M Tintore

Summary

Affiliation: Hospital Vall d'Hebron
Country: Spain

Publications

  1. ncbi [Optic neuritis, brain stem syndromes and myelitis: rapid conversion to multiple sclerosis]
    M Tintore
    Unitat de Neuroinmunologia Clínica Esclerosi Múltiple, Hospital General Universitari Vall d Hebron, Barcelona
    Med Clin (Barc) 112:693-4. 1999
  2. ncbi New diagnostic criteria for multiple sclerosis: application in first demyelinating episode
    M Tintore
    Clinical Neuroimmunology Unit, Department of Neurology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Neurology 60:27-30. 2003
  3. doi Brainstem lesions in clinically isolated syndromes
    M Tintore
    Unitat de Neuroimmunologia Clinica UNIC, Edif Escola d Infermeria Planta 2, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Neurology 75:1933-8. 2010
  4. ncbi Clinical impact of early brain atrophy in clinically isolated syndromes
    F Perez-Miralles
    Multiple Sclerosis Center of Catalonia Cemcat, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Mult Scler 19:1878-86. 2013
  5. ncbi Do multimodal evoked potentials add information to MRI in clinically isolated syndromes?
    R Pelayo
    Multiple Sclerosis Center of Catalonia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Mult Scler 16:55-61. 2010
  6. ncbi A single-center, randomized, double-blind, placebo-controlled study of interferon beta-1b on primary progressive and transitional multiple sclerosis
    X Montalban
    Unitat de Neuroimmunologia Clinica, Multiple Sclerosis Centre of Catalonia CEM Cat, Barcelona, Spain
    Mult Scler 15:1195-205. 2009
  7. ncbi Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?
    M Tintore
    Unit of Clinical Neuroimmunology, Department of Neurology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Neurology 70:1079-83. 2008
  8. ncbi Neuromyelitis optica diagnosis in clinically isolated syndromes suggestive of multiple sclerosis
    M Rubiera
    Unitat de Neuroinmunologia Clínica, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Neurology 66:1568-70. 2006
  9. ncbi Variations in chemokine receptor and cytokine expression during pregnancy in multiple sclerosis patients
    C Lopez
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Barcelona, Spain
    Mult Scler 12:421-7. 2006
  10. ncbi Can we predict flu-like symptoms in patients with multiple sclerosis treated with interferon-beta?
    X Montalban
    Unitat de Neuroimmunologia Clinica, Servei de Neurologia, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    J Neurol 247:259-62. 2000

Collaborators

Detail Information

Publications39

  1. ncbi [Optic neuritis, brain stem syndromes and myelitis: rapid conversion to multiple sclerosis]
    M Tintore
    Unitat de Neuroinmunologia Clínica Esclerosi Múltiple, Hospital General Universitari Vall d Hebron, Barcelona
    Med Clin (Barc) 112:693-4. 1999
    ..To establish the early risk of multiple sclerosis (MS) following isolated demyelinating syndromes...
  2. ncbi New diagnostic criteria for multiple sclerosis: application in first demyelinating episode
    M Tintore
    Clinical Neuroimmunology Unit, Department of Neurology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Neurology 60:27-30. 2003
    ....
  3. doi Brainstem lesions in clinically isolated syndromes
    M Tintore
    Unitat de Neuroimmunologia Clinica UNIC, Edif Escola d Infermeria Planta 2, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Neurology 75:1933-8. 2010
    ..Number of baseline lesions has been shown to predict future attacks and disability in clinically isolated syndromes (CIS)...
  4. ncbi Clinical impact of early brain atrophy in clinically isolated syndromes
    F Perez-Miralles
    Multiple Sclerosis Center of Catalonia Cemcat, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Mult Scler 19:1878-86. 2013
    ..The impact of global and tissue-specific brain atrophy on conversion to multiple sclerosis (MS) after a clinically isolated syndrome (CIS) is not fully gauged...
  5. ncbi Do multimodal evoked potentials add information to MRI in clinically isolated syndromes?
    R Pelayo
    Multiple Sclerosis Center of Catalonia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Mult Scler 16:55-61. 2010
    ..However, the utility of MMEPs is limited by the low percentage of CIS patients having the three abnormal at baseline...
  6. ncbi A single-center, randomized, double-blind, placebo-controlled study of interferon beta-1b on primary progressive and transitional multiple sclerosis
    X Montalban
    Unitat de Neuroimmunologia Clinica, Multiple Sclerosis Centre of Catalonia CEM Cat, Barcelona, Spain
    Mult Scler 15:1195-205. 2009
    ..Positive effects of interferon beta on secondary clinical and magnetic resonance imaging outcomes were observed, but a beneficial effect on Expanded Disability Status Scale progression was not demonstrated...
  7. ncbi Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?
    M Tintore
    Unit of Clinical Neuroimmunology, Department of Neurology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Neurology 70:1079-83. 2008
    ..To evaluate whether oligoclonal bands (OB) add information to MRI in predicting both a second attack and development of disability in patients with clinically isolated syndromes (CIS)...
  8. ncbi Neuromyelitis optica diagnosis in clinically isolated syndromes suggestive of multiple sclerosis
    M Rubiera
    Unitat de Neuroinmunologia Clínica, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Neurology 66:1568-70. 2006
    ..2%) patients fulfilled NMO absolute criteria at some time and 1 (0.3%) also fulfilled one major supportive criterion. Therefore, even by systematically applying NMO criteria in patients with CIS, NMO diagnosis is reached infrequently...
  9. ncbi Variations in chemokine receptor and cytokine expression during pregnancy in multiple sclerosis patients
    C Lopez
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Barcelona, Spain
    Mult Scler 12:421-7. 2006
    ..These findings indicate immunomodulatory effects of pregnancy on the expression of chemokine receptors and cytokines, which may be related to changes in the clinical disease activity of T cell-mediated autoimmune diseases, such as MS...
  10. ncbi Can we predict flu-like symptoms in patients with multiple sclerosis treated with interferon-beta?
    X Montalban
    Unitat de Neuroimmunologia Clinica, Servei de Neurologia, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    J Neurol 247:259-62. 2000
    ..In vitro stimulation of peripheral blood leukocytes with interferon-beta1b before the beginning of therapy shows that patients who develop fever generally have increased levels of interleukin-6...
  11. ncbi Baseline MRI predicts future attacks and disability in clinically isolated syndromes
    M Tintore
    Unit of Clinical Neuroimmunology Department of Neurology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Spain
    Neurology 67:968-72. 2006
    ..To determine the relation between baseline MRI and both conversion to multiple sclerosis (MS) and development of disability in a cohort of patients with clinically isolated syndromes (CIS)...
  12. doi Measures in the first year of therapy predict the response to interferon beta in MS
    J Rio
    Unitat de Neuroimmunologia Clinica, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Mult Scler 15:848-53. 2009
    ..Hence, the aim of this study was to investigate magnetic resonance imaging (MRI) and clinical predictors of response during the first 12 months of therapy...
  13. ncbi Relationship between MRI lesion activity and response to IFN-beta in relapsing-remitting multiple sclerosis patients
    J Rio
    Unitat de Neuroimmunologia Clinica, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Mult Scler 14:479-84. 2008
    ....
  14. ncbi Polyregional and hemispheric syndromes: a study of these uncommon first attacks in a CIS cohort
    R Pelayo
    Department of Neurology, Unit of Clinical Neuroinmunology, Hospital Universitari Vall d Hebron, Universitat Autonoma UAB, Barcelona, Spain
    Mult Scler 13:731-6. 2007
    ..There are differences between several studies in the definition, and, therefore, the prevalence of these so-called atypical CIS. Consensus on the denomination and definition of these syndromes must be reached...
  15. doi Clinical features of CIS of the brainstem/cerebellum of the kind seen in MS
    Jaume Sastre-Garriga
    Unitat de Neuroimmunologia Clinica, MS Centre of Catalonia, Hospital Universitari Vall d Hebron, EUI 2a planta, Passeig de la Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Neurol 257:742-6. 2010
    ..Results indicate that diplopia, facial sensory symptoms and gait disturbance occur in more than 30% of patients with CISB. Facial sensory symptoms are less associated with conversion to CDMS...
  16. ncbi Very early scans for demonstrating dissemination in time in multiple sclerosis
    C Tur
    Clinical Neuroimmunology Unit, Vall d Hebron University Hospital, Barcelona, Spain
    Mult Scler 14:631-5. 2008
    ....
  17. ncbi Isolated demyelinating syndromes: comparison of CSF oligoclonal bands and different MR imaging criteria to predict conversion to CDMS
    M Tintore
    Unit of Clinical Neuroimmunology Department of Neurology, Vall d Hebron University Hospitals, Barcelona, Spain
    Mult Scler 7:359-63. 2001
    ..To evaluate and compare the capacity of oligoclonal bands (OB) and three sets of MR imaging criteria to predict the conversion of clinically isolated syndromes (CIS) to clinically definite multiple sclerosis (CDMS)...
  18. ncbi [Acute disseminated encephalomyelitis: study of factors involved in a possible development towards multiple sclerosis]
    C Tur
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron, Barcelona
    Neurologia 23:546-54. 2008
    ..Our work supports that also observed in recent publications: that both conversion to MS or presence of sequelae after an episode of ADEM are more frequent than traditionally considered...
  19. doi Induction of serum soluble tumor necrosis factor receptor II (sTNF-RII) and interleukin-1 receptor antagonist (IL-1ra) by interferon beta-1b in patients with progressive multiple sclerosis
    Manuel Comabella
    Unitat de Neuroimmunologia Clinica, Edif EUI 2a planta, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035, Barcelona, Spain
    J Neurol 255:1136-41. 2008
    ....
  20. doi Value of NMO-IgG determination at the time of presentation as CIS
    C Costa
    Unitat de Neuroimmunologia Clinica UNIC, Centre d Esclerosi Mu ltiple de Catalunya, Vall d Hebron Institut de Recerca, Barcelona, Spain
    Neurology 78:1608-11. 2012
    ..Despite the availability of diagnostic criteria, an overlap between neuromyelitis optica (NMO) and multiple sclerosis (MS) exists, particularly in the early stage of the disease...
  21. ncbi Fatigue in multiple sclerosis persists over time: a longitudinal study
    N Tellez
    2a planta EUI Unitat de Neuroimmunología, Clínica Hospital, Universitari Vall d Hebron Ps, Vall d Hebron 119 120, 08035, Barcelona, Spain
    J Neurol 253:1466-70. 2006
    ..The aim of our study was to investigate changes in fatigue in a large cohort of MS patients and to determine the relationship between changes in disability and depression with changes in fatigue severity...
  22. ncbi The basal ganglia: a substrate for fatigue in multiple sclerosis
    N Tellez
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035, Barcelona, Spain
    Neuroradiology 50:17-23. 2008
    ..We aimed to study the relationship between fatigue in MS and the presence of focal dysfunction in the basal ganglia and frontal white matter...
  23. ncbi Myelopathy in seronegative Sjögren syndrome and/or primary progressive multiple sclerosis
    I Pericot
    Unitat de Neuroimmunologia Clinica, Escola d enfermeria, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Mult Scler 9:256-9. 2003
    ..The relationship between multiple sclerosis (MS) and Sjögren syndrome (SS) is controversial. Nine patients, previously diagnosed with primary progressive MS (PPMS) and who fulfilled the diagnostic criteria for SS, are described...
  24. ncbi [The development of multiple sclerosis following an isolated episode of optic neuritis. Magnetic resonance study]
    J Rio
    Unitat d Esclerosi Múltiple, Hospital General Universitari Vall d Hebron, Barcelona
    Med Clin (Barc) 109:370-2. 1997
    ..The current study was designed to determine the prevalence of brain abnormalities on MRI and to asses the further development of MS after an isolated idiopathic ON in our population...
  25. ncbi Emotional state of patients with relapsing-remitting MS treated with interferon beta-1b
    C Borras
    Unit of Clinical Neuroimmunology, Hospital Vall d Hebron, Barcelona, Spain
    Neurology 52:1636-9. 1999
    ..Depression has been cited as a possible side effect of interferon beta-1b (IFNbeta-1b) therapy in patients with MS. This association remains unproven because of a lack of longitudinal studies...
  26. ncbi Similar pro- and anti-inflammatory cytokine production in the different clinical forms of multiple sclerosis
    I Duran
    Servei de Neurologia, Hospital Vall d Hebron, Barcelona, Spain
    Mult Scler 7:151-6. 2001
    ..We found a similar percentage of cytokines producing cells between healthy controls and the different clinical forms of multiple sclerosis patients...
  27. doi MRI criteria for MS in patients with clinically isolated syndromes
    X Montalban
    Unit of Clinical Neuroimmunology, EUI 2 P, Hospital Universitari Vall d Hebron, Paseig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Neurology 74:427-34. 2010
    ..New data that are now published were reviewed and discussed and together with a new proposal are integrated in this position paper...
  28. ncbi Does the Modified Fatigue Impact Scale offer a more comprehensive assessment of fatigue in MS?
    N Tellez
    Unitat de Neuroimmunologia Clinica, Edif EUI, Planta 2, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, 08035 Barcelona, Spain
    Mult Scler 11:198-202. 2005
    ..As a symptom of multiple sclerosis (MS), fatigue is difficult to manage because of its unknown etiology, the lack of efficacy of the drugs tested to date and the absence of consensus about which would be the ideal measure to assess fatigue...
  29. ncbi The immune response against herpesvirus is more prominent in the early stages of MS
    P Villoslada
    Neuroimmunology Unit, Hospital Vall d Hebron, Barcelona, Spain
    Neurology 60:1944-8. 2003
    ..To assess antibody levels against human herpesvirus type 6 (HHV-6), Epstein-Barr virus (EBV), and Chlamydia pneumoniae (CP) in serum from individuals in the early and late phase of MS...
  30. ncbi [Descriptive study of first visits in a multiple sclerosis specialised unit]
    J Sastre-Garriga
    Unidad de Neuroinmunología Clínica Hospital Vall d Hebron Barcelona Spain
    Neurologia 17:179-82. 2002
    ..Since information on multiple sclerosis prognosis is crucial, accurate diagnosis is one of their major roles...
  31. ncbi Decreased MMP-9 production in primary progressive multiple sclerosis patients
    J Sastre-Garriga
    Unitat de Neuroimmunologia Clinica, Hospital Vail d Hebron, Barcelona, Espanya
    Mult Scler 10:376-80. 2004
    ..However, data regarding primary progressive (PP) MS is scarce...
  32. ncbi [Neutralizing antibodies in patients with multiple sclerosis treated with interferon beta-1b]
    J Rio
    Unidad de Neuroinmunología Clínica, Hospital General Universitario Vall d Hebron, Barcelona
    Med Clin (Barc) 114:169-70. 2000
    ..Neutralising antibodies (NABs) against interferon beta have been described in one third of patients with multiple sclerosis treated with interferon beta. We have analysed the frequency of NABs and their clinical consequences...
  33. ncbi Conversion to multiple sclerosis after a clinically isolated syndrome of the brainstem: cranial magnetic resonance imaging, cerebrospinal fluid and neurophysiological findings
    J Sastre-Garriga
    Unitat de Neuroimmunologia Clinica, Hospital Vall d Hebron, Escola d Infermeria, Barcelona, Espana
    Mult Scler 9:39-43. 2003
    ..The aim of this study was to investigate conversion to MS in patients with CISB...
  34. ncbi [Intracranial involvement in neurosarcoidosis: a report of 4 cases as initial manifestation of the disease]
    M D Ortega
    Servicio de Neurologia, Departamento de Radiologia, Hospital General Universitari Vall d Hebron, Barcelona, Espana
    Rev Neurol 28:491-4. 1999
    ..Three patients started treatment with corticosteroids but one of them required adjuvant treatment with immunosuppressor. Cranial nerve palsy resolved spontaneously in the last patient...
  35. doi Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis
    E Canto
    Centre d esclerosi multiple de Catalunya, CEM Cat, Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Universitat Autonoma de Barcelona, Barcelona, Spain
    Mult Scler 18:983-90. 2012
    ..Chitinase 3-like 1 (CHI3L1) is upregulated in a wide variety of inflammatory conditions. Recent studies have pointed to a role of CHI3L1 in multiple sclerosis (MS) pathogenesis...
  36. doi Natalizumab for relapsing-remitting multiple sclerosis
    A Horga
    Centro de Esclerosis Múltiple de Cataluña, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Neurologia 26:357-68. 2011
    ..Natalizumab is a monoclonal antibody that inhibits leukocyte migration across the blood-brain barrier and has been approved for the treatment of relapsing-remitting multiple sclerosis...
  37. ncbi Expression of chemokine receptors in the different clinical forms of multiple sclerosis
    E M Martínez-Cáceres
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Mult Scler 8:390-5. 2002
    ..These results support that chemokines and their receptors are involved in the pathogenesis of MS However, a pattem of chemokine-chemokine receptor expression characteristic of each clinical form of the disease failed to be observed...
  38. ncbi Early MS treatment
    M Tintore
    Clinical Neuroimmunology Unit, Vall d Hebron University Hospital, 08035 Barcelona, Spain
    Int MS J 14:5-10. 2007
    ..While MRI can be used to determine who will benefit most from treatment, the use of other biological markers needs to be confirmed in different settings before they can be used in clinical practice...
  39. ncbi [Multiple sclerosis epidemiological situation update: pertinence and set-up of a population based registry of new cases in Catalonia]
    S Otero
    Servicio de Medicina Preventiva y Epidemiologia, Hospital General Universitari Vall d Hebron, Barcelona, Espana
    Rev Neurol 50:623-33. 2010
    ..The few prospective studies in our area together with the increase in the disease in other regions, justifies an epidemiological MS project in order to describe the incidence and temporal trends of MS...