Javier Santos

Summary

Affiliation: Hospital Universitari Vall d'Hebron
Country: Spain

Publications

  1. ncbi request reprint Pathogenesis of irritable bowel syndrome: the mast cell connection
    Javier Santos
    Digestive Diseases Research Unit, Hospital General Vall d Hebron, Autonomous University of Barcelona, ES 08035 Barcelona, Spain
    Scand J Gastroenterol 40:129-40. 2005
  2. ncbi request reprint Neuropharmacology of stress-induced mucosal inflammation: implications for inflammatory bowel disease and irritable bowel syndrome
    Javier Santos
    Digestive Diseases Research Unit, Department of Gastroenterology, Institut de Recerça Vall d Hebron and Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Department of Medicine, Barcelona, Spain
    Curr Mol Med 8:258-73. 2008
  3. pmc Cellular and molecular basis of intestinal barrier dysfunction in the irritable bowel syndrome
    Cristina Martinez
    Department of Gastroenterology, Digestive System Research Unit, Hospital Universitari Vall d Hebron, Institut de Recerca Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Gut Liver 6:305-15. 2012
  4. doi request reprint Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon
    Javier Santos
    Digestive Diseases Research Unit, Institut de Recerca Vall d Hebron, Department of Gastroenterology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Department of Medicine, Barcelona, Spain
    Psychoneuroendocrinology 33:1248-56. 2008
  5. ncbi request reprint Targeting mast cells in the treatment of functional gastrointestinal disorders
    Javier Santos
    Digestive Diseases Research Unit, Department of Gastroenterology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, 08035 Barcelona, Spain
    Curr Opin Pharmacol 6:541-6. 2006
  6. doi request reprint The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations
    Cristina Martinez
    Department of Gastroenterology, Digestive System Research Unit, Hospital Universitari Vall d Hebron, Institut de Recerca Vall d Hebron, Universitat Autònoma de Barcelona Departmento de Medicina, Barcelona, Spain
    Am J Gastroenterol 107:736-46. 2012
  7. doi request reprint Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation
    Carmen Alonso
    Digestive Diseases Research Unit, Institut de Recerca, Department of Gastroenterology, Barcelona, Spain
    Gastroenterology 135:163-172.e1. 2008
  8. doi request reprint Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier
    Cristina Martinez
    Digestive System Research Unit, Laboratory of Neuro Immuno Gastroenterology, Department of Gastroenterology, Vall d Hebron Institut de Recerca, Paseo Vall d Hebron 119 129, 08035, Barcelona, Spain
    Gut 62:1160-8. 2013
  9. doi request reprint Chronic psychosocial stress induces reversible mitochondrial damage and corticotropin-releasing factor receptor type-1 upregulation in the rat intestine and IBS-like gut dysfunction
    Maria Vicario
    Department of Gastroenterology, Institut de Recerca Vall d Hebron, CIBERehd, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Departament of Medicine, Barcelona, Spain
    Psychoneuroendocrinology 37:65-77. 2012
  10. doi request reprint Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress
    Maria Vicario
    Digestive Diseases Research Unit, Lab Neuro Immuno Gastroenterology, Institut de Recerca Vall d Hebron, CIBERehd, Department of Gastroenterology, Barcelona, Spain
    Brain Behav Immun 24:1166-75. 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Pathogenesis of irritable bowel syndrome: the mast cell connection
    Javier Santos
    Digestive Diseases Research Unit, Hospital General Vall d Hebron, Autonomous University of Barcelona, ES 08035 Barcelona, Spain
    Scand J Gastroenterol 40:129-40. 2005
  2. ncbi request reprint Neuropharmacology of stress-induced mucosal inflammation: implications for inflammatory bowel disease and irritable bowel syndrome
    Javier Santos
    Digestive Diseases Research Unit, Department of Gastroenterology, Institut de Recerça Vall d Hebron and Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Department of Medicine, Barcelona, Spain
    Curr Mol Med 8:258-73. 2008
    ....
  3. pmc Cellular and molecular basis of intestinal barrier dysfunction in the irritable bowel syndrome
    Cristina Martinez
    Department of Gastroenterology, Digestive System Research Unit, Hospital Universitari Vall d Hebron, Institut de Recerca Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Gut Liver 6:305-15. 2012
    ..This review summarizes the clinical and experimental evidences indicating the cellular and molecular mechanisms of IBS symptomatology, and its relevance for future translational research...
  4. doi request reprint Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon
    Javier Santos
    Digestive Diseases Research Unit, Institut de Recerca Vall d Hebron, Department of Gastroenterology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Department of Medicine, Barcelona, Spain
    Psychoneuroendocrinology 33:1248-56. 2008
    ..However, the ability of CRF-sensitive mucosal/submucosal loops to regulate intestinal barrier and the participation of resident mast cells are unclear...
  5. ncbi request reprint Targeting mast cells in the treatment of functional gastrointestinal disorders
    Javier Santos
    Digestive Diseases Research Unit, Department of Gastroenterology, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, 08035 Barcelona, Spain
    Curr Opin Pharmacol 6:541-6. 2006
    ..Such observations have stimulated the development of candidate drugs, such as tryptase or Syk inhibitors, that might be useful for the treatment of gastrointestinal functional disorders...
  6. doi request reprint The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations
    Cristina Martinez
    Department of Gastroenterology, Digestive System Research Unit, Hospital Universitari Vall d Hebron, Institut de Recerca Vall d Hebron, Universitat Autònoma de Barcelona Departmento de Medicina, Barcelona, Spain
    Am J Gastroenterol 107:736-46. 2012
    ..The objective of this study was to determine the molecular events and mechanisms and the clinical role of upper small intestinal alterations...
  7. doi request reprint Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation
    Carmen Alonso
    Digestive Diseases Research Unit, Institut de Recerca, Department of Gastroenterology, Barcelona, Spain
    Gastroenterology 135:163-172.e1. 2008
    ..Irritable bowel syndrome (IBS), a highly prevalent disorder among women, has been associated with life stress, but the peripheral mechanisms involved remain largely unexplored...
  8. doi request reprint Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier
    Cristina Martinez
    Digestive System Research Unit, Laboratory of Neuro Immuno Gastroenterology, Department of Gastroenterology, Vall d Hebron Institut de Recerca, Paseo Vall d Hebron 119 129, 08035, Barcelona, Spain
    Gut 62:1160-8. 2013
    ..The aim of the authors here was to determine whether these alterations are associated with structural abnormalities in AJC and their relationship with mast cell activation and IBS-D clinical manifestations...
  9. doi request reprint Chronic psychosocial stress induces reversible mitochondrial damage and corticotropin-releasing factor receptor type-1 upregulation in the rat intestine and IBS-like gut dysfunction
    Maria Vicario
    Department of Gastroenterology, Institut de Recerca Vall d Hebron, CIBERehd, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Departament of Medicine, Barcelona, Spain
    Psychoneuroendocrinology 37:65-77. 2012
    ..These findings support crowding stress as a suitable animal model to unravel the complex pathophysiology underlying to common human intestinal stress-related disorders, such as IBS...
  10. doi request reprint Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress
    Maria Vicario
    Digestive Diseases Research Unit, Lab Neuro Immuno Gastroenterology, Institut de Recerca Vall d Hebron, CIBERehd, Department of Gastroenterology, Barcelona, Spain
    Brain Behav Immun 24:1166-75. 2010
    ..The notable resemblance of these findings with those in some IBS patients, support the potential interest and translational validity of this experimental model for the research of stress-sensitive intestinal disorders, particularly IBS...
  11. pmc Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
    Mar Guilarte
    Department of Medicine, Hospital Universitari General Vall d Hebron, 08035 Barcelona, Spain
    Gut 56:203-9. 2007
    ..Although upper gut symptoms are common, mast cells have not been thoroughly evaluated in proximal gut in IBS patients...
  12. ncbi request reprint [Stress-mast cell axis and regulation of gut mucosal inflammation: from intestinal health to an irritable bowel]
    Laura Ramos
    Unidad de Investigación en Enfermedades Digestivas, Servicio de Aparato Digestivo, Hospital Universitari Vall d Hebron, Departamento de Medicina, Universitat Autonoma de Barcelona, Barcelona, Espana
    Med Clin (Barc) 129:61-9. 2007
    ..In this article we will review the role of the stress-mast cell axis in the modulation of the gut mucosal inflammation and in the pathophysiology of the irritable bowel syndrome...
  13. ncbi request reprint Intestinal barrier function and the brain-gut axis
    Carmen Alonso
    Neuro Immuno Gastroenterology Group, Digestive Diseases Research Unit, Gastroenterology Department, Hospital Universitari Vall d Hebron, Vall d Hebron Research Institute, Paseo Vall d Hebron 119 129, 08035, Barcelona, Spain
    Adv Exp Med Biol 817:73-113. 2014
    ..In this chapter, we describe the structure, function and interactions of intestinal barrier, microbiota and brain-gut axis in both healthy and pathological conditions. ..
  14. ncbi request reprint Anisakis simplex-induced small bowel obstruction after fish ingestion: preliminary evidence for response to parenteral corticosteroids
    Laura Ramos
    Digestive System Research Unit, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Clin Gastroenterol Hepatol 3:667-71. 2005
    ....
  15. doi request reprint Unstable composition of the fecal microbiota in ulcerative colitis during clinical remission
    Cristina Martinez
    Digestive Disease Research Unit, University Hospital Vall d Hebron, CIBERehd, Barcelona, Spain
    Am J Gastroenterol 103:643-8. 2008
    ..We investigated dynamics of fecal microbiota in ulcerative colitis (UC) during remission by genomic technology...
  16. ncbi request reprint Prevalence of functional gastrointestinal disorders in women who report domestic violence to the police
    Monica Perona
    Institute of Functional and Motor Digestive Disorders, Centro Medico Teknon, Barcelona, Spain
    Clin Gastroenterol Hepatol 3:436-41. 2005
    ....
  17. pmc Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
    Chaysavanh Manichanh
    Digestive System Research Unit, Departament de Medicina, University Hospital Vall d Hebron, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Universitat Autonoma de Barcelona, Barcelona, Spain
    Gut 63:401-8. 2014
    ..To characterise the influence of diet on abdominal symptoms, anal gas evacuation, intestinal gas distribution and colonic microbiota in patients complaining of flatulence...
  18. ncbi request reprint Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH
    Paul R Saunders
    Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Dig Dis Sci 47:208-15. 2002
    ..We speculate that a stress-induced barrier defect may allow uptake of immunogenic substances into the colonic mucosa, initiating or exacerbating intestinal inflammation...