Joan Vendrell

Summary

Affiliation: Hospital Universitari de Tarragona Joan XXIII
Country: Spain

Publications

  1. ncbi request reprint Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study
    J Vendrell
    Diabetes and Research Unit, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    Diabet Med 22:387-92. 2005
  2. ncbi request reprint Mannose-binding lectin gene polymorphisms are associated with gestational diabetes mellitus
    Anna Megia
    Endocrinology and Diabetes Unit, Research Department, University Hospital of Tarragona Joan XXIII, School of Medicine, Rovira i Virgili University, Tarragona 43007, Spain
    J Clin Endocrinol Metab 89:5081-7. 2004
  3. ncbi request reprint Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity
    Joan Vendrell
    Secció d Endocrinología, Hospital Universitari Joan XXIII de Tarragona, c Mallafré Guasch 4, 43007, Spain
    Obes Res 12:962-71. 2004
  4. ncbi request reprint A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients
    Joan Vendrell
    Endocrinology Unit, Internal Medicine Service, Tarragona, Spain
    Atherosclerosis 167:257-64. 2003
  5. doi request reprint Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes
    Merce Miranda
    Endocrinology and Diabetes Unit, Hospital Universitari Joan XXIII, C Dr Mallafré Guasch 4, Tarragona, Spain
    Am J Physiol Endocrinol Metab 299:E308-17. 2010
  6. ncbi request reprint Tumor necrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia
    Joan Vendrell
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, Hospital Universitari de Tarragona Joan XXIII, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43007 Tarragona, Spain
    J Clin Endocrinol Metab 95:2983-92. 2010
  7. doi request reprint LMNA mRNA expression is altered in human obesity and type 2 diabetes
    Merce Miranda
    Endocrinology and Diabetes Unit, Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Rovira i Virgili University, Tarragona, Spain
    Obesity (Silver Spring) 16:1742-8. 2008
  8. doi request reprint Insulin sensitivity and resistin levels in gestational diabetes mellitus and after parturition
    Ana Megia
    Endocrinology and Diabetes Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Rovira i Virgili University, 43007, Tarragona, Spain
    Eur J Endocrinol 158:173-8. 2008
  9. doi request reprint Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Cytokine 58:253-60. 2012
  10. doi request reprint Lipodystrophy and insulin resistance in combination antiretroviral treated HIV-1-infected patients: implication of resistin
    Xavier Escote
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 57:16-23. 2011

Detail Information

Publications79

  1. ncbi request reprint Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study
    J Vendrell
    Diabetes and Research Unit, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    Diabet Med 22:387-92. 2005
    ..Likewise, we have analysed the genetic susceptibility of 196T > G exon6/CA-repeat intron 4 mutations in the TNFR2 gene in this population...
  2. ncbi request reprint Mannose-binding lectin gene polymorphisms are associated with gestational diabetes mellitus
    Anna Megia
    Endocrinology and Diabetes Unit, Research Department, University Hospital of Tarragona Joan XXIII, School of Medicine, Rovira i Virgili University, Tarragona 43007, Spain
    J Clin Endocrinol Metab 89:5081-7. 2004
    ..320; P = 0.002) was found, remaining significant after adjustment for confounding variables. In conclusion, pregnant women bearing the G54D MBL allele have a greater risk for developing GDM and having heavier infants...
  3. ncbi request reprint Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity
    Joan Vendrell
    Secció d Endocrinología, Hospital Universitari Joan XXIII de Tarragona, c Mallafré Guasch 4, 43007, Spain
    Obes Res 12:962-71. 2004
    ..To evaluate interactions among leptin, adiponectin, resistin, ghrelin, and proinflammatory cytokines [tumor necrosis factor receptors (TNFRs), interleukin-6 (IL-6)] in nonmorbid and morbid obesity...
  4. ncbi request reprint A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients
    Joan Vendrell
    Endocrinology Unit, Internal Medicine Service, Tarragona, Spain
    Atherosclerosis 167:257-64. 2003
    ..We have studied the association of this polymorphism with CHD in a Mediterranean non-diabetic and type 2 diabetic population...
