Pablo Martinez-Martin

Summary

Affiliation: Instituto de Salud Carlos III
Country: Spain

Publications

  1. ncbi request reprint Longitudinal metric properties of disability rating scales for Parkinson's disease
    Pablo Martinez-Martin
    Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Value Health 9:386-93. 2006
  2. ncbi request reprint Independent validation of SCOPA-psychosocial and metric properties of the PDQ-39 Brazilian version
    Francisco Javier Carod-Artal
    Department of Neurology, Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brasilia, Brazil
    Mov Disord 22:91-8. 2007
  3. doi request reprint Burden, perceived health status, and mood among caregivers of Parkinson's disease patients
    Pablo Martinez-Martin
    Department of Applied Epidemiology, National Center for Epidemiology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 23:1673-80. 2008
  4. doi request reprint Composite rating scales
    Pablo Martinez-Martin
    Alzheimer s Disease Research Unit, Alzheimer Center, Reina Sofia Foundation, Spain
    J Neurol Sci 289:7-11. 2010
  5. doi request reprint The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease
    Pablo Martinez-Martin
    Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 26:399-406. 2011
  6. ncbi request reprint [Psychometric attributes of Scales for Outcomes in Parkinson's Disease-Cognition (SCOPA-Cog), Castilian language]
    P Martinez-Martin
    Centro Nacional de Epidemiologia Instituto de Salud Carlos III, 28029 Madrid, Espana
    Rev Neurol 47:337-43. 2008
  7. doi request reprint SCOPA-sleep and PDSS: two scales for assessment of sleep disorder in Parkinson's disease
    Pablo Martinez-Martin
    National Centre of Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 23:1681-8. 2008
  8. doi request reprint Longitudinal psychometric attributes, responsiveness, and importance of change: An approach using the SCOPA-Psychosocial questionnaire
    Pablo Martinez-Martin
    Consortium for Biomedical Research in Neurodegenerative Diseases Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 23:1516-23. 2008
  9. doi request reprint Validation of the "QUICK" questionnaire--a tool for diagnosis of "wearing-off" in patients with Parkinson's disease
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Centre for Epidemiology, Carlos III, Institute of Health, Madrid, Spain
    Mov Disord 23:830-6. 2008
  10. ncbi request reprint The Patient Card questionnaire to identify wearing-off in Parkinson disease
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, C Sinesio Delgado 6, 28029 Madrid, Spain
    Clin Neuropharmacol 30:266-75. 2007

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Longitudinal metric properties of disability rating scales for Parkinson's disease
    Pablo Martinez-Martin
    Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Value Health 9:386-93. 2006
    ..This study analyzes the longitudinal metric attributes of three Parkinson's disease (PD) disability scales, taking Hoehn and Yahr (HY) staging as the reference measure of PD progression...
  2. ncbi request reprint Independent validation of SCOPA-psychosocial and metric properties of the PDQ-39 Brazilian version
    Francisco Javier Carod-Artal
    Department of Neurology, Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brasilia, Brazil
    Mov Disord 22:91-8. 2007
    ..42 and -0.52, respectively) and mental components (-0.41) was found. Correlation between SCOPA-PS and PDQ-39 SI was 0.73 (all coefficients, P < 0.0001). The SCOPA-PS and PDQ-39, Brazilian versions, have satisfactory metric attributes...
  3. doi request reprint Burden, perceived health status, and mood among caregivers of Parkinson's disease patients
    Pablo Martinez-Martin
    Department of Applied Epidemiology, National Center for Epidemiology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 23:1673-80. 2008
    ..In PD, prevalence of affective disorders among patients' caregivers is high and influences both burden and HRQoL...
  4. doi request reprint Composite rating scales
    Pablo Martinez-Martin
    Alzheimer s Disease Research Unit, Alzheimer Center, Reina Sofia Foundation, Spain
    J Neurol Sci 289:7-11. 2010
    ..Bearing in mind that no alternative is perfect, additional research in this field and judicious decisions are called for...
  5. doi request reprint The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease
    Pablo Martinez-Martin
    Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 26:399-406. 2011
    ..In this study, the Non-Motor Symptoms Scale (NMSS) was used to assess the impact of the non-motor symptoms on HRQoL of Parkinson's disease patients...
  6. ncbi request reprint [Psychometric attributes of Scales for Outcomes in Parkinson's Disease-Cognition (SCOPA-Cog), Castilian language]
    P Martinez-Martin
    Centro Nacional de Epidemiologia Instituto de Salud Carlos III, 28029 Madrid, Espana
    Rev Neurol 47:337-43. 2008
    ..To test the psychometric attributes of the Scales for Outcomes in Parkinson's Disease-Cognition (SCOPA-Cog), in Castilian language...
  7. doi request reprint SCOPA-sleep and PDSS: two scales for assessment of sleep disorder in Parkinson's disease
    Pablo Martinez-Martin
    National Centre of Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 23:1681-8. 2008
    ....
