Rafael Simo

Summary

Affiliation: Hospital Vall d'Hebron
Country: Spain

Publications

  1. ncbi Short-term hypothyroidism has no effect on serum leptin concentrations
    R Simo
    Division of Endocrinology, Hospital General Vall d Hebron, Barcelona, Spain
    Diabetes Obes Metab 2:317-21. 2000
  2. ncbi Free insulin growth factor-I and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy
    Rafael Simo
    Division of Endocrinology, Diabetes Research Unit, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Am J Ophthalmol 134:376-82. 2002
  3. ncbi Deficit of somatostatin-like immunoreactivity in the vitreous fluid of diabetic patients: possible role in the development of proliferative diabetic retinopathy
    Rafael Simo
    Diabetes Unit, Division of Endocrinology, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 25:2282-6. 2002
  4. ncbi Free insulin-like growth factor 1 in the vitreous fluid of diabetic patients with proliferative diabetic retinopathy: a case-control study
    Rafael Simo
    Division of Endocrinology, Hospital General Vall d Hebron, Barcelona 08035, Spain
    Clin Sci (Lond) 104:223-30. 2003
  5. doi Apolipoprotein A1 is overexpressed in the retina of diabetic patients
    Rafael Simo
    CIBERDEM Carlos III Health Institute, Barcelona, Spain
    Am J Ophthalmol 147:319-325.e1. 2009
  6. ncbi Intravitreous hepatocyte growth factor in patients with proliferative diabetic retinopathy: a case-control study
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Univesitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Res Clin Pract 71:36-44. 2006
  7. doi Identification of new pathogenic candidates for diabetic macular edema using fluorescence-based difference gel electrophoresis analysis
    Cristina Hernandez
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Barcelona, Spain Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Barcelona, Spain
    Diabetes Metab Res Rev 29:499-506. 2013
  8. ncbi High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury
    Albert Lecube
    Diabetes Research Unit, Division of Endocrinology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 27:1171-5. 2004
  9. ncbi Deficit of somatostatin in the vitreous fluid of patients with diabetic macular edema
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 30:725-7. 2007
  10. ncbi Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients
    Rafael Simo
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Arch Ophthalmol 126:1076-81. 2008

Collaborators

Detail Information

Publications66

  1. ncbi Short-term hypothyroidism has no effect on serum leptin concentrations
    R Simo
    Division of Endocrinology, Hospital General Vall d Hebron, Barcelona, Spain
    Diabetes Obes Metab 2:317-21. 2000
    ..We conclude that short-term hypothyroidism does not alter serum leptin concentrations. Furthermore, our results suggest that thyroid hormones do not operate through changes in serum leptin levels to regulate energy expenditure...
  2. ncbi Free insulin growth factor-I and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy
    Rafael Simo
    Division of Endocrinology, Diabetes Research Unit, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Am J Ophthalmol 134:376-82. 2002
    ..To investigate the relationship between insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in the vitreous fluid of diabetic patients with proliferative diabetic retinopathy (PDR)...
  3. ncbi Deficit of somatostatin-like immunoreactivity in the vitreous fluid of diabetic patients: possible role in the development of proliferative diabetic retinopathy
    Rafael Simo
    Diabetes Unit, Division of Endocrinology, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 25:2282-6. 2002
    ..To evaluate the vitreous levels of somatostatin-like immunoreactivity (SLI) in patients with proliferative diabetic retinopathy (PDR)...
  4. ncbi Free insulin-like growth factor 1 in the vitreous fluid of diabetic patients with proliferative diabetic retinopathy: a case-control study
    Rafael Simo
    Division of Endocrinology, Hospital General Vall d Hebron, Barcelona 08035, Spain
    Clin Sci (Lond) 104:223-30. 2003
    ..In addition, these findings support the concept that intraocular-produced free IGF-1 plays a relevant role in retinal homoeostasis...