  5. doi request reprint Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes
    Merce Miranda
    Endocrinology and Diabetes Unit, Hospital Universitari Joan XXIII, C Dr Mallafré Guasch 4, Tarragona, Spain
    Am J Physiol Endocrinol Metab 299:E308-17. 2010
    ..As shown in the in vitro analysis, the low-grade proinflammatory environment and the insulin resistance associated with obesity may contribute to downregulate LPIN1 in adipose tissue, leading to a worse metabolic profile...
  6. ncbi request reprint Tumor necrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia
    Joan Vendrell
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, Hospital Universitari de Tarragona Joan XXIII, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43007 Tarragona, Spain
    J Clin Endocrinol Metab 95:2983-92. 2010
    ..We previously reported the up-regulation of TNF-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in adipose tissue of severely obese type 2 diabetic subjects...
  7. doi request reprint LMNA mRNA expression is altered in human obesity and type 2 diabetes
    Merce Miranda
    Endocrinology and Diabetes Unit, Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Rovira i Virgili University, Tarragona, Spain
    Obesity (Silver Spring) 16:1742-8. 2008
    ....
  8. doi request reprint Insulin sensitivity and resistin levels in gestational diabetes mellitus and after parturition
    Ana Megia
    Endocrinology and Diabetes Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Rovira i Virgili University, 43007, Tarragona, Spain
    Eur J Endocrinol 158:173-8. 2008
    ..Increased serum resistin levels have been found in the second half of normal pregnancy, but its role in the pathogenesis of the insulin resistance of pregnancy is undetermined...
  9. doi request reprint Leptin and adiponectin, but not IL18, are related with insulin resistance in treated HIV-1-infected patients with lipodystrophy
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Cytokine 58:253-60. 2012
    ..Plasma IL18 levels are increased in infected patients irrespective of the presence of lipodystrophy. The polymorphisms assessed are not associated with lipodystrophy or metabolic disturbances in treated HIV-1-infected patients...
  10. doi request reprint Lipodystrophy and insulin resistance in combination antiretroviral treated HIV-1-infected patients: implication of resistin
    Xavier Escote
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 57:16-23. 2011
    ..We determined whether the resistin (rest) -420C>G single-nucleotide polymorphism and plasma resistin are associated with the development of lipodystrophy and metabolic disturbances in HIV-1-infected patients treated with cART...
  11. doi request reprint The rise of soluble TWEAK levels in severely obese subjects after bariatric surgery may affect adipocyte-cytokine production induced by TNFα
    Elsa Maymó-Masip
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 28027 Madrid, Spain
    J Clin Endocrinol Metab 98:E1323-33. 2013
    ..sTWEAK levels are reduced in diseases with an inflammatory component. Additionally, sTWEAK hampers TNFα activity in human cells...
  12. ncbi request reprint LMNA messenger RNA expression in highly active antiretroviral therapy-treated HIV-positive patients
    Merce Miranda
    Endocrinology and Diabetes Unit, Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Rovira i Virgili University, Tarragona, Spain
    J Acquir Immune Defic Syndr 46:384-9. 2007
    ..Hence, in the present study, the lower lamin A expression observed in HIV-positive patients is related to HIV itself or to treatments rather than to the presence of lipodystrophy...
  13. pmc Munc18c in adipose tissue is downregulated in obesity and is associated with insulin
    Lourdes Garrido-Sanchez
    Endocrinology and Diabetes Unit, Joan XXIII University Hospital, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    PLoS ONE 8:e63937. 2013
    ..However, little is known about the regulation of Munc18c expression. We analyzed Munc18c gene expression in human visceral (VAT) and subcutaneous (SAT) adipose tissue and its relationship with obesity and insulin...
  14. doi request reprint Gender determines the actions of adiponectin multimers on fetal growth and adiposity
    Inmaculada Simón-Muela
    Division of Endocrinology, Department of Medicine, Hospital Universitari de Tarragona Joan XXIII, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain
    Am J Obstet Gynecol 208:481.e1-7. 2013
    ..We sought to analyze the role of cord blood adiponectin and its multimeric forms in neonatal adiposity and fetal growth velocity (FGV) during the third trimester of pregnancy according to fetal gender...