  8. doi request reprint Longitudinal psychometric attributes, responsiveness, and importance of change: An approach using the SCOPA-Psychosocial questionnaire
    Pablo Martinez-Martin
    Consortium for Biomedical Research in Neurodegenerative Diseases Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 23:1516-23. 2008
    ..The SCOPA-PS showed satisfactory longitudinal attributes and responsiveness in stage-2 Brazilian patients with PD across 1 year of follow-up...
  9. doi request reprint Validation of the "QUICK" questionnaire--a tool for diagnosis of "wearing-off" in patients with Parkinson's disease
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Centre for Epidemiology, Carlos III, Institute of Health, Madrid, Spain
    Mov Disord 23:830-6. 2008
    ..The area under the ROC curve resulted 0.90 (CI95%: 0.86-0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO...
  10. ncbi request reprint The Patient Card questionnaire to identify wearing-off in Parkinson disease
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, C Sinesio Delgado 6, 28029 Madrid, Spain
    Clin Neuropharmacol 30:266-75. 2007
    ..Accordingly, the PC may potentially help clinicians identify W-O phenomena and thereby allow for better management of patients with Parkinson disease...
  11. ncbi request reprint Two questionnaires for Parkinson's disease: are the PDQ-39 and PDQL equivalent?
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, C Sinesio Delgado, 6, 28029 Madrid, Spain
    Qual Life Res 16:1221-30. 2007
    ..Although there is a wide range of specific health-related quality of life (HRQoL) measures for Parkinson's disease (PD), their psychometric attributes have never been compared...
  12. ncbi request reprint Effect of medical and surgical interventions on health-related quality of life in Parkinson's disease
    Pablo Martinez-Martin
    Unit of Neuroepidemiology, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 22:757-65. 2007
    ..HRQoL should be part of future trial designs and more research is necessary to understand the determinants of QoL in PD...
  13. doi request reprint The Clinical Impression of Severity Index for Parkinson's Disease: international validation study
    Pablo Martinez-Martin
    National Centre for Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 24:211-7. 2009
    ..Its simplicity and easy application make it an attractive and useful tool for clinical practice and research...
  14. doi request reprint [Validation of the functional independence scale]
    Pablo Martinez-Martin
    Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, Madrid, Espana
    Gac Sanit 23:49-54. 2009
    ..The study was carried out in the autonomous region of Madrid in community-dwelling elders...
  15. ncbi request reprint [Psychometric attributes of the Scales for Outcomes in Parkinson's Disease-Psychosocial (SCOPA-PS): validation in Spain and review]
    P Martinez-Martin
    Centro Nacional de Epidemiologia, CIBERNED e Instituto de Salud Carlos III, Madrid, Espana
    Rev Neurol 49:1-7. 2009
    ..To evaluate the psychometric attributes of the Scales for Outcomes in Parkinson's Disease-Psychosocial (SCOPA-PS) in Spain and to compare them with previous studies...
  16. doi request reprint Alzheimer Center Reina Sofia Foundation: fighting the disease and providing overall solutions
    Pablo Martinez-Martin
    Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain
    J Alzheimers Dis 21:337-48. 2010
    ..The involvement of all social strata in the Alzheimer Project makes evident the unitary effort that Spain is carrying out in the fight against neurodegenerative diseases and, particularly, AD...
  17. doi request reprint Dementia associated with Parkinson's disease: applying the Movement Disorder Society Task Force criteria
    P Martinez-Martin
    Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain
    Parkinsonism Relat Disord 17:621-4. 2011
    ..The objective of this study was to explore the utility of the new MDS-TF criteria and procedures in clinical practice...
  18. ncbi request reprint Specific patient-reported outcome measures for Parkinson's disease: analysis and applications
    Pablo Martinez-Martin
    Neuroepidemiology Unit Consortium for Biomedical Research in Neurodegenerative Diseases CIBERNED, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Expert Rev Pharmacoecon Outcomes Res 8:401-18. 2008
    ..New PRO instruments and active research to improve their scientific quality are to be expected in the next 5 years...
  19. doi request reprint Health-related quality-of-life scales in Parkinson's disease: critique and recommendations
    Pablo Martinez-Martin
    Alzheimer Disease Research Unit, CIEN Foundation Reina Sofia Foundation, Alzheimer Center Reina Sofia Foundation, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 26:2371-80. 2011
    ..Selection of the most appropriate instrument for a particular objective requires consideration of the characteristics of each scale and the goals of the assessment...
  20. doi request reprint Systematic review of the effect of dopamine receptor agonists on patient health-related quality of life
    Pablo Martinez-Martin
    Area of Applied Epidemiology, National Center for Epidemiology, and CIBERNED, Carlos III Institute of Health, Madrid, Spain
    Parkinsonism Relat Disord 15:S58-64. 2009
    ..The reviewed trials were highly variable in design, objectives and presentation of results. Therefore, specific evaluation of intervention impact in each of the tested clinical settings was required...
