina Preventiva y Salud Publica, Universidad Rey Juan Carlos, Alcorcon, Madrid, Spain
    Pediatr Infect Dis J 30:764-8. 2011
    ..The aim of this study was to evaluate changes in the pattern of cancer rates in HIV-infected children on HAART during over a decade of follow-up...
  66. doi request reprint Genetic polymorphisms located in TGFB1, AGTR1, and VEGFA genes are associated to chronic renal allograft dysfunction
    María A Jiménez-Sousa
    Unidad de Epidemiología Molecular de Enfermedades Infecciosas, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Spain
    Cytokine 58:321-6. 2012
    ..The aim of this study was to determine the impact of single-nucleotide polymorphisms (SNPs) located in regions related to inflammatory and immune processes on the development of chronic renal allograft dysfunction (CRAD)...
  67. ncbi request reprint Effectiveness and safety of abacavir, lamivudine, and zidovudine in antiretroviral therapy-naive HIV-infected patients: results from a large multicenter observational cohort
    Juan Berenguer
    Infectious Diseases and HIV Unit, Hospital Gregorio Maranon, Madrid, Spain
    J Acquir Immune Defic Syndr 41:154-9. 2006
    ..To analyze the safety and effectiveness of abacavir, lamivudine, and zidovudine (ABC/3TC/ZDV) in antiretroviral therapy (ART)-naive HIV-infected patients...
  68. doi request reprint Trend of pneumonia incidence among children infected with HIV in the era of highly active antiretroviral therapy
    Dariela Micheloud
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Spain
    Pediatr Infect Dis J 31:599-601. 2012
    ..Non-AIDS-defining pneumonia remains a significant health problem for HIV-infected children...
  69. doi request reprint Reduction in mycobacterial disease among HIV-infected children in the highly active antiretroviral therapy era (1997-2008)
    Julia Jensen
    Servicio de Pediatria, Hospital Infanta Cristina, Parla, Madrid, Spain
    Pediatr Infect Dis J 31:278-83. 2012
    ..The aim of this study was to estimate the change in mycobacterial disease rate in HIV-infected children and adolescents in the highly active antiretroviral therapy (HAART) era...
  70. ncbi request reprint Rate and timing of hepatitis C virus relapse after a successful course of pegylated interferon plus ribavirin in HIV-infected and HIV-uninfected patients
    Jose Medrano
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Clin Infect Dis 49:1397-401. 2009
    ..However, episodes of HCV relapse occurred before week 12 in most cases, regardless of HIV status...
  71. ncbi request reprint [Immunologic recovery after 2-years on HAART in vertically HIV-infected children]
    Salvador Resino
    Servicio de Inmunologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Med Clin (Barc) 118:601-4. 2002
    ..Our purpose was to carry out an analysis of T cells subsets involved in the recovery of the immune system in vertically HIV-1-infected children, on highly active antiretroviral therapy (HAART) over more than 24 months...
  72. ncbi request reprint Identification of liver fibrosis in HIV/HCV-coinfected patients using a simple predictive model based on routine laboratory data
    J Berenguer
    Infectious Diseases Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Viral Hepat 14:859-69. 2007
    ..3, and the PPV to confirm F > or = 3 was 64.3%. Thus, HGM-2 accurately predicted F > or = 3 among HIV/HCV-coinfected patients. HGM-1 was less accurate at predicting F > or = 2...
  73. pmc Naïve and memory CD4+ T cells and T cell activation markers in HIV-1 infected children on HAART
    S Resino
    Department of Immunology, , Madrid, Spain
    Clin Exp Immunol 125:266-73. 2001
    ..Specific CD4+ T cell subsets may be more informative than routine surrogate markers in defining the evolution of HIV infection and immune reconstitution in children...
  74. ncbi request reprint NK cell increase in neonates from the preterm to the full-term period of gestation
    Alicia Perez
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Neonatology 92:158-63. 2007
    ..This will be helpful for clinical practice to find the best way to prevent neonatal infections or strengthen the immune system of newborns with some kind of immunodeficiency...
  75. pmc Impact of antiretroviral protocols on dynamics of AIDS progression markers
    S Resino
    Department of Immunology, General University Hospital Gregorio Marañon, Madrid, Spain
    Arch Dis Child 86:119-24. 2002
    ..To assess the "real life" effectiveness of different antiretroviral therapies (ART)...
