M Meseguer


Affiliation: Instituto Valenciano de Infertilidad
Country: Spain


  1. Rubio I, Galán A, Larreategui Z, Ayerdi F, Bellver J, Herrero J, et al. Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope. Fertil Steril. 2014;102:1287-1294.e5 pubmed publisher
    ..9% (95% CI, 41.4-48.4) versus 37.1% (95% CI, 33.6-40.7). The strategy of culturing and selecting embryos in the integrated EmbryoScope time-lapse monitoring system improves reproductive outcomes. NCT01549262. ..
  2. Marcos J, Pérez Albalá S, Mifsud A, Mollá M, Landeras J, Meseguer M. Collapse of blastocysts is strongly related to lower implantation success: a time-lapse study. Hum Reprod. 2015;30:2501-8 pubmed publisher
    ..7 and 31%, respectively. The retrospective nature of the study limits its potential value. Study the collapse pattern of the blastocyst, may assist selection of the blastocysts most likely to implant and increase IVF/ICSI success rates. ..
  3. Basile N, Vime P, Florensa M, Aparicio Ruiz B, García Velasco J, Remohí J, et al. The use of morphokinetics as a predictor of  implantation: a multicentric study to define and validate an algorithm for embryo selection. Hum Reprod. 2015;30:276-83 pubmed publisher
    ..The elaboration of an algorithm based on a larger database derived from different (albeit related) clinics raises the possibility that such algorithms could be applied in different clinical settings. ..
  4. Motato Y, de los Santos M, Escriba M, Ruiz B, Remohí J, Meseguer M. Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system. Fertil Steril. 2016;105:376-84.e9 pubmed publisher
    ..We propose two multivariable models based on our findings to classify embryos according to their probabilities of blastocyst stage and implantation in the largest data set ever reported of human blastocysts. ..
  5. request reprint
    Meseguer M, Martínez Conejero J, O Connor J, Pellicer A, Remohi J, Garrido N. The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor. Fertil Steril. 2008;89:1191-9 pubmed
    ..An association between early and late embryo quality and sperm DNA oxidation supports the relevance of the hydroxylation of 8-oxoguanine as a biomarker of sperm quality reflecting the free radical damage in human sperm. ..
  6. Meseguer M, Herrero J, Tejera A, Hilligsøe K, Ramsing N, Remohi J. The use of morphokinetics as a predictor of embryo implantation. Hum Reprod. 2011;26:2658-71 pubmed publisher
    ..The efficacy of this classification will be evaluated in a prospective randomized study that ultimately will determine if implantation rates can be improved by time-lapse analysis. ..
  7. Aparicio Ruiz B, Basile N, Pérez Albalá S, Bronet F, Remohi J, Meseguer M. Automatic time-lapse instrument is superior to single-point morphology observation for selecting viable embryos: retrospective study in oocyte donation. Fertil Steril. 2016;106:1379-1385.e10 pubmed publisher
    ..Our results suggest that the automated embryo diagnostic test provided extra information to the embryologist to select the best embryos, independently from clinical features of the patient or day of transfer. ..
  8. Romany L, Garrido N, Cobo A, Aparicio Ruiz B, Serra V, Meseguer M. Obstetric and perinatal outcome of babies born from sperm selected by MACS from a randomized controlled trial. J Assist Reprod Genet. 2017;34:201-207 pubmed publisher
  9. Tejera A, Aparicio Ruiz B, Meseguer M. The use of morphokinetic as a predictor of implantation. Minerva Ginecol. 2017;69:555-567 pubmed publisher
    ..This article focuses on the different time-lapse systems burgeoning on the market and the use of morphokinetics as a predictor of embryo implantation. ..

More Information


  1. request reprint
    Meseguer M, de los Santos M, Simon C, Pellicer A, Remohi J, Garrido N. Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles. Fertil Steril. 2006;86:1376-85 pubmed
    ..The correlation of the sperm GPX family mRNA expression with embryo health appears quite promising for discovery of molecular causes of male infertility. ..
  2. Coello A, Meseguer M, Galán A, Alegre L, Remohí J, Cobo A. Analysis of the morphological dynamics of blastocysts after vitrification/warming: defining new predictive variables of implantation. Fertil Steril. 2017;108:659-666.e4 pubmed publisher
    ..The observed correlations and the proposed algorithm should be validated in a prospective trial to evaluate its efficacy. ..
  3. Insua M, Cobo A, Larreategui Z, Ferrando M, Serra V, Meseguer M. Obstetric and perinatal outcomes of pregnancies conceived with embryos cultured in a time-lapse monitoring system. Fertil Steril. 2017;108:498-504 pubmed publisher
    ..Our results suggest that this technology is an effective and safe alternative for embryo incubation, though trials of larger numbers of patients are required to further confirm our conclusions. NCT01549262. ..