  21. doi request reprint Most of the Quality of Life in Essential Tremor Questionnaire (QUEST) psychometric properties resulted in satisfactory values
    Pablo Martinez-Martin
    Area of Applied Epidemiology, National Center for Epidemiology, and Consortium for Biomedical Research in Neurodegenerative Diseases Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Carlos III Institute of Health, CI, Sinesio Delgado, 6, 28029 Madrid, Spain
    J Clin Epidemiol 63:767-73. 2010
    ..This study sought to assess the psychometric attributes of the Quality of Life in Essential Tremor Questionnaire (QUEST) by undertaking an independent validation...
  22. doi request reprint International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease
    P Martinez-Martin
    National Center of Epidemiology, Carlos III Institute of Health, Av Monforte de Lemos, 3, 28029 Madrid, Spain
    Neurology 73:1584-91. 2009
    ..The Non-Motor Symptoms Scale (NMSS) is an instrument specifically designed for the comprehensive assessment of NMS in patients with PD. NMSS psychometric properties have been tested in this study...
  23. ncbi request reprint Caregiver burden in Parkinson's disease
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Center for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Mov Disord 22:924-31; quiz 1060. 2007
    ..This study underscores the need to consider the impact of PD on caregivers' well-being...
  24. ncbi request reprint [A pilot study on a specific measure for sleep disorders in Parkinson's disease: SCOPA-Sleep]
    P Martinez-Martin
    Sección de Neuroepidemiología, Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, 28029 Madrid, Spain
    Rev Neurol 43:577-83. 2006
    ....
  25. ncbi request reprint Quality of life of caregivers in Parkinson's disease
    Pablo Martinez-Martin
    National Center for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Qual Life Res 14:463-72. 2005
    ..To assess the impact of PD on informal caregivers of patients and identify the main factors related to caregiver strain...
  26. ncbi request reprint Psychometric characteristics of the Parkinson's disease questionnaire (PDQ-39)--Ecuadorian version
    Pablo Martinez-Martin
    Neuroepidemiology Unit, Department of Applied Epidemiology, National Centre for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Parkinsonism Relat Disord 11:297-304. 2005
    ..91), and known-groups validity proved satisfactory. Results agreed in part with those yielded by an international study, identifying specific flaws probably linked to socio-cultural influence...
  27. ncbi request reprint [Neuropsychological disorders in Parkinson's disease: evaluating them and their impact on the caregiver]
    P Martinez-Martin
    Area de Epidemiología Aplicada, Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, Madrid, Spain
    Rev Neurol 39:639-45. 2004
    ..Moreover, the information about their impact on the quality of life of caregivers (QLC) is scarce...
  28. ncbi request reprint Global versus factor-related impression of severity in Parkinson's disease: a new clinimetric index (CISI-PD)
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Center for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Mov Disord 21:208-14. 2006
    ..90) and convergent (r>0.75) and known-groups validity. The CISI-PD is a valid and reliable measure that expands the information obtained via the CGIS...
  29. ncbi request reprint Parkinson's Disease Sleep Scale: validation study of a Spanish version
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Public Health, and the Spanish Network HOHSR, Madrid, Spain
    Mov Disord 19:1226-32. 2004
    ..The assessment of PD sleep disorders with the PDSS met some basic standards required for health status measures...
  30. ncbi request reprint [Reading-elaboration studies on quality of life in neurology]
    P Martinez Martin
    Sección de Neuroepidemiología, Area de Epidemiología Aplicada, Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, Madrid
    Neurologia 19:55-63. 2004
    ..This review presents concepts, some methodological aspects, and information that may help in answering these questions...
  31. ncbi request reprint Impact of fatigue in Parkinson's disease: the Fatigue Impact Scale for Daily Use (D-FIS)
    Pablo Martinez-Martin
    Unit of Neuroepidemiology, National Centre for Epidemiology, ISCIII, Madrid, The Spanish Network HOHSR, Spain
    Qual Life Res 15:597-606. 2006
    ..In PD, D-FIS is a consistent and valid measure for fatigue, a frequent symptom previously found to impair patients' HRQoL. Fatigue was also linked to depression and disability in this study...
  32. ncbi request reprint [Impact of the cognitive impairment on the quality of life in patients with Parkinson's disease]
    P Martinez-Martin
    Sección de Neuroepidemiología, Centro Nacional de Epidemiologia Instituto de Salud Carlos III, 28029 Madrid, Spain
    Rev Neurol 43:168-72. 2006
    ..To review aspects related to the impact caused by the cognitive deterioration on the health-related quality of life (HRQL) of patients with Parkinson's disease...
  33. ncbi request reprint Health-related quality of life evaluation by proxy in Parkinson's disease: approach using PDQ-8 and EuroQoL-5D
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Mov Disord 19:312-8. 2004
    ..The degree of agreement varied for individual dimensions. Proxy evaluation of PD patients' HRQoL showed limitations mainly with assessments using the EuroQoL and especially in patients with severe disease and depression...
