Research Topics
Genomes and GenesSpecies | Francesc SoleSummaryAffiliation: Hospital del Mar Country: Spain Publications
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Detail Information
Publications
Identification of novel cytogenetic markers with prognostic significance in a series of 968 patients with primary myelodysplastic syndromesFrancesc Sole
Laboratori de Citogenètica i Biologia Molecular, Hospital del Mar IMAS, 08003 Barcelona, Spain
Haematologica 90:1168-78. 2005..The main aim of the present study was to identify chromosomal abnormalities with a previously unrecognized good or poor prognosis in order to find new cytogenetic markers with predictive value...
Polysomy of chromosome 17 in breast cancer tumors showing an overexpression of ERBB2: a study of 175 cases using fluorescence in situ hybridization and immunohistochemistryMarta Salido
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Breast Cancer Res 7:R267-73. 2005....- The MYC oncogene in breast cancer progression: from benign epithelium to invasive carcinomaCristina Corzo
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, URTTS, PRBB, Pg Maritim 25 29, 08003 Barcelona, Spain
Cancer Genet Cytogenet 165:151-6. 2006..The presence of MYC amplification only in invasive cells suggests that the finding of MYC amplification could reflect an advanced tumor progression... 
Blast cells with nuclear extrusions in the form of micronuclei are associated with MYC amplification in acute myeloid leukemiaOlaya Villa
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia Hospital del Mar, URNHE, URTTS, PRBB IMIM, Pg Maritim 25 29, 08003 Barcelona, Spain
Cancer Genet Cytogenet 185:32-6. 2008..The appearance of chromatin extrusion in cytological analysis should draw attention of the presence of dmin aggregation and possible MYC amplification...- Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinomaMarta Salido
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Universitat Autonoma de Barcelona, Passeig Maritim 25 29, Barcelona 08003, Spain
Cancer Genet Cytogenet 163:160-3. 2005..FISH techniques on paraffin tissue sections may help to identify genetic aberrations such as CCND1 rearrangement in order to establish a diagnosis of oncocytoma... - Gain of multiple copies of the CBFB gene: a new genetic aberration in a case of granulocytic sarcomaMar Mallo
Laboratory of Cytogenetics and Molecular Biology and Laboratory of Hematological Cytology URNHE IMAS IMIM and URTTS IMAS IMIM, Pathology Service, Hospital del Mar, Passeig Maritim, 25 29, 08003 Barcelona, Spain
Cancer Genet Cytogenet 179:62-5. 2007..To our knowledge, no cases with this rare genetic anomaly have been previously described... - Is fluorescence in situ hybridization a useful method in diagnosis of polycythemia vera patients?Lurdes Zamora
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, Barcelona 08003, Spain
Cancer Genet Cytogenet 151:139-45. 2004..3%. We conclude that, probably, the application of FISH with the mentioned probes, is not very useful to detect cytogenetic aberrations in untreated PV patients... - Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemiaElisabet Lloveras
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Passeig Maritim 25 29, 08003 Barcelona, Spain
Cancer Genet Cytogenet 148:71-6. 2004..Although these results do not confirm our previous hypothesis, further observations of this group of patients (with monosomy 18) regarding malignant transformation is warranted... - Comparative genomic hybridization analysis of cutaneous large B-cell lymphomasSonia Giménez
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar IMAS, Unitat de Recerca en Neoplàsies Hematològiques, PRBB, Barcelona, Spain
Exp Dermatol 14:883-90. 2005..Our study seems to confirm clear-cut differences between primary cutaneous LBCL and nodal diffuse LBCL, and it suggests the presence of genotypic differences between cases of PCLBCL leg type and cases of PCFCL... - Comparative analysis of TCR-gamma gene rearrangements by Genescan and polyacrylamide gel-electrophoresis in cutaneous T-cell lymphomaCarlota Costa
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Acta Derm Venereol 84:6-11. 2004..On sequencing the PCR products we demonstrated non-clonality of these five samples. Our results confirm that PCR-Genescan is a useful, reliable and specific screening method for detecting dominant clones in patients with T-cell lymphoma... - Genetic characterization of Sézary's syndrome by conventional cytogenetics and cross-species color banding fluorescent in situhybridizationBlanca Espinet