  5. doi Apolipoprotein A1 is overexpressed in the retina of diabetic patients
    Rafael Simo
    CIBERDEM Carlos III Health Institute, Barcelona, Spain
    Am J Ophthalmol 147:319-325.e1. 2009
    ..To compare apolipoprotein A1 (ApoA1) expression in the retina from diabetic and nondiabetic donors...
  6. ncbi Intravitreous hepatocyte growth factor in patients with proliferative diabetic retinopathy: a case-control study
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Univesitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Res Clin Pract 71:36-44. 2006
    ..Our findings suggest that HGF is related to pathological conditions in which fibroproliferative processes or wound healing are involved rather than with angiogenesis itself...
  7. doi Identification of new pathogenic candidates for diabetic macular edema using fluorescence-based difference gel electrophoresis analysis
    Cristina Hernandez
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Barcelona, Spain Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Barcelona, Spain
    Diabetes Metab Res Rev 29:499-506. 2013
    ..The aim of the present study was to explore the differential proteomic pattern of the vitreous fluid from diabetic macular edema patients by means of fluorescence-based difference gel electrophoresis (DIGE)...
  8. ncbi High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury
    Albert Lecube
    Diabetes Research Unit, Division of Endocrinology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 27:1171-5. 2004
    ....
  9. ncbi Deficit of somatostatin in the vitreous fluid of patients with diabetic macular edema
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 30:725-7. 2007
  10. ncbi Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients
    Rafael Simo
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Arch Ophthalmol 126:1076-81. 2008
    ....
  11. doi Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and nondiabetic subjects
    Marta Garcia-Ramírez
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, Instituto de Salud Carlos III, Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Spain
    Diabetes Care 31:1189-94. 2008
    ..To gain insight into the mechanisms responsible for the regulation of Epo production in the retina, we also assessed retinal expression of hypoxia-inducible factors (HIF-1alpha and HIF-2alpha)...
  12. pmc Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation
    Esther Carrasco
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salut Carlos III ISCIII, Barcelona, Spain
    Mol Vis 14:1496-502. 2008
    ..Retinal neurodegeneration was assessed by measuring glial fibrilar acidic protein (GFAP) by confocal laser microscopy and counting the apoptotic TUNEL positive cells in which nuclear fragmentation as well as condensation were present...
  13. doi Effect of intensive insulin therapy on macular biometrics, plasma VEGF and its soluble receptor in newly diagnosed diabetic patients
    Cristina Hernandez
    CIBERDEM ISCIII, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Diabetes Metab Res Rev 26:386-92. 2010
    ....
  14. ncbi Biological variation of lipoprotein(a) in a diabetic population. Analysis of the causes and clinical implications
    Cristina Hernandez
    Diabetes Research Unit, Hospital General Vall d Hebron, Barcelona, Spain
    Clin Chem Lab Med 41:1075-80. 2003
    ..Finally, triglycerides and AER are the main factors influencing Lp(a) serum levels in the diabetic population...
  15. ncbi Intravitreous leptin concentrations in patients with proliferative diabetic retinopathy
    Cristina Hernandez
    Diabetes Research Unit, Hospital General Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Retina 24:30-5. 2004
    ..The aim of the present study was to investigate the source of intravitreal leptin and to determine whether it is related to PDR activity...
  16. pmc Diabetes protects from prostate cancer by downregulating androgen receptor: new insights from LNCaP cells and PAC120 mouse model
    Anna Barbosa-Desongles
    Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca VHIR Universitat Autònoma de Barcelona and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, ISCIII, Barcelona, Spain
    PLoS ONE 8:e74179. 2013
    ..In conclusion, our results suggest that hyperglycemia and TNF-α play an important role in protecting against prostate cancer by reducing androgen receptor levels via NF-κB. ..
  17. ncbi Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects
    Cristina Hernandez
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 28:1941-7. 2005
    ..Somatostatin-14, somatostatin-28 and cortistatin were measured by radioimmunoassay but separation by high-performance liquid chromatography was required to measure somatostatin-14...
  18. ncbi Diabetes is the main factor accounting for the high ferritin levels detected in chronic hepatitis C virus infection
    Albert Lecube
    Diabetes Research Unit, Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Diabetes Care 27:2669-75. 2004
    ..The aim of this study was to investigate the contribution of diabetes to the high ferritin levels observed in HCV-infected patients with chronic hepatitis...
  19. ncbi CD4-CD8 and CD28 expression in T cells infiltrating the vitreous fluid in patients with proliferative diabetic retinopathy: a flow cytometric analysis
    Ana Canton
    Diabetes Research Unit, Division of Endocrinology, Hospital General Universitari Vall d Hebron, Pg Vall d Hebron 119 129, Barcelona, Spain
    Arch Ophthalmol 122:743-9. 2004
    ....
  20. pmc Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes
    Cristina Hernandez
    Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    Diabetes 62:2569-78. 2013
    ..In addition, our findings open up a new preventive pharmacological strategy targeted to early stages of DR. ..
  21. ncbi Lipopolysaccharide-binding protein and soluble CD14 in the vitreous fluid of patients with proliferative diabetic retinopathy
    Cristina Hernandez
    CIBERDEM ISCIII, Universitat Autonoma de Barcelona, Barcelona, Spain
    Retina 30:345-52. 2010
    ..The purpose of this study was to compare intravitreous levels of lipopolysaccharide-binding protein and soluble CD14 (sCD14) between patients with proliferative diabetic retinopathy (PDR) and nondiabetic subjects...
  22. ncbi Lipoprotein(a) as a risk factor for cardiovascular mortality in type 2 diabetic patients: a 10-year follow-up study
    Cristina Hernandez
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 28:931-3. 2005
  23. ncbi Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Curr Diabetes Rev 2:71-98. 2006
    ..The main antiangiogenic factor is the pigment epithelium derived factor (PEDF) but the transforming growth factor beta (TGF-beta), thrombospondin (TSP) and somatostatin are also among the intraocullary synthesized antiangiogenic factors...
  24. ncbi Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance
    David M Selva
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Clin Endocrinol Metab 94:4499-507. 2009
    ..Zinc-alpha2 glycoprotein (ZAG) has been proposed as a new candidate in the pathogenesis of obesity, but most of the information stems from studies performed in rodents and in vitro assays...
  25. ncbi Glucose abnormalities are an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C
    Albert Lecube
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Am J Gastroenterol 102:2189-95. 2007
    ..This study investigated whether glucose abnormalities (impaired fasting glucose and type 2 diabetes) influence the response to antiviral therapy with interferon plus ribavirin in patients with chronic hepatitis C...
  26. doi Measuring permeability in human retinal epithelial cells (ARPE-19): implications for the study of diabetic retinopathy
    Marta Garcia-Ramírez
    Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autònoma de Barcelona and CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Barcelona, Spain
    Methods Mol Biol 763:179-94. 2011
    ..Finally, we provide the methods required for confocal immunofluorescence detection of the TJ proteins, as well as for assessing the capacity of ARPE-19 cells to retain their functional properties...
  27. ncbi Erythropoietin is expressed in the human retina and it is highly elevated in the vitreous fluid of patients with diabetic macular edema
    Cristina Hernandez
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 29:2028-33. 2006
    ....
  28. ncbi Glucose abnormalities in patients with hepatitis C virus infection: Epidemiology and pathogenesis
    Albert Lecube
    Division of Endocrinology, Diabetes Research Unit, Institut de Recerca, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 29:1140-9. 2006
  29. doi Erythropoietin produced by the retina: its role in physiology and diabetic retinopathy
    Cristina Hernandez
    CIBERDEM, Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    Endocrine 41:220-6. 2012
    ..Finally, the reasons as to why Epo could be contemplated as a potential new treatment for the early stages of diabetic retinopathy will be given...