  34. ncbi request reprint [Theoretical bases for the critical reading of neurological articles on diagnostic tests]
    P Martinez Martin
    Sección de Neuroepidemiología, Centro Nacional de Epidemiologia Instituto de Salud Carlos III, Madrid, Spain
    Neurologia 18:39-45. 2003
    ..Moreover, the evaluation should include data about test utility, and explain risk-benefit balance for the patients in whom it is used...
  35. ncbi request reprint Patients', doctors', and caregivers' assessment of disability using the UPDRS-ADL section: are these ratings interchangeable?
    Pablo Martinez-Martin
    National Center for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Mov Disord 18:985-92. 2003
    ..In PD, UPDRS-section 2-based assessment of disability by patients themselves and caregivers is a valid and reliable outcome...
  36. ncbi request reprint Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease
    Pablo Martinez-Martin
    Department of Applied Epidemiology, National Center of Epidemiology, I S Carlos III, Madrid, Spain
    Mov Disord 17:372-7. 2002
    ..There was no correlation between the change obtained in the QoL (PDQ-39SI) and in the other variables. As measured by the PDQ-39, STN-DBS significantly improves important aspects of QoL in patients with advanced PD...
  37. ncbi request reprint The SCOPA-Motor Scale for assessment of Parkinson's disease is a consistent and valid measure
    Pablo Martinez-Martin
    National Center for Epidemiology, Carlos III Institute of Public Health, C Sinesio Delgado, 6, 28029 Madrid, Spain
    J Clin Epidemiol 58:674-9. 2005
    ..The SCOPA-Motor Scale (S-MS) for assessment of Parkinson's disease (PD), contains 21 items in three domains: Motor examination, Disability, and Complications. Our objective was to validate the S-MS Spanish version...
  38. doi request reprint Psychometric attributes of the Hospital Anxiety and Depression Scale in Parkinson's disease
    Carmen Rodriguez-Blazquez
    Area of Applied Epidemiology and CIBERNED, National Center for Epidemiology, Madrid 28029, Spain
    Mov Disord 24:519-25. 2009
    ..The SEM was 1.84 for HADS-Anxiety and 1.72 for HADS-Depression. The HADS is an acceptable, consistent, valid, precise, and potentially responsive scale for use in PD...
  39. doi request reprint Cross-cultural validation of the Scales for Outcomes in Parkinson's Disease-Psychosocial questionnaire (SCOPA-PS) in four Latin American countries
    Javier Virues-Ortega
    National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Value Health 12:385-91. 2009
    ..To conduct a cross-national validation of the Scales for Outcomes in Parkinson's Disease-PsychoSocial questionnaire (SCOPA-PS) in four Latin American Countries...
  40. doi request reprint Individual's perspective of local community environment and health indicators in older adults
    Carolina Giraldez-Garcia
    Department of Preventive Medicine, La Paz University Hospital, Madrid, Spain
    Geriatr Gerontol Int 13:130-8. 2013
    ..This study evaluated the relationship between individual's perspective of local community environment and health in older people...
  41. ncbi request reprint Health status and well-being of older adults living in the community and in residential care settings: are differences influenced by age?
    Carmen Rodriguez-Blazquez
    National Center of Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Aging Ment Health 16:884-91. 2012
    ..This finding has implications for resource allocation and interventions addressed to improve health and well-being in older adults...
  42. doi request reprint Medical, environmental and personal factors of disability in the elderly in Spain: a screening survey based on the International Classification of Functioning
    Javier Virues-Ortega
    CIBER de Enfermedades Neurodegenerativas Carlos III Institute of Health, Madrid, Spain
    Gac Sanit 25:29-38. 2011
    ..The assessment scheme was consistent with the ICF model of disability...
  43. doi request reprint Measurement properties of the Community Wellbeing Index in older adults
    Maria João Forjaz
    National School of Public Health, Carlos III Institute of Health and CIBERNED, C Monforte de Lemos 5, Madrid, Spain
    Qual Life Res 20:733-43. 2011
    ..The community wellbeing index (CWI) is a new measure of the individual's level of satisfaction with the local place of residence. The main goal of this paper is to validate the CWI in a sample of older adults...
  44. doi request reprint Rasch analysis of the hospital anxiety and depression scale in Parkinson's disease
    Maria João Forjaz
    National School of Public Health and CIBERNED, Carlos III Institute of Health, C Sinesio Delgado, 6, Madrid 28029, Spain
    Mov Disord 24:526-32. 2009
    ..Our results supported the use of HADS-T as a measure of psychological distress in PD patients. Moreover, the HADS-A was also an adequate anxiety measure. Further research is required to address the use of HADS-D in PD...
