Daniel Lopez

Summary

Affiliation: Centro Nacional de Microbiología - Instituto de Salud Carlos III
Location: Majadahonda, Spain
URL: http://publicationslist.org/dlopez

Publications

  1. ncbi request reprint Asymmetric selection of T cell antigen receptor alpha- and beta-chains in HLA-B27 alloreactivity
    P Lauzurica
    Department of Immunology, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 148:3624-30. 1992
  2. ncbi request reprint An endogenous HIV envelope-derived peptide without the terminal NH3+ group anchor is physiologically presented by major histocompatibility complex class I molecules
    Yolanda Samino
    Centro Nacional de Microbiologia Instituto de Salud Carlos III, E 28220 Madrid, Spain
    J Biol Chem 279:1151-60. 2004
  3. ncbi request reprint Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum
    Loredana Saveanu
    Institut National de la Sante et Recherche Médicale Unité 580, Universite Rene Descartes Paris 5, 75015 Paris, France
    Nat Immunol 6:689-97. 2005
  4. ncbi request reprint A long N-terminal-extended nested set of abundant and antigenic major histocompatibility complex class I natural ligands from HIV envelope protein
    Yolanda Samino
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Madrid, Spain
    J Biol Chem 281:6358-65. 2006
  5. ncbi request reprint Antigen processing of a short viral antigen by proteasomes
    Daniel Lopez
    Unidad de Proteómica, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Madrid, Spain
    J Biol Chem 281:30315-8. 2006
  6. doi request reprint Relevance of viral context and diversity of antigen-processing routes for respiratory syncytial virus cytotoxic T-lymphocyte epitopes
    Carolina Johnstone
    Unidad de Inmunología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Pozuelo km 2, E 28220 Majadahonda, Madrid, Spain
    J Gen Virol 89:2194-203. 2008
  7. doi request reprint Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes
    Miguel Angel Rico
    Unidad de Proteómica, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Immunol Cell Biol 87:344-50. 2009
  8. pmc Multiple, non-conserved, internal viral ligands naturally presented by HLA-B27 in human respiratory syncytial virus-infected cells
    Susana Infantes
    Unidad de Protemica, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    Mol Cell Proteomics 9:1533-9. 2010
  9. doi request reprint H-2Ld class I molecule protects an HIV N-extended epitope from in vitro trimming by endoplasmic reticulum aminopeptidase associated with antigen processing
    Susana Infantes
    Unidad de Proteómica, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 184:3351-5. 2010
  10. doi request reprint Caspases in virus-infected cells contribute to recognition by CD8+ T lymphocytes
    Daniel Lopez
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Spain
    J Immunol 184:5193-9. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Asymmetric selection of T cell antigen receptor alpha- and beta-chains in HLA-B27 alloreactivity
    P Lauzurica
    Department of Immunology, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 148:3624-30. 1992
    ..They suggest recognition of multiple peptides and involvement of beta-chain junctional regions in recognizing shared motifs among some of these peptides...
  2. ncbi request reprint An endogenous HIV envelope-derived peptide without the terminal NH3+ group anchor is physiologically presented by major histocompatibility complex class I molecules
    Yolanda Samino
    Centro Nacional de Microbiologia Instituto de Salud Carlos III, E 28220 Madrid, Spain
    J Biol Chem 279:1151-60. 2004
    ..This may help raise the plasticity and thus the effectiveness of the immune response against the viral infection. These data have implications for HIV vaccine development...
  3. ncbi request reprint Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum
    Loredana Saveanu
    Institut National de la Sante et Recherche Médicale Unité 580, Universite Rene Descartes Paris 5, 75015 Paris, France
    Nat Immunol 6:689-97. 2005
    ..Thus, the human endoplasmic reticulum is equipped with a pair of trimming aminopeptidases that have complementary functions in HLA class I peptide presentation...
  4. ncbi request reprint A long N-terminal-extended nested set of abundant and antigenic major histocompatibility complex class I natural ligands from HIV envelope protein
    Yolanda Samino
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Madrid, Spain
    J Biol Chem 281:6358-65. 2006
    ..This 15-mer is the longest natural peptide known recognized by cytotoxic T lymphocytes and is surprisingly protected from aminopeptidase trimming in living cells...
  5. ncbi request reprint Antigen processing of a short viral antigen by proteasomes
    Daniel Lopez
    Unidad de Proteómica, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Madrid, Spain
    J Biol Chem 281:30315-8. 2006
    ..The results suggest that the degradation of short antigens by the proteasome occurs by sequential cleavage...
  6. doi request reprint Relevance of viral context and diversity of antigen-processing routes for respiratory syncytial virus cytotoxic T-lymphocyte epitopes
    Carolina Johnstone
    Unidad de Inmunología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Pozuelo km 2, E 28220 Majadahonda, Madrid, Spain
    J Gen Virol 89:2194-203. 2008
    ..This underscores both the diversity of pathways available and the influence of virus infection on presentation of epitopes to CTLs...
