Rafael Simo

Summary

Affiliation: Hospital Universitari Vall d'Hebron
Country: Spain

Publications

  1. doi request reprint Apolipoprotein A1 is overexpressed in the retina of diabetic patients
    Rafael Simo
    CIBERDEM Carlos III Health Institute, Barcelona, Spain
    Am J Ophthalmol 147:319-325.e1. 2009
  2. pmc Phagocytic activity is impaired in type 2 diabetes mellitus and increases after metabolic improvement
    Albert Lecube
    Diabetes and Metabolism Research Unit, CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Vall d Hebron Institut de Recerca, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 6:e23366. 2011
  3. ncbi request reprint Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Barcelona, Spain
    Br J Ophthalmol 96:1285-90. 2012
  4. pmc Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes
    Gianluca Tamagno
    Department of Endocrinology and Diabetes Mellitus, St Vincent s University Hospital, University College Dublin, Dublin, Ireland
    BMC Neurol 10:27. 2010
  5. ncbi request reprint Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 29:2462-6. 2006
  6. ncbi request reprint Deficit of somatostatin in the vitreous fluid of patients with diabetic macular edema
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 30:725-7. 2007
  7. ncbi request reprint Fenofibrate for diabetic retinopathy
    Rafael Simo
    Diabetes Research Unit, Vall d Hebron University Hospital, 08035 Barcelona, Spain
    Lancet 370:1667-8. 2007
  8. ncbi request reprint Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients
    Rafael Simo
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Arch Ophthalmol 126:1076-81. 2008
  9. ncbi request reprint Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy
    R Simo
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas CIBERDEM Carlos III Health Institute, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Diabetologia 51:1574-80. 2008
  10. ncbi request reprint Different effects of thiazolidinediones on cardiovascular risk in patients with type 2 diabetes mellitus: pioglitazone versus rosiglitazone
    R Simo
    Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Curr Drug Saf 5:234-44. 2010

Collaborators

Detail Information

Publications77

  1. doi request reprint Apolipoprotein A1 is overexpressed in the retina of diabetic patients
    Rafael Simo
    CIBERDEM Carlos III Health Institute, Barcelona, Spain
    Am J Ophthalmol 147:319-325.e1. 2009
    ..To compare apolipoprotein A1 (ApoA1) expression in the retina from diabetic and nondiabetic donors...
  2. pmc Phagocytic activity is impaired in type 2 diabetes mellitus and increases after metabolic improvement
    Albert Lecube
    Diabetes and Metabolism Research Unit, CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Vall d Hebron Institut de Recerca, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 6:e23366. 2011
    ....
  3. ncbi request reprint Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Barcelona, Spain
    Br J Ophthalmol 96:1285-90. 2012
    ..However, clinical trials to determine the safety and effectiveness of this non-invasive route, as well as a standardisation of the methods for monitoring neurodegeneration, are needed...
  4. pmc Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes
    Gianluca Tamagno
    Department of Endocrinology and Diabetes Mellitus, St Vincent s University Hospital, University College Dublin, Dublin, Ireland
    BMC Neurol 10:27. 2010
    ..Almost all EAATD patients are affected by Hashimoto's thyroiditis (HT), although fourteen EAATD patients with Graves' disease (GD) have been also reported...
  5. ncbi request reprint Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 29:2462-6. 2006
    ..The main aim of this study was to compare the incidence of glucose abnormalities (diabetes plus impaired fasting glucose) between HCV-infected patients with or without sustained virological response (SVR) after antiviral therapy...
  6. ncbi request reprint Deficit of somatostatin in the vitreous fluid of patients with diabetic macular edema
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 30:725-7. 2007
  7. ncbi request reprint Fenofibrate for diabetic retinopathy
    Rafael Simo
    Diabetes Research Unit, Vall d Hebron University Hospital, 08035 Barcelona, Spain
    Lancet 370:1667-8. 2007
  8. ncbi request reprint Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients
    Rafael Simo
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Arch Ophthalmol 126:1076-81. 2008
    ....
  9. ncbi request reprint Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy
    R Simo
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas CIBERDEM Carlos III Health Institute, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Diabetologia 51:1574-80. 2008
    ..In this regard, head-to-head studies designed to evaluate not only the efficacy, but also the systemic adverse effects of these drugs in a high-risk population such as diabetic patients are warranted...