  30. doi Molecular Mechanism of TNFα-Induced Down-Regulation of SHBG Expression
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Mol Endocrinol 26:438-46. 2012
    ..We conclude that sustained exposition to elevated levels of TNFα decreases SHBG production by reducing hepatic HNF-4α levels via NF-κB activation in HepG2 cells...
  31. ncbi Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegeneration
    Esther Carrasco
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 30:2902-8. 2007
    ..To test the hypothesis that a reduction of somatostatin (SST) in the retina exists in patients without clinically detectable diabetic retinopathy and that it is associated with retinal neurodegeneration...
  32. doi Asymptomatic sleep-disordered breathing in premenopausal women awaiting bariatric surgery
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Obes Surg 20:454-61. 2010
    ..To evaluate the prevalence and characteristics of sleep apnea-hypopnea syndrome (SAHS) and obesity hypoventilation syndrome (OHS) in morbidly obese pre-menopausal women included in a program of bariatric surgery...
  33. pmc Diabetes is an independent risk factor for severe nocturnal hypoxemia in obese patients. A case-control study
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    PLoS ONE 4:e4692. 2009
    ..The aim of this cross-sectional case-control study was to evaluate whether obese patients with T2DM are more prone to severe SAHS than obese non-diabetic subjects...
  34. doi Testosterone induces cell proliferation and cell cycle gene overexpression in human visceral preadipocytes
    Anna Barbosa-Desongles
    Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca VHIR, Universitat Autònoma de Barcelona and CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, ISCIII, Barcelona, Spain
    Am J Physiol Cell Physiol 305:C355-9. 2013
    ..We conclude that testosterone exerts a proliferative effect on preadipocytes that may participate in the sex differences in fat distribution and that it may explain visceral fat accumulation in women with hyperandrogenism. ..
  35. ncbi Glucose abnormalities in non-alcoholic fatty liver disease and chronic hepatitis C virus infection: the role of iron overload
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Metab Res Rev 25:403-10. 2009
    ..Therefore, glucose abnormalities, and specially type 2 diabetes, should be taken into account when evaluating serum ferritin levels in patients with HCV infection...
  36. ncbi Metabolic fingerprints of proliferative diabetic retinopathy: an 1H-NMR-based metabonomic approach using vitreous humor
    Ignasi Barba
    Laboratory of Experimental Cardiology, Heart Department, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Invest Ophthalmol Vis Sci 51:4416-21. 2010
    ..To explore the metabolic profile of vitreous fluid of patients with proliferative diabetic retinopathy (PDR) using 1H-NMR-based metabonomic analysis...
  37. doi Insulin resistance is related to impaired lung function in morbidly obese women: a case-control study
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Diabetes Metab Res Rev 26:639-45. 2010
    ..The aim of the study is to determine whether obese patients with insulin resistance without diabetes have reduced pulmonary function in comparison with non-diabetic obese subjects without insulin resistance...
  38. doi Normoalbuminuric type 1 diabetic patients with retinopathy have an impaired tubular response to desmopressin: its relationship with plasma endothelin-1
    Cristina Hernandez
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona 08035, Spain
    J Clin Endocrinol Metab 94:2060-5. 2009
    ....
  39. ncbi Glycogen storage in the human retinal pigment epithelium: a comparative study of diabetic and non-diabetic donors
    Cristina Hernandez
    Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Pg Vall d Hebron 119 129, 08035, Barcelona, Spain
    Acta Diabetol 51:543-52. 2014
    ..Further studies aimed at determining the role of glycogen deposits in the pathogenesis of diabetic retinopathy are warranted. ..
  40. ncbi Somatostatin replacement: a new strategy for treating diabetic retinopathy
    Cristina Hernandez
    CIBERDEM CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    Curr Med Chem 20:3251-7. 2013
    ..The main aim of the present review is to provide experimental evidence supporting the promising therapeutical use of SST to prevent or arrest DR. ..
  41. pmc Variables involved in the discordance between HbA1c and fructosamine: the glycation gap revisited
    Carles Zafon
    Diabetes and Metabolism Research Unit VHIR and Department of Endocrinology, Hospital Vall d Hebron and Universitat Autònoma de Barcelona, Barcelona, Spain
    PLoS ONE 8:e66696. 2013
    ..Given that metformin might increase glucose transport through the erythrocyte membrane, this treatment was also considered in the analyses of the results...
  42. ncbi Albumin excretion rate is not affected by asymptomatic urinary tract infection: a prospective study
    Cristina Hernandez
    Diabetes Research Unit, Division of Endocrinology, Hospital Universitari Vall d Hebron, Pg Vall d Hebron, Barcelona, Spain
    Diabetes Care 27:1565-9. 2004
    ..The aim of the study was to evaluate whether asymptomatic urinary tract infection (UTI) significantly influences the level of albumin excretion rate (AER) in diabetic patients...
  43. ncbi Fenofibrate for diabetic retinopathy
    Rafael Simo
    Diabetes Research Unit, Vall d Hebron University Hospital, 08035 Barcelona, Spain
    Lancet 370:1667-8. 2007
  44. ncbi Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Barcelona, Spain
    Br J Ophthalmol 96:1285-90. 2012
    ..However, clinical trials to determine the safety and effectiveness of this non-invasive route, as well as a standardisation of the methods for monitoring neurodegeneration, are needed...
  45. pmc Potential role of tumor necrosis factor-α in downregulating sex hormone-binding globulin
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas ISCIII, Barcelona, Spain
    Diabetes 61:372-82. 2012
    ..Our results suggest that TNF-α plays an important role downregulating SHBG in chronic low-grade inflammatory diseases such as obesity and type 2 diabetes...
  46. ncbi Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 29:2462-6. 2006
    ..The main aim of this study was to compare the incidence of glucose abnormalities (diabetes plus impaired fasting glucose) between HCV-infected patients with or without sustained virological response (SVR) after antiviral therapy...
  47. pmc The db/db mouse: a useful model for the study of diabetic retinal neurodegeneration
    Patricia Bogdanov
    Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Madrid, Spain
    PLoS ONE 9:e97302. 2014
    ..To characterize the sequential events that are taking place in retinal neurodegeneration in a murine model of spontaneous type 2 diabetes (db/db mouse)...
  48. ncbi Oleic acid increases hepatic sex hormone binding globulin production in men
    Cristina Sáez-Lopez
    Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, ISCIII, Barcelona, Spain
    Mol Nutr Food Res 58:760-7. 2014
    ..We aimed to test the hypothesis that the increase of circulating MUFA associated with olive oil consumption (primary fat source in Mediterranean diet) increases SHBG serum levels...
  49. pmc Thyroid hormone upregulates zinc-α2-glycoprotein production in the liver but not in adipose tissue
    Rafael Simo
    Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autònoma de Barcelona and CIBERDEM ISCIII, Barcelona, Spain
    PLoS ONE 9:e85753. 2014
    ..The neutral effect of thyroid hormones on zinc-α2-glycoprotein expression in adipose tissue could be the reason why zinc-α2-glycoprotein is not related to weight loss in hyperthyroidism. ..
  50. ncbi Effects of hypolipidemic treatment on serum markers of vascular inflammation in dyslipidemic men
    Cristina Hernandez
    Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Med Sci Monit 9:CR114-9. 2003
    ..The purpose of our study was to assess the effect of hypolipidemiant drugs on serum markers of vascular inflammation (E-Selectin, VCAM-1 and MCP-1) in dyslipidemic men without cardiovascular disease...
  51. ncbi V804M RET mutation and familial medullary thyroid carcinoma: report of a large family with expression of the disease only in the homozygous gene carriers
    Albert Lecube
    Department of Endocrinology, Hospital Vall d Hebron, Barcelona, Spain
    Surgery 131:509-14. 2002
    ..We describe a large kindred with not only heterozygous but also homozygous members with the V804M mutation. This is, to our knowledge, the first report of a homozygous RET mutation...
  52. ncbi Serum markers of vascular inflammation in dyslipemia
    Gemma Francisco
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Clin Chim Acta 369:1-16. 2006
    ..Nevertheless, several issues have to be evaluated before the measurements of inflammatory markers can be used for cardiovascular risk prediction in either clinical practice or in clinical trials evaluating anti-atherosclerotic drugs...
  53. pmc Usefulness of the vitreous fluid analysis in the translational research of diabetic retinopathy
    Olga Simó-Servat
    Department of Endocrinology, Hospital Vall d Hebron, Barcelona, Spain
    Mediators Inflamm 2012:872978. 2012
    ..Finally, a more personalized treatment based on vitreous fluid analysis aiming to reduce the burden associated with DR is suggested...
  54. ncbi Prevention and treatment of diabetic retinopathy: evidence from large, randomized trials. The emerging role of fenofibrate
    Rafael Simo
    CIBERDEM, Vall Hebron Institut de Recerca VHIR, Universitat Autonoma de Barcelona, Barcelona, Spain
    Rev Recent Clin Trials 7:71-80. 2012
    ..The results of ACCORD-EYE, together with those of FIELD, identify a place for fenofibrate for the prevention of retinopathy alongside intensive management of traditional risk factors, such as hyperglycemia and high blood pressure...
  55. pmc Diabetes is the main factor accounting for hypomagnesemia in obese subjects
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Diabetes and Metabolism Research Unit, Endocrinology Department, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 7:e30599. 2012
    ..Type 2 diabetes (T2DM) and obesity are associated with magnesium deficiency. We aimed to determine whether the presence of type 2 diabetes and the degree of metabolic control are related to low serum magnesium levels in obese individuals...
  56. ncbi Iron deficiency in obese postmenopausal women
    Albert Lecube
    Obesity Research Unit, Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Obesity (Silver Spring) 14:1724-30. 2006
    ..This study evaluates whether the iron deficiency suggested in children and adolescents with overweight is also present with increasing age...
  57. ncbi Advanced glycation end products are associated with arterial stiffness in type 1 diabetes
    Gemma Llauradó
    Department of DiabetesEndocrinology and Nutrition, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí Universitat Autònoma de Barcelona, Parc Taul s n, 08208 Sabadell, SpainCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición CIBERobn Hospital Clínico Virgen de la Victoria, Malaga, SpainDiabetesEndocrinology and Nutrition Unit, Hospital Sant Joan de Deu de Manresa, Xarxa Assistencial Althaia, Manresa, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM and Diabetes and Metabolism Research UnitInstitut de Recerca Hospital Universitari Vall d Hebrón VHIR, Universitat Autonoma de Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM Hospital Universitari Joan XXIII de Tarragona, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, SpainDepartment of DiabetesEndocrinology and Nutrition, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí Universitat Autònoma de Barcelona, Parc Taul s n, 08208 Sabadell, SpainCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición CIBERobn Hospital Clínico Virgen de la Victoria, Malaga, SpainDiabetesEndocrinology and Nutrition Unit, Hospital Sant Joan de Deu de Manresa, Xarxa Assistencial Althaia, Manresa, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM and Diabetes and Metabolism Research UnitInstitut de Recerca Hospital Universitari Vall d Hebrón VHIR, Universitat Autonoma de Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM Hospital Universitari Joan XXIII de Tarragona, Institut d Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain
    J Endocrinol 221:405-13. 2014
    ..These findings indicate that determination of tissue AGE accumulation may be a useful marker for AS in type 1 diabetes. ..