  15. doi request reprint The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes
    Maria Saumoy
    Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    AIDS 22:893-6. 2008
    ..The IL-6 -174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy...
  16. pmc Zinc-α2-glycoprotein is unrelated to gestational diabetes: anthropometric and metabolic determinants in pregnant women and their offspring
    Sílvia Näf
    Endocrinology and Diabetes Unit, Hospital Universitari de Tarragona Joan XXIII, Institut d Investigació Sanitària Pere Virgili IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    PLoS ONE 7:e47601. 2012
    ..We hypothesize that ZAG may be related with hydrocarbonate metabolism disturbances observed in gestational diabetes mellitus (GDM)...
  17. doi request reprint Adipocyte fatty acid-binding protein as a determinant of insulin sensitivity in morbid-obese women
    Inmaculada Simon
    CIBERDEM, Endocrinology and Diabetes Research Department, University Hospital Joan XXIII from Tarragona, School of Medicine, Rovira i Virgili University, Pere Virgili Institute, Tarragona, Spain
    Obesity (Silver Spring) 17:1124-8. 2009
    ..Further studies are warranted to elucidate the role of A-FABP in the pathogenesis of insulin resistance in morbid obesity...
  18. doi request reprint Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormalities
    Merce Miranda
    Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, IISPV, 43007 Tarragona, Spain
    Metabolism 58:1762-8. 2009
    ....
  19. ncbi request reprint PPARgamma Pro12Ala polymorphism in HIV-1-infected patients with HAART-related lipodystrophy
    Maria Saumoy
    Hospital Universitari Joan XXIII, Tarragona, Spain
    Curr HIV Res 7:533-40. 2009
    ..054). PPARgamma Pro12Ala SNP has no effect on the risk of developing lipodystrophy in HIV-1-infected patients treated with HAART. PPARgamma mRNA SAT expression appears decreased in lipodystrophy...
  20. ncbi request reprint Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population
    Nuria Vilarrasa
    Endocrinology and Diabetes Unit, Hospital Universitari de Bellvitge, Barcelona, Spain
    Clin Endocrinol (Oxf) 63:329-35. 2005
    ..The aim of our study was to analyse the distribution among sexes and all decades of the adult life of adiponectin, resistin and ghrelin and their relationship with anthropometric, body composition parameters and the IGF-I system...
  21. pmc Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients
    Lourdes Garrido-Sanchez
    CIBERDEM, Hospital Universitari Joan XXIII, Pere Virgili Institute, Tarragona, Spain
    PLoS ONE 7:e33264. 2012
    ..The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR)...
  22. pmc Serum activin A and follistatin levels in gestational diabetes and the association of the Activin A-Follistatin system with anthropometric parameters in offspring
    Sílvia Näf
    Endocrinology and Diabetes Unit, Hospital Universitari Joan XXIII, Tarragona, Spain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain Institut d Investigació Sanitaria Pere Virgili IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    PLoS ONE 9:e92175. 2014
    ..The Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth...
  23. ncbi request reprint Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome
    Merce Miranda
    Research Department, Endocrinology and Diabetes Unit, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, University Rovira i Virgili, 43007 Tarragona, Spain
    Metabolism 56:1518-26. 2007
    ..001). LPIN1 messenger RNA levels positively correlated with insulin sensitivity in all subjects. Moreover, an inverse correlation with proinflammatory cytokines was observed...
  24. doi request reprint No relationship between TNF-α genetic variants and combination antiretroviral therapy-related lipodystrophy syndrome in HIV type 1-infected patients: a case-control study and a meta-analysis
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, Spain
    AIDS Res Hum Retroviruses 27:143-52. 2011
    ..In HIV-1-infected patients under cART there is a systemic overproduction of sTNF-α R2, which is unrelated to the presence of lipodystrophy...
  25. doi request reprint Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population?
    Nuria Vilarrasa
    Endocrinology and Diabetes Unit, Hospital Universitari de Bellvitge, c Feixa Llarga s n, 08907, L Hospitalet de Llobregat, Barcelona, Spain
    Endocrine 38:235-42. 2010
    ..In addition, subjects with vitamin D deficiency are not characterized by a greater inflammatory state...