  10. ncbi request reprint Different effects of thiazolidinediones on cardiovascular risk in patients with type 2 diabetes mellitus: pioglitazone versus rosiglitazone
    R Simo
    Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Curr Drug Saf 5:234-44. 2010
    ..By contrast, it seems that rosiglitazone increases cardiovascular risk. The difference in lipid profile may be the main factor accounting for the superiority of pioglitazone in reducing cardiovascular risk...
  11. pmc The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier--implications for the pathogenesis of diabetic retinopathy
    Rafael Simo
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Unitat de Diabetis i Metabolisme, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Biomed Biotechnol 2010:190724. 2010
    ..By contrast, the effects of diabetes on the RPE and in particular on its secretory activity have received less attention. In this regard, new therapeutic strategies addressed to modulating RPE impairment are warranted...
  12. ncbi request reprint Intravitreous hepatocyte growth factor in patients with proliferative diabetic retinopathy: a case-control study
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Univesitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Res Clin Pract 71:36-44. 2006
    ..Our findings suggest that HGF is related to pathological conditions in which fibroproliferative processes or wound healing are involved rather than with angiogenesis itself...
  13. doi request reprint Measuring permeability in human retinal epithelial cells (ARPE-19): implications for the study of diabetic retinopathy
    Marta Garcia-Ramírez
    Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autònoma de Barcelona and CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Barcelona, Spain
    Methods Mol Biol 763:179-94. 2011
    ..Finally, we provide the methods required for confocal immunofluorescence detection of the TJ proteins, as well as for assessing the capacity of ARPE-19 cells to retain their functional properties...
  14. pmc Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation
    Esther Carrasco
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salut Carlos III ISCIII, Barcelona, Spain
    Mol Vis 14:1496-502. 2008
    ..Retinal neurodegeneration was assessed by measuring glial fibrilar acidic protein (GFAP) by confocal laser microscopy and counting the apoptotic TUNEL positive cells in which nuclear fragmentation as well as condensation were present...
  15. doi request reprint Identification of new pathogenic candidates for diabetic macular edema using fluorescence-based difference gel electrophoresis analysis
    Cristina Hernandez
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Barcelona, Spain Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Barcelona, Spain
    Diabetes Metab Res Rev 29:499-506. 2013
    ..The aim of the present study was to explore the differential proteomic pattern of the vitreous fluid from diabetic macular edema patients by means of fluorescence-based difference gel electrophoresis (DIGE)...
  16. doi request reprint Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and nondiabetic subjects
    Marta Garcia-Ramírez
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, Instituto de Salud Carlos III, Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Spain
    Diabetes Care 31:1189-94. 2008
    ..To gain insight into the mechanisms responsible for the regulation of Epo production in the retina, we also assessed retinal expression of hypoxia-inducible factors (HIF-1alpha and HIF-2alpha)...
  17. ncbi request reprint High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury
    Albert Lecube
    Diabetes Research Unit, Division of Endocrinology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 27:1171-5. 2004
    ....
  18. ncbi request reprint Deficit of somatostatin-like immunoreactivity in the vitreous fluid of diabetic patients: possible role in the development of proliferative diabetic retinopathy
    Rafael Simo
    Diabetes Unit, Division of Endocrinology, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 25:2282-6. 2002
    ..To evaluate the vitreous levels of somatostatin-like immunoreactivity (SLI) in patients with proliferative diabetic retinopathy (PDR)...
  19. ncbi request reprint Biological variation of lipoprotein(a) in a diabetic population. Analysis of the causes and clinical implications
    Cristina Hernandez
    Diabetes Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Clin Chem Lab Med 41:1075-80. 2003
    ..Finally, triglycerides and AER are the main factors influencing Lp(a) serum levels in the diabetic population...
  20. ncbi request reprint Erythropoietin is expressed in the human retina and it is highly elevated in the vitreous fluid of patients with diabetic macular edema
    Cristina Hernandez
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 29:2028-33. 2006
    ....
  21. doi request reprint Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions: essential role of JAK2/ PI3K signaling
    Marta Garcia-Ramírez
    Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Spain
    Cell Signal 23:1596-602. 2011
    ..We conclude that RPE disruption induced by high glucose plus IL-1β is prevented by Epo through the downstream signaling of JAK2 and PI3K/AKT pathways...