  58. ncbi Somatostatin and diabetic retinopathy: current concepts and new therapeutic perspectives
    Cristina Hernandez
    Diabetes and Metabolism Research Unit, Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Pg Vall d Hebron 119 129 08035, Barcelona, Spain
    Endocrine 46:209-14. 2014
    ..However, clinical trials will be needed to establish the exact position of targeting SST in the treatment of this disabling complication of diabetes...
  59. ncbi Fenofibrate: a new treatment for diabetic retinopathy. Molecular mechanisms and future perspectives
    Rafael Simo
    Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron and CIBERDEM, Barcelona, Spain
    Curr Med Chem 20:3258-66. 2013
    ..A deeper understanding of the mode of action of fenofibrate will further help to define how best to use fenofibrate clinically as an adjunct to current management of DR. ..
  60. ncbi Update on cardiovascular safety of PPARgamma agonists and relevance to medicinal chemistry and clinical pharmacology
    Andreea Ciudin
    Diabetes and Metabolism Research Unit, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III, Vall d Hebron Institut de Recerca VHIR, Hospital Universitari Vall d Hebron, Universitatautonoma de Barcelona, Barcelona, Spain
    Curr Top Med Chem 12:585-604. 2012
    ..However, further experimental and clinical studies evaluating the theoretical benefit and safety of this therapeutic strategy are needed...
  61. ncbi [Treatment of diabetes mellitus: general goals, and clinical practice management]
    Rafael Simo
    Sección de Endocrinología, Hospital General Vall d Hebron, Barcelona, Spain
    Rev Esp Cardiol 55:845-60. 2002
    ..Therefore, the treatment selection will depend on the stage of the disease and the individual characteristics of the patient. This article examines the general goals of the treatment and reviews the management of type 2 diabetes...
  62. ncbi Strategies for blocking angiogenesis in diabetic retinopathy: from basic science to clinical practice
    Cristina Hernandez
    Hospital Universitari Vall d Hebron, Diabetes and Metabolism Research Unit, Endocrinology Division, Pg Vall d Hebron, Barcelona, Spain
    Expert Opin Investig Drugs 16:1209-26. 2007
    ....
  63. pmc Phagocytic activity is impaired in type 2 diabetes mellitus and increases after metabolic improvement
    Albert Lecube
    Diabetes and Metabolism Research Unit, CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Vall d Hebron Institut de Recerca, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 6:e23366. 2011
    ....
  64. pmc Neurodegeneration: An early event of diabetic retinopathy
    Marta Villarroel
    Marta Villarroel, Andreea Ciudin, Cristina Hernández, Rafael Simó, Diabetes and Metabolism Research Unit Institut de Recerca Hospital Universitari Vall D Hebron, Universitat Autonoma de Barcelona, Barcelona 08035, Spain
    World J Diabetes 1:57-64. 2010
    ..Whether these novel therapies will eventually supplement or prevent the need for laser photocoagulation or vitrectomy awaits the results of additional clinical research...
  65. pmc Impact of glucose-lowering agents on the risk of cancer in type 2 diabetic patients. The barcelona case-control study
    Rafael Simo
    Grup de Recerca en Diabetis i Metabolisme i CIBER de Diabetis i Malalties Metabòliques Associades CIBERDEM, Institut de Recerca Hospital Vall d Hebron, Barcelona, Spain Universitat Autònoma de Barcelona, Bellaterra, Spain
    PLoS ONE 8:e79968. 2013
    ..The aim of the present study is to evaluate the impact of glucose-lowering agents in the risk of cancer in a large type 2 diabetic population...
  66. doi Neuroprotection in diabetic retinopathy
    Cristina Hernandez
    CIBERDEM and Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Spain
    Curr Diab Rep 12:329-37. 2012
    ..In this review we will focus on neurotrophic factors already synthesized by the retina in physiological conditions as a new therapy strategy for neuroprotection...