Francisco J Tinahones

Summary

Affiliation: Hospital Universitario
Country: Spain

Publications

  1. ncbi Green tea reduces LDL oxidability and improves vascular function
    F J Tinahones
    Servicio de Endocrinologia, Hospital Clinico Virgen de la Victoria de Malaga, Spain
    J Am Coll Nutr 27:209-13. 2008
  2. ncbi Recovery of menstrual cycle after therapy for anorexia nervosa
    F J Tinahones
    Unidad de Trastornos del Comportamiento Alimentario, Servicio de Endocrinologia, Hospital Regional Carlos Haya, Malaga, Spain
    Eat Weight Disord 10:e52-5. 2005
  3. ncbi Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance
    F J Tinahones
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario Virgen de la Victoria, Málaga and CIBER Fisiopatología de la obesidad y nutrición CB06 03 Instituto de Salud Carlos III, Malaga, Spain
    Br J Nutr 99:44-8. 2008
  4. ncbi Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population
    Francisco J Tinahones
    Servicio de Endocrinologia y Nutricion, Carlos Haya Regional University Hospital, Malaga, Spain
    J Lipid Res 46:452-7. 2005
  5. doi PPARgamma expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese persons
    Eduardo Garcia-Fuentes
    Ciber Fisiopatologia Obesidad y Nutricion, Hospital Clinico Virgen de la Victoria, Malaga, Spain
    Obesity (Silver Spring) 18:952-8. 2010
  6. doi Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus
    Federico Soriguer
    Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
    Obes Surg 19:1574-80. 2009
  7. doi Continuous positive airway pressure therapy reduces oxidative stress markers and blood pressure in sleep apnea-hypopnea syndrome patients
    Mora Murri
    Laboratorio de Investigaciones Biomedicas, Fundacion IMABIS, Hospital Clinico Universitario Virgen de la Victoria, 29010, Malaga, Spain
    Biol Trace Elem Res 143:1289-301. 2011
  8. doi Oxidative stress in severely obese persons is greater in those with insulin resistance
    Francisco J Tinahones
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Virgen de la Victoria, Malaga, Spain
    Obesity (Silver Spring) 17:240-6. 2009
  9. doi Changes in the serum composition of free-fatty acids during an intravenous glucose tolerance test
    Federico Soriguer
    Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
    Obesity (Silver Spring) 17:10-5. 2009
  10. doi Changes in oxidative stress and insulin resistance in morbidly obese patients after bariatric surgery
    Mora Murri
    Servicio de Endocrinologia y Nutricion, Campus Teatinos s n, Hospital Clinico Universitario Virgen de la Victoria, 29010 Malaga, Spain
    Obes Surg 20:363-8. 2010

Collaborators

Detail Information

Publications48

  1. ncbi Green tea reduces LDL oxidability and improves vascular function
    F J Tinahones
    Servicio de Endocrinologia, Hospital Clinico Virgen de la Victoria de Malaga, Spain
    J Am Coll Nutr 27:209-13. 2008
    ..The aim of this study was to determine the short-to medium-term effect of a green tea extract on vascular function and lipid peroxidation as compared with placebo...
  2. ncbi Recovery of menstrual cycle after therapy for anorexia nervosa
    F J Tinahones
    Unidad de Trastornos del Comportamiento Alimentario, Servicio de Endocrinologia, Hospital Regional Carlos Haya, Malaga, Spain
    Eat Weight Disord 10:e52-5. 2005
    ..We therefore studied the variations in anthropometric variables in women with restrictive anorexia nervosa (AN) at the time they recovered their menstrual cycle...
  3. ncbi Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance
    F J Tinahones
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario Virgen de la Victoria, Málaga and CIBER Fisiopatología de la obesidad y nutrición CB06 03 Instituto de Salud Carlos III, Malaga, Spain
    Br J Nutr 99:44-8. 2008
    ..077). Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels...
  4. ncbi Influence of age and sex on levels of anti-oxidized LDL antibodies and anti-LDL immune complexes in the general population
    Francisco J Tinahones
    Servicio de Endocrinologia y Nutricion, Carlos Haya Regional University Hospital, Malaga, Spain
    J Lipid Res 46:452-7. 2005
    ..The higher prevalence of anti-oxidized LDL (MDA-LDL) antibodies in females and young persons is in agreement with studies that found an inverse association between atherosclerosis and the level of these antibodies...
  5. doi PPARgamma expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese persons
    Eduardo Garcia-Fuentes
    Ciber Fisiopatologia Obesidad y Nutricion, Hospital Clinico Virgen de la Victoria, Malaga, Spain
    Obesity (Silver Spring) 18:952-8. 2010
    ..733, P = 0.016). In conclusion, the decreased expression of PPARgamma in PBMC in morbidly obese persons after a high-fat meal was associated with the state of IR, the plasma SOD activity, and the changes in the concentration of FFA...
  6. doi Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus
    Federico Soriguer
    Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
    Obes Surg 19:1574-80. 2009
    ..We measured the changes in apelin levels in morbidly obese subjects, with and without diabetes, and in the inverse situation of improvement in carbohydrate metabolism as a result of bariatric surgery...
  7. doi Continuous positive airway pressure therapy reduces oxidative stress markers and blood pressure in sleep apnea-hypopnea syndrome patients
    Mora Murri
    Laboratorio de Investigaciones Biomedicas, Fundacion IMABIS, Hospital Clinico Universitario Virgen de la Victoria, 29010, Malaga, Spain
    Biol Trace Elem Res 143:1289-301. 2011
    ..Consequently, we believe that the decrease in oxidative stress after 1 month of CPAP treatment in these patients is not contributing much to IR genesis, though it could be related to the hypertension etiology...
  8. doi Oxidative stress in severely obese persons is greater in those with insulin resistance
    Francisco J Tinahones
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Virgen de la Victoria, Malaga, Spain
    Obesity (Silver Spring) 17:240-6. 2009
    ..However, we are unable to determine from this study whether there is first an increase in oxidative stress or in insulin resistance...
  9. doi Changes in the serum composition of free-fatty acids during an intravenous glucose tolerance test
    Federico Soriguer
    Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
    Obesity (Silver Spring) 17:10-5. 2009
    ..In conclusion, during an IVGTT, severely obese persons with IFG or T2DM experienced a lower fall in the FFA than the severely obese persons with NFG and the controls, becoming normal after bariatric surgery...
  10. doi Changes in oxidative stress and insulin resistance in morbidly obese patients after bariatric surgery
    Mora Murri
    Servicio de Endocrinologia y Nutricion, Campus Teatinos s n, Hospital Clinico Universitario Virgen de la Victoria, 29010 Malaga, Spain
    Obes Surg 20:363-8. 2010
    ....
  11. pmc Antioxidized LDL antibodies are associated with different metabolic pathways in patients with atherosclerotic plaque and type 2 diabetes
    M Rosa Bernal-Lopez
    Biomedical Research Laboratory, Endocrinology and Nutrition Department, Hospital Clinico Virgen de la Victoria, Malaga, Spain
    Diabetes Care 36:1006-11. 2013
    ....
  12. doi Postprandial hypertriglyceridemia predicts improvement in insulin resistance in obese patients after bariatric surgery
    Francisco J Tinahones
    Endocrinology and Nutrition Service, Hospital Virgen de la Victoria, Malaga, Spain
    Surg Obes Relat Dis 9:213-8. 2013
    ..However, it is unknown whether patients with postprandial HTG have a different clinical evolution after bariatric surgery. The setting of our study was a university hospital...
  13. doi Educational inequalities and cardiovascular risk factors. A cross-sectional population-based study in southern Spain
    José Miguel Morales-Asencio
    Faculty of Health Sciences, University of Malaga, Malaga, Spain
    Public Health Nurs 30:202-12. 2013
    ..To determine the prevalence and distribution of modifiable cardiovascular risk factors focused on educational level differences, in an adult population in Southern Spain...
  14. doi Effect of CPAP on oxidative stress and circulating progenitor cell levels in sleep patients with apnea-hypopnea syndrome
    Mora Murri
    Servicio de Hematologia, Hospital Clinico Universitario Virgen de la Victoria, Malaga, Spain
    Respir Care 56:1830-6. 2011
    ..The sleep apnea-hypopnea syndrome is associated with elevated oxidative stress, which is associated with reduced levels and functional impairment of progenitor cells...
  15. pmc Gut microbiota composition in male rat models under different nutritional status and physical activity and its association with serum leptin and ghrelin levels
    María Isabel Queipo-Ortuño
    Biomedical Research Laboratory, Virgen de la Victoria Hospital FIMABIS, Malaga, Spain
    PLoS ONE 8:e65465. 2013
    ..Several evidences indicate that gut microbiota is involved in the control of host energy metabolism...
  16. pmc Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study
    Mora Murri
    Biomedical Research Laboratory, Virgen de la Victoria Hospital FIMABIS, Campus de Teatinos s n, Malaga, 29010, Spain
    BMC Med 11:46. 2013
    ....
  17. pmc FABP4 dynamics in obesity: discrepancies in adipose tissue and liver expression regarding circulating plasma levels
    María Isabel Queipo-Ortuño
    Laboratorio de Investigaciones Biomédicas del Hospital Virgen de la Victoria Fundación IMABIS, Malaga, Spain
    PLoS ONE 7:e48605. 2012
    ..FABP4 is predominantly expressed in adipose tissue, and its circulating levels are linked with obesity and a poor atherogenic profile...
  18. doi The retinoic acid receptor-related orphan nuclear receptor γ1 (RORγ1): a novel player determinant of insulin sensitivity in morbid obesity
    Francisco J Tinahones
    Laboratorio de Investigación Biomédica, Servicio de Endocrinologia Nutricion, Hospital Virgen de la Victoria Fundacion IMABIS, Malaga, Spain
    Obesity (Silver Spring) 20:488-97. 2012
    ..Measurement of RORγ1 and PPARγ2 in adipose tissue might be useful for evaluating the outcomes of various clinical interventions for obesity-related diabetes type II...
  19. ncbi The obese healthy paradox: is inflammation the answer?
    Nuria Barbarroja
    Hospital Virgen de la Victoria, Malaga, CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Biochem J 430:141-9. 2010
    ....
  20. ncbi Prevalence of metabolically discordant phenotypes in a mediterranean population-The IMAP study
    Ricardo Gómez-Huelgas
    Internal Medicine Department, Carlos Haya Hospital, Malaga, Spain CIBER Fisiopatologia de la Obesidad y la Nutricion CB06 003, Malaga, Spain
    Endocr Pract 19:758-68. 2013
    ..To study the prevalence and correlates of body size phenotypes in an adult Spanish population...
  21. ncbi The -1131T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: a postprandial study
    Fernando Cardona
    Servicio de Endocrinologia y Nutricion, Hospital Virgen de la Victoria, Malaga, Malaga, Spain
    Atherosclerosis 206:148-52. 2009
    ..We hypothesised that variability in the promoter of the APOA5 gene may affect the individual response to fibrate therapy, in both the fasting and postprandial states...
  22. doi Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers
    María Isabel Queipo-Ortuño
    Laboratorio de Investigaciones Biomédicas del Hospital Virgen de la Victoria, Malaga, Spain
    Am J Clin Nutr 95:1323-34. 2012
    ..Few studies have investigated the effect of dietary polyphenols on the complex human gut microbiota, and they focused mainly on single polyphenol molecules and select bacterial populations...
  23. pmc Improved carbohydrate metabolism after bariatric surgery raises antioxidized LDL antibody levels in morbidly obese patients
    Lourdes Garrido-Sanchez
    CIBER Fisiopatologia de la Obesidad y Nutricion CB06 03, ISCIII, Malaga, Spain
    Diabetes Care 31:2258-64. 2008
    ..We measured the changes in anti-oxLDL antibody levels in the inverse situation of improvement in carbohydrate metabolism...
  24. doi Particular characteristics of the metabolic syndrome in patients with morbid obesity
    Francisco J Tinahones
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario Virgen de la Victoria, Malaga, Spain
    Endocrinol Nutr 60:127-35. 2013
    ..Criteria for the diagnosis of the metabolic syndrome are currently being reconsidered, as their usefulness is not the same for all phenotypes in relation to the risk of cardiovascular disease...
  25. doi Metabolic syndrome and vascular risk estimation in a Mediterranean non-diabetic population without cardiovascular disease
    Sergio Jansen-Chaparro
    Internal Medicine Department, Hospital Regional Universitario Carlos Haya, Malaga, Spain
    Eur J Intern Med 23:558-63. 2012
    ..Our aim was to compare the REGICOR and SCORE equations in a general population and in persons with the metabolic syndrome (MS) according to the criteria of the International Diabetes Federation...
  26. doi Oxidative stress and metabolic changes after continuous positive airway pressure treatment according to previous metabolic disorders in sleep apnea-hypopnea syndrome patients
    Mora Murri
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario Virgen de la Victoria, Malaga, Spain
    Transl Res 154:111-21. 2009
    ..Moreover, the blood pressure decreased after CPAP treatment, particularly in the obese, nondyslipidemic, and hypertensive patients. No significant change in IR was found in any of the SAHS patients after CPAP treatment...
  27. doi Benefits of polyphenols on gut microbiota and implications in human health
    Fernando Cardona
    Laboratorio de Investigaciones Biomédicas del Hospital Virgen de la Victoria FIMABIS, Malaga, Spain
    J Nutr Biochem 24:1415-22. 2013
    ..This review focuses on the reciprocal interactions between the gut microbiota and polyphenols, the mechanisms of action and the consequences of these interactions on human health. ..
  28. ncbi Response to a urate-lowering diet according to polymorphisms in the apolipoprotein AI-CIII-AIV cluster
    Fernando Cardona
    Endocrinology and Nutrition Service, Hospital Civil, Carlos Haya University Hospital, Malaga, Spain
    J Rheumatol 32:903-5. 2005
    ..We assessed the influence of polymorphisms in the apolipoprotein AI-CIII-AIV cluster on the response to a urate-lowering diet in patients with hyperuricemia...
  29. doi Decrease in FASN expression in adipose tissue of hypertensive individuals
    María D Mayas
    Servicio de Endocrinologia y Nutricion, Hospital Clínico Universitario Virgen de Victoria de Málaga y CIBEROBN CB06 03 010, Instituto de Salud Carlos III, Madrid, Spain
    Am J Hypertens 22:1258-62. 2009
    ..Due to the fact that there is no literature that relates FASN and ACC expression with hypertension, we investigate how FASN and ACC expression in adipose tissue is related to hypertension...
  30. ncbi GLP-1 and peptide YY secretory response after fat load is impaired by insulin resistance, impaired fasting glucose and type 2 diabetes in morbidly obese subjects
    José C Fernández-García
    Department of Endocrinology, Virgen de la Victoria University Hospital, Malaga, Spain Research Laboratory, Virgen de la Victoria University Hospital, Malaga, Spain Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition CIBERObn CB06 003, Instituto de Salud Carlos III, Madrid, Spain
    Clin Endocrinol (Oxf) 80:671-6. 2014
    ..Thus, we evaluated GLP-1 and PYY response after fat load in morbidly obese patients with different degrees of insulin resistance and glycemic status...
  31. ncbi Seasonal variability of glycated hemoglobin in a diabetic population from southern Europe
    Ricardo Gómez-Huelgas
    Internal Medicine Department, Hospital Regional Universitario Carlos Haya, Malaga, Spain Ciber Fisiopatología de la Obesidad y Nutrición CB06 003 Instituto de Salud Carlos III, Madrid, Spain
    J Diabetes Complications 27:618-20. 2013
    ..To analyze the seasonal variations in A1c levels among a southern European diabetic population...
  32. pmc Hemoglobin A1c versus oral glucose tolerance test in postpartum diabetes screening
    María Jose Picon
    Departament of Endocrinology, Virgen de la Victoria University Hospital, Malaga, Spain
    Diabetes Care 35:1648-53. 2012
    ....
  33. ncbi Why not use the HbA1c as a criterion of dysglycemia in the new definition of the metabolic syndrome? Impact of the new criteria in the prevalence of the metabolic syndrome in a Mediterranean urban population from Southern Europe (IMAP study. Multidiscipli
    M Rosa Bernal-Lopez
    Biomedical Research Laboratory, Endocrinology Department, Hospital Virgen de la Victoria, Malaga, Spain
    Diabetes Res Clin Pract 93:e57-60. 2011
    ..We studied 2006 adults without cardiovascular disease or diabetes. The use of the new criteria and the HbA1c resulted in an increase in the population prevalence of MS...
  34. ncbi Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome
    Fernando Cardona
    Servicio de Endocrinología y Nutrición Hospital Clínico Virgen de la Victoria de Málaga, Malaga, Spain
    Clin Chem 52:1920-5. 2006
    ..Variations in these genes may affect postprandial hypertriglyceridemia in the context of the metabolic syndrome...
  35. ncbi Increased levels of anti-oxidized low-density lipoprotein antibodies are associated with reduced levels of cholesterol in the general population
    F J Tinahones
    Metabolic Unit, Endocrinology Service, Carlos Haya Regional Hospital, Malaga, Spain
    Metabolism 51:429-31. 2002
    ....
  36. doi Anti-oxidized low-density lipoprotein antibody levels are associated with the development of type 2 diabetes mellitus
    L Garrido-Sanchez
    Endocrinology and Nutrition Service, Virgen de la Victoria Clinical Hospital, Malaga, Spain
    Eur J Clin Invest 38:615-21. 2008
    ..We undertook a prospective study to determine the predictive capacity of anti-oxidized LDL antibodies for the onset of type 2 diabetes mellitus (T2DM)...
  37. pmc Alterations of specific biomarkers of metabolic pathways in vascular tree from patients with Type 2 diabetes
    Bernal Lopez M Rosa
    Biomedical Research Laboratory, Endocrinology Department, Hospital Virgen de la Victoria, Malaga, Spain
    Cardiovasc Diabetol 11:86. 2012
    ..However, the effect of glycemic control on pro-atherosclerotic gene expression was very low in arteries with established atherosclerosis...
  38. doi Obesity short-circuits stemness gene network in human adipose multipotent stem cells
    Mar Roldan
    Fundacion Instituto Mediterráneo para el Avance de la Biotecnología y la Investigación Sanitaria IMABIS, Malaga, Spain
    FASEB J 25:4111-26. 2011
    ..Altogether, our data show that obesity causes a general short circuit in the stemness gene network of hO-MSCs...
  39. doi Modulation of human monocyte CD36 by type 2 diabetes mellitus and other atherosclerotic risk factors
    Rosa M Bernal-Lopez
    Endocrinology Department, Biomedical Research Laboratory, Hospital Virgen de la Victoria, Malaga, Spain
    Eur J Clin Invest 41:854-62. 2011
    ....
  40. ncbi Thin healthy women have a similar low bone mass to women with anorexia nervosa
    D Fernàndez-Garcia
    Servicio de Endocrinologia y Nutricion, Hospital Virgen de la Victoria, Malaga, Spain
    Br J Nutr 102:709-14. 2009
    ..57; P = 0.04). We concluded that patients with AN had similar BMD to healthy thin women. Anthropometric parameters could contribute more significantly than oestrogen deficiency in the achievement of peak bone mass in AN patients...
  41. ncbi Assessment of cellular and plasma oxidative stress in SAHS patients before and after continuous positive airway pressure treatment
    M Murri
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario Virgen de la Victoria, 29010 Malaga, Spain
    Clin Lab 56:397-406. 2010
    ..The purpose of this study was to find out if both, cellular or plasma oxidative stress evaluations, are good estimators to assess oxidative stress in SAHS patients before and after one month's CPAP treatment...
  42. ncbi PPARgamma2 protects against obesity by means of a mechanism that mediates insulin resistance
    M Macias-Gonzalez
    CIBER Fisiopatología Obesidad y Nutrición CB06 03, ISC III, Malaga, Spain
    Eur J Clin Invest 39:972-9. 2009
    ..We investigated whether the PPARgamma2 mRNA expression levels are associated with IR in morbid obesity in adipose and muscle tissues...
  43. doi Similar increase in oxidative stress after fat overload in persons with baseline hypertriglyceridemia with or without the metabolic syndrome
    F Cardona
    Servicio de Endocrinologia y Nutricion, Hospital Clínico Universitario Virgen de Victoria, 29009 Malaga and CIBER Fisiopatología Obesidad y Nutrición CB06 03 Instituto de Salud Carlos III, Spain
    Clin Biochem 41:701-5. 2008
    ..We compared the levels of biomarkers of oxidative stress before and after a fat overload in three groups...
  44. ncbi The apolipoprotein E genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndrome
    F Cardona
    Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, 29009 Malaga, Spain
    J Clin Endocrinol Metab 90:2972-5. 2005
    ..5 (confidence interval, 1.04-39.31; P = 0.02). This study shows that patients with the metabolic syndrome who do not have the E3/3 genotype have a greater risk of hyperuricemia and postprandial hypertriglyceridemia after a fat overload...
  45. ncbi Prevalence of obesity in south-east Spain and its relation with social and health factors
    F Soriguer
    Endocrinology and Nutrition Service, Hospital Universitario Carlos Haya, Malaga, Spain
    Eur J Epidemiol 19:33-40. 2004
    ..An increased level of general education in the population may well contribute decisively to a reduction in the prevalence of obesity...
  46. ncbi Association of biological markers of activity of systemic lupus erythematosus with levels of anti-oxidized low-density lipoprotein antibodies
    J M Gomez-Zumaquero
    Endocrinology and Nutrition Service, Carlos Haya University Hospital, Malaga, Spain
    Rheumatology (Oxford) 43:510-3. 2004
    ....
  47. ncbi Dietary palmitic acid influences LDL-mediated lymphocyte proliferation differently to other mono- and polyunsaturated fatty acids in rats
    F J Tinahones
    Endocrinology and Nutrition Service, Carlos Haya Hospital Complex, Malaga, Spain
    Diabetes Nutr Metab 17:250-8. 2004
    ....
  48. ncbi PPARgamma mRNA expression is reduced in peripheral blood mononuclear cells after fat overload in patients with metabolic syndrome
    Manuel Macias-Gonzalez
    CIBER Fisiopatologia de la Obesidad y Nutricion, CB06 03, Instituto de Salud Carlos III, Madrid 28029, Spain
    J Nutr 138:903-7. 2008
    ..These data provide evidence that the Ala12 sequence variant is associated with a worse metabolic profile than Pro12. This is related to differences in the expression of PPARgamma and to oxidative imbalance after fat overload...