  22. doi request reprint Effect of intensive insulin therapy on macular biometrics, plasma VEGF and its soluble receptor in newly diagnosed diabetic patients
    Cristina Hernandez
    CIBERDEM ISCIII, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Diabetes Metab Res Rev 26:386-92. 2010
    ....
  23. ncbi request reprint Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects
    Cristina Hernandez
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 28:1941-7. 2005
    ..Somatostatin-14, somatostatin-28 and cortistatin were measured by radioimmunoassay but separation by high-performance liquid chromatography was required to measure somatostatin-14...
  24. ncbi request reprint Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case-control study
    Albert Lecube
    Diabetes Research Unit Endocrinology Division, Institut de Recerca, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 29:1096-101. 2006
    ..The purpose of this study was to explore the initial pathogenic mechanisms of diabetes associated with hepatitis C virus (HCV) infection...
  25. ncbi request reprint Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegeneration
    Esther Carrasco
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 30:2902-8. 2007
    ..To test the hypothesis that a reduction of somatostatin (SST) in the retina exists in patients without clinically detectable diabetic retinopathy and that it is associated with retinal neurodegeneration...
  26. ncbi request reprint Free insulin growth factor-I and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy
    Rafael Simo
    Division of Endocrinology, Diabetes Research Unit, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Am J Ophthalmol 134:376-82. 2002
    ..To investigate the relationship between insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in the vitreous fluid of diabetic patients with proliferative diabetic retinopathy (PDR)...
  27. ncbi request reprint Lipopolysaccharide-binding protein and soluble CD14 in the vitreous fluid of patients with proliferative diabetic retinopathy
    Cristina Hernandez
    CIBERDEM ISCIII, Universitat Autonoma de Barcelona, Barcelona, Spain
    Retina 30:345-52. 2010
    ..The purpose of this study was to compare intravitreous levels of lipopolysaccharide-binding protein and soluble CD14 (sCD14) between patients with proliferative diabetic retinopathy (PDR) and nondiabetic subjects...
  28. ncbi request reprint Advanced glycation end products are associated with arterial stiffness in type 1 diabetes
    Gemma Llauradó
    Department of DiabetesEndocrinology and Nutrition, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí Universitat Autònoma de Barcelona, Parc Taul s n, 08208 Sabadell, SpainCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición CIBERobn Hospital Clínico Virgen de la Victoria, Malaga, SpainDiabetesEndocrinology and Nutrition Unit, Hospital Sant Joan de Deu de Manresa, Xarxa Assistencial Althaia, Manresa, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM and Diabetes and Metabolism Research UnitInstitut de Recerca Hospital Universitari Vall d Hebrón VHIR, Universitat Autonoma de Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM Hospital Universitari Joan XXIII de Tarragona, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, SpainDepartment of DiabetesEndocrinology and Nutrition, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí Universitat Autònoma de Barcelona, Parc Taul s n, 08208 Sabadell, SpainCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición CIBERobn Hospital Clínico Virgen de la Victoria, Malaga, SpainDiabetesEndocrinology and Nutrition Unit, Hospital Sant Joan de Deu de Manresa, Xarxa Assistencial Althaia, Manresa, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM and Diabetes and Metabolism Research UnitInstitut de Recerca Hospital Universitari Vall d Hebrón VHIR, Universitat Autonoma de Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM Hospital Universitari Joan XXIII de Tarragona, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain
    J Endocrinol 221:405-13. 2014
    ..These findings indicate that determination of tissue AGE accumulation may be a useful marker for AS in type 1 diabetes. ..
  29. pmc Diabetes protects from prostate cancer by downregulating androgen receptor: new insights from LNCaP cells and PAC120 mouse model
    Anna Barbosa-Desongles
    Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca VHIR Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, ISCIII, Barcelona, Spain
    PLoS ONE 8:e74179. 2013
    ..In conclusion, our results suggest that hyperglycemia and TNF-α play an important role in protecting against prostate cancer by reducing androgen receptor levels via NF-κB. ..
  30. ncbi request reprint Diabetes is the main factor accounting for the high ferritin levels detected in chronic hepatitis C virus infection
    Albert Lecube
    Diabetes Research Unit, Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Diabetes Care 27:2669-75. 2004
    ..The aim of this study was to investigate the contribution of diabetes to the high ferritin levels observed in HCV-infected patients with chronic hepatitis...
