Genomes and Genes
Affiliation: Hospital Universitario
- Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethalityThomas D Arnold
Department of Pediatrics, University of California, San Francisco, CA 94143, USA
Dis Model Mech 6:1205-12. 2013..In addition, our conditional Ilk mutant mice might prove useful as a model to study aortic aneurysms caused by reduced Smad3 signaling, as occurs in the newly described aneurysms-osteoarthritis syndrome, for example. ..
- A novel method that improves sensitivity of protein detection in PAGE and Western blotAinara Vallejo-Illarramendi
Department of Physiology, University of California, San Francisco, CA, USA
Electrophoresis 34:1148-50. 2013..As a result, less protein is required for loading and signal detection. Our protocol is a straightforward modification of a standard experimental technique, and is especially useful when only limited sample quantities are available...
- Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular developmentAinara Vallejo-Illarramendi
Department of Physiology, UCSF, San Francisco, California 94158 2611, USA
J Clin Invest 119:2218-30. 2009..Our results indicate that FAK plays an essential role in cardiac outflow tract development by promoting the activation of molecules such as Crkl and Erk1/2...
- Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiencyAnia L Gheyara
Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA
Am J Pathol 171:1966-77. 2007..These findings resemble those seen in humans and mice lacking the alpha 7-integrin subunit and suggest that Ilk may act as a cytoplasmic effector of alpha 7 beta1-integrin in the pathogenesis of these deficiencies...