Research Topics
Genomes and Genes | Manuel Romero-GomezSummaryAffiliation: Hospital Universitario de Valme Country: Spain Publications
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Publications
Altered response to oral glutamine challenge as prognostic factor for overt episodes in patients with minimal hepatic encephalopathyManuel Romero-Gomez
Unit of Hepatology, Hospital Universitario de Valme, Ctra Cádiz s n 41014 Seville, Spain
J Hepatol 37:781-7. 2002..We assessed the usefulness of oral glutamine challenge (OGC) and minimal hepatic encephalopathy in evaluating risk of overt hepatic encephalopathy in cirrhotic patients...- Effect of sustained virological response to treatment on the incidence of abnormal glucose values in chronic hepatitis CManuel Romero-Gomez
Unit for the Clinical Management of Digestive Diseases and CIBEREHD, Hospital Universitario de Valme, Seville, Spain
J Hepatol 48:721-7. 2008..To investigate the effect of sustained virological response (SVR) on impaired fasting glucose (IFG) and/or type 2 diabetes (T2DM); to assess the influence of glucose abnormalities on the SVR rate... - [Comparative study of two models that use biochemical parameters for the non-invasive diagnosis of fibrosis in patients with hepatitis C]Manuel Romero Gomez
Unidad de Hepatologia, Hospital Universitario de Valme, Sevilla, Espana
Med Clin (Barc) 124:761-4. 2005..Our study was aimed to compare both non-invasive methods to predict mild fibrosis (F0-F1) or to confirm advanced fibrosis (F3, F4) in patients with chronic hepatitis C... - Role of phosphate-activated glutaminase in the pathogenesis of hepatic encephalopathyManuel Romero-Gomez
Hepatology Unit, Hospital Universitario de Valme, Sevilla, Spain
Metab Brain Dis 20:319-25. 2005..These data support an important role for intestinal and brain glutaminase in the pathogenesis of hepatic encephalopathy and could be a new target for future therapies... - Acute hepatitis due to Mycoplasma pneumoniae infection without lung involvement in adult patientsManuel Romero-Gomez
Digestive Diseases Unit, Hospital Universitario de Valme, Ctra Cádiz s n 41014, Sevilla, Spain
J Hepatol 44:827-8. 2006..Controversial data have been reported about the possibility of liver involvement with M. pneumoniae community-acquired pneumonia. We present two cases of acute hepatitis associated with M. pneumoniae infection without lung involvement... - Optical analysis of computed tomography images of the liver predicts fibrosis stage and distribution in chronic hepatitis CManuel Romero-Gomez
Unit for the Clinical Management of Digestive Diseases and CIBEREHD, Hospital Universitario de Valme, Sevilla, Spain
Hepatology 47:810-6. 2008..Fibro-CT is a simple to use, readily available, and useful method for the diagnosis of fibrosis in patients with chronic hepatitis C... - Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosisManuel Romero-Gomez
Unit for Clinical Management of Digestive Diseases, Hospital Universitario de Valme, ctra Cadiz s n, 41014 Seville, Spain
World J Gastroenterol 12:2406-11. 2006.... - [Normality tables in the Spanish population for psychometric tests used in the diagnosis of minimal hepatic encephalopathy]Manuel Romero Gomez
Unidad de Gestión Clínica de Enfermedades Digestivas, Hospital Universitario de Valme, Sevilla, Spain
Med Clin (Barc) 127:246-9. 2006..Psychometric Hepatic Encephalopathy Score (PHES) is a psychometric test battery widely utilized in the diagnosis of MHE which requires correction by age and education... - Hepatitis C and insulin resistance: steatosis, fibrosis and non-responseM Romero-Gomez
Unit for the Clinical Management of Digestive Diseases, Hospital Universitario de Valme, Seville, Spain
Rev Esp Enferm Dig 98:605-15. 2006..The treatment of insulin resistance by decreasing hyperinsulinemia could improve sustained response rates in patients with chronic hepatitis C treated with peginterferon plus ribavirin... - Insulin resistance and hepatitis CManuel Romero-Gomez
Unit for The Clinical Management of Digestive Diseases Hospital Universitario de Valme Ctra de Cadiz s n Sevilla 41014, Spain
World J Gastroenterol 12:7075-80. 2006..In summary, hepatitis C promotes insulin resistance and insulin resistance induces interferon resistance, steatosis and fibrosis progression... - Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patientsManuel Romero-Gomez
Hepatology Unit, Hospital Universitario de Valme, Sevilla, Spain
Gastroenterology 128:636-41. 2005..We evaluated the effect of insulin resistance and viral factors on sustained virological response in patients with chronic hepatitis C treated with peginterferon plus ribavirin... - [Hepatitis C: cryoglobulinemia and non-Hodgkin lymphoma]M Romero-Gomez
Unidad de Gestión Clínica de Enfermedades Digestivas, Hospital Universitario de Valme, Carretera de Cádiz s n, Seville
Rev Esp Enferm Dig 100:164-70. 2008..Therefore, in chronic hepatitis C, the combination of peginterferon + ribavirin is strongly recommended in treating symptomatic mixed cryoglobulinemia and HCV-related non-Hodgkin lymphomas... - Three-day intravenous triple therapy is not effective for the eradication of Helicobacter pylori infection in patients with bleeding gastro-duodenal ulcerM Romero-Gomez
Digestive and Hepatology Unit, Hospital Universitario de Valme, Seville, Spain
Aliment Pharmacol Ther 18:1023-9. 2003..To test the efficacy of an ultra-short intravenous triple therapy against Helicobacter pylori infection in patients with bleeding peptic ulcer against standard oral 1-week triple therapy in a randomised, double-blind prospective trial... 