  31. ncbi request reprint CD4-CD8 and CD28 expression in T cells infiltrating the vitreous fluid in patients with proliferative diabetic retinopathy: a flow cytometric analysis
    Ana Canton
    Diabetes Research Unit, Division of Endocrinology, Hospital General Universitari Vall d Hebron, Pg Vall d Hebron 119 129, Barcelona, Spain
    Arch Ophthalmol 122:743-9. 2004
    ....
  32. ncbi request reprint Lipoprotein(a) as a risk factor for cardiovascular mortality in type 2 diabetic patients: a 10-year follow-up study
    Cristina Hernandez
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 28:931-3. 2005
  33. ncbi request reprint Intravitreous leptin concentrations in patients with proliferative diabetic retinopathy
    Cristina Hernandez
    Diabetes Research Unit, Hospital General Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Retina 24:30-5. 2004
    ..The aim of the present study was to investigate the source of intravitreal leptin and to determine whether it is related to PDR activity...
  34. pmc Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes
    Cristina Hernandez
    Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    Diabetes 62:2569-78. 2013
    ..In addition, our findings open up a new preventive pharmacological strategy targeted to early stages of DR. ..
  35. doi request reprint Effects of high glucose concentration on the barrier function and the expression of tight junction proteins in human retinal pigment epithelial cells
    Marta Villarroel
    Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Exp Eye Res 89:913-20. 2009
    ..Further studies addressed to unravel the complexity of permeability regulation in RPE are needed...
  36. ncbi request reprint Glucose abnormalities in patients with hepatitis C virus infection: Epidemiology and pathogenesis
    Albert Lecube
    Division of Endocrinology, Diabetes Research Unit, Institut de Recerca, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 29:1140-9. 2006
  37. doi request reprint Testosterone induces cell proliferation and cell cycle gene overexpression in human visceral preadipocytes
    Anna Barbosa-Desongles
    Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca VHIR, Universitat Autònoma de Barcelona and CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, ISCIII, Barcelona, Spain
    Am J Physiol Cell Physiol 305:C355-9. 2013
    ..We conclude that testosterone exerts a proliferative effect on preadipocytes that may participate in the sex differences in fat distribution and that it may explain visceral fat accumulation in women with hyperandrogenism. ..
  38. ncbi request reprint Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Curr Diabetes Rev 2:71-98. 2006
    ..The main antiangiogenic factor is the pigment epithelium derived factor (PEDF) but the transforming growth factor beta (TGF-beta), thrombospondin (TSP) and somatostatin are also among the intraocullary synthesized antiangiogenic factors...
  39. doi request reprint Erythropoietin produced by the retina: its role in physiology and diabetic retinopathy
    Cristina Hernandez
    CIBERDEM, Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    Endocrine 41:220-6. 2012
    ..Finally, the reasons as to why Epo could be contemplated as a potential new treatment for the early stages of diabetic retinopathy will be given...
  40. ncbi request reprint Glucose abnormalities are an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C
    Albert Lecube
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Am J Gastroenterol 102:2189-95. 2007
    ..This study investigated whether glucose abnormalities (impaired fasting glucose and type 2 diabetes) influence the response to antiviral therapy with interferon plus ribavirin in patients with chronic hepatitis C...
  41. ncbi request reprint Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance
    David M Selva
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Clin Endocrinol Metab 94:4499-507. 2009
    ..Zinc-alpha2 glycoprotein (ZAG) has been proposed as a new candidate in the pathogenesis of obesity, but most of the information stems from studies performed in rodents and in vitro assays...
  42. ncbi request reprint Usefulness of homeostasis model assessment for identifying subjects at risk for hypoglycemia failure during the insulin hypoglycemia test
    Gemma Francisco
    Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Clin Endocrinol Metab 89:3408-12. 2004
    ..In these patients, either alternative tests or a higher dose of insulin should be considered...
  43. doi request reprint Molecular Mechanism of TNFα-Induced Down-Regulation of SHBG Expression
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Mol Endocrinol 26:438-46. 2012
    ..We conclude that sustained exposition to elevated levels of TNFα decreases SHBG production by reducing hepatic HNF-4α levels via NF-κB activation in HepG2 cells...
  44. doi request reprint Neuroprotection in diabetic retinopathy
    Cristina Hernandez
    CIBERDEM and Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Spain
    Curr Diab Rep 12:329-37. 2012
    ..In this review we will focus on neurotrophic factors already synthesized by the retina in physiological conditions as a new therapy strategy for neuroprotection...
  45. pmc Diabetes is an independent risk factor for severe nocturnal hypoxemia in obese patients. A case-control study
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    PLoS ONE 4:e4692. 2009
    ..The aim of this cross-sectional case-control study was to evaluate whether obese patients with T2DM are more prone to severe SAHS than obese non-diabetic subjects...
  46. doi request reprint Normoalbuminuric type 1 diabetic patients with retinopathy have an impaired tubular response to desmopressin: its relationship with plasma endothelin-1
    Cristina Hernandez
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona 08035, Spain
    J Clin Endocrinol Metab 94:2060-5. 2009
    ....
  47. ncbi request reprint Metabolic fingerprints of proliferative diabetic retinopathy: an 1H-NMR-based metabonomic approach using vitreous humor
    Ignasi Barba
    Laboratory of Experimental Cardiology, Heart Department, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Invest Ophthalmol Vis Sci 51:4416-21. 2010
    ..To explore the metabolic profile of vitreous fluid of patients with proliferative diabetic retinopathy (PDR) using 1H-NMR-based metabonomic analysis...
  48. doi request reprint Asymptomatic sleep-disordered breathing in premenopausal women awaiting bariatric surgery
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Obes Surg 20:454-61. 2010
    ..To evaluate the prevalence and characteristics of sleep apnea-hypopnea syndrome (SAHS) and obesity hypoventilation syndrome (OHS) in morbidly obese pre-menopausal women included in a program of bariatric surgery...
  49. ncbi request reprint Adiponectin Upregulates SHBG Production: Molecular Mechanisms and Potential Implications
    Rafael Simo
    Diabetes and Metabolism Research Unit R S, C S L, C H, D M S, Vall d Hebron Institut de Recerca, 08035 Barcelona, Universitat Autonoma de Barcelona, 08193 Barcelona, Centro de Investigación Biomédica en Red, 28029 Madrid, Spain Endocrinology and Nutrition Unit A L, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain Endocrine, Metabolic and Bariatric Unit J M F, General Surgery Department, Hospital Universitari Vall d Hebron, 08035 Barcelona, Spain
    Endocrinology 155:2820-30. 2014
    ..Our results suggest for the first time that adiponectin increases SHBG production by activating AMPK, which reduces hepatic lipid content and increases HNF-4α levels. ..
  50. pmc Overexpression of hemopexin in the diabetic eye: a new pathogenic candidate for diabetic macular edema
    Cristina Hernandez
    Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Spain
    Diabetes Care 36:2815-21. 2013
    ....
  51. pmc Variables involved in the discordance between HbA1c and fructosamine: the glycation gap revisited
    Carles Zafon
    Diabetes and Metabolism Research Unit VHIR and Department of Endocrinology, Hospital Vall d Hebron and Universitat Autònoma de Barcelona, Barcelona, Spain
    PLoS ONE 8:e66696. 2013
    ..Given that metformin might increase glucose transport through the erythrocyte membrane, this treatment was also considered in the analyses of the results...
  52. doi request reprint IL1β down-regulation of sex hormone-binding globulin production by decreasing HNF-4α via MEK-1/2 and JNK MAPK pathways
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas Instituto de Salud Carlos III, 08035 Barcelona, Spain
    Mol Endocrinol 26:1917-27. 2012
    ..In addition, our findings suggest that IL1β could be involved the low plasma SHBG levels reported in chronic low-grade inflammatory diseases...
  53. ncbi request reprint Update on cardiovascular safety of PPARgamma agonists and relevance to medicinal chemistry and clinical pharmacology
    Andreea Ciudin
    Diabetes and Metabolism Research Unit, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III, Vall d Hebron Institut de Recerca VHIR, Hospital Universitari Vall d Hebron, Universitatautonoma de Barcelona, Barcelona, Spain
    Curr Top Med Chem 12:585-604. 2012
    ..However, further experimental and clinical studies evaluating the theoretical benefit and safety of this therapeutic strategy are needed...
  54. ncbi request reprint Non-invasive methods of glucose measurement: current status and future perspectives
    Andreea Ciudin
    Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Curr Diabetes Rev 8:48-54. 2012
    ..In this paper we will give an overview of the noninvasive devices tested so far and their implications for the clinical management of the diabetic patient...