  45. doi request reprint Psychometric properties of the International Wellbeing Index in community-dwelling older adults
    C Rodriguez-Blazquez
    National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Int Psychogeriatr 23:161-9. 2011
    ..This is the first study to analyze the psychometric properties of the International Wellbeing Index (IWI), which comprises the Personal Wellbeing Index (PWI) and National Wellbeing Index (NWI), among community-dwelling older adults...
  46. ncbi request reprint Self-perceived health status in older adults: regional and sociodemographic inequalities in Spain
    Beatriz Fernandez-Martinez
    Hospital Universitario La Paz, Madrid, Spain
    Rev Saude Publica 46:310-9. 2012
    ..To assess regional and sociodemographic differences in self-perceived health status among older adults...
  47. doi request reprint Motor effects of REAC in advanced Alzheimer's disease: results from a pilot trial
    Javier Olazarán
    Alzheimer Disease Research Unit, Alzheimer Center Reina Sofia Foundation, CIEN Foundation, Carlos III Institute of Health, Madrid, Spain
    J Alzheimers Dis 36:297-302. 2013
    ..05). NPO administration was comfortable and safe. These results warrant further research with NPO and other REAC protocols to improve motor deterioration in AD...
  48. pmc Modeling depression in Parkinson disease: disease-specific and nonspecific risk factors
    Albert F G Leentjens
    From the Department of Psychiatry A F G L, A J H M, Maastricht University Medical Center, Maastricht School for Mental Health and Neuroscience A F G L, A J H M, S K, Maastricht University, Maastricht, the Netherlands Neurology and Movement Disorders Unit K D, Lille University Medical Center, Lille, France Mental Health Care Line L M, Michael E DeBakey Veterans Administration Medical Center and Departments of Psychiatry and Neurology, Baylor College of Medicine, Houston, TX Alzheimer Disease Research Unit and CIBERNED P M M, Alzheimer Center Reina Sofia Foundation, Carlos III Institute of Health, Madrid, Spain Departments of Neurology and Psychiatry I H R, University of Rochester School of Medicine and Dentistry, Rochester, NY and School of Psychiatry S E S, University of Western Australia and Fremantle Hospital, Fremantle, Australia
    Neurology 81:1036-43. 2013
    ..To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model...
  49. doi request reprint Rasch analysis of the International Wellbeing Index in older adults
    Maria João Forjaz
    National School of Public Health, Carlos III Institute of Health, Madrid, Spain
    Int Psychogeriatr 24:324-32. 2012
    ..This paper studies the psychometric properties of the PWI and NWI, using Rasch analysis and classic psychometric methods...
  50. pmc Prevalence of disability in a composite ≥75 year-old population in Spain: a screening survey based on the International Classification of Functioning
    Javier Virues-Ortega
    Research Network in Neurodegenerative Diseases CIBERNED, Carlos III Institute of Health, Madrid, Spain
    BMC Public Health 11:176. 2011
    ..The present study reports prevalence rates for mild, moderate, and severe/extreme disability by the domains of activities and participation of the ICF...
  51. doi request reprint Factors associated with loneliness of noninstitutionalized and institutionalized older adults
    Maria Eugenia Prieto-Flores
    Carlos III Institute of Health, Madrid, Spain
    J Aging Health 23:177-94. 2011
    ....
  52. doi request reprint Comorbidity, health status, and quality of life in institutionalized older people with and without dementia
    Salomé Martín-García
    EULEN Socio sanitary services, Madrid, Spain
    Int Psychogeriatr 25:1077-84. 2013
    ..The objective of this study is to analyze the relationship between comorbidity, health status, QoL, and dementia in institutionalized older adults...
  53. doi request reprint The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson's disease
    Carmen Rodriguez-Blazquez
    National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain
    Parkinsonism Relat Disord 19:889-93. 2013
    ....
  54. pmc A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob disease
    Olga Calero
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain
    PLoS ONE 7:e43926. 2012
    ..These findings underscore the interplay in both pathologies of APP, Aβ oligomers, ApoE, PrP and BACE1, and suggest that aging and perhaps vascular risk factors may modulate disease pathologies in part through these key players...
  55. doi request reprint [Psychometric properties of the Functional Social Support Questionnaire and the Loneliness Scale in non-institutionalized older adults in Spain]
    Alba Ayala
    Escuela Nacional de Sanidad, Instituto de Salud Carlos III, Madrid, Espana
    Gac Sanit 26:317-24. 2012
    ..To examine the psychometric properties of the Social Support Questionnaire Duke-UNC (DUFSS) and the De Jong-Gierveld Loneliness Scale in a sample of non-institutionalized older adults...
  56. doi request reprint [Influence of chronic health problems in dimensions of EQ-5D: study of institutionalized and non-institutionalized elderly]
    María Concepción Delgado-Sanz
    Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, Madrid, Espana
    Rev Esp Salud Publica 85:555-68. 2011
    ..The aim of this study is to analyze the influence of self-reported chronic health conditions in HRQOL, measured through the EQ-5D dimensions, in non-institutionalized and institutionalized older adults...
