Angels Sierra

Summary

Affiliation: Hospital Duran i Reynals
Country: Spain

Publications

  1. ncbi Metastases and their microenvironments: linking pathogenesis and therapy
    Angels Sierra
    Centre d Oncologia Molecular, Institut de Recerca Oncològica IDIBELL, Hospital Duran i Reynals C S U B, Gran Via, Km 2 7, E 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Drug Resist Updat 8:247-57. 2005
  2. ncbi Expression of death-related genes and their relationship to loss of apoptosis in T1 ductal breast carcinomas
    A Sierra
    Department of Càncer i Metàstasis, Institut de Recerca Oncologica, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    Int J Cancer 79:103-10. 1998
  3. ncbi Synergistic cooperation between c-Myc and Bcl-2 in lymph node progression of T1 human breast carcinomas
    A Sierra
    Dpt Cancer i Metàstasis, Institut de Recerca Oncologica, Hospital Duran i Reynals, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    Breast Cancer Res Treat 54:39-45. 1999
  4. ncbi Bcl-2 with loss of apoptosis allows accumulation of genetic alterations: a pathway to metastatic progression in human breast cancer
    A Sierra
    Departament i Càncer Metàstasis, Institut de Recerca Oncologica, Hospital Duran i Reynals, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    Int J Cancer 89:142-7. 2000
  5. pmc Bcl-x(L)-mediated changes in metabolic pathways of breast cancer cells: from survival in the blood stream to organ-specific metastasis
    Laura España
    Centre d Oncologia Molecular, Institut de Recerca Oncològica IDIBELL, Hosp Duran i Reynals, C S U B, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Am J Pathol 167:1125-37. 2005
  6. doi Functional clustering of metastasis proteins describes plastic adaptation resources of breast-cancer cells to new microenvironments
    Berta Martín
    Centre d Oncologia Molecular, IDIBELL, Hospital Duran i Reynals, CSUB, L Hospitalet Llobregat, Barcelona, Spain
    J Proteome Res 7:3242-53. 2008
  7. ncbi Overexpression of Bcl-xL in human breast cancer cells enhances organ-selective lymph node metastasis
    Laura España
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Hospital Duran i Reynals, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    Breast Cancer Res Treat 87:33-44. 2004
  8. pmc Expression of endoplasmic reticulum stress proteins is a candidate marker of brain metastasis in both ErbB-2+ and ErbB-2- primary breast tumors
    Rebeca Sanz-Pamplona
    Biological Clues of the Invasive and Metastatic Phenotype Group, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain
    Am J Pathol 179:564-79. 2011
  9. ncbi Underexpression of transcriptional regulators is common in metastatic breast cancer cells overexpressing Bcl-xL
    Olga Mendez
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, IDIBELL, Hospital Duran i Reynals, Gran Via s n, Km 2, 7, E 08907 L Hospitalet Ll, Barcelona, Spain
    Carcinogenesis 27:1169-79. 2006
  10. doi Biological pathways contributing to organ-specific phenotype of brain metastatic cells
    Berta Martín
    Centre d Oncologia Molecular, IDIBELL, Hospital Duran i Reynals, L Hospitalet Ll, Barcelona 08907, Spain
    J Proteome Res 7:908-20. 2008

Collaborators

  • Baldo Oliva
  • Ramon Aragues
  • Yolanda Fernandez
  • Verena Stresing
  • Keltouma Driouch
  • Ander Urruticoechea
  • Marc J van de Vijver
  • Pedro L Fernandez
  • Eva Gonzalez-Suarez
  • Fabien Reyal
  • Berta Martín
  • Rebeca Sanz
  • Victor Moreno
  • Olga Mendez
  • Laura España
  • Rosette Lidereau
  • Thomas Landemaine
  • Antonio Martínez-Aranda
  • Miguel Gil
  • Claudia Nieva
  • Rebeca Sanz-Pamplona
  • Antonio Martinez
  • Susana Boluda
  • Angels Torregrosa
  • Bin Gu
  • Eva Castella
  • Miquel A Seguí
  • Rosa Ballester
  • Vanessa Hernandez
  • Nuria Baixeras
  • Emre Guney
  • Ferran Moreno
  • Laia Muixí
  • Daniel Cuadras
  • Ruben Foj
  • Noemi Vidal
  • Xavier Andreu
  • Pedro J Real
  • Dmitri Petrov
  • Satish Rao
  • Monica Marro
  • Naiara Santana-Codina
  • Juan J Acebes
  • Enrico Ricevuto
  • Alain Boudinet
  • Marianne Briffod
  • Vincent Castronovo
  • Berta Martin Abad
  • Amanda Jackson
  • Nadia Rucci
  • Anna Teti
  • Jean Marc Guinebretiere
  • Akeila Bellahcene
  • Soraya Sin
  • Catherine Nogues
  • Pascal Cherel
  • Ivan Bieche
  • Teresa Garcia
  • Miguel A Peinado
  • Cristina Chiva
  • David Andreu
  • Jeronimo Blanco
  • Nuria Rubio
  • Ana de Juan
  • Jose L Fernandez-Luna
  • Jose M Lopez-Vega
  • Jose C Segovia