  55. ncbi request reprint Glucose abnormalities in non-alcoholic fatty liver disease and chronic hepatitis C virus infection: the role of iron overload
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Metab Res Rev 25:403-10. 2009
    ..Therefore, glucose abnormalities, and specially type 2 diabetes, should be taken into account when evaluating serum ferritin levels in patients with HCV infection...
  56. doi request reprint Insulin resistance is related to impaired lung function in morbidly obese women: a case-control study
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Diabetes Metab Res Rev 26:639-45. 2010
    ..The aim of the study is to determine whether obese patients with insulin resistance without diabetes have reduced pulmonary function in comparison with non-diabetic obese subjects without insulin resistance...
  57. ncbi request reprint Somatostatin replacement: a new strategy for treating diabetic retinopathy
    Cristina Hernandez
    CIBERDEM CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    Curr Med Chem 20:3251-7. 2013
    ..The main aim of the present review is to provide experimental evidence supporting the promising therapeutical use of SST to prevent or arrest DR. ..
  58. ncbi request reprint Albumin excretion rate is not affected by asymptomatic urinary tract infection: a prospective study
    Cristina Hernandez
    Diabetes Research Unit, Division of Endocrinology, Hospital Universitari Vall d Hebron, Pg Vall d Hebron, Barcelona, Spain
    Diabetes Care 27:1565-9. 2004
    ..The aim of the study was to evaluate whether asymptomatic urinary tract infection (UTI) significantly influences the level of albumin excretion rate (AER) in diabetic patients...
  59. ncbi request reprint Serum markers of vascular inflammation in dyslipemia
    Gemma Francisco
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Clin Chim Acta 369:1-16. 2006
    ..Nevertheless, several issues have to be evaluated before the measurements of inflammatory markers can be used for cardiovascular risk prediction in either clinical practice or in clinical trials evaluating anti-atherosclerotic drugs...
  60. doi request reprint Can augmentation index substitute aortic pulse wave velocity in the assessment of central arterial stiffness in type 1 diabetes?
    Gemma Llauradó
    Department of Diabetes, Endocrinology and Nutrition, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí, Universitat Autonoma de Barcelona, Parc Tauli, 08208 Sabadell, Spain
    Acta Diabetol 49:S253-7. 2012
    ..342; healthy subjects: p = 0.976). Our findings suggest that AIx@HR75 should not be used as a substitute for aPWV for measuring AS in type 1 diabetes...
  61. ncbi request reprint Prevention and treatment of diabetic retinopathy: evidence from large, randomized trials. The emerging role of fenofibrate
    Rafael Simo
    CIBERDEM, Vall Hebron Institut de Recerca VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    Rev Recent Clin Trials 7:71-80. 2012
    ..The results of ACCORD-EYE, together with those of FIELD, identify a place for fenofibrate for the prevention of retinopathy alongside intensive management of traditional risk factors, such as hyperglycemia and high blood pressure...
  62. ncbi request reprint [Treatment of diabetes mellitus: general goals, and clinical practice management]
    Rafael Simo
    Sección de Endocrinología, Hospital General Vall d Hebron, Barcelona, Spain
    Rev Esp Cardiol 55:845-60. 2002
    ..Therefore, the treatment selection will depend on the stage of the disease and the individual characteristics of the patient. This article examines the general goals of the treatment and reviews the management of type 2 diabetes...
  63. pmc Potential role of tumor necrosis factor-α in downregulating sex hormone-binding globulin
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas ISCIII, Barcelona, Spain
    Diabetes 61:372-82. 2012
    ..Our results suggest that TNF-α plays an important role downregulating SHBG in chronic low-grade inflammatory diseases such as obesity and type 2 diabetes...
  64. pmc Prevalence and risk factors accounting for true silent myocardial ischemia: a pilot case-control study comparing type 2 diabetic with non-diabetic control subjects
    Cristina Hernandez
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Spain
    Cardiovasc Diabetol 10:9. 2011
    ....
  65. pmc Thyroid hormone upregulates zinc-α2-glycoprotein production in the liver but not in adipose tissue
    Rafael Simo
    Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autònoma de Barcelona and CIBERDEM ISCIII, Barcelona, Spain
    PLoS ONE 9:e85753. 2014
    ..The neutral effect of thyroid hormones on zinc-α2-glycoprotein expression in adipose tissue could be the reason why zinc-α2-glycoprotein is not related to weight loss in hyperthyroidism. ..