  7. doi request reprint Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes
    Miguel Angel Rico
    Unidad de Proteómica, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Immunol Cell Biol 87:344-50. 2009
    ..In B lymphocytes, HRSV infection upregulated major histocompatibility complex (MHC) class II but not MHC class I molecules and induced the expression of the activation marker CD86...
  8. pmc Multiple, non-conserved, internal viral ligands naturally presented by HLA-B27 in human respiratory syncytial virus-infected cells
    Susana Infantes
    Unidad de Protemica, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    Mol Cell Proteomics 9:1533-9. 2010
    ..These data have implications for vaccine development as well as for analysis of the CTL response...
  9. doi request reprint H-2Ld class I molecule protects an HIV N-extended epitope from in vitro trimming by endoplasmic reticulum aminopeptidase associated with antigen processing
    Susana Infantes
    Unidad de Proteómica, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 184:3351-5. 2010
    ..The in vitro data indicate that this N-extended peptide is efficiently trimmed to a 9-mer, unless its binding to the MHC molecules protects the full-length peptide...
  10. doi request reprint Caspases in virus-infected cells contribute to recognition by CD8+ T lymphocytes
    Daniel Lopez
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Spain
    J Immunol 184:5193-9. 2010
    ....
  11. doi request reprint TLR4-independent upregulation of activation markers in mouse B lymphocytes infected by HRSV
    Miguel Angel Rico
    Unidad de Proteómica Procesamiento Antigénico, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    Mol Immunol 47:1802-7. 2010
    ..Since the activation of monocytes and macrophages by HRSV was previously reported to depend on TLR4, the current study indicates that these cells and B lymphocytes respond to HRSV infection with different activation pathways...
  12. doi request reprint Unusual viral ligand with alternative interactions is presented by HLA-Cw4 in human respiratory syncytial virus-infected cells
    Susana Infantes
    Unidad de Procesamiento Antigénico, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Immunol Cell Biol 89:558-65. 2011
    ..These data have implications for the identification of antiviral cytotoxic T lymphocyte responses and for vaccine development...
  13. doi request reprint TAP-independent human histocompatibility complex-Cw1 antigen processing of an HIV envelope protein conserved peptide
    Elena Lorente
    Unidad de Procesamiento Antigénico, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    AIDS 25:265-9. 2011
    ..It was concluded that HLA class I peptides derived from a large fraction of the N-terminal HIV envelope protein could be presented even in the absence of the TAP complex...
  14. pmc Concerted antigen processing of a short viral antigen by human caspase-5 and -10
    Daniel Lopez
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, E 28220 Madrid, Spain
    J Biol Chem 286:16910-3. 2011
    ..These in vitro data suggest that each enzyme can use the degradation products of the other as substrate for new cleavages, indicating concerted endoproteolytic activity of caspase-5 and -10...
  15. pmc Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells
    Elena Lorente
    From the Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda Madrid, Spain
    J Biol Chem 286:38054-9. 2011
    ..These data demonstrate the different allele-dependent complex processing pathways involved in the generation of the HLA class I peptide repertoire in TAP-deficient cells...
  16. ncbi request reprint Multiple proteases process viral antigens for presentation by MHC class I molecules to CD8(+) T lymphocytes
    Margarita Del-Val
    Centro Nacional de Microbiologi a, Instituto de Salud Carlos III, Ctra Pozuelo, Km 2, E 28220 Majadahonda, Madrid, Spain
    Mol Immunol 39:235-47. 2002
    ..This expands the number of tissues and physiological and pathological situations compatible with antigen presentation, as well as the universe of pathogen-derived sequences available for recognition by CD8(+) T lymphocytes...
  17. ncbi request reprint HIV envelope protein inhibits MHC class I presentation of a cytomegalovirus protective epitope
    D Lopez
    Centro Nacional de Biologia Fundamental, Instituto de Salud Carlos III, Madrid, Spain
    J Immunol 167:4238-44. 2001
    ..These studies have implications for vaccine development and for understanding immunodominance...
  18. ncbi request reprint Generation of MHC class I peptide antigens by protein processing in the secretory route by furin
    B C Gil-Torregrosa
    Centro Nacional de Biologia Fundamental, Instituto de Salud Carlos III, 28220 Madrid, Spain
    Traffic 1:641-51. 2000
    ..These results define the furin proteolytic maturation pathway of HBe in the secretory route as a general antigen processing route for MHC class I presentation...
  19. ncbi request reprint Peptide-presenting similarities among functionally distant HLA-B27 subtypes revealed by alloreactive T lymphocytes of unusual specificity
    D Lopez
    Department of Immunology, Fundacion Jimenez Diaz, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 148:996-1002. 1992
    ....
  20. ncbi request reprint Role of binding pockets for amino-terminal peptide residues in HLA-B27 allorecognition
    J A Villadangos
    Department of Immunology, Fundacion Jimenez Diaz, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 149:505-10. 1992
    ....