  76. ncbi request reprint Homeostatic role of IL-7 in HIV-1 infected children on HAART: association with immunological and virological parameters
    S Resino
    Laboratorio de Inmuno Biología Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Acta Paediatr 94:170-7. 2005
    ..To investigate the role of IL-7 in HIV-infected children on highly active antiretroviral therapy (HAART) and its association with laboratory parameters related to disease progression...
  77. pmc Preserved immune system in long-term asymptomatic vertically HIV-1 infected children
    S Resino
    Laboratory of Immno Molecular Biology, General University Hospital Gregorio Marañon, Madrid, Spain
    Clin Exp Immunol 132:105-12. 2003
    ..Moreover, our results identified new markers of HIV disease, such as TRECs and IL-7, that could be used to monitor disease...
  78. ncbi request reprint Impaired interleukin-5 (IL-5) production by T cells as a prognostic marker of disease progression in human immunodeficiency virus type 1 (HIV-1)-infected children
    S Resino
    Department of Immunology, , Madrid, Spain
    Eur Cytokine Netw 12:253-9. 2001
    ..Our data suggest a dysfunctional cytokine production by PBMC from HIV-infected children as regards both Th1 and Th2 cytokines resulting from quantitative as well as qualitative defects induced by HIV-1...
  79. doi request reprint Serum levels of fibrosis biomarkers measured early after liver transplantation are associated with severe hepatitis C virus recurrence
    D Micheloud
    Unidad de Investigacion, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Transpl Infect Dis 11:183-8. 2009
    ..94; P=0.035) have good predictive capacity for identifying severe HCV infection. The evaluation of these biomarkers may be useful in the early identification of patients in whom a more aggressive therapeutic approach could be necessary...
  80. pmc Stimulated proliferative responses in vertically HIV-infected children on HAART correlate with clinical and immunological markers
    S Resino
    Laboratory of Immuno Molecular Biology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin Exp Immunol 131:130-7. 2003
    ..01) were associated with higher VL. Our data show that higher proliferative responses to PWM, anti-CD3 + anti-CD28 and PHA are associated with both non-activated and naive CD4+ T cell subsets in HIV-1-infected children on HAART...
  81. ncbi request reprint Immunological recovery after 3 years' antiretroviral therapy in HIV-1-infected children
    Salvador Resino
    Department of Immunology, General University Hospital Gregorio Marañon, Madrid, Spain
    AIDS 16:483-6. 2002
  82. ncbi request reprint Opportunistic infections and organ-specific diseases in HIV-1-infected children: a cohort study (1990-2006)
    S Guillen
    Pediatric Immunology Department, Getafe Hospital, Madrid, Spain
    HIV Med 11:245-52. 2010
    ..The aim of this study was to describe the influence of the widespread use of HAART on the development of opportunistic infections and organ-specific diseases in HIV-infected children...
  83. doi request reprint CD81 expression in peripheral blood lymphocytes before and after treatment with interferon and ribavirin in HIV/HCV coinfected patients
    D Micheloud
    Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    HIV Med 11:161-9. 2010
    ....
  84. ncbi request reprint Tumor necrosis factor-alpha and nitric oxide in vertically HIV-1-infected children: implications for pathogenesis
    J Gonzalez-Nicolas
    Departamento de Inmunologia, Hospital General Universitario Gregorio Maranon, C Doctor Esquerdo 46, 28007 Madrid, Spain
    Eur Cytokine Netw 12:437-44. 2001
    ..These data suggest a detrimental role of NO in HIV-1 infection, and that NOS inhibitors may have some therapeutic benefit in HIV-1-infection...
  85. ncbi request reprint Disruption in cytokine and chemokine production by T-cells in vertically HIV-1-infected children
    S Resino
    Department of Immunology, , Madrid, Spain
    Acta Paediatr 90:989-97. 2001
    ..An important observation was an increased RANTES production associated with viral isolates of NSI/R5 phenotype and S/L kinetics...
  86. pmc Antibodies to an epitope from the Cha human autoantigen are markers of Chagas' disease
    N Girones
    Centro de Biologia Molecular, CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Clin Diagn Lab Immunol 8:1039-43. 2001
    ..Those results suggest that the presence of anti-R3 antibodies is a highly specific marker of Chagas' disease and that R3 ELISA could be helpful in the diagnosis and monitoring of this disease...
  87. doi request reprint High rate of infection and immune disorders in patients with hepatitis C virus after liver transplantation
    D Micheloud
    Department of Internal Medicine, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Transpl Infect Dis 11:367-72. 2009
    ..05). Our data suggest that HCV recurrence after LT was associated with a high incidence of early severe infections and immunological alterations, which may be related to this increased risk...