  26. ncbi request reprint Monocyte chemoattractant protein-1 in obesity and type 2 diabetes. Insulin sensitivity study
    Matilde R Chacon
    Research Department, University Hospital of Tarragona Joan XXIII, Rovira i Virgili University, Pere Virgili Institute, Tarragona, Spain
    Obesity (Silver Spring) 15:664-72. 2007
    ....
  27. doi request reprint Resveratrol induces antioxidant defence via transcription factor Yap1p
    Xavier Escote
    Hospital Universitari de Tarragona Joan XXIII IISPV, Universitat Rovira i Virgili, CIBERDEM, Spain
    Yeast 29:251-63. 2012
    ..Thus, resveratrol may enhance cellular lifespan by hormetic ROS accumulation, which leads to strengthening the cells' antioxidant capacity...
  28. pmc Maternal and cord blood adiponectin multimeric forms in gestational diabetes mellitus: a prospective analysis
    Monica Ballesteros
    Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Diabetes Care 34:2418-23. 2011
    ....
  29. ncbi request reprint Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and nonobese subjects
    Montserrat Broch
    Reseach Unit, Pere Virgili Institute for Biomedical Research, Tarragona, Spain
    Diabetes Care 30:1802-6. 2007
    ..There is some experimental evidence that RBP4 also could been linked to insulin secretion...
  30. doi request reprint Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazone-flutamide-metformin for adolescent girls with androgen excess: divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN expression in subcutaneous adipose tissue
    Marta Diaz
    Endocrinology Unit, Department of Obstetrics and Gynecology, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 97:3630-8. 2012
    ..The aim was to compare the effects of a traditional therapy (an oral estroprogestagen) to those of a novel treatment (a low-dose combination of generics) in adolescent girls with androgen excess...
  31. pmc De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery
    Lourdes Garrido-Sanchez
    CIBERDEM, Hospital Universitari Joan XXIII, IISPV, Tarragona, Spain
    PLoS ONE 7:e31280. 2012
    ..In this prospective study we analyze the association between the improvement in the morbidly obese patients as a result of bariatric surgery and the basal expression of lipogenic and lipolytic genes...
  32. doi request reprint Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
    Joan Vendrell
    University Hospital of Tarragona Joan XXIII, IISPV, Rovira i Virgili University, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, 43007 Tarragona, Spain
    Endocrinology 152:4072-9. 2011
    ..Altogether these results indicate that the GLP-1/GLP-1R system in AT represents another potential candidate for improving insulin sensitivity in obese patients...
  33. ncbi request reprint Lower rate of tumor necrosis factor-alpha -863A allele and higher concentration of tumor necrosis factor-alpha receptor 2 in first-degree relatives of subjects with type 2 diabetes
    A Costa
    Endocrinology Unit, Hospital Clinic i Universitari de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Metabolism 52:1068-71. 2003
    ..The presence of abnormalities in the TNF-alpha pathway could predispose to the development of DM in subjects at risk for the disease...
  34. ncbi request reprint Beta 3-adrenoreceptor gene polymorphism and leptin. Lack of relationship in type 2 diabetic patients
    J Vendrell
    Endocrinology Unit, University Hospital Joan XXIII of Tarragona, Spain
    Clin Endocrinol (Oxf) 49:679-83. 1998
    ....
  35. pmc Reduced circulating sTWEAK levels are associated with metabolic syndrome in elderly individuals at high cardiovascular risk
    Andrés Díaz-López
    Human Nutrition Unit, Faculty of Medicine and Health Sciences, IISPV, Universitat Rovira i Virgili, C Sant Llorenc, 21, Reus, Tarragona 43201, Spain
    Cardiovasc Diabetol 13:51. 2014
    ..We investigated the association between sTWEAK levels and metabolic syndrome (MetS) and its components in older subjects at high cardiovascular risk...
  36. doi request reprint Serum sTWEAK concentrations and risk of developing type 2 diabetes in a high cardiovascular risk population: a nested case-control study
    Andrés Díaz-López
    Human Nutrition Unit, Faculty of Medicine and Health Sciences, IISPV, Universitat Rovira i Virgili, 43201 Reus, Tarragona, Spain
    J Clin Endocrinol Metab 98:3482-90. 2013
    ....
  37. ncbi request reprint High expression of tumor necrosis factor alpha receptors in peripheral blood mononuclear cells of obese type 2 diabetic women
    Marta Fogeda
    Endocrinology Research Unit, Joan XXIII University Hospital, Rovira i Virgili University, School of Medicine, Tarragona, Spain
    Eur Cytokine Netw 15:60-6. 2004
    ..These findings are in agreement with a functional role for the TNF system in obese women in obesity-linked, type 2 diabetes...
  38. ncbi request reprint Grape-seed procyanidins modulate inflammation on human differentiated adipocytes in vitro
    Matilde R Chacon
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, University Hospital of Tarragona, Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    Cytokine 47:137-42. 2009
    ....
  39. doi request reprint Role of energy- and nutrient-sensing kinases AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in adipocyte differentiation
    Sonia Fernández-Veledo
    Research Unit, Hospital Universitari de Tarragona Joan XXIII IISPV Universitat Rovira i Virgili, Tarragona, Spain
    IUBMB Life 65:572-83. 2013
    ..2013 IUBMB Life, 65(7):572-583, 2013. ..
  40. ncbi request reprint Bone mineral mass is associated with interleukin 1 receptor autoantigen and TNF-alpha gene polymorphisms in post-menopausal Mediterranean women
    R Fontova
    University Hospital of Tarragona Joan XXIII, Medicine and Surgery Department, Spain
    J Endocrinol Invest 25:684-90. 2002
    ..02). We conclude that both IL-1ra and TNF-alpha can be candidate loci to be studied in the susceptibility to develop post-menopausal osteoporosis...
  41. ncbi request reprint Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus
    I Simon
    Medicine and Surgery Department, University Hospital Joan XXIII, Tarragona, Institut d Estudis Avançats, Universitat Rovira i Virgilli, Tarragona, Spain
    Horm Res 58:143-9. 2002
    ....
  42. ncbi request reprint GLUT1 gene polymorphism in non-insulin-dependent diabetes mellitus: genetic susceptibility relationship with cardiovascular risk factors and microangiopathic complications in a Mediterranean population
    C Gutierrez
    Internal Medicine Department, Hospital Universitari Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    Diabetes Res Clin Pract 41:113-20. 1998
    ....
  43. ncbi request reprint Advanced glycation end products are associated with arterial stiffness in type 1 diabetes
    Gemma Llauradó
    Department of DiabetesEndocrinology and Nutrition, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí Universitat Autònoma de Barcelona, Parc Taul s n, 08208 Sabadell, SpainCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición CIBERobn Hospital Clínico Virgen de la Victoria, Malaga, SpainDiabetesEndocrinology and Nutrition Unit, Hospital Sant Joan de Deu de Manresa, Xarxa Assistencial Althaia, Manresa, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM and Diabetes and Metabolism Research UnitInstitut de Recerca Hospital Universitari Vall d Hebrón VHIR, Universitat Autonoma de Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM Hospital Universitari Joan XXIII de Tarragona, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, SpainDepartment of DiabetesEndocrinology and Nutrition, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí Universitat Autònoma de Barcelona, Parc Taul s n, 08208 Sabadell, SpainCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición CIBERobn Hospital Clínico Virgen de la Victoria, Malaga, SpainDiabetesEndocrinology and Nutrition Unit, Hospital Sant Joan de Deu de Manresa, Xarxa Assistencial Althaia, Manresa, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM and Diabetes and Metabolism Research UnitInstitut de Recerca Hospital Universitari Vall d Hebrón VHIR, Universitat Autonoma de Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM Hospital Universitari Joan XXIII de Tarragona, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain
    J Endocrinol 221:405-13. 2014
    ..These findings indicate that determination of tissue AGE accumulation may be a useful marker for AS in type 1 diabetes. ..
  44. ncbi request reprint Cardiovascular abnormalities in hyperthyroidism: a prospective Doppler echocardiographic study
    Jordi Mercé
    Cardiology Service, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain
    Am J Med 118:126-31. 2005
    ..We investigated the prevalence and clinical importance of cardiovascular abnormalities in patients with hyperthyroidism...
  45. doi request reprint A study of fatty acid binding protein 4 in HIV-1 infection and in combination antiretroviral therapy-related metabolic disturbances and lipodystrophy
    X Escote
    Joan XXIII University Hospital of Tarragona, IISPV, Rovira i Virgili University, Tarragona, Spain
    HIV Med 12:428-37. 2011
    ....
  46. ncbi request reprint Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity
    M R Chacon
    Endocrinology and Diabetes Unit, Research Department, University Hospital of Tarragona Joan XXIII, School of Medicine, University Rovira i Virgili, c Mallafré Guasch 4, 43007 Tarragona, Spain
    Cytokine 33:129-37. 2006
    ..Our results suggest that the expression of TNF-derived pro-inflammatory cytokines are increased in severe obesity, where macrophage infiltrate could modulate the inflammatory environment through activation of its receptors...
  47. ncbi request reprint Association between 4G/5G polymorphism of the plasminogen activator inhibitor 1 gene with stroke or encephalopathy after cardiac surgery
    Gonzalo Sirgo
    Intensive Care Department, Joan XXIII University Hospital, University Rovira i Virgili, Institut Pere Virgili, Mallafre Guasch N 4, 43007, Tarragona, Spain
    Intensive Care Med 32:668-75. 2006
    ....
  48. doi request reprint The stress-activated protein kinase Hog1 develops a critical role after resting state
    Xavier Escote
    Unitat de Recerca Hospital Universitari Joan XXIII, IISPV, Tarragona, Spain
    Mol Microbiol 80:423-35. 2011
    ..Similar results are obtained in higher eukaryotic cells by activation of p38. Thus, these results reveal a novel role of the SAPK Hog1p in the control of cell cycle progression as cells leave a resting state...
  49. doi request reprint Paired subcutaneous and visceral adipose tissue aquaporin-7 expression in human obesity and type 2 diabetes: differences and similarities between depots
    M Miranda
    Endocrinology and Diabetes Unit, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, 43007 Tarragona, Spain
    J Clin Endocrinol Metab 95:3470-9. 2010
    ..AQP7 is considered to be the sole adipose glycerol channel, and its regulation is crucial for glycemia control...
  50. doi request reprint Human serum levels of fetal antigen 1 (FA1/Dlk1) increase with obesity, are negatively associated with insulin sensitivity and modulate inflammation in vitro
    M R Chacon
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Universitat Rovira i Virgili, Tarragona, Spain
    Int J Obes (Lond) 32:1122-9. 2008
    ..To investigate fetal antigen 1 (FA1) protein within the context of human obesity and its relation with insulin sensitivity...
  51. doi request reprint Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue
    M Miranda
    Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, IISPV, Tarragona, Spain
    Int J Obes (Lond) 34:679-86. 2010
    ..Among others, hypoxia and endoplasmic reticulum (ER) stress are being shown to be related to the adipose dysfunction found in human obesity...
  52. ncbi request reprint IL-18: relationship with anthropometry, body composition parameters, leptin and arterial hypertension
    N Vilarrasa
    Endocrinology and Diabetes Unit, Hospital Universitari de Bellvitge, Barcelona, Spain
    Horm Metab Res 38:507-12. 2006
    ..We also studied the relationship of IL-18 with smoking and arterial hypertension, known risk factors implicated in atherogenesis...
  53. ncbi request reprint Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes
    V Ceperuelo-Mallafré
    Endocrinology and Diabetes Unit, Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, 43007 Tarragona, Spain
    J Clin Endocrinol Metab 92:3640-5. 2007
    ..Aquaporin-7 is required for efflux of glycerol from adipocytes and influences whole-body glucose homeostasis in animal studies...
  54. ncbi request reprint Different TNFalpha expression elicited by glucose in monocytes from type 2 diabetes mellitus patients
    M R Chacon
    Endocrinology and Diabetes Unit, Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Tarragona, Spain
    Atherosclerosis 194:e18-25. 2007
    ..These results indicate the existence of differences, elicited by LPS or high glucose related stimulus, between monocytes isolated from non-diabetic subjects or from type 2 diabetes patients...
  55. ncbi request reprint Effect of weight loss induced by gastric bypass on proinflammatory interleukin-18, soluble tumour necrosis factor-alpha receptors, C-reactive protein and adiponectin in morbidly obese patients
    N Vilarrasa
    Endocrinology and Diabetes Unit, Hospital Universitari de Bellvitge, Barcelona, Spain
    Clin Endocrinol (Oxf) 67:679-86. 2007
    ....
  56. doi request reprint Circulating and adipose tissue gene expression of zinc-alpha2-glycoprotein in obesity: its relationship with adipokine and lipolytic gene markers in subcutaneous and visceral fat
    V Ceperuelo-Mallafré
    Endocrinology and Nutrition Unit, Research Department, University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, 43007 Tarragona, Spain
    J Clin Endocrinol Metab 94:5062-9. 2009
    ..We hypothesized that ZAG mRNA expression in adipose tissue may be linked with lipolytic and adipokine gene expression and have a close relationship with clinical phenotype...
  57. ncbi request reprint Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women
    Melania Manco
    Department of Internal Medicine, Catholic University, Rome, Italy
    J Clin Endocrinol Metab 92:483-90. 2007
    ..Obesity may be regarded as a low-grade inflammatory state...
  58. ncbi request reprint Serum corticosteroid-binding globulin concentration and insulin resistance syndrome: a population study
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, Dr Josep Trueta, 17007 Girona, Spain
    J Clin Endocrinol Metab 87:4686-90. 2002
    ....
  59. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  60. ncbi request reprint Insulin resistance, inflammation, and serum fatty acid composition
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain
    Diabetes Care 26:1362-8. 2003
    ..However, the relation among insulin resistance, obesity, inflammatory activity (circulating interleukin [IL]-6) and dietary FAs has been scarcely studied in otherwise healthy subjects...
  61. ncbi request reprint Interleukin-6 in obese children and adolescents with and without glucose intolerance
    Diego Yeste
    Pediatric Endocrinology Service, Children s Hospital Vall d Hebron, Center for Biomedical Research on Rare Diseases, Autonomous University, Barcelona, Spain
    Diabetes Care 30:1892-4. 2007
  62. ncbi request reprint Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, 17001 Girona, Spain
    Am J Physiol Endocrinol Metab 282:E952-9. 2002
    ..Our findings suggest that insulin resistance and blood pressure are linked to altered shedding of TNF-alpha receptors in DM-2. The latter seems reversible and is not genetically determined...
  63. ncbi request reprint Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity
    Eduardo Esteve
    Unit of Diabetes, Endocrinology, and Nutrition, Department of Internal Medicine, Hospital of Girona Dr Josep Trueta, Girona, Spain
    Diabetes Care 30:939-45. 2007
    ..We aimed to evaluate whether increased serum IL-6 concentrations associated with endothelial dysfunction are independent of insulin sensitivity in apparently healthy men...
  64. ncbi request reprint Circulating soluble transferrin receptor according to glucose tolerance status and insulin sensitivity
    Jose Manuel Fernandez-Real
    Unit of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Girona, Spain
    Diabetes Care 30:604-8. 2007
    ..The mechanisms of these interactions depend on poorly known factors. We aimed to study the contribution of the serum soluble transferrin receptor (sTfR)...
  65. ncbi request reprint Divergent relationships among soluble tumor necrosis factor-alpha receptors 1 and 2, insulin resistance, and endothelial function
    Eduardo Esteve
    Diabetes Care 29:1460-1. 2006
  66. ncbi request reprint G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Hypertension 41:124-9. 2003
    ..The GNB3 gene polymorphism might be an example of pharmacogenetics, with the underlying etiological genetic defect altering the response to treatment...
  67. ncbi request reprint The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Hum Genet 112:409-13. 2003
    ..001). These findings are consistent with a role for genetic determinants of inflammation in the development of T2DM in both Native Americans and Caucasians...
  68. doi request reprint Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver
    Victoria Catalan
    Metabolic Research Laboratory, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Spain
    Obes Surg 18:695-701. 2008
    ..The aim of the present work was to evaluate the effect of obesity and type 2 diabetes mellitus (T2DM) on gene expression levels of AQP7 in visceral adipose tissue (VAT) and AQP9 in liver...
  69. ncbi request reprint Circulating soluble CD14 monocyte receptor is associated with increased alanine aminotransferase
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Chem 50:1456-8. 2004
  70. ncbi request reprint Potential role of interleukin-18 in liver disease associated with insulin resistance
    Abel Lopez-Bermejo
    Unit of Diabetes, Endocrinology, and Nutrition, Dr Josep Trueta Hospital, Av Francia s n, 17007 Girona, Spain
    Obes Res 13:1925-31. 2005
    ..We hypothesized that circulating IL-18 would be related to serum concentrations of liver chemistry tests (LCTs) in apparently healthy subjects and wished to study whether this correlation was dependent on insulin sensitivity (S(I))...
  71. ncbi request reprint Insulin resistance, leptin and TNF-alpha system in morbidly obese women after gastric bypass
    Ana Molina
    Department of Endocrinology, Princeps D Espanya Hospital, Barcelona, Spain
    Obes Surg 13:615-21. 2003
    ..Gastric bypass (GBP) is a surgical treatment for morbidly obese patients. We conducted a study after GBP to analyze the pattern of variation of anthropometric and body composition variables, leptin and sTNFR1 and 2...
  72. ncbi request reprint Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome
    Eduardo Esteve
    Department of Endocrinology, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Endocrinol (Oxf) 65:88-91. 2006
    ....
  73. ncbi request reprint CD14 monocyte receptor, involved in the inflammatory cascade, and insulin sensitivity
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, 17007 Girona, Spain
    J Clin Endocrinol Metab 88:1780-4. 2003
    ..To our knowledge, this is the first study to suggest an effect of a genetic polymorphism on both SI (healthy subjects and type 2 diabetic patients) and endothelial dysfunction (sICAM-1 levels) in type 2 diabetes mellitus...
  74. ncbi request reprint Natural antibiotics and insulin sensitivity: the role of bactericidal/permeability-increasing protein
    Carme Gubern
    Unit of Diabetes, Endocrinology and Nutrition, Hospital de Girona Dr Josep Trueta, Ctra França s n, 17007 Girona, Spain
    Diabetes 55:216-24. 2006
    ..These findings suggest that this component of the innate immune system is associated with metabolic pathways...
  75. ncbi request reprint A polymorphism in the 3' untranslated region of the gene for tumor necrosis factor receptor 2 modulates reporter gene expression
    Irene Puga
    Department Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain
    Endocrinology 146:2210-20. 2005
    ..These findings may explain the association of this haplotype with obesity and increased leptin levels...
  76. ncbi request reprint Burden of infection and insulin resistance in healthy middle-aged men
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, Avinguda de França s n, 17007 Girona, Spain
    Diabetes Care 29:1058-64. 2006
    ..We aimed to study the effect of exposure to four infections on insulin sensitivity in apparently healthy middle-aged men (n = 124)...
  77. ncbi request reprint An inflammation score is better associated with basal than stimulated surrogate indexes of insulin resistance
    Mònica Recasens
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Spain
    J Clin Endocrinol Metab 90:112-6. 2005
    ..Basal rather than stimulated indexes should be used in the evaluation of therapeutic measures aimed at modifying IR-associated inflammatory activity...
  78. ncbi request reprint Opposite relationship between circulating soluble CD14 concentration and endothelial function in diabetic and nondiabetic subjects
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio and Servei de Medicina Interna, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Thromb Haemost 94:615-9. 2005
    ..While in non-diabetic subjects sCD14 behaves as an acute phase reactant, its role in type 2 diabetic patients should be further clarified. These findings need to be confirmed in further studies with larger number of patients...
  79. ncbi request reprint Circulating adiponectin and plasma fatty acid profile
    Jose Manuel Fernandez-Real
    Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Chem 51:603-9. 2005
    ..Knowledge of the possible influence of dietary habits on circulating adiponectin, a molecule with putative antiinflammatory properties, may be helpful in preventing atherosclerosis and type 2 diabetes...