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Passeig Maritim 25 29, E 08003 Barcelona, Spain
Haematologica 89:165-73. 2004..Cytogenetic studies are scarce. This study was designed to increase cytogenetic information on this disorder... - Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemiaEulàlia Puigdecanet
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
Cancer Genet Cytogenet 167:39-42. 2006..Our results suggest a lack of structural and numerical rearrangements (deletions, translocations, or amplifications) of PRV-1, TPO, and c-MPL genes in ET patients... - Study of chromosomal abnormalities in 11 cases of cervical dysplasia using comparative genomic hybridization on cotton-lint cervical samplesCarlota Costa
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain
Cancer Genet Cytogenet 164:61-5. 2006..In the laboratory, the manipulation of this type of sample obtained by a noninvasive system is much simpler, easier, and faster than the obtained with a conventional biopsy... - Monosomy 15 in chronic myelomonocytic leukemia. description of a case and review of the literatureLourdes Zamora
Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Hospital del Mar, Pg Marítim, 25 29, 08003, Barcelona, Spain
Cancer Genet Cytogenet 134:165-7. 2002..On the other hand, monosomy 15 in complex karyotypes is a frequent chromosome aberration in myelodysplastic syndromes, particularly in refractory anemia with excess of blasts... - Characterization of HER1 (c-erbB1) status in locally advanced breast cancer using fluorescence in situ hybridization and immunohistochemistryCristina Corzo
Laboratori de Citogenètica i Biologia Molecular, Unitat de Recerca Traslacional en Tumors Sólids, Hospital del Mar, IMAS, Barcelona, Spain
Tumour Biol 26:25-30. 2005..Only 2 cases presented EGFR expression. LABC presented a low level of EGFR expression. HER1 amplification was not present in LABC, although the polysomy of chromosome 7 was a common finding... - Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a familyBlanca Espinet
Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Cancer Genet Cytogenet 143:172-3. 2003.... - 3q26 (hTERC) gain studied by fluorescence in situ hybridization as a persistence-progression indicator in low-grade squamous intraepithelial lesion casesFrancesc Alameda
Department of Pathology and Laboratory of Molecular Cytogenetics, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
Hum Pathol 40:1474-8. 2009.... - FISH is better than BIOMED-2 PCR to detect IgH/BCL2 translocation in follicular lymphoma at diagnosis using paraffin-embedded tissue sectionsBlanca Espinet
Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Hospital del Mar, IMAS, URNHE, PRBB, Escola de Citologia Hematològica Soledad Woessner IMAS, Barcelona, Spain
Leuk Res 32:737-42. 2008..In 4% of cases, the IgH/BCL2 translocation was not detected by any of the two techniques tested. Our results show that FISH represents the best technique to detect t(14;18) at diagnosis... - Analysis of gene status in cervical dysplastic lesions and squamous cell carcinoma using tissue microarraysCarlota Costa
Pathology Department, Cytogenetic and Molecular Biology Laboratory, Citology Section, Mar Hospital, IMAS, Barcelona, Spain
Histol Histopathol 24:821-9. 2009..With regards to proteins, the expression of MYC and CCND1 in the initial stages of the illness would help in the acquisition of the altered cellular phenotype... - Cytogenetic characterization of NCI-H69 and NCI-H69AR small cell lung cancer cell lines by spectral karyotypingMarta Salido
Pathology Department, Molecular Cytogenetic Laboratory, IMAS, GRETNHE Escola de Citologia Hematologica S Woessner IMAS, Barcelona, Spain
Cancer Genet Cytogenet 191:97-101. 2009..In conclusion, SKY provides a useful complementary technique to routine cytogenetics for the accurate characterization of SCLC cell lines and could provide some relevant information concerning regions involved in chemoresistance... - New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)Cristina Baro
Department Biologia Animal, Vegetal i Ecologia, Unitat d Antropologia Biològica, Facultat de Biociencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