  57. doi request reprint Cross-cultural evaluation of the modified Parkinson Psychosis Rating Scale across disease stages
    Javier Virues-Ortega
    Consortium for Biomedical Research in Neurodegenerative Diseases, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain
    Mov Disord 25:1391-8. 2010
    ..The results show that some psychometric properties of the mPPRS are satisfactory albeit there is room for the improvement of scale's content validity and internal consistency. (c) 2010 Movement Disorder Society...
  58. doi request reprint An effective environmental intervention for management of the 'mirror sign' in a case of probable Lewy body dementia
    Nuria Gil-Ruiz
    Alzheimer s Disease Research Unit, CIEN Foundation Queen Sofia Foundation UIPA, Carlos III Institute of Health, Alzheimer Center Queen Sofia Foundation, Madrid, Spain
    Neurocase 19:1-13. 2013
    ..Following a straightforward, ecological, non-pharmacological intervention, her 'mirror sign' delusion was no longer present...
  59. doi request reprint Expanded and independent validation of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)
    Pablo Martinez-Martin
    AD Research Unit, Alzheimer Center Reina Sofia Foundation and CIBERNED, Carlos III Institute of Health, C Valderrebollo, 5, 28031, Madrid, Spain
    J Neurol 260:228-36. 2013
    ..Results confirm those of the original study and add information on scale reliability, construct validity, and precision. The MDS-UPDRS Spanish version shows satisfactory clinimetric characteristics...
  60. doi request reprint Quality of life and burden in caregivers for patients with Parkinson's disease: concepts, assessment and related factors
    Pablo Martinez-Martin
    Alzheimer Disease Research Unit, CIEN Foundation Reina Sofia Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Cl Valderrebollo, 5, 28031 Madrid, Spain
    Expert Rev Pharmacoecon Outcomes Res 12:221-30. 2012
    ..The implementation of effective interventions to preserve the caregiver's wellbeing and allow the patients to remain at home and be properly assisted is a pragmatic consequence of this knowledge...
  61. doi request reprint Design, measures and sample characteristics of the CadeViMa-Spain survey on quality of life in community-dwelling older adults
    Gloria Fernández-Mayoralas
    Institute of Economics, Geography and Demography, Centre for Human and Social Sciences, Spanish National Research Council, Madrid, Spain
    Int Psychogeriatr 24:425-38. 2012
    ..This paper presents the overall description, methodology, sample characteristics and reliability of the measures used...
  62. doi request reprint Discrimination analysis of blood plasma associated with Alzheimer's disease using vibrational spectroscopy
    Pedro Carmona
    Instituto de Estructura de la Materia, CSIC, Madrid, Spain
    J Alzheimers Dis 34:911-20. 2013
    ..In summary, our results open the possibility of using this spectroscopic approach as a non-invasive, rapid, and relatively inexpensive procedure for early accurate diagnosis of AD...
  63. doi request reprint Quality of life (QoL) in community-dwelling and institutionalized Alzheimer's disease (AD) patients
    Beatriz León-Salas
    Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Valderrebollo 5, 28031 Madrid, Spain
    Arch Gerontol Geriatr 57:257-62. 2013
    ..Once those variables were controlled a marginal effect of setting on QoL was found, which favored the nursing home (β=0.20, p<0.05)...
  64. doi request reprint A short scale for evaluation of neuropsychiatric disorders in Parkinson's disease: first psychometric approach
    Pablo Martinez-Martin
    Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, C Valderrebollo, 5, 28031, Madrid, Spain
    J Neurol 259:2299-308. 2012
    ..The precision of the scale dimensions was acceptable. The SEND-PD performed as an acceptable, consistent, valid, and precise scale for evaluation of neuropsychiatric symptoms in Parkinson's disease...
  65. doi request reprint The importance of non-motor disturbances to quality of life in Parkinson's disease
    Pablo Martinez-Martin
    Alzheimer Disease Research Unit, Alzheimer Center Reina Sofia Foundation, and CIBERNED, Carlos III Institute of Health, Madrid, Spain
    J Neurol Sci 310:12-6. 2011
    ..In that scenario, the whole NMS showed a close association with the quality of life deterioration, exceeding even the effects of the motor disorder...
  66. doi request reprint Caregivers' estimation of patients' quality of life (QoL) in Alzheimer's disease (AD): an approach using the ADRQL
    Beatriz León-Salas
    Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Valderrebollo, 5, 28031 Madrid, Spain
    Arch Gerontol Geriatr 53:13-8. 2011
    ..03). In conclusion, the main determinants of QoL in PAD are functional capacities and behavior. Other medical, psychological and social variables could also be contributing to specific aspects of QoL on an individual basis...