  66. ncbi request reprint V804M RET mutation and familial medullary thyroid carcinoma: report of a large family with expression of the disease only in the homozygous gene carriers
    Albert Lecube
    Department of Endocrinology, Hospital Vall d Hebron, Barcelona, Spain
    Surgery 131:509-14. 2002
    ..We describe a large kindred with not only heterozygous but also homozygous members with the V804M mutation. This is, to our knowledge, the first report of a homozygous RET mutation...
  67. ncbi request reprint Effects of hypolipidemic treatment on serum markers of vascular inflammation in dyslipidemic men
    Cristina Hernandez
    Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Med Sci Monit 9:CR114-9. 2003
    ..The purpose of our study was to assess the effect of hypolipidemiant drugs on serum markers of vascular inflammation (E-Selectin, VCAM-1 and MCP-1) in dyslipidemic men without cardiovascular disease...
  68. pmc Usefulness of the vitreous fluid analysis in the translational research of diabetic retinopathy
    Olga Simó-Servat
    Department of Endocrinology, Hospital Vall d Hebron, Barcelona, Spain
    Mediators Inflamm 2012:872978. 2012
    ..Finally, a more personalized treatment based on vitreous fluid analysis aiming to reduce the burden associated with DR is suggested...
  69. pmc Diabetes is the main factor accounting for hypomagnesemia in obese subjects
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Diabetes and Metabolism Research Unit, Endocrinology Department, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 7:e30599. 2012
    ..Type 2 diabetes (T2DM) and obesity are associated with magnesium deficiency. We aimed to determine whether the presence of type 2 diabetes and the degree of metabolic control are related to low serum magnesium levels in obese individuals...
  70. ncbi request reprint Iron deficiency in obese postmenopausal women
    Albert Lecube
    Obesity Research Unit, Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Obesity (Silver Spring) 14:1724-30. 2006
    ..This study evaluates whether the iron deficiency suggested in children and adolescents with overweight is also present with increasing age...
  71. pmc Molecular Implications of the PPARs in the Diabetic Eye
    Andreea Ciudin
    Unidad de Investigación en Diabetes y Metabolism, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III, Instituto de Investigación Vall d Hebron, Universitat Autonoma de Barcelona, Paseo Vall d Hebron, 119 129 Barcelona, Spain
    PPAR Res 2013:686525. 2013
    ..2010))...
  72. pmc Neurodegeneration: An early event of diabetic retinopathy
    Marta Villarroel
    Marta Villarroel, Andreea Ciudin, Cristina Hernández, Rafael Simó, Diabetes and Metabolism Research Unit Institut de Recerca Hospital Universitari Vall D Hebron, Universitat Autonoma de Barcelona, Barcelona 08035, Spain
    World J Diabetes 1:57-64. 2010
    ..Whether these novel therapies will eventually supplement or prevent the need for laser photocoagulation or vitrectomy awaits the results of additional clinical research...
  73. doi request reprint Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
    Joan Vendrell
    University Hospital of Tarragona Joan XXIII, IISPV, Rovira i Virgili University, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, 43007 Tarragona, Spain
    Endocrinology 152:4072-9. 2011
    ..Altogether these results indicate that the GLP-1/GLP-1R system in AT represents another potential candidate for improving insulin sensitivity in obese patients...
  74. ncbi request reprint Strategies for blocking angiogenesis in diabetic retinopathy: from basic science to clinical practice
    Cristina Hernandez
    Hospital Universitari Vall d Hebron, Diabetes and Metabolism Research Unit, Endocrinology Division, Pg Vall d Hebron, Barcelona, Spain
    Expert Opin Investig Drugs 16:1209-26. 2007
    ....
  75. pmc Arterial stiffness is increased in patients with type 1 diabetes without cardiovascular disease: a potential role of low-grade inflammation
    Gemma Llauradó
    Department of Diabetes, Hospital of Sabadell, Corporació Sanitària i Universitària Parc Taulí, Universitat Autonoma de Barcelona, Sabadell, Spain
    Diabetes Care 35:1083-9. 2012
    ..To investigate the relationship between arterial stiffness and low-grade inflammation in subjects with type 1 diabetes without clinical cardiovascular disease...