Juan M Guerrero

Summary

Affiliation: Instituto de la Grasa
Country: Spain

Publications

  1. ncbi request reprint Nuclear receptors are involved in the enhanced IL-6 production by melatonin in U937 cells
    J M Guerrero
    Department of Medical Biochemistry, The University of Seville School of Medicine, Seville, Spain
    Biol Signals Recept 9:197-202. 2000
  2. ncbi request reprint Involvement of nuclear receptors in the enhanced IL-2 production by melatonin in Jurkat cells
    J M Guerrero
    Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine, Virgen Macarena Hospital, Seville, Spain
    Ann N Y Acad Sci 917:397-403. 2000
  3. ncbi request reprint Melatonin-immune system relationships
    Juan M Guerrero
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Spain
    Curr Top Med Chem 2:167-79. 2002
  4. doi request reprint Treatment with testosterone or estradiol in melatonin treated females and males MRL/MpJ-Faslpr mice induces negative effects in developing systemic lupus erythematosus
    Antonio J Jimenez-Caliani
    Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine and Virgin Macarena University Hospital, Seville, Spain
    J Pineal Res 45:204-11. 2008
  5. ncbi request reprint Mitochondrial damage induced by fetal hyperphenylalaninemia in the rat brain and liver: its prevention by melatonin, Vitamin E, and Vitamin C
    Francisco Martinez-Cruz
    Department of Medical Biochemistry and Molecular Biology, University of Seville, School of Medicine, Virgen del Rocio Hospital, Avda Sanchez Pizjuan 4, Spain
    Neurosci Lett 392:1-4. 2006
  6. ncbi request reprint Melatonin synthesized by Jurkat human leukemic T cell line is implicated in IL-2 production
    Patricia J Lardone
    Department of Medical Biochemistry and Molecular Biology, School of Medicine and Virgen Macarena Hospital, University of Seville, Seville, Spain
    J Cell Physiol 206:273-9. 2006
  7. ncbi request reprint mRNA expression of nuclear receptor RZR/RORalpha, melatonin membrane receptor MT, and hydroxindole-O-methyltransferase in different populations of human immune cells
    David Pozo
    Department of Medical Biochemistry and Molecular Biology, The University of Sevilla Medical School, Sevilla, Spain
    J Pineal Res 37:48-54. 2004
  8. ncbi request reprint Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    J Pineal Res 39:400-8. 2005
  9. ncbi request reprint RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell line
    Mercedes M Leon-Blanco
    Department of Medical Biochemistry and Molecular Biology, University of Seville Medical School and Virgen Macarena Hospital, Avda Sanchez Pizjuan, 4, E 41009 Sevilla, Spain
    Cancer Lett 216:73-80. 2004
  10. ncbi request reprint Evidence for melatonin synthesis in the rat brain during development
    Silvia Jimenez-Jorge
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen del Rocio Hospital, Seville, Spain
    J Pineal Res 42:240-6. 2007

Collaborators

  • David Pozo
  • Russel J Reiter
  • P Molinero
  • M Karasek
  • M Pawlikowski
  • Antonio Carrillo-Vico
  • Patricia J Lardone
  • Carmen Osuna
  • Ines Martin-Lacave
  • Antonio J Jimenez-Caliani
  • Francisco Martinez-Cruz
  • Jose M Fernandez-Santos
  • Silvia Jimenez-Jorge
  • Juan R Calvo
  • Amalia Rubio
  • Marina Sanchez-Hidalgo
  • Mercedes M Leon-Blanco
  • Maria C Naranjo
  • Latifa Naji
  • Cristina Garzon
  • Mounir Bouzouf
  • Sergio Regodón
  • Sofía García-Mauriño
  • Katarzyna Winczyk
  • Maria L Pita
  • Auxiliadora Espinar
  • Catalina A de la Lastra
  • Graham Packham
  • Melanie Lee
  • Araceli Gómez-Corvera
  • Victor Sanchez-Margalet
  • Patricia Fernández-Riejos
  • Isabel Cerrillo
  • Oscar Aramburu
  • Rocío García-Marín
  • Esperanza Conde
  • María J Borrero
  • Tomás Guzman
  • Jesús Morillo
  • José C Utrilla
  • Manuel de Miguel
  • Oscar Alvarez-Garcia
  • Beatriz Caballero
  • Beatriz De Felipe
  • Ignacio Vega-Naredo
  • Ana Coto-Montes
  • Alejandro Vallejo
  • Juan Luis Herrera
  • Santiago Vadillo
  • Segundo Píriz
  • M Pilar Carrascosa-Salmoral
  • Pedro Martín-Palomino
  • Rafael Fernandez-Montesinos
  • Pedro Abreu
  • Concepcion Marchante
  • Marta Hoyos

Detail Information

Publications35

  1. ncbi request reprint Nuclear receptors are involved in the enhanced IL-6 production by melatonin in U937 cells
    J M Guerrero
    Department of Medical Biochemistry, The University of Seville School of Medicine, Seville, Spain
    Biol Signals Recept 9:197-202. 2000
    ..These results show that the expression of nuclear melatonin receptor but not membrane receptors is sufficient for melatonin to activate cytokine production in human lymphocytic and monocytic cell lines...
  2. ncbi request reprint Involvement of nuclear receptors in the enhanced IL-2 production by melatonin in Jurkat cells
    J M Guerrero
    Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine, Virgen Macarena Hospital, Seville, Spain
    Ann N Y Acad Sci 917:397-403. 2000
    ..In the absence of the membrane receptor, melatonin still activates the IL-2 production. These results show that the expression of the nuclear melatonin receptor is sufficient for melatonin to activate IL-2 production by Jurkat cells...
  3. ncbi request reprint Melatonin-immune system relationships
    Juan M Guerrero
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Spain
    Curr Top Med Chem 2:167-79. 2002
    ..In summary, although there is overwhelming information demonstrating the immunoenhancing properties of melatonin, many questions related to the cytokines involved and the mechanisms of action of the indoleamine require answers...
  4. doi request reprint Treatment with testosterone or estradiol in melatonin treated females and males MRL/MpJ-Faslpr mice induces negative effects in developing systemic lupus erythematosus
    Antonio J Jimenez-Caliani
    Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine and Virgin Macarena University Hospital, Seville, Spain
    J Pineal Res 45:204-11. 2008
    ..These findings confirm that melatonin action in MRL/MpJ-Fas(lpr) mice could be gender-dependent through modulation of sex hormones...
  5. ncbi request reprint Mitochondrial damage induced by fetal hyperphenylalaninemia in the rat brain and liver: its prevention by melatonin, Vitamin E, and Vitamin C
    Francisco Martinez-Cruz
    Department of Medical Biochemistry and Molecular Biology, University of Seville, School of Medicine, Virgen del Rocio Hospital, Avda Sanchez Pizjuan 4, Spain
    Neurosci Lett 392:1-4. 2006
    ..We therefore conclude that maternal hyperphenylalaninemia induces a clear state of oxidative stress that is somehow directly involved in brain and liver impairment, which can be prevented by melatonin, Vitamin E, and Vitamin C...
  6. ncbi request reprint Melatonin synthesized by Jurkat human leukemic T cell line is implicated in IL-2 production
    Patricia J Lardone
    Department of Medical Biochemistry and Molecular Biology, School of Medicine and Virgen Macarena Hospital, University of Seville, Seville, Spain
    J Cell Physiol 206:273-9. 2006
    ..These findings indicate that endogenous melatonin synthesized by human T cells would contribute to regulation of its own IL-2 production, acting as an intracrine, autocrine, and/or paracrine substance...
  7. ncbi request reprint mRNA expression of nuclear receptor RZR/RORalpha, melatonin membrane receptor MT, and hydroxindole-O-methyltransferase in different populations of human immune cells
    David Pozo
    Department of Medical Biochemistry and Molecular Biology, The University of Sevilla Medical School, Sevilla, Spain
    J Pineal Res 37:48-54. 2004
    ..Thus, in addition to its classical function in the nervous and endocrine system, melatonin could act directly as a paracrine and/or autocrine agent in the human immune system...
  8. ncbi request reprint Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    J Pineal Res 39:400-8. 2005
    ..In conclusion, we have demonstrated that melatonin improves the survival of mice with septic shock via its pleiotropic functions as an immunomodulator, antioxidant and anti-apoptotic mediator...
  9. ncbi request reprint RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell line
    Mercedes M Leon-Blanco
    Department of Medical Biochemistry and Molecular Biology, University of Seville Medical School and Virgen Macarena Hospital, Avda Sanchez Pizjuan, 4, E 41009 Sevilla, Spain
    Cancer Lett 216:73-80. 2004
    ..These results support a cross-talk between membrane and nuclear melatonin signalling and provide new data on the hormonal regulation of telomerase function...
  10. ncbi request reprint Evidence for melatonin synthesis in the rat brain during development
    Silvia Jimenez-Jorge
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen del Rocio Hospital, Seville, Spain
    J Pineal Res 42:240-6. 2007
    ..These results demonstrate that, when the pineal is not yet producing melatonin, there is melatonin synthesis by the brain that could be used as protection from free radical damage and/or could exert some actions through MT(1) receptors...
  11. ncbi request reprint Melatonin synthesis and melatonin-membrane receptor (MT1) expression during rat thymus development: role of the pineal gland
    Silvia Jimenez-Jorge
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    J Pineal Res 39:77-83. 2005
    ..In conclusion, these results show, for the first time, the presence of the biosynthetic machinery of melatonin and melatonin production in developing rat thymus and that the pineal gland may regulate this process...
  12. ncbi request reprint Melatonin prevents focal rat cerebellum injury as assessed by induction of heat shock protein (HO-1) following subarachnoid injections of lysed blood
    Francisco Martinez-Cruz
    Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine, Seville, Spain
    Neurosci Lett 331:208-10. 2002
    ..The results presented in this study show that antioxidants, especially melatonin, prevent focal regions of injury as assessed by heat shock protein expression in a rat model of SAH...
  13. ncbi request reprint Sex-dependent effect of melatonin on systemic erythematosus lupus developed in Mrl/Mpj-Faslpr mice: it ameliorates the disease course in females, whereas it exacerbates it in males
    Antonio J Jimenez-Caliani
    Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine, Spain
    Endocrinology 147:1717-24. 2006
    ..These findings suggest that melatonin action in MRL/MpJ-Fas(lpr) mice is gender dependent, probably through modulation and inhibition of sex hormones...
  14. doi request reprint Blocking of melatonin synthesis and MT(1) receptor impairs the activation of Jurkat T cells
    Patricia J Lardone
    Instituto de Biomedicina de Sevilla IBiS, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine, Sanchez Pizjuan 4, 41009, Seville, Spain
    Cell Mol Life Sci 67:3163-72. 2010
    ..The results shown here support the relevance of endogenous melatonin and its signaling in T cell activation...
  15. ncbi request reprint Oxidative stress induced by phenylketonuria in the rat: Prevention by melatonin, vitamin E, and vitamin C
    Francisco Martinez-Cruz
    Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine and Virgen Macarena Hospital, Spain
    J Neurosci Res 69:550-8. 2002
    ..Moreover, melatonin and other antioxidants are capable of preventing completely the damage induced by PKU...
  16. ncbi request reprint A review of the multiple actions of melatonin on the immune system
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    Endocrine 27:189-200. 2005
    ..The review focuses on melatonin's actions in several immune pathologies including infection, inflammation, and autoimmunity together with the relation between melatonin, immunity, and cancer...
  17. ncbi request reprint Melatonin prevents hyperhomocysteinemia and neural lipid peroxidation induced by methionine intake
    Mounir Bouzouf
    Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine and Virgen Macarena Hospital, Sevilla, Spain
    Curr Neurovasc Res 2:175-8. 2005
    ..Melatonin lowered plasma hcy levels and could potentially be beneficial in prevention of neurodegeneration caused by mild hyperhomocysteinemia...
  18. ncbi request reprint Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine, Avda Sanchez Pizjuan 4, 41009 Seville, Spain
    J Clin Endocrinol Metab 90:992-1000. 2005
    ..In conclusion, these data show that endogenous melatonin is an essential part for an accurate response of human lymphocytes through the modulation of IL-2/IL-2 receptor system...
  19. ncbi request reprint Melatonin counteracts the inhibitory effect of PGE2 on IL-2 production in human lymphocytes via its mt1 membrane receptor
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine, Virgen Macarena Hospital, 41009 Seville, Spain
    FASEB J 17:755-7. 2003
    ..Therefore, we postulate, for the first time, a physiological role of the mt1 melatonin membrane receptor in the human immune system...
  20. doi request reprint Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor
    Patricia J Lardone
    Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine, Seville, Spain
    J Pineal Res 51:454-62. 2011
    ..Therefore, the identification of melatonin as a natural modulator of RORα gives it a tremendous therapeutic potential for a variety of clinical disorders...
  21. ncbi request reprint Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine, Avda Sanchez Pizjuan 4, 41009 Seville, Spain
    FASEB J 18:537-9. 2004
    ....
  22. ncbi request reprint Inverse correlation between endogenous melatonin levels and oxidative damage in some tissues of SAM P8 mice
    Patricia J Lardone
    Department of Medical Biochemistry and Molecular Biology, School of Medicine and Virgen Macarena Hospital, University of Seville, Seville, Asturias, Spain
    J Pineal Res 40:153-7. 2006
    ....
  23. ncbi request reprint Dual effect of melatonin as proinflammatory and antioxidant in collagen-induced arthritis in rats
    Antonio J Jimenez-Caliani
    Department of Medical Biochemistry, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    J Pineal Res 38:93-9. 2005
    ..In a process of inflammation as CIA, melatonin acts with a markedly proinflammatory effect at local and peripheral levels maintaining its antioxidant effect only at peripheral level...
  24. ncbi request reprint Expression of membrane and nuclear melatonin receptors in mouse peripheral organs
    Latifa Naji
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Avda Sanchez Pizjuan 4, 41009 Seville, Spain
    Life Sci 74:2227-36. 2004
    ..These results suggest that melatonin, acting through its different subtypes receptors, plays a role in the neuroendocrine regulation of peripheral tissues function...
  25. ncbi request reprint Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro
    Mercedes M Leon-Blanco
    The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    J Pineal Res 35:204-11. 2003
    ....
  26. pmc C cells evolve at the same rhythm as follicular cells when thyroidal status changes in rats
    Ines Martin-Lacave
    Department of Normal and Pathological Cytology and Histology, School of Medicine, University of Seville, Av Sánchez Pizjuán S N, Seville, Spain
    J Anat 214:301-9. 2009
    ..Considering that TSH serum levels are increased in hypothyroid rats and decreased in thyroxine-treated rats, we discuss the potential involvement of thyrotropin in the observed results...
  27. ncbi request reprint Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study
    Cristina Garzon
    Department of Internal and Geriatric Medicine, Virgen Macarena Hospital, Seville, Spain
    Aging Clin Exp Res 21:38-42. 2009
    ..The aim of the study was to evaluate the effect of melatonin administration on sleep and behavioral disorders in the elderly and the facilitation of the discontinuation of regular hypnotic drugs...
  28. doi request reprint Melatonin inhibits cell proliferation and induces caspase activation and apoptosis in human malignant lymphoid cell lines
    Marina Sanchez-Hidalgo
    Faculty of Medicine, Cancer Research UK Centre, Cancer Sciences, Southampton General Hospital, University of Southampton, Southampton, UK
    J Pineal Res 53:366-73. 2012
    ..However, it is necessary to take into account that different lymphoid malignancies may differ in their response to melatonin...
  29. ncbi request reprint Melatonin prevents the formation of pyrrolized proteins in human plasma induced by hydrogen peroxide
    Francisco Martinez-Cruz
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Avda Sanchez Pizjuan 4, 41009, Seville, Spain
    Neurosci Lett 326:147-50. 2002
    ..In conclusion, the results presented in this paper add new perspectives to other well known antioxidant properties of melatonin such as prevention of protein pyrrolization...
  30. ncbi request reprint Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit LPS-stimulated MIP-1alpha production and mRNA expression
    David Pozo
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine, Sevilla, Spain
    Cytokine 18:35-42. 2002
    ..Taken together, the present work strongly supports an anti-inflammatory role of VIP and PACAP by a new mechanism associated with impairment of a key component of the chemokine network...
  31. ncbi request reprint Long-term melatonin administration increases polyunsaturated fatty acid percentage in plasma lipids of hypercholesterolemic rats
    Maria L Pita
    Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine and Virgen Macarena Hospital, Spain
    J Pineal Res 32:179-86. 2002
    ..These changes were prevented by melatonin. We conclude that long-term melatonin administration modifies the fatty acid composition of rat plasma and liver lipids and ameliorates the arterial fatty infiltration induced by cholesterol...
  32. ncbi request reprint Expression of melatonin MT(1) and MT(2) receptors, and ROR alpha(1) receptor in transplantable murine Colon 38 cancer
    Michal Karasek
    Laboratory of Electron Microscopy, Chair of Pathology, Medical University of Lodz, Lodz, Poland
    Neuro Endocrinol Lett 23:55-60. 2002
    ..Therefore, the aim of the present study was to determine whether the membrane melatonin receptors MT(1) and MT(2) as well as the nuclear receptor RZR/ROR alpha are expressed in Colon 38 cells...
  33. ncbi request reprint Possible involvement of the nuclear RZR/ROR-alpha receptor in the antitumor action of melatonin on murine Colon 38 cancer
    Katarzyna Winczyk
    Department of Experimental Endocrinology and Hormone Diagnostics, Institute of Endocrinology, Medical University of Lodz, Lodz, Poland
    Tumour Biol 23:298-302. 2002
    ..Given alone, MLT strongly lowered the P/A ratio, and addition of CGP to MLT abolished the effect of MLT on the P/A ratio. Based on our data, we conclude that nuclear RZR/RORalpha receptors participate in the oncostatic action of MLT...
  34. ncbi request reprint Melatonin triggers Crohn's disease symptoms
    Juan R Calvo
    J Pineal Res 32:277-8. 2002
  35. ncbi request reprint The use of melatonin as a vaccine agent
    Sergio Regodón
    Section of Histology, Department of Veterinary Medicine, The University of Extremadura Veterinary School, Avda de la Universidad, 10071 Caceres, Spain
    Vaccine 23:5321-7. 2005
    ..The finding that melatonin enhances a defined immune response in vivo opens new perspectives for the improvement of Th2-biased immune responses by alum adjuvants...