Research Topics

Genomes and Genes


Luis Ruilope


Affiliation: Hypertension Unit
Country: Spain


  1. Márquez D, Ruiz Hurtado G, Ruilope L, Segura J. An update of the blockade of the renin angiotensin aldosterone system in clinical practice. Expert Opin Pharmacother. 2015;16:2283-92 pubmed publisher
  2. Ruilope L, Hanefeld M, Lincoff A, Viberti G, Meyer Reigner S, Mudie N, et al. Effects of the dual peroxisome proliferator-activated receptor-α/γ agonist aleglitazar on renal function in patients with stage 3 chronic kidney disease and type 2 diabetes: a Phase IIb, randomized study. BMC Nephrol. 2014;15:180 pubmed publisher
    ..NCT01043029 January 5, 2010. ..
  3. Baldan Martin M, De la Cuesta F, Alvarez Llamas G, Gonzalez Calero L, Ruiz Hurtado G, Moreno Luna R, et al. Prediction of development and maintenance of high albuminuria during chronic renin-angiotensin suppression by plasma proteomics. Int J Cardiol. 2015;196:170-7 pubmed publisher
    ..Our findings show that these proteins may potentially be useful for predicting the development of high albuminuria and to monitor renal damage. ..
  4. Martin Lorenzo M, Gonzalez Calero L, Martinez P, Baldan Martin M, Lopez J, Ruiz Hurtado G, et al. Author Correction: Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria. Sci Rep. 2018;8:4154 pubmed publisher
    ..A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ..
  5. Ruilope L, Schaefer A. Efficacy of Sevikar® compared to the combination of perindopril plus amlodipine on central arterial blood pressure in patients with moderate-to-severe hypertension: Rationale and design of the SEVITENSION study. Contemp Clin Trials. 2011;32:710-6 pubmed publisher
    ..EudraCT number: 2009-012966-30; identifier: NCT01101009). ..
  6. Gonzalez Calero L, Martin Lorenzo M, De la Cuesta F, Maroto A, Baldan Martin M, Ruiz Hurtado G, et al. Urinary alpha-1 antitrypsin and CD59 glycoprotein predict albuminuria development in hypertensive patients under chronic renin-angiotensin system suppression. Cardiovasc Diabetol. 2016;15:8 pubmed publisher
  7. Gonzalez Calero L, Martin Lorenzo M, Martínez P, Baldan Martin M, Ruiz Hurtado G, Segura J, et al. Hypertensive patients exhibit an altered metabolism. A specific metabolite signature in urine is able to predict albuminuria progression. Transl Res. 2016;178:25-37.e7 pubmed publisher
    ..These metabolic signatures open new possibilities in hypertensive therapy and cardiovascular risk control, providing prompt and more efficient intervention, particularly in patients with worse cardiovascular prognosis. ..
  8. Ruiz Hurtado G, Ruilope L. Cardiorenal protection during chronic renin-angiotensin-aldosterone system suppression: evidences and caveats. Eur Heart J Cardiovasc Pharmacother. 2015;1:126-31 pubmed publisher
  9. Abellán Alemán J, Zafrilla Rentero M, Montoro García S, Mulero J, Pérez Garrido A, Leal M, et al. Adherence to the "Mediterranean Diet" in Spain and Its Relationship with Cardiovascular Risk (DIMERICA Study). Nutrients. 2016;8: pubmed
    ..The adherence score could help identify individuals at greater cardiovascular risk. ..

More Information


  1. Ruilope L, Chagas A, Brandão A, Gómez Berroterán R, Alcalá J, Paris J, et al. Hypertension in Latin America: Current perspectives on trends and characteristics. Hipertens Riesgo Vasc. 2017;34:50-56 pubmed publisher
    ..We focus somewhat on the countries of Brazil, Mexico and Venezuela, the experience of which may reflect other Latin American countries that currently have less published data regarding epidemiology and management practices. ..
  2. Ruilope L, Nunes Filho A, Nadruz W, Rodríguez Rosales F, Verdejo Paris J. Obesity and hypertension in Latin America: Current perspectives. Hipertens Riesgo Vasc. 2018;35:70-76 pubmed publisher
  3. Martin Lorenzo M, Gonzalez Calero L, Martinez P, Baldan Martin M, Lopez J, Ruiz Hurtado G, et al. Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria. Sci Rep. 2017;7:8894 pubmed publisher
    ..This study reveals specific links between immune response and controlled hypertension in patients who develop albuminuria, pointing to potential protein targets for novel and future therapeutic interventions. ..