Lourdes Ibanez

Summary

Country: Spain

Publications

  1. doi request reprint Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
    Lourdes Ibanez
    Endocrinology, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Madrid, Spain
    Fertil Steril 95:727-30. 2011
  2. doi request reprint Divergent effects of ethinylestradiol-drospirenone and flutamide-metformin on follistatin in adolescents and women with hyperinsulinemic androgen excess
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    Gynecol Endocrinol 27:197-8. 2011
  3. pmc IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance
    Rinki Murphy
    Faculty of Medical and Health Sciences, University of Auckland, Auckland, Private Bag 92019, New Zealand
    BMC Med Genet 13:42. 2012
  4. doi request reprint Oral contraception vs insulin sensitization for 18 months in nonobese adolescents with androgen excess: posttreatment differences in C-reactive protein, intima-media thickness, visceral adiposity, insulin sensitivity, and menstrual regularity
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 98:E902-7. 2013
  5. doi request reprint Breast-feeding vs formula-feeding for infants born small-for-gestational-age: divergent effects on fat mass and on circulating IGF-I and high-molecular-weight adiponectin in late infancy
    Francis de Zegher
    Department of Reproduction, Development, and Regeneration, University of Leuven, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:1242-7. 2013
  6. doi request reprint Placental expression of peroxisome proliferator-activated receptor γ (PPARγ): relation to placental and fetal growth
    Marta Diaz
    Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 97:E1468-72. 2012
  7. pmc Body composition and circulating high-molecular-weight adiponectin and IGF-I in infants born small for gestational age: breast- versus formula-feeding
    Francis de Zegher
    Department of Pediatrics, University of Leuven, Leuven, Belgium
    Diabetes 61:1969-73. 2012
  8. pmc Abundance of circulating preadipocyte factor 1 in early life
    Francis de Zegher
    Department of Woman and Child, University of Leuven, Leuven, Belgium
    Diabetes Care 35:848-9. 2012
  9. ncbi request reprint Polycystic ovaries in nonobese adolescents and young women with ovarian androgen excess: relation to prenatal growth
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 93:196-9. 2008
  10. ncbi request reprint Pioglitazone (7.5 mg/day) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high molecular weight adiponectin
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Clin Endocrinol (Oxf) 68:317-20. 2008

Collaborators

Detail Information

Publications80

  1. doi request reprint Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
    Lourdes Ibanez
    Endocrinology, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Madrid, Spain
    Fertil Steril 95:727-30. 2011
    ..Low-birthweight (LBW) girls with precocious pubarche (PP) are at risk for an early menarche (<12 years), an adult stature below target level, and PCOS. Hyperinsulinemic insulin resistance is thought to be a key factor...
  2. doi request reprint Divergent effects of ethinylestradiol-drospirenone and flutamide-metformin on follistatin in adolescents and women with hyperinsulinemic androgen excess
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    Gynecol Endocrinol 27:197-8. 2011
    ..Hyperfollistatinemia may be among the mechanisms whereby oral contraceptives aggravate the body adiposity of adolescents and young women with hyperinsulinemic androgen excess...
  3. pmc IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance
    Rinki Murphy
    Faculty of Medical and Health Sciences, University of Auckland, Auckland, Private Bag 92019, New Zealand
    BMC Med Genet 13:42. 2012
    ....
  4. doi request reprint Oral contraception vs insulin sensitization for 18 months in nonobese adolescents with androgen excess: posttreatment differences in C-reactive protein, intima-media thickness, visceral adiposity, insulin sensitivity, and menstrual regularity
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 98:E902-7. 2013
    ..An oral estro-progestagen is the standard medication given to adolescent girls with androgen excess, even when those girls are not at risk of pregnancy...
  5. doi request reprint Breast-feeding vs formula-feeding for infants born small-for-gestational-age: divergent effects on fat mass and on circulating IGF-I and high-molecular-weight adiponectin in late infancy
    Francis de Zegher
    Department of Reproduction, Development, and Regeneration, University of Leuven, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:1242-7. 2013
    ....
