Affiliation: Hospital Universitari de Tarragona Joan XXIII
Ejarque M, Guerrero Pérez F, de la Morena N, Casajoana A, Virgili N, López Urdiales R, et al
. Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes. Sci Rep. 2019;9:6274 pubmed publisher
..Thus, GLP-1R expression in AT is of limited value to predict incretin response and does not play a role in metabolic outcomes after bariatric surgery. ..
Keiran N, Ceperuelo Mallafré V, Calvo E, Hernández Alvarez M, Ejarque M, Nuñez Roa C, et al
. SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity. Nat Immunol. 2019;20:581-592 pubmed publisher
..Our findings highlight the importance of succinate-SUCNR1 signaling in determining macrophage polarization and assign a role to succinate in limiting inflammation. ..
Ejarque M, Ceperuelo Mallafré V, Serena C, Maymó Masip E, Duran X, Diaz Ramos A, et al
. Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells. Int J Obes (Lond). 2018;: pubmed publisher
..We identified a DNA methylation signature in adipocyte precursors associated with obesity, which has a significant impact on the metabolic phenotype of mature adipocytes. ..
Casajoana A, Pujol J, García A, Elvira J, Virgili N, de Oca F, et al
. Predictive Value of Gut Peptides in T2D Remission: Randomized Controlled Trial Comparing Metabolic Gastric Bypass, Sleeve Gastrectomy and Greater Curvature Plication. Obes Surg. 2017;27:2235-2245 pubmed publisher
..Enhanced GLP-1 secretion 1Â month after surgery was a determinant of glucose metabolism improvement. Registration number ( http://www.clinicaltrials.gov ): NCT14104758. ..
Serena C, Ceperuelo Mallafré V, Keiran N, Queipo Ortuño M, Bernal R, Gómez Huelgas R, et al
. Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota. ISME J. 2018;12:1642-1657 pubmed publisher
..Our data support the importance of microbe-microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk. ..
Vendrell J, Fernandez Real J, Gutierrez C, Zamora A, Simon I, Bardaji A, et al
. A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients. Atherosclerosis. 2003;167:257-64 pubmed
..29; CI 95%: 1.6-11.76). These results suggest that -308 TNF-alpha gene polymorphism may contribute to CHD risk in patients with type 2 diabetes and it could constitute an useful predictive marker for CHD in type 2 diabetic women. ..
Vendrell J, Broch M, Fernandez Real J, Gutierrez C, Simon I, Megia A, et al
. Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study. Diabet Med. 2005;22:387-92 pubmed
..Genetic variations in exon 6/intron 4 of the TNFR2 gene do not predispose to a major risk for DM2 or its microvascular complications. ..
Serena C, Keiran N, Ceperuelo Mallafré V, Ejarque M, Fradera R, Roche K, et al
. Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells. Stem Cells. 2016;34:2559-2573 pubmed publisher
..These results are relevant not only for understanding the physiology of ASCs in terms of cell-based therapies but also for their role as key regulators of the immune response. Stem Cells 2016;34:2559-2573. ..
Serena C, Keiran N, Madeira A, Maymó Masip E, Ejarque M, Terron Puig M, et al
. Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation. Stem Cell Reports. 2017;9:1109-1123 pubmed publisher
..Thus, CD alters the biological functions of ASCs as adipocyte precursors, but also their immune properties. Selection of ASCs with the best immunomodulatory properties is advocated for the success of cell-based therapies. ..