  21. pmc T cell receptor V beta gene usage in a human alloreactive response. Shared structural features among HLA-B27-specific T cell clones
    R Bragado
    Department of Immunology, Fundacion Jimenez Diaz, Madrid, Spain
    J Exp Med 171:1189-204. 1990
    ..In addition, two new V beta 13 members are reported...
  22. ncbi request reprint Structure and diversity of HLA-B27-specific T cell epitopes. Analysis with site-directed mutants mimicking HLA-B27 subtype polymorphism
    V Calvo
    Department of Immunology, Fundacion Jimenez Diaz, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 144:4038-45. 1990
    ..The results are compatible with the idea that HLA-B27 allorecognition may involve multiple peptides bound to the alloantigen on the cell surface...
  23. ncbi request reprint Structure and immune recognition of HLA-B27 antigens: implications for disease association
    J A Lopez de Castro
    Department of Immunology, Fundacion Jimenez Diaz, Consejo Superior de Investigaciones Cientificas C S I C, Madrid, Spain
    Scand J Rheumatol Suppl 87:21-31. 1990
    ..The analysis shows a certain bias in V beta gene segment usage, as well as other recurrent structural motives, among T cell receptor beta chains from HLA-B27-specific cytotoxic T cell clones...
  24. ncbi request reprint Conservation and alteration of HLA-B27-specific T cell epitopes on mouse cells. Implications for peptide-mediated alloreactivity
    S Rojo
    Department of Immunology, Fundacion Jimenez Diaz, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 146:634-42. 1991
    ..Such peptides could arise from related proteins in both species, and be polymorphic as a result of phylogenetic divergence...
  25. ncbi request reprint Structure of HLA-B27-specific T cell epitopes. Antigen presentation in B*2703 is limited mostly to a subset of the antigenic determinants on B*2705
    J A Villadangos
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Eur J Immunol 24:2548-55. 1994
    ....
  26. ncbi request reprint T cell receptor diversity in alloreactive responses against HLA-B27 (B*2705) is limited by multiple-level restrictions in both alpha and beta chains
    D F Barber
    Centro de Biologia Molecular, Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Facultad de Ciencias, Spain
    Eur J Immunol 25:2479-85. 1995
    ..These results are best explained by differential selection of TCR elements by different epitopes, providing a key to the inner structure of allospecific TCR repertoires...
  27. ncbi request reprint Clonal heterogeneity in LFA-3 and ICAM-1 requirement for lysis by alloreactive T lymphocytes
    B Galocha
    Centro de Biologia Molecular, Universidad Autómoma de Madrid, Cantablanco, Spain
    J Immunol 150:1653-62. 1993
    ..Most likely, the basis for such alteration is allorecognition of HLA-B27-bound peptides that are expressed on human but not on mouse cells, mainly as a consequence of phylogenetic protein divergence between both species...
  28. ncbi request reprint Cross-reactive T cell clones from unrelated individuals reveal similarities in peptide presentation between HLA-B27 and HLA-DR2
    D Lopez
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    J Immunol 150:2675-86. 1993
    ..We speculate on the potential implications of these results for the pathogeny of HLA-B27-associated spondyloarthropathies...
  29. ncbi request reprint T cell allorecognition and endogenous HLA-B27-bound peptides in a cell line with defective HLA-B27-restricted antigen presentation
    D Lopez
    Centro de Biologia Molecular, Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Eur J Immunol 24:1194-9. 1994
    ..Differences in the capacity to present certain peptides could cause differential susceptibility among HLA-B27+ individuals to ankylosing spondylitis...
  30. ncbi request reprint Clonal analysis of alloreactive T cell responses against the closely related B*2705 and B*2703 subtypes. Implications for HLA-B27 association to spondyloarthropathy
    D Lopez
    Center of Molecular Biology Severo Ochoa, Council of Scientific Investigations and Autonomous University of Madrid, Cantoblanco, Spain
    J Immunol 152:5557-71. 1994
    ....
  31. ncbi request reprint Selective involvement of proteasomes and cysteine proteases in MHC class I antigen presentation
    D Lopez
    Centro Nacional de Biologia Fundamental, Instituto de Salud Carlos III, Madrid, Spain
    J Immunol 159:5769-72. 1997
    ....
  32. ncbi request reprint Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation
    D Lopez
    Centro Nacional de Biologia Fundamental, Instituto de Salud Carlos III, Madrid, Spain
    J Immunol 164:5070-7. 2000
    ..These results show that, in the classical TAP-dependent MHC class I pathway, endogenous Ag processing of viral proteins to yield the p18 10-mer epitope requires metallo-endopeptidases in addition to proteasomes...
  33. pmc Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells
    Elena Lorente
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    J Virol 86:527-41. 2012
    ..These data have implications for the study of the effectiveness of early empirical vaccination with cowpox virus against smallpox disease...