  6. doi request reprint Placental expression of peroxisome proliferator-activated receptor γ (PPARγ): relation to placental and fetal growth
    Marta Diaz
    Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 97:E1468-72. 2012
    ..We tested the hypothesis that placental PPARγ expression relates to placental and fetal growth...
  7. pmc Body composition and circulating high-molecular-weight adiponectin and IGF-I in infants born small for gestational age: breast- versus formula-feeding
    Francis de Zegher
    Department of Pediatrics, University of Leuven, Leuven, Belgium
    Diabetes 61:1969-73. 2012
    ....
  8. pmc Abundance of circulating preadipocyte factor 1 in early life
    Francis de Zegher
    Department of Woman and Child, University of Leuven, Leuven, Belgium
    Diabetes Care 35:848-9. 2012
    ..Soluble preadipocyte factor 1 (Pref-1) inhibits adipocyte differentiation. We tested whether circulating levels of soluble Pref-1 are higher in smaller fetuses...
  9. ncbi request reprint Polycystic ovaries in nonobese adolescents and young women with ovarian androgen excess: relation to prenatal growth
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 93:196-9. 2008
    ..We studied whether prenatal growth relates also to ovarian size and polycystic ovary (PCO) morphology in nonobese adolescents and young women with ovarian androgen excess...
  10. ncbi request reprint Pioglitazone (7.5 mg/day) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high molecular weight adiponectin
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Clin Endocrinol (Oxf) 68:317-20. 2008
    ..In a search for mediators of PioFluMet's actions, we measured serum levels of visfatin and high molecular weight (HMW) adiponectin...
  11. ncbi request reprint Early development of visceral fat excess after spontaneous catch-up growth in children with low birth weight
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 93:925-8. 2008
    ..We studied whether the adiposity of post-catch-up children born small for gestational age (SGA) is further amplified between age 4 and 6 yr and whether visceral fat excess has already emerged by the age of 6 yr...
  12. doi request reprint Metformin treatment for four years to reduce total and visceral fat in low birth weight girls with precocious pubarche
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 93:1841-5. 2008
    ..4 kg; age 7.9 yr; body mass index 18.4 kg/m(2)) were studied. Girls were randomly assigned to remain untreated (n=19) or receive metformin for 4 yr (n = 19; 425 mg/d for 2 yr, then 850 mg/d for 2 yr)...
  13. doi request reprint Visceral adiposity without overweight in children born small for gestational age
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 93:2079-83. 2008
    ..Weight control is advocated as a preventive measure, but it is unknown whether such control suffices to prevent visceral fat excess and hypoadiponectinemia...
  14. doi request reprint Low-dose pioglitazone and low-dose flutamide added to metformin and oestro-progestagens for hyperinsulinaemic women with androgen excess: add-on benefits disclosed by a randomized double-placebo study over 24 months
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Clin Endocrinol (Oxf) 71:351-7. 2009
    ..We explored whether low-dose pioglitazone (Pio) and flutamide (Flu) has readily detectable add-on effects...
  15. ncbi request reprint Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 92:1710-4. 2007
    ..We tested whether adding low-dose pioglitazone (Pio; 7.5 mg/d) confers more benefit...
  16. ncbi request reprint Polycystic ovaries after precocious pubarche: relation to prenatal growth
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod 22:395-400. 2007
    ..3 kg/m2) belonging to the original cohort of 35 girls in whom the PP-PCOS sequence was described...
  17. ncbi request reprint Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in nonobese adolescents and women
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Fertil Steril 86:S24-5. 2006
    ..For safety reasons, it is wise to combine flutamide-metformin with a contraceptive, for example, an oral or transdermal estroprogestagen...
  18. ncbi request reprint Puberty and prenatal growth
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
    Mol Cell Endocrinol 254:22-5. 2006
    ..Current evidence suggests that insulin resistance is a key mechanism linking a post-SGA state to early menarche; hence, insulin sensitization may become a valid approach to prevent early menarche and early growth arrest in SGA girls...