SLC11A1 promoter gene polymorphisms and fibrosis progression in chronic hepatitis CM Romero-Gomez
Hepatology Unit, Hospital Universitario de Valme, Sevilla, Spain
Gut 53:446-50. 2004..We investigated the possible role of the functional polymorphism located in the promoter region of SLC11A1 and tumour necrosis factor (TNF) genes in the progression of fibrosis in chronic hepatitis C...- Gut ammonia production and its modulationManuel Romero-Gomez
Unit for the Clinical Management of Digestive Diseases and CIBEREHD, Hospital Universitario de Valme, Universidad de Sevilla, 41014 Sevilla, Spain
Metab Brain Dis 24:147-57. 2009..Lastly, some genetic alterations in the glutaminase gene such as the haplotype TACC could modulate intestinal ammonia production and the risk of overt hepatic encephalopathy in cirrhotics... - [New concepts in the physiopathology of hepatic encephalopathy and therapeutic prospects]M Romero Gomez
Unidad de Hepatologia, Hospital Universitario de Valme, Ctra Cádiz, S N, 41014 Sevilla, Espana
Gastroenterol Hepatol 27:40-8. 2004 - Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathyManuel Romero-Gomez
Hepatology Unit, Hospital Universitario de Valme, ctra Cadiz s n, 41014 Sevilla, Spain
J Hepatol 41:49-54. 2004..We performed the current study to assess the intestinal activity of enterocyte phosphate-activated glutaminase (PAG) in cirrhosis... - Value of the critical flicker frequency in patients with minimal hepatic encephalopathyManuel Romero-Gomez
Unit for the Clinical Management of Digestive Diseases, Hospital Universitario de Valme, Sevilla, Spain
Hepatology 45:879-85. 2007..CONCLUSION: CFF is a simple, reliable, and accurate method for the diagnosis of MHE. It is not influenced by age or education and could predict the development of overt HE... - Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirinManuel Romero-Gomez
Unit for the Clinical Management of Digestive Diseases and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Hospital Universitario de Valme, Sevilla, Spain
Hepatology 50:1702-8. 2009..05). CONCLUSION: Adding metformin to peginterferon and ribavirin was safe and improved insulin sensitivity. Although the study failed to show a statistically significant difference between arms, it did show an improved SVR in females... - HLA class I B44 is associated with sustained response to interferon + ribavirin therapy in patients with chronic hepatitis CManuel Romero-Gomez
Hepatology Unit, Hospital Universitario de Valme, Seville, Spain
Am J Gastroenterol 98:1621-6. 2003..The aim of this study was to assess the influence of host genetic factors on response to combination therapy for chronic hepatitis C infection... - Serum leptin levels correlate with hepatic steatosis in chronic hepatitis CManuel Romero-Gomez
Units of Hepatology, Hospital Universitario de Valme, Sevilla, Spain
Am J Gastroenterol 98:1135-41. 2003..Hepatic steatosis (HS) has been related to obesity and fibrosis in chronic hepatitis C (CHC). The aim of this study was to determine the role of leptin system in HS development... - Incidence of and factors associated with hepatocellular carcinoma among hepatitis C virus and human immunodeficiency virus coinfected patients with decompensated cirrhosisJosé A García-García
Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario de Valme, Sevilla, Spain
AIDS Res Hum Retroviruses 22:1236-41. 2006..This is probably due to the fact that HIV infection shortens the survival of HCV-coinfected patients with end-stage liver disease to such an extent that HCC not had a chance to emerge... - Prognostic value of altered oral glutamine challenge in patients with minimal hepatic encephalopathyManuel Romero-Gomez
Unit of Hepatology, Hospital Universitario de Valme, Seville, Spain
Hepatology 39:939-43. 2004..In conclusion, a pathological OGC response in patients with MHE appears to be associated with lower survival rate and may prove useful in the selection of candidates for liver transplantation... - Insulin resistance impairs viral dynamics independently of ethnicity or genotypesMohammed Eslam
Unit for the Clinical Management of Digestive Diseases and CIBEREHD, Hospital Universitario de Valme, Ctra de Cadiz s n, Sevilla, Spain
J Clin Gastroenterol 46:228-34. 2012..Data concerning the influence of insulin resistance (IR) and ethnicity on early phases of viral kinetics after initiation of peginterferon plus ribavirin in treatment-naive, chronic hepatitis C (CHC) patients are limited... - HAVCR1 gene haplotypes and infection by different viral hepatitis C virus genotypesCristina Abad-Molina
Servicio de Inmunologia, Hospital Universitario Virgen del Rocío Instituto de Biomedicina, Sevilla, Spain
Clin Vaccine Immunol 19:223-7. 2012..72%, respectively; corrected P value [P(c)], 3.2 × 10(-4); odds ratio [OR], 2.30; 95% confidence interval [CI], 1.51 to 3.47). Thus, HAVCR1 could be involved in susceptibility or resistance to infection by a particular HCV genotype... - Insulin resistance and response to antiviral therapy in chronic hepatitis C: mechanisms and managementJose A Del Campo
Unit for Clinical Management of Digestive Diseases and CIBERehd, Valme University Hospital, Seville, Spain
Dig Dis 28:285-93. 2010..Insulin resistance is a new target in the challenging management of chronic hepatitis C... - Histologic features of steatohepatitis in patients with a clinical diagnosis of autoimmune cholestasisDiego Sanchez-Munoz
Hospital Universitario de Valme, Sevilla, Spain
Dig Dis Sci 49:1957-61. 2004 - Variations in the promoter region of the glutaminase gene and the development of hepatic encephalopathy in patients with cirrhosis: a cohort studyManuel Romero-Gomez
Hospital Universitario de Valme, Universidad de Sevilla, Spain
Ann Intern Med 153:281-8. 2010..Hepatic encephalopathy is a major complication of cirrhosis and is associated with a poor prognosis... - Tumour necrosis factor alpha polymorphisms are not involved in the development of steatosis in chronic hepatitis CDiego Sanchez-Munoz
Hepatology Unit, Hospital Universitario de Valme, Seville, Spain
Eur J Gastroenterol Hepatol 16:761-5. 2004..To determine whether the different tumour necrosis factor alpha (TNF-alpha) promoter gene polymorphisms are involved in the development of steatosis in chronic hepatitis C... - Interleukin-28B genetic variants and hepatitis virus infection by different viral genotypesMarco Antonio Montes-Cano
Servicio de Inmunologia, Hospital Universitario Virgen del Rocio Instituto de Biomedicina de Sevilla, Sevilla, Spain
Hepatology 52:33-7. 2010..1 x 10(-5), OR = 0.31; 95%CI, 0.17-0.56). CONCLUSION: We have found different rates of viral genotype infection depending on the IL28B variant as well as an association of this locus with natural and treatment-mediated response... - The role of insulin resistance in HIV/hepatitis C virus-coinfected patientsMohammed Eslam
Unit for the Clinical Management of Digestive Diseases and CIBEREHD, Hospital Universitario de Valme, Ctra de Cadiz s n, Spain
Curr Opin HIV AIDS 6:553-8. 2011..The objective of this review was to explore the meaning of insulin resistance in HIV-HCV-coinfected patients and how it may impact on sustained virological response (SVR) and disease progression... 
Genes and hepatitis C: susceptibility, fibrosis progression and response to treatmentManuel Romero-Gomez
Unit for the Clinical Management of Digestive Diseases and CIBEREHD, Hospital Universitario de Valme, Sevilla, Spain
Liver Int 31:443-60. 2011..However, nearly half of patients achieving SVR did not show favourable genotype. Further genetic signals are warranted to complete the puzzle of factors influencing hepatitis C...- Metformin Inhibits Glutaminase Activity and Protects against Hepatic EncephalopathyJavier Ampuero
Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain
PLoS ONE 7:e49279. 2012..To analyze the impact of metformin on glutaminase activity and ammonia production in vitro... - Pharmacotherapy of hepatic encephalopathy in cirrhosisManuel Romero-Gomez
Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Seville, Seville, Spain
Expert Opin Pharmacother 11:1317-27. 2010..Hepatic encephalopathy (HE) is a major complication encountered in nearly half of the patients with liver cirrhosis... - Steatosis and insulin resistance in hepatitis C: a way out for the virus?Jose A Del Campo
Unit for the Clinical Management of Digestive Diseases and CIBEREHD, Hospital Universitario de Valme, Ctra de Cadiz s n, Sevilla 41014, Spain
World J Gastroenterol 15:5014-9. 2009..Steatosis and insulin resistance have been associated with fibrosis progression and a reduced rate of sustained response to peginterferon plus ribavirin... - HIV coinfection shortens the survival of patients with hepatitis C virus-related decompensated cirrhosisJuan A Pineda
Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario de Valme, 41014 Sevilla, Spain
Hepatology 41:779-89. 2005..This fact must be taken into account to establish the adequate timing of liver transplantation in HIV-coinfected subjects... - Serum immunological profile in patients with chronic autoimmune cholestasisManuel Romero-Gomez
Unidad de Hepatologia, Hospital Universitario de Valme, Sevilla, Spain
Am J Gastroenterol 99:2150-7. 2004..To compare patients who had biochemical and histological features of chronic autoimmune cholestasis (CAIC) using serological autoantibody profiling... - [Hepatitis C and metabolic syndrome]Reyes Aparcero López
Unidad de Gestión Clínica de Enfermedades Digestivas, Hospital Universitario de Valme, Sevilla, Espana
Gastroenterol Hepatol 33:530-40. 2010..The TRIC-1 study demonstrated that adding metformin to routine treatment improves the possibilities of cure in women and in patients whose insulin sensitivity returns to normal during treatment... - Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registryRaul J Andrade
Unidad de Hepatologia, Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos, Co ordinating Centre, Hospital Universitario Virgen de la Victoria, Facultad de Medicina, Campus Universitario de Teatinos s n, Malaga, Spain
Hepatology 44:1581-8. 2006..Cardiovascular and central nervous system drugs are the main groups leading to chronic liver damage... - HLA-C and KIR genes in hepatitis C virus infectionMarco Antonio Montes-Cano
Servicio de Inmunologia, Hospital Universitario Virgen del Rocio, Sevilla, Spain
Hum Immunol 66:1106-9. 2005..02, OR = 1.68, 95% CI = 1.07-2.65). Trends toward lower frequencies of the HLA-C2C2 genotype and NK-HLA interactions with strong and moderate affinity among the patients with persistent infection were also observed... - Brain biomolecules oxidation in portacaval-shunted ratsPilar Carbonero-Aguilar
Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain
Liver Int 31:964-9. 2011..Therefore, oxidative damage of brain biomolecules could contribute towards explaining the neurological and motor alterations observed in HE... - The hepatitis C virus modulates insulin signaling pathway in vitro promoting insulin resistanceJose A Del Campo
Unit for Medical and Surgical Management of Digestive Diseases and CIBERehd, Valme University Hospital, Sevilla, Spain
PLoS ONE 7:e47904. 2012..A strong effect of HCV infection on insulin pathway-related gene and protein expression was found in vitro. These results could lead to the identification of new therapeutic targets in HCV infection and its co-morbidities... - Cutaneous lymphoma in a patient with ulcerative colitis after immunosuppressive therapyMaria Rojas-Feria
Unit for the Clinical Management of Digestive Diseases and CIBEREHD, Hospital Universitario de Valme, Ctra de Cadiz s n, Sevilla 41014, Spain
J Crohns Colitis 5:608-11. 2011..Biologics are generally safe and well tolerated. However, the risk of haematopoietic cancer in patients with inflammatory bowel disease receiving infliximab has been a growing concern... - [Virological response to adefovir dipivoxil predicts the long-term development of resistance in previously untreated patients with HBeAg-negative chronic hepatitis B]Emilio Suarez
Unidad de Gestión Clínica de Enfermedades Digestivas, Hospital Universitario Virgen de Valme, Sevilla, Espana
Gastroenterol Hepatol 34:69-74. 2011..The aims of this study were to assess the efficacy of adefovir dipivoxil treatment in naïve and lamivudine-resistant patients and to determine whether virological response predicts the development of adefovir resistance... - Propranolol-induced angioedema in a patient with chronic hepatitis C virus infectionEsther Márquez-Saavedra
Andalusian Health Service, Seville, Spain
Am J Health Syst Pharm 67:1182-4. 2010..A case of angioedema secondary to propranolol therapy in a patient with chronic hepatitis C virus (HCV) infection is reported...