Detail Information

Publications19

  1. ncbi Metastases and their microenvironments: linking pathogenesis and therapy
    Angels Sierra
    Centre d Oncologia Molecular, Institut de Recerca Oncològica IDIBELL, Hospital Duran i Reynals C S U B, Gran Via, Km 2 7, E 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Drug Resist Updat 8:247-57. 2005
    ....
  2. ncbi Expression of death-related genes and their relationship to loss of apoptosis in T1 ductal breast carcinomas
    A Sierra
    Department of Càncer i Metàstasis, Institut de Recerca Oncologica, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    Int J Cancer 79:103-10. 1998
    ..Our results suggest that the loss or gain of apoptosis is regulated tightly in T1 breast carcinomas through the expression of different effectors along with tumor cell differentiation...
  3. ncbi Synergistic cooperation between c-Myc and Bcl-2 in lymph node progression of T1 human breast carcinomas
    A Sierra
    Dpt Cancer i Metàstasis, Institut de Recerca Oncologica, Hospital Duran i Reynals, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    Breast Cancer Res Treat 54:39-45. 1999
    ..It is concluded that the synergism between Bcl-2 and c-Myc oncogenes may promote metastasis in breast tumors, linked to loss of apoptosis...
  4. ncbi Bcl-2 with loss of apoptosis allows accumulation of genetic alterations: a pathway to metastatic progression in human breast cancer
    A Sierra
    Departament i Càncer Metàstasis, Institut de Recerca Oncologica, Hospital Duran i Reynals, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    Int J Cancer 89:142-7. 2000
    ..Thus, in breast cancer, there are at least 2 pathways to progression: Bcl-2- and p53-dependent mechanisms...
  5. pmc Bcl-x(L)-mediated changes in metabolic pathways of breast cancer cells: from survival in the blood stream to organ-specific metastasis
    Laura España
    Centre d Oncologia Molecular, Institut de Recerca Oncològica IDIBELL, Hosp Duran i Reynals, C S U B, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Am J Pathol 167:1125-37. 2005
    ..In conclusion, Bcl-x(L) mediates a phenotype in which redox pathways and glycolysis are coupled to protect breast cancer metastatic cells during transit from the primary tumor to the metastatic state...
  6. doi Functional clustering of metastasis proteins describes plastic adaptation resources of breast-cancer cells to new microenvironments
    Berta Martín
    Centre d Oncologia Molecular, IDIBELL, Hospital Duran i Reynals, CSUB, L Hospitalet Llobregat, Barcelona, Spain
    J Proteome Res 7:3242-53. 2008
    ..71 x 10(-2)) and protein amino acid phosphorylation (p-value FDR = 3.28 x 10(-2)) might be the most significant biological process differentially increased in liver metastasis...
  7. ncbi Overexpression of Bcl-xL in human breast cancer cells enhances organ-selective lymph node metastasis
    Laura España
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Hospital Duran i Reynals, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    Breast Cancer Res Treat 87:33-44. 2004
    ..These results point to the relevance of Bcl-xL overexpression inducing lymph node metastasis of breast cancer cells, and to the value of this gene as a target for therapy in order to prevent metastasis...
  8. pmc Expression of endoplasmic reticulum stress proteins is a candidate marker of brain metastasis in both ErbB-2+ and ErbB-2- primary breast tumors
    Rebeca Sanz-Pamplona
    Biological Clues of the Invasive and Metastatic Phenotype Group, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain
    Am J Pathol 179:564-79. 2011
    ..16) than ErbB-2 (LR = 0.42). We conclude that, in breast carcinomas, certain proteins associated with the endoplasmic reticulum stress phenotype are candidate markers of brain metastasis...
  9. ncbi Underexpression of transcriptional regulators is common in metastatic breast cancer cells overexpressing Bcl-xL
    Olga Mendez
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, IDIBELL, Hospital Duran i Reynals, Gran Via s n, Km 2, 7, E 08907 L Hospitalet Ll, Barcelona, Spain
    Carcinogenesis 27:1169-79. 2006
    ....
  10. doi Biological pathways contributing to organ-specific phenotype of brain metastatic cells
    Berta Martín
    Centre d Oncologia Molecular, IDIBELL, Hospital Duran i Reynals, L Hospitalet Ll, Barcelona 08907, Spain
    J Proteome Res 7:908-20. 2008
    ..Further functional analyses in cells, expression analyses in experimental tissues, and in human brain metastasis were addressed to validate the biological pathways contributing to organ-specific phenotype of brain metastasis...
  11. ncbi Anti-apoptotic proteins induce non-random genetic alterations that result in selecting breast cancer metastatic cells
    Olga Mendez
    Centre d Oncologia Molecular, Institut de Recerca Oncològica IDIBELL, Barcelona, Spain
    Clin Exp Metastasis 22:297-307. 2005
    ..We therefore propose that genetic instability is a molecular mechanism favored by anti-apoptotic proteins involved in the selection of highly metastatic cells during tumorigenesis, a pathogenic event favoring the expansion of metastasis...
  12. ncbi Organ-selective chemoresistance in metastasis from human breast cancer cells: inhibition of apoptosis, genetic variability and microenvironment at the metastatic focus
    Bin Gu
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Hospital Duran i Reynals, Ciutat Sanitaria i Universitaria de Bellvitge, Barcelona, Spain
    Carcinogenesis 25:2293-301. 2004
    ....
  13. ncbi Functional pathways shared by liver and lung metastases: a mitochondrial chaperone machine is up-regulated in soft-tissue breast cancer metastasis
    Rebeca Sanz
    Centre d Oncologia Molecular, Institut de Recerca Oncològica IDIBELL, Hospital Duran i Reynals, Gran Via, S N, Km 2 7, L Hospitalet Ll, 08907, Barcelona, Spain
    Clin Exp Metastasis 24:673-83. 2007
    ....
  14. ncbi Inhibition of apoptosis in human breast cancer cells: role in tumor progression to the metastatic state
    Yolanda Fernandez
    Centro de Oncologia Molecular, Institut de Recerca Oncològica I R O, Ciutat Sanitària i Universitària de Bellvitge C S U B, Barcelona, Spain
    Int J Cancer 101:317-26. 2002
    ..These genes increase tumor metastasis when the oncogenic background has triggered the metastatic process, in which anoikis might determine tumor progression when the life span of the cells is extended...
  15. ncbi Animal models of breast cancer for the study of pathogenesis and therapeutic insights
    Angels Sierra
    Institut d Investigacio Biomedica de Bellvitge, L Hospitalet de Llobregat, Barcelona, Spain
    Clin Transl Oncol 11:721-7. 2009
    ..This review highlights some of the current strategies for modelling breast cancer in vitro and in the mouse, in order to answer biological or translational questions about human breast malignancies...
  16. pmc FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies
    Antonio Martínez-Aranda
    Biological Clues of the Invasive and Metastatic Phenotype Group, Molecular Oncology Department, Bellvitge Biomedical Research Institute IDIBELL, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Oncotarget 6:44254-73. 2015
    ..In conclusion our results indicate that FN14 and GRP94 are prediction/prognosis markers which open up new possibilities for preventing/treating brain metastasis. ..
  17. pmc The lipid phenotype of breast cancer cells characterized by Raman microspectroscopy: towards a stratification of malignancy
    Claudia Nieva
    IDIBELL Institut d Investigació Biomèdica de Bellvitge, L Hospitalet de Llobregat, Barcelona, Spain
    PLoS ONE 7:e46456. 2012
    ..The algorithm for the discrimination of metastatic ability is a first step towards stratifying breast cancer cells using this rapid and reagent-free tool...
  18. doi A six-gene signature predicting breast cancer lung metastasis
    Thomas Landemaine
    Centre Rene Huguenin, Fédération Nationale des Centres de Lutte Contre le Cancer and Institut National de la Sante et de la Recherche Medicale, U735, Saint Cloud, France
    Cancer Res 68:6092-9. 2008
    ..Finally, we show that the signature improves risk stratification independently of known standard clinical variables and a previously established lung metastasis signature based on an experimental breast cancer metastasis model...
  19. ncbi Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells
    Pedro J Real
    Unidad de Genetica Molecular, Hospital Universitario Marques de Valdecilla, 39008 Santander, Spain
    Oncogene 21:7611-8. 2002
    ..Our data suggest that an increased activation of the Stat3-Bcl-2 pathway in estrogen receptor-negative metastatic breast cancer cell lines confer a survival advantage to these cells and contribute to their chemoresistance...