  19. ncbi request reprint Metformin treatment to prevent early puberty in girls with precocious pubarche
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 91:2888-91. 2006
    ..4 kg; age, 7.9 yr; body mass index (BMI), 18.4 kg/m(2)]. These girls were randomly assigned to remain untreated (n = 19) or to receive metformin (n = 19; 425 mg/d) for 2 yr...
  20. ncbi request reprint Puberty after prenatal growth restraint
    L Ibanez
    University of Barcelona, Spain
    Horm Res 65:112-5. 2006
    ....
  21. ncbi request reprint Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 91:2153-8. 2006
    ..SETTING, DESIGN, AND PATIENTS: This was a longitudinal cohort study in low birth weight (SGA; birth weight < -2 sd; n = 29) and normal birth weight (AGA; n = 22) children from Barcelona...
  22. ncbi request reprint Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 91:2068-73. 2006
    ..0 yr). All girls remained untreated between 36 and 42 months...
  23. doi request reprint Pubertal adiposity after fetal growth restraint: toward a calorie restriction mimetic approach
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    Metabolism 57:672-5. 2008
    ..2 kg less gain of fat; 1.6 kg more gain of lean mass; P<.0001)...
  24. doi request reprint Gender specificity of body adiposity and circulating adiponectin, visfatin, insulin, and insulin growth factor-I at term birth: relation to prenatal growth
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 93:2774-8. 2008
    ..We studied the potential relationship between these gender specificities and fetal growth...
  25. doi request reprint Clinical spectrum of premature pubarche: links to metabolic syndrome and ovarian hyperandrogenism
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    Rev Endocr Metab Disord 10:63-76. 2009
    ..Long-term follow-up of these patients is needed to fully determine the ultimate effects of insulin sensitization as well as the maintenance of these benefits after discontinuation of therapy...
  26. doi request reprint Endocrinology and gynecology of girls and women with low birth weight
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Fetal Diagn Ther 30:243-9. 2011
    ..During the post-menarcheal period, LBW girls are at increased risk of developing polycystic ovary syndrome. Early insulin sensitization may prevent or delay some of the endocrine-metabolic abnormalities associated to LBW...
  27. doi request reprint Treatment of androgen excess in adolescent girls: ethinylestradiol-cyproteroneacetate versus low-dose pioglitazone-flutamide-metformin
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 96:3361-6. 2011
    ..The aim was to perform a first comparison between the effects of a classic therapy and those of a novel treatment for androgen excess in adolescent girls...
  28. doi request reprint Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence
    Lourdes Ibanez
    Department of Endocrinology, Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain
    J Clin Endocrinol Metab 96:E1262-7. 2011
    ..Girls with a combined history of low(-normal) birth weight (LBW) and precocious pubarche (PP) are at high risk to develop polycystic ovary syndrome (PCOS)...
  29. doi request reprint Catch-up growth in girls born small for gestational age precedes childhood progression to high adiposity
    Lourdes Ibanez
    Endocrinology, Hospital Sant Joan de Deu, University of Barcelona, and CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Barcelona, Spain
    Fertil Steril 96:220-3. 2011
    ..To study across childhood the features of small for gestational age (SGA) girls with spontaneous catch-up growth...
  30. doi request reprint Low-dose pioglitazone, flutamide, metformin plus an estro-progestagen for non-obese young women with polycystic ovary syndrome: increasing efficacy and persistent safety over 30 months
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Gynecol Endocrinol 26:869-73. 2010
    ..4 year; BMI: 23.7 kg/m(2)) received metformin (850 mg/day), flutamide (62.5 mg/day), pioglitazone (7.5 mg/day), ethinylestradiol (20 μg/day) plus drospirenone (3 mg/day) for 24/28 days...
  31. doi request reprint Growth hormone therapy in short children born small for gestational age: effects on abdominal fat partitioning and circulating follistatin and high-molecular-weight adiponectin
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 95:2234-9. 2010
    ....
  32. doi request reprint Low body adiposity and high leptinemia in breast-fed infants born small-for-gestational-age
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    J Pediatr 156:145-7. 2010
    ..001) levels of circulating leptin at 4 months. This paradoxical hyperleptinemia in early infancy may contribute to a program that produces a process from fetal underweight to adult overweight...