  67. doi request reprint Gender-related differences in the burden of non-motor symptoms in Parkinson's disease
    Pablo Martinez-Martin
    Research Unit, Alzheimer Center Reina Sofia Foundation, and CIBERNED Carlos III Institute of Health, C Valderrebollo, 5, 28031 Madrid, Spain
    J Neurol 259:1639-47. 2012
    ..Gender-related patterns of NMS involvement may be relevant for clinical trials in PD...
  68. doi request reprint Clinical and anatomical correlates of gait dysfunction in Alzheimer's disease
    Javier Olazarán
    Alzheimer Disease Research Unit, Alzheimer Center Reina Sofia Foundation, CIEN Foundation, Carlos III Institute of Health, Madrid, Spain
    J Alzheimers Dis 33:495-505. 2013
    ..e., motor cortex, cingulate, insula, and cerebellum) producing gait dysfunction and, eventually, gait loss in AD...
  69. doi request reprint Residential satisfaction, sense of belonging and loneliness among older adults living in the community and in care facilities
    Maria Eugenia Prieto-Flores
    National School of Public Health, Carlos III Institute of Health, Madrid 28029, Spain
    Health Place 17:1183-90. 2011
    ....
  70. ncbi request reprint [Cross-cultural validation of Antonovsky's Sense of Coherence Scale (OLQ-13) in Spanish elders aged 70 years or more]
    Javier Virues-Ortega
    Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, Madrid, Espana
    Med Clin (Barc) 128:486-92. 2007
    ..This paper reports on the cross-cultural validation of Antonovsky's Sense of Coherence Scale (OLQ-13) in a sample of Spanish senior citizens...
  71. ncbi request reprint Metric attributes of the unified Parkinson's disease rating scale 3.0 battery: Part I, feasibility, scaling assumptions, reliability, and precision
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 21:1182-8. 2006
    ..Factor structure of the UPDRS mentation, activities of daily living, and complications subscales was replicated. As a whole, the HY, SE, and UPDRS are acceptable, consistent, and potentially sensitive rating scales...
  72. doi request reprint The CAREQOL-MS was a useful instrument to measure caregiver quality of life in multiple sclerosis
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Clin Epidemiol 64:675-86. 2011
    ..To develop and test the first specific instrument for assessing caregiver health-related quality of life (HRQOL) in multiple sclerosis (MS) (CAREQOL-MS)...
  73. doi request reprint Promoting research in advanced dementia: early clinical results of the Alzheimer Center Reina Sofía Foundation
    Javier Olazarán
    Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain
    J Alzheimers Dis 28:211-22. 2012
    ....
  74. doi request reprint The Q10 questionnaire for detection of wearing-off phenomena in Parkinson's disease
    Pablo Martinez-Martin
    Alzheimer Disease Research Unit, CIEN Foundation Reina Sofia Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain
    Parkinsonism Relat Disord 18:382-5. 2012
    ..62-0.64). Comparison with the QUICK and WOQ-9 shows that the Q10 can be a new tool for detection of wearing-off with satisfactory properties and a good balance between brevity and performance...
  75. ncbi request reprint Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients
    Pablo Martinez-Martin
    Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 22:1623-9. 2007
    ....
  76. doi request reprint ICF-based disability survey in a rural population of adults and older adults living in Cinco Villas, Northeastern Spain: design, methods and population characteristics
    Jesus de Pedro-Cuesta
    Department of Applied Epidemiology, National Centre for Epidemiology, Carlos III Institute of Health, ES 28029 Madrid, Spain
    Neuroepidemiology 35:72-82. 2010
    ..This study will set the basis for the development of disability-related services for the rural elderly in northeastern Spain...
  77. ncbi request reprint Burden of disease related to Parkinson's disease in Spain in the year 2000
    Esther Cubo
    Department of Applied Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 20:1481-7. 2005
    ..PD burden in Spain in 2000 was high, with disability being the major contributing factor. Although BPD in Spain was greater than both world and European A subregion BPD, these differences should nevertheless be interpreted with caution...
  78. ncbi request reprint [The current state of the art concerning quality of life in Parkinson's disease: II. Determining and associated factors]
    M J Forjaz
    Escuela Nacional de Sanidad, Instituto de Salud Carlos III, E 28029 Madrid, Espana
    Rev Neurol 49:655-60. 2009
    ..AIM. This paper is the second part of a review of the current state of the art concerning HRQL in PD and focuses on its main determining and associated factors...
  79. ncbi request reprint Metric attributes of the unified Parkinson's disease rating scale 3.0 battery: part II, construct and content validity
    Maria João Forjaz
    Neuroepidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 21:1892-8. 2006
    ..3% (UPDRS Motor Examination). In conclusion, while the modified H&Y, S&E, and UPDRS displayed satisfactory construct validity, the content validity of all scales except UPDRS Motor Examination failed to attain adequate standards...
  80. doi request reprint Prospects on the origin of Alzheimer's disease
    Jesus Avila
    Center of Molecular Biology Severo Ochoa, CSIC UAM, Madrid, Spain
    J Alzheimers Dis 20:669-72. 2010
    ....