Leuk Res 32:727-36. 2008..Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected... - Does polysomy of chromosome 17 have a role in ERBB2 and topoisomerase IIalpha expression? Gene, mRNA and protein expression: a comprehensive analysisCristina Corzo
Servei d Oncologia Medica, Hospital del Mar, IMAS, Barcelona, Spain
Tumour Biol 28:221-8. 2007..The aim of the present study was to clarify the implication of polysomy 17 in ERBB2 and topoisomerase IIalpha expression. In addition, we assessed the relation of ERBB2 and topoisomerase IIalpha gene dosage to mRNA and protein levels... - Gastrointestinal involvement in mantle cell lymphoma: a prospective clinic, endoscopic, and pathologic studyAntonio Salar
Department of Clinical Hematology, Hospital del Mar, Barcelona, Spain
Am J Surg Pathol 30:1274-80. 2006..IHC for cyclin D1 was significantly more sensitive than FISH t(11;14) or PCR for immunoglobulin heavy chain gene to confirm MCL in this setting... - Aberrant nuclear BCL10 expression and lack of t(11;18)(q21;q21) in primary cutaneous marginal zone B-cell lymphomaFernando Gallardo
Department of Dermatology, Hospital del Mar, IMAS, Barcelona, Spain Catalonian Cutaneous Lymphoma Network, Barcelona, Spain
Hum Pathol 37:867-73. 2006..t(11;18)(q21;q21), strongly linked to extracutaneous MALT lymphomas, does not seem to play a role in PCMZL. The participation of other MALT1 gene translocations in PCMZL pathogenesis seems also unlikely... - Pentasomy 21 with two isochromosomes 21 in a case of acute myeloid leukemia without maturationMarta Salido
Laboratori de Citologia Hematologica, Escola de Citologia Hematològica S Woessner IMAS, Hospital del Mar, IMAS, IMIM, Barcelona, Spain
Cancer Genet Cytogenet 132:71-3. 2002..To our knowledge, this is the first report of pentasomy 21q in AML without Down syndrome... - Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma?Blanca Espinet
Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Laboratori de Citologia Hematologica, Laboratori de Patologia, Hospital del Mar, IMAS, URNHE, PRBB, Barcelona 08003, Spain
Hum Pathol 36:1232-7. 2005..The existence of such asymptomatic patients with an indolent clinical course should induce a strict clinical judgment in terms of therapeutic decisions... - Correlation between histologic findings and cytogenetic abnormalities in bladder carcinoma: a FISH studyJose Placer
Department of Urology, Laboratory of Cytogenetics and Molecular Biology, Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain
Urology 65:913-8. 2005..To investigate the chromosomal abnormalities present in bladder carcinoma using a fluorescence in situ hybridization assay and to correlate the genetic findings with the pathologic grade and stage... - Lymphomatoid papulosis associated with mycosis fungoides: clinicopathological and molecular studies of 12 casesFernando Gallardo
Department of Dermatology and Pathology, Hospital del Mar, IMAS, Barcelona, Spain
Acta Derm Venereol 84:463-8. 2004..Our results also seem to confirm that the association of mycosis fungoides with a primary cutaneous CD30+ lymphoproliferative disorder usually carries a favourable prognosis... - Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphomaBlanca Espinet
Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Servei d Hematologia Clinica, GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
Genes Chromosomes Cancer 49:439-51. 2010..Additionally, we observed that 3q gains and 17p losses detected by conventional cytogenetics are proliferation-independent prognostic markers indicating poor outcome... - Clinical utility of a multiprobe FISH assay in voided urine specimens for the detection of bladder cancer and its recurrences, compared with urinary cytologyJose Placer
Department of Urology, Hospital del Mar, IMAS, Passeig Maritim 25 29, 08003 Barcelona, Spain
Eur Urol 42:547-52. 2002.... - Genetic characterization of the paraimmunoblastic variant of small lymphocytic lymphoma/chronic lymphocytic leukemia: A case report and review of the literatureBlanca Espinet
, Departament de Patologia, , Barcelona, Spain
Hum Pathol 33:1145-8. 2002..A literature review shows only 20 previously reported cases, 6 of which involve genetic studies... - A new case of acute nonlymphocytic leukemia (French-American-British subtype M1) with double minutes and c-MYC amplificationNatalia Rodon
Laboratori de Citogenètica i Biologia Molecular, Departament de Patologia, Hospital del Mar, IMAS, Barcelona, Spain
Cancer Genet Cytogenet 132:161-4. 2002..A review of dmins in ANLL is presented...