  33. doi request reprint High-molecular-weight adiponectin in children born small- or appropriate-for-gestational-age
    Lourdes Ibanez
    Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    J Pediatr 155:740-2. 2009
    ....
  34. doi request reprint Pubertal metformin therapy to reduce total, visceral, and hepatic adiposity
    Lourdes Ibanez
    Endocrinology, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain
    J Pediatr 156:98-102.e1. 2010
    ..We tested this hypothesis in low-birthweight (LBW) girls with precocious pubarche (PP), who are at risk for hyperinsulinemic body adiposity during and beyond puberty...
  35. doi request reprint Low-birth weight children develop lower sex hormone binding globulin and higher dehydroepiandrosterone sulfate levels and aggravate their visceral adiposity and hypoadiponectinemia between six and eight years of age
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 94:3696-9. 2009
    ..STUDY DESIGN AND POPULATION: Longitudinal study over 2 yr comparing data from 32 AGA vs. 32 SGA children, matched for gender, height, weight, and body mass index at the age of 6 yr...
  36. doi request reprint Abdominal fat partitioning and high-molecular-weight adiponectin in short children born small for gestational age
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 94:1049-52. 2009
    ..We studied whether the same applies to SGA children, who failed to develop spontaneous catch-up growth...
  37. ncbi request reprint Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod Update 12:243-52. 2006
    ..Until the abovementioned effects have been broadly confirmed, Flu-Met should not be regarded as a standard therapy for widespread clinical practice...
  38. ncbi request reprint Hyperandrogenism and excess weight gain
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Esplugues, Spain
    J Pediatr Endocrinol Metab 18:1199-205. 2005
  39. ncbi request reprint Adrenal hyperandrogenism in adolescent girls with a history of low birthweight and precocious pubarche
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Clin Endocrinol (Oxf) 53:523-7. 2000
    ....
  40. ncbi request reprint Low-dose flutamide-metformin therapy reverses insulin resistance and reduces fat mass in nonobese adolescents with ovarian hyperandrogenism
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona 08950, Spain
    J Clin Endocrinol Metab 88:2600-6. 2003
    ..Improved insulin sensitivity and reduced androgen activity led to a marked redistribution of body fat and lean mass, resulting in a more feminine body shape...
  41. ncbi request reprint Reduced ovulation rate in adolescent girls born small for gestational age
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig Sant Joan de Deu, 2 08950 Esplugues, 08950 Barcelona, Spain
    J Clin Endocrinol Metab 87:3391-3. 2002
    ..If it does, then fetal growth restraint may prove to be one of the enigmatic components underpinning hitherto unexplained female subfertility...
  42. ncbi request reprint Low-dose combination of flutamide, metformin and an oral contraceptive for non-obese, young women with polycystic ovary syndrome
    Lourdes Ibanez
    Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    Hum Reprod 18:57-60. 2003
    ..In this follow-up study, we assess whether the endocrine-metabolic benefits of combined flutamide-metformin treatment are maintained in the presence of a low-dose oral contraceptive (OC)...
  43. ncbi request reprint Anovulation in eumenorrheic, nonobese adolescent girls born small for gestational age: insulin sensitization induces ovulation, increases lean body mass, and reduces abdominal fat excess, dyslipidemia, and subclinical hyperandrogenism
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain
    J Clin Endocrinol Metab 87:5702-5. 2002
    ....
  44. ncbi request reprint Additive effects of insulin-sensitizing and anti-androgen treatment in young, nonobese women with hyperinsulinism, hyperandrogenism, dyslipidemia, and anovulation
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 87:2870-4. 2002
    ..In contrast, anovulation seems to be mainly attributable to insulin resistance and hyperinsulinemia...
  45. ncbi request reprint Early menarche and subclinical ovarian hyperandrogenism in girls with reduced adult height after low birth weight
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    J Pediatr Endocrinol Metab 15:431-3. 2002
  46. ncbi request reprint Hypersecretion of FSH in infant boys and girls born small for gestational age
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain
    J Clin Endocrinol Metab 87:1986-8. 2002
    ..It remains to be studied whether FSH hypersecretion in infancy is a marker of subsequent subfertility...
  47. ncbi request reprint Polycystic ovary syndrome after precocious pubarche: ontogeny of the low-birthweight effect
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Clin Endocrinol (Oxf) 55:667-72. 2001
    ..Resistance to insulin is thought to be a key factor in the pathogenesis of this sequence. We aimed to elucidate the peripubertal ontogeny of the low birthweight effect on hyperinsulinism, dyslipidaemia and ovarian dysfunction after PP...
  48. ncbi request reprint Treatment of hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism in nonobese, adolescent girls: effect of flutamide
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    J Clin Endocrinol Metab 85:3251-5. 2000
    ..However, flutamide failed to increase high-density lipoprotein cholesterol levels or decrease hyperinsulinemia, i.e. to affect two major risk factors for subsequent cardiovascular disease...
  49. ncbi request reprint Plasminogen activator inhibitor-1 in girls with precocious pubarche: a premenarcheal marker for polycystic ovary syndrome?
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Pediatr Res 51:244-8. 2002
    ..61, p = 0.06). Together with low birth weight, increased plasma PAI-1-act levels in early pubertal PP girls may indicate those girls with greater risk of developing hyperinsulinemic-hyperandrogenism features of PCOS...
  50. ncbi request reprint Sensitization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 86:3595-8. 2001
    ..Metformin treatment was well tolerated. In conclusion, sensitization to insulin was found to be an effective approach to induce ovulation in nonobese adolescents with anovulatory hyperandrogenism...
  51. ncbi request reprint Increased bone mineral density and serum leptin in non-obese girls with precocious pubarche: relation to low birthweight and hyperinsulinism
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Horm Res 54:192-7. 2000
    ..We therefore assessed lumbar BMD and serum leptin in girls with the sequence of a low birthweight and precocious pubarche (PP) in childhood, in whom hyperinsulinism and hyperandrogenism have been described...
  52. ncbi request reprint Precocious pubarche in girls and the development of androgen excess
    L Ibanez
    Hospital Sant Joan de Deu, University of Barcelona, Spain
    J Pediatr Endocrinol Metab 13:1261-3. 2000
    ....
  53. ncbi request reprint Early puberty: rapid progression and reduced final height in girls with low birth weight
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Pediatrics 106:E72. 2000
    ..To assess whether, in girls with early onset of puberty, low birth weight is a risk factor for rapid progression to menarche and for short adult stature...
  54. ncbi request reprint Sensitization to insulin in adolescent girls to normalize hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism after precocious pubarche
    L Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    J Clin Endocrinol Metab 85:3526-30. 2000
    ....
  55. ncbi request reprint Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Esplugues, Spain
    Hum Reprod 18:1565-9. 2003
    ..It is unknown whether these reproductive anomalies persist, respectively, into late infancy and into the reproductive age range...
  56. ncbi request reprint Flutamide-metformin therapy to reduce fat mass in hyperinsulinemic ovarian hyperandrogenism: effects in adolescents and in women on third-generation oral contraception
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, 08950 Barcelona, Spain
    J Clin Endocrinol Metab 88:4720-4. 2003
    ....
  57. ncbi request reprint Insulin sensitization for girls with precocious pubarche and with risk for polycystic ovary syndrome: effects of prepubertal initiation and postpubertal discontinuation of metformin treatment
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 89:4331-7. 2004
    ....
  58. ncbi request reprint Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of early, low-dose flutamide
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 89:4716-20. 2004
    ..Finally, these data challenge any claim that drospirenone, as currently used in a contraceptive, is a clinically significant antiandrogen...
  59. ncbi request reprint Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of metformin at the start and after more than one year of therapy
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 90:39-43. 2005
    ..3 kg (B)]. In conclusion, Met proved to be a pivotal component of a prime combination therapy that attenuates the dysadipocytokinemia, the lean mass deficit, and the central adiposity of young patients with polycystic ovary syndrome...
  60. ncbi request reprint Neutrophil count in small-for-gestational age children: contrasting effects of metformin and growth hormone therapy
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 90:3435-9. 2005
    ..Future studies with combined GH plus metformin treatment in short SGA children may clarify whether insulin resistance is a mechanism linking GH therapy to markers of inflammation...
  61. ncbi request reprint Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod 20:1833-6. 2005
    ..There is a need for evidence on the potential hepatotoxicity of low- and ultralow-dose flutamide therapy...
  62. ncbi request reprint High neutrophil count in girls and women with hyperinsulinaemic hyperandrogenism: normalization with metformin and flutamide overcomes the aggravation by oral contraception
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Hum Reprod 20:2457-62. 2005
    ..The endocrine hallmark of polycystic ovary syndrome (PCOS) is hyperinsulinaemic hyperandrogenism; another facet of PCOS is low-grade inflammation...
  63. ncbi request reprint Discontinuous low-dose flutamide-metformin plus an oral or a transdermal contraceptive in patients with hyperinsulinaemic hyperandrogenism: normalizing effects on CRP, TNF-alpha and the neutrophil/lymphocyte ratio
    Lourdes Ibanez
    Endocrinology Unit and Hormonal Laboratory, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Hum Reprod 21:451-6. 2006
    ....
  64. ncbi request reprint Early puberty-menarche after precocious pubarche: relation to prenatal growth
    Lourdes Ibanez
    Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Pediatrics 117:117-21. 2006
    ..The objective of this study was to assess the interrelationship among prenatal growth, PP, the timing of puberty-menarche, and adult stature...
  65. ncbi request reprint Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Hum Reprod 19:1725-7. 2004
    ..We verified whether the lipolytic efficacy of flutamide-metformin in women with PCOS is enhanced by giving an oral contraceptive (OC) co-therapy that contains drospirenone, instead of gestodene, as progestin...
  66. ncbi request reprint Insulin sensitization early after menarche prevents progression from precocious pubarche to polycystic ovary syndrome
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    J Pediatr 144:23-9. 2004
    ..In addition, overnight growth hormone (GH) and gonadotropin secretion was analyzed in 10 girls (6 treated; 4 untreated) at 0 and 6 months...
  67. ncbi request reprint Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Déu L I, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 89:1592-7. 2004
    ....
  68. doi request reprint Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazone-flutamide-metformin for adolescent girls with androgen excess: divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN expression in subcutaneous adipose tissue
    Marta Diaz
    Endocrinology Unit, Department of Obstetrics and Gynecology, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 97:3630-8. 2012
    ..The aim was to compare the effects of a traditional therapy (an oral estroprogestagen) to those of a novel treatment (a low-dose combination of generics) in adolescent girls with androgen excess...
  69. ncbi request reprint Fat distribution in non-obese girls with and without precocious pubarche: central adiposity related to insulinaemia and androgenaemia from prepuberty to postmenarche
    Lourdes Ibanez
    Endocrine Unit, Hospital Sant Joan de Deu, University of Barcelona, Spain
    Clin Endocrinol (Oxf) 58:372-9. 2003
    ..While such PP girls do not have increased body mass index (BMI), we hypothesized that body fat mass and fat distribution may differ between PP girls and matched controls, and may relate to insulin and androgen levels...
  70. ncbi request reprint The tumour necrosis factor (TNF)-alpha-308GA promoter polymorphism is related to prenatal growth and postnatal insulin resistance
    Paula Casano-Sancho
    Paediatric Endocrinology, Sant Joan de Déu Children s Hospital, Barcelona, Spain
    Clin Endocrinol (Oxf) 64:129-35. 2006
    ..We questioned whether the TNF-308G/A polymorphism is associated with birthweight and insulin resistance in children born small for gestational age (SGA), a patient population known to be at risk for insulin resistance...
  71. ncbi request reprint Fasting insulin sensitivity and post-oral glucose hyperinsulinaemia related to cardiovascular risk factors in adolescents with precocious pubarche
    Neus Potau
    Hormonal Laboratory, Hospital Materno Infantil Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    Clin Endocrinol (Oxf) 59:756-62. 2003
    ..The aim of this study was to determine the relative contribution of fasting insulin sensitivity, and post oral glucose tolerance test (OGTT) measures of insulin secretion to metabolic risk markers of adult disease...
  72. ncbi request reprint Improvement in growth after two years of growth hormone therapy in very young children born small for gestational age and without spontaneous catch-up growth: results of a multicenter, controlled, randomized, open clinical trial
    Jesus Argente
    Department of Endocrinology, Hospital Infantil Universitario Nino Jesus, Avenida Menéndez Pelayo, 65 E28009 Madrid, Spain
    J Clin Endocrinol Metab 92:3095-101. 2007
    ..GH treatment is effective in children born small for gestational age (SGA); however, its effectiveness and safety in very young SGA children is unknown...
  73. ncbi request reprint Increased frequency of the G972R variant of the insulin receptor substrate-1 (irs-1) gene among girls with a history of precocious pubarche
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
    Fertil Steril 78:1288-93. 2002
    ..The low mean SHBG concentration found among G972R carriers suggests that this variant may be a minor locus associated with development of hyperinsulinemic insulin resistance and ovarian androgen excess in girls with a history of PP...
  74. doi request reprint The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children
    Hans Burghardt
    Institute for Research in Biomedicine IRB, Barcelona, Spain
    Clin Endocrinol (Oxf) 69:730-6. 2008
    ..Our objective was to evaluate genetic variants located on AIB3 associated with beta-cell function in children and to analyse the effect of AIB3 overexpression on gene expression in insulin 1 (INS-1) beta-pancreatic cells...
  75. ncbi request reprint Cerebral folate deficiency and leukoencephalopathy caused by a mitochondrial DNA deletion
    Merce Pineda
    Servicios de Neuropediatría, Bioquímica y Endocrinología, Hospital Sant Joan de Deu, Clinic, Barcelona, Spain
    Ann Neurol 59:394-8. 2006
    ..Our aim was to describe a child with an incomplete form of Kearns-Sayre syndrome who presented profound cerebrospinal fluid (CSF) folate deficiency and his response to folinic acid supplementation..
  76. ncbi request reprint Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism
    Lourdes Ibanez
    Endocrine Unit L I, Hospital Sant Joan de Deu, University of Barcelona, E 08950 Barcelona, Spain
    J Clin Endocrinol Metab 88:3333-8. 2003
    ..Shorter CAG repeat alleles in Barcelona compared with United Kingdom women could lead to higher prevalences of these conditions...
  77. ncbi request reprint Rapid corticotropin versus corticotropin-releasing hormone test in girls with precocious pubarche
    Maria Victoria Marcos
    Endocrinology Unit, Consorci Hospitalari de Terrassa, Barcelona, Spain
    J Pediatr Endocrinol Metab 15:89-91. 2002
  78. ncbi request reprint Insulin gene variable number of tandem repeat genotype and the low birth weight, precocious pubarche, and hyperinsulinism sequence
    L Ibanez
    Endocrine Unit, Hospital Sant Joan de Deu, University of Barcelona L I, 08950 Barcelona, Spain
    J Clin Endocrinol Metab 86:5788-93. 2001
    ..A similar interaction between genotype and intrauterine growth restraint may underlie other reported links between low birth weight and adulthood disease risks...
  79. ncbi request reprint Molecular defects of the CYP21 gene in Spanish girls with isolated precocious pubarche
    N Potau
    Hormonal Laboratory, Hospital Materno Infantil Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    Eur J Endocrinol 147:485-8. 2002
    ..To determine the frequency of mutant alleles in the CYP21 gene in Spanish girls presenting with precocious pubarche (PP) and to assess the relationships between genotype and endocrine-metabolic variables...
  80. ncbi request reprint Risk of upper gastrointestinal bleeding and the degree of serotonin reuptake inhibition by antidepressants: a case-control study
    Xavier Vidal
    Department of Pharmacology, Therapeutics and Toxicology, Universitat Autonoma de Barcelona, Passeig Vall d Hebron 129 139, Barcelona, Spain
    Drug Saf 31:159-68. 2008
    ..We present the results related to the use of antidepressants by the degree of serotonin reuptake inhibition they induce, the selectivity at monoamine transporters and the dose...