  81. ncbi request reprint [Psychometric attributes of the Parkinson's Disease-Cognitive Rating Scale. An independent validation study]
    P Martinez-Martin
    Unidad de Investigación del Proyecto Alzheimer, Fundación Cien Fundación Reina Sofía, Madrid, Espana
    Rev Neurol 49:393-8. 2009
    ..To perform an independent evaluation of the psychometric attributes of the Parkinson's Disease-Cognitive Rating Scale (PD-CRS)...
  82. ncbi request reprint [The current state of the art concerning quality of life in Parkinson's disease: I. Instruments, comparative studies and treatments]
    B Frades-Payo
    Area de Epidemiología Aplicada y CIBERNED, Sección de Neuroepidemiología, Instituto de Salud Carlos III, 28029 Madrid, Espana
    Rev Neurol 49:594-8. 2009
    ..This review is part of a series of two papers, the aim of which is to describe the current situation of studies on HRQL in PD and to detect areas in which knowledge is lacking, as a possible guide to researchers in future projects...
  83. pmc Prevalence of dementia and major dementia subtypes in Spanish populations: a reanalysis of dementia prevalence surveys, 1990-2008
    Jesus de Pedro-Cuesta
    National Centre for Epidemiology, CIBERNED and Alzheimer Disease Research Unit, Carlos III Institute of Public Health, Madrid, Spain
    BMC Neurol 9:55. 2009
    ..This study describes the prevalence of dementia and major dementia subtypes in Spanish elderly...
  84. ncbi request reprint The PDQ-39 Spanish version: reliability and correlation with the short-form health survey (SF-36)
    P Martinez Martin
    Department of Neurology, Hospital Universitario de Getafe, Madrid, Spain
    Neurologia 14:159-63. 1999
    ..The present study assess the test-retest reliability and the convergent validity of the PDQ-39SV with a generic QoL instrument (SF-36)...
  85. doi request reprint Infrared spectroscopic analysis of mononuclear leukocytes in peripheral blood from Alzheimer's disease patients
    Pedro Carmona
    Instituto de Estructura de la Materia, CSIC, Madrid, Spain
    Anal Bioanal Chem 402:2015-21. 2012
    ....
  86. pmc Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases
    Olga Calero
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Madrid, Spain
    PLoS ONE 6:e22090. 2011
    ..Moreover, these results suggest that the genetic interaction between APOE and PRNP may have a biological correlate that is indicative of shared neurodegenerative pathways involved in AD and sCJD...
  87. pmc Surgery and risk of sporadic Creutzfeldt-Jakob disease in Denmark and Sweden: registry-based case-control studies
    Ignacio Mahillo-Fernandez
    Department of Applied Epidemiology, National Center for Epidemiology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Carlos III Institute of Health, Madrid, Spain
    Neuroepidemiology 31:229-40. 2008
    ..Epidemiologic evidence of surgical transmission of sporadic Creutzfeldt-Jakob disease (sCJD) remains controversial...
  88. ncbi request reprint Impact of fatigue in multiple sclerosis: the Fatigue Impact Scale for Daily Use (D-FIS)
    J Benito-Leon
    Department of Neurology, Mostoles General Hospital, and Gregorio Marañón University, Madrid, Spain
    Mult Scler 13:645-51. 2007
    ..The Fatigue Impact Scale for Daily Use (D-FIS) is an eight-item instrument designed to measure subjective daily experience of fatigue. This study sought to determine the metric properties of the D-FIS in multiple sclerosis (MS) patients...
  89. ncbi request reprint Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan
    Christopher G Goetz
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 22:41-7. 2007
    ....
  90. ncbi request reprint Determinants of quality of life in Brazilian patients with Parkinson's disease
    Francisco Javier Carod-Artal
    Department of Neurology, The Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brasilia DF, Brazil
    Mov Disord 22:1408-15. 2007
    ..Depression showed to be the most consistent determinant of HRQoL, followed by disability, motor complications, and education years. There was a close association between the PDQ-39 and SCOPA-PS summary scores...
  91. ncbi request reprint International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study
    Kallol Ray Chaudhuri
    Movement Disorders Unit, Kings College Hospital, University Hospital Lewisham, Guy s King s and St Thomas School of Medicine, London, United Kingdom
    Mov Disord 21:916-23. 2006
    ..Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals...
  92. ncbi request reprint Clinical assessment of nocturnal disability in Parkinson's disease: the Parkinson's Disease Sleep Scale
    K Ray Chaudhuri
    Regional Movement Disorders Unit, King s College Hospital, University Hospital Lewisham, Guy s, King s and St Thomas School of Biomedical Medicine, King s College, London, United Kingdom
    Neurology 63:S17-20. 2004
  93. ncbi request reprint The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study
    Kallol Ray Chaudhuri
    National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom
    Mov Disord 22:1901-11. 2007
    ..70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire...