Francesc Sole

Summary

Affiliation: Hospital del Mar
Country: Spain

Publications

  1. ncbi request reprint Identification of novel cytogenetic markers with prognostic significance in a series of 968 patients with primary myelodysplastic syndromes
    Francesc Sole
    Laboratori de Citogenètica i Biologia Molecular, Hospital del Mar IMAS, 08003 Barcelona, Spain
    Haematologica 90:1168-78. 2005
  2. pmc Polysomy of chromosome 17 in breast cancer tumors showing an overexpression of ERBB2: a study of 175 cases using fluorescence in situ hybridization and immunohistochemistry
    Marta Salido
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Breast Cancer Res 7:R267-73. 2005
  3. ncbi request reprint The MYC oncogene in breast cancer progression: from benign epithelium to invasive carcinoma
    Cristina Corzo
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, URTTS, PRBB, Pg Maritim 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 165:151-6. 2006
  4. doi request reprint Blast cells with nuclear extrusions in the form of micronuclei are associated with MYC amplification in acute myeloid leukemia
    Olaya Villa
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia Hospital del Mar, URNHE, URTTS, PRBB IMIM, Pg Maritim 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 185:32-6. 2008
  5. ncbi request reprint Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma
    Marta Salido
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Universitat Autonoma de Barcelona, Passeig Maritim 25 29, Barcelona 08003, Spain
    Cancer Genet Cytogenet 163:160-3. 2005
  6. ncbi request reprint Gain of multiple copies of the CBFB gene: a new genetic aberration in a case of granulocytic sarcoma
    Mar Mallo
    Laboratory of Cytogenetics and Molecular Biology and Laboratory of Hematological Cytology URNHE IMAS IMIM and URTTS IMAS IMIM, Pathology Service, Hospital del Mar, Passeig Maritim, 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 179:62-5. 2007
  7. ncbi request reprint Is fluorescence in situ hybridization a useful method in diagnosis of polycythemia vera patients?
    Lurdes Zamora
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, Barcelona 08003, Spain
    Cancer Genet Cytogenet 151:139-45. 2004
  8. ncbi request reprint Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemia
    Elisabet Lloveras
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Passeig Maritim 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 148:71-6. 2004
  9. ncbi request reprint Comparative genomic hybridization analysis of cutaneous large B-cell lymphomas
    Sonia Giménez
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Unitat de Recerca en Neoplàsies Hematològiques, PRBB, Barcelona, Spain
    Exp Dermatol 14:883-90. 2005
  10. ncbi request reprint Comparative analysis of TCR-gamma gene rearrangements by Genescan and polyacrylamide gel-electrophoresis in cutaneous T-cell lymphoma
    Carlota Costa
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Acta Derm Venereol 84:6-11. 2004

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Identification of novel cytogenetic markers with prognostic significance in a series of 968 patients with primary myelodysplastic syndromes
    Francesc Sole
    Laboratori de Citogenètica i Biologia Molecular, Hospital del Mar IMAS, 08003 Barcelona, Spain
    Haematologica 90:1168-78. 2005
    ..The main aim of the present study was to identify chromosomal abnormalities with a previously unrecognized good or poor prognosis in order to find new cytogenetic markers with predictive value...
  2. pmc Polysomy of chromosome 17 in breast cancer tumors showing an overexpression of ERBB2: a study of 175 cases using fluorescence in situ hybridization and immunohistochemistry
    Marta Salido
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Breast Cancer Res 7:R267-73. 2005
    ....
  3. ncbi request reprint The MYC oncogene in breast cancer progression: from benign epithelium to invasive carcinoma
    Cristina Corzo
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, URTTS, PRBB, Pg Maritim 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 165:151-6. 2006
    ..The presence of MYC amplification only in invasive cells suggests that the finding of MYC amplification could reflect an advanced tumor progression...
  4. doi request reprint Blast cells with nuclear extrusions in the form of micronuclei are associated with MYC amplification in acute myeloid leukemia
    Olaya Villa
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia Hospital del Mar, URNHE, URTTS, PRBB IMIM, Pg Maritim 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 185:32-6. 2008
    ..The appearance of chromatin extrusion in cytological analysis should draw attention of the presence of dmin aggregation and possible MYC amplification...
  5. ncbi request reprint Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma
    Marta Salido
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Universitat Autonoma de Barcelona, Passeig Maritim 25 29, Barcelona 08003, Spain
    Cancer Genet Cytogenet 163:160-3. 2005
    ..FISH techniques on paraffin tissue sections may help to identify genetic aberrations such as CCND1 rearrangement in order to establish a diagnosis of oncocytoma...
  6. ncbi request reprint Gain of multiple copies of the CBFB gene: a new genetic aberration in a case of granulocytic sarcoma
    Mar Mallo
    Laboratory of Cytogenetics and Molecular Biology and Laboratory of Hematological Cytology URNHE IMAS IMIM and URTTS IMAS IMIM, Pathology Service, Hospital del Mar, Passeig Maritim, 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 179:62-5. 2007
    ..To our knowledge, no cases with this rare genetic anomaly have been previously described...
  7. ncbi request reprint Is fluorescence in situ hybridization a useful method in diagnosis of polycythemia vera patients?
    Lurdes Zamora
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, Barcelona 08003, Spain
    Cancer Genet Cytogenet 151:139-45. 2004
    ..3%. We conclude that, probably, the application of FISH with the mentioned probes, is not very useful to detect cytogenetic aberrations in untreated PV patients...
  8. ncbi request reprint Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemia
    Elisabet Lloveras
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Passeig Maritim 25 29, 08003 Barcelona, Spain
    Cancer Genet Cytogenet 148:71-6. 2004
    ..Although these results do not confirm our previous hypothesis, further observations of this group of patients (with monosomy 18) regarding malignant transformation is warranted...
  9. ncbi request reprint Comparative genomic hybridization analysis of cutaneous large B-cell lymphomas
    Sonia Giménez
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Unitat de Recerca en Neoplàsies Hematològiques, PRBB, Barcelona, Spain
    Exp Dermatol 14:883-90. 2005
    ..Our study seems to confirm clear-cut differences between primary cutaneous LBCL and nodal diffuse LBCL, and it suggests the presence of genotypic differences between cases of PCLBCL leg type and cases of PCFCL...
  10. ncbi request reprint Comparative analysis of TCR-gamma gene rearrangements by Genescan and polyacrylamide gel-electrophoresis in cutaneous T-cell lymphoma
    Carlota Costa
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Acta Derm Venereol 84:6-11. 2004
    ..On sequencing the PCR products we demonstrated non-clonality of these five samples. Our results confirm that PCR-Genescan is a useful, reliable and specific screening method for detecting dominant clones in patients with T-cell lymphoma...
  11. ncbi request reprint Genetic characterization of Sézary's syndrome by conventional cytogenetics and cross-species color banding fluorescent in situhybridization
    Blanca Espinet
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, E 08003 Barcelona, Spain
    Haematologica 89:165-73. 2004
    ..Cytogenetic studies are scarce. This study was designed to increase cytogenetic information on this disorder...
  12. ncbi request reprint Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia
    Eulàlia Puigdecanet
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
    Cancer Genet Cytogenet 167:39-42. 2006
    ..Our results suggest a lack of structural and numerical rearrangements (deletions, translocations, or amplifications) of PRV-1, TPO, and c-MPL genes in ET patients...
  13. ncbi request reprint Study of chromosomal abnormalities in 11 cases of cervical dysplasia using comparative genomic hybridization on cotton-lint cervical samples
    Carlota Costa
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
    Cancer Genet Cytogenet 164:61-5. 2006
    ..In the laboratory, the manipulation of this type of sample obtained by a noninvasive system is much simpler, easier, and faster than the obtained with a conventional biopsy...
  14. ncbi request reprint Monosomy 15 in chronic myelomonocytic leukemia. description of a case and review of the literature
    Lourdes Zamora
    Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Hospital del Mar, Pg Marítim, 25 29, 08003, Barcelona, Spain
    Cancer Genet Cytogenet 134:165-7. 2002
    ..On the other hand, monosomy 15 in complex karyotypes is a frequent chromosome aberration in myelodysplastic syndromes, particularly in refractory anemia with excess of blasts...
  15. ncbi request reprint Characterization of HER1 (c-erbB1) status in locally advanced breast cancer using fluorescence in situ hybridization and immunohistochemistry
    Cristina Corzo
    Laboratori de Citogenètica i Biologia Molecular, Unitat de Recerca Traslacional en Tumors Sólids, Hospital del Mar, IMAS, Barcelona, Spain
    Tumour Biol 26:25-30. 2005
    ..Only 2 cases presented EGFR expression. LABC presented a low level of EGFR expression. HER1 amplification was not present in LABC, although the polysomy of chromosome 7 was a common finding...
  16. ncbi request reprint Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family
    Blanca Espinet
    Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Cancer Genet Cytogenet 143:172-3. 2003
    ....
  17. doi request reprint 3q26 (hTERC) gain studied by fluorescence in situ hybridization as a persistence-progression indicator in low-grade squamous intraepithelial lesion cases
    Francesc Alameda
    Department of Pathology and Laboratory of Molecular Cytogenetics, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
    Hum Pathol 40:1474-8. 2009
    ....
  18. ncbi request reprint FISH is better than BIOMED-2 PCR to detect IgH/BCL2 translocation in follicular lymphoma at diagnosis using paraffin-embedded tissue sections
    Blanca Espinet
    Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Hospital del Mar, IMAS, URNHE, PRBB, Escola de Citologia Hematològica Soledad Woessner IMAS, Barcelona, Spain
    Leuk Res 32:737-42. 2008
    ..In 4% of cases, the IgH/BCL2 translocation was not detected by any of the two techniques tested. Our results show that FISH represents the best technique to detect t(14;18) at diagnosis...
  19. ncbi request reprint Analysis of gene status in cervical dysplastic lesions and squamous cell carcinoma using tissue microarrays
    Carlota Costa
    Pathology Department, Cytogenetic and Molecular Biology Laboratory, Citology Section, Mar Hospital, IMAS, Barcelona, Spain
    Histol Histopathol 24:821-9. 2009
    ..With regards to proteins, the expression of MYC and CCND1 in the initial stages of the illness would help in the acquisition of the altered cellular phenotype...
  20. doi request reprint Cytogenetic characterization of NCI-H69 and NCI-H69AR small cell lung cancer cell lines by spectral karyotyping
    Marta Salido
    Pathology Department, Molecular Cytogenetic Laboratory, IMAS, GRETNHE Escola de Citologia Hematologica S Woessner IMAS, Barcelona, Spain
    Cancer Genet Cytogenet 191:97-101. 2009
    ..In conclusion, SKY provides a useful complementary technique to routine cytogenetics for the accurate characterization of SCLC cell lines and could provide some relevant information concerning regions involved in chemoresistance...
  21. ncbi request reprint New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)
    Cristina Baro
    Department Biologia Animal, Vegetal i Ecologia, Unitat d Antropologia Biològica, Facultat de Biociencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Leuk Res 32:727-36. 2008
    ..Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected...
  22. ncbi request reprint Does polysomy of chromosome 17 have a role in ERBB2 and topoisomerase IIalpha expression? Gene, mRNA and protein expression: a comprehensive analysis
    Cristina Corzo
    Servei d Oncologia Medica, Hospital del Mar, IMAS, Barcelona, Spain
    Tumour Biol 28:221-8. 2007
    ..The aim of the present study was to clarify the implication of polysomy 17 in ERBB2 and topoisomerase IIalpha expression. In addition, we assessed the relation of ERBB2 and topoisomerase IIalpha gene dosage to mRNA and protein levels...
  23. ncbi request reprint Gastrointestinal involvement in mantle cell lymphoma: a prospective clinic, endoscopic, and pathologic study
    Antonio Salar
    Department of Clinical Hematology, Hospital del Mar, Barcelona, Spain
    Am J Surg Pathol 30:1274-80. 2006
    ..IHC for cyclin D1 was significantly more sensitive than FISH t(11;14) or PCR for immunoglobulin heavy chain gene to confirm MCL in this setting...
  24. ncbi request reprint Aberrant nuclear BCL10 expression and lack of t(11;18)(q21;q21) in primary cutaneous marginal zone B-cell lymphoma
    Fernando Gallardo
    Department of Dermatology, Hospital del Mar, IMAS, Barcelona, Spain Catalonian Cutaneous Lymphoma Network, Barcelona, Spain
    Hum Pathol 37:867-73. 2006
    ..t(11;18)(q21;q21), strongly linked to extracutaneous MALT lymphomas, does not seem to play a role in PCMZL. The participation of other MALT1 gene translocations in PCMZL pathogenesis seems also unlikely...
  25. ncbi request reprint Pentasomy 21 with two isochromosomes 21 in a case of acute myeloid leukemia without maturation
    Marta Salido
    Laboratori de Citologia Hematologica, Escola de Citologia Hematològica S Woessner IMAS, Hospital del Mar, IMAS, IMIM, Barcelona, Spain
    Cancer Genet Cytogenet 132:71-3. 2002
    ..To our knowledge, this is the first report of pentasomy 21q in AML without Down syndrome...
  26. ncbi request reprint Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma?
    Blanca Espinet
    Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Laboratori de Citologia Hematologica, Laboratori de Patologia, Hospital del Mar, IMAS, URNHE, PRBB, Barcelona 08003, Spain
    Hum Pathol 36:1232-7. 2005
    ..The existence of such asymptomatic patients with an indolent clinical course should induce a strict clinical judgment in terms of therapeutic decisions...
  27. ncbi request reprint Correlation between histologic findings and cytogenetic abnormalities in bladder carcinoma: a FISH study
    Jose Placer
    Department of Urology, Laboratory of Cytogenetics and Molecular Biology, Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain
    Urology 65:913-8. 2005
    ..To investigate the chromosomal abnormalities present in bladder carcinoma using a fluorescence in situ hybridization assay and to correlate the genetic findings with the pathologic grade and stage...
  28. ncbi request reprint Lymphomatoid papulosis associated with mycosis fungoides: clinicopathological and molecular studies of 12 cases
    Fernando Gallardo
    Department of Dermatology and Pathology, Hospital del Mar, IMAS, Barcelona, Spain
    Acta Derm Venereol 84:463-8. 2004
    ..Our results also seem to confirm that the association of mycosis fungoides with a primary cutaneous CD30+ lymphoproliferative disorder usually carries a favourable prognosis...
  29. doi request reprint Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma
    Blanca Espinet
    Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Servei d Hematologia Clinica, GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
    Genes Chromosomes Cancer 49:439-51. 2010
    ..Additionally, we observed that 3q gains and 17p losses detected by conventional cytogenetics are proliferation-independent prognostic markers indicating poor outcome...
  30. ncbi request reprint Clinical utility of a multiprobe FISH assay in voided urine specimens for the detection of bladder cancer and its recurrences, compared with urinary cytology
    Jose Placer
    Department of Urology, Hospital del Mar, IMAS, Passeig Maritim 25 29, 08003 Barcelona, Spain
    Eur Urol 42:547-52. 2002
    ....
  31. ncbi request reprint Genetic characterization of the paraimmunoblastic variant of small lymphocytic lymphoma/chronic lymphocytic leukemia: A case report and review of the literature
    Blanca Espinet
    Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Escola de Citologia Hematològica Soledad Woessner IMAS, Barcelona, Spain
    Hum Pathol 33:1145-8. 2002
    ..A literature review shows only 20 previously reported cases, 6 of which involve genetic studies...
  32. ncbi request reprint A new case of acute nonlymphocytic leukemia (French-American-British subtype M1) with double minutes and c-MYC amplification
    Natalia Rodon
    Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
    Cancer Genet Cytogenet 132:161-4. 2002
    ..A review of dmins in ANLL is presented...