Research Topics
Species | Ramon PlanasSummaryAffiliation: Hospital Universitari Germans Trias i Pujol Country: Spain Publications
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Detail Information
Publications
[Induction therapy with interferon alfa-2a in compensated hepatitis C virus-related cirrhosis. Randomized, multicenter study]Ramon Planas
Hospital Universitari Germans Trias i Pujol Badalona BArcelona Spain
Med Clin (Barc) 118:641-4. 2002..Based on HCV kinetics, daily IFN may improve response rates...- Natural history of decompensated hepatitis C virus-related cirrhosis. A study of 200 patientsRamon Planas
Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
J Hepatol 40:823-30. 2004..Since few data are available concerning the clinical course of decompensated hepatitis C virus (HCV)-related cirrhosis, the aim of the present study was to define the natural long-term course after the first hepatic decompensation... - Serum concentrations of insulin-like growth factor-I (igf-I) as a marker of liver fibrosis in patients with chronic hepatitis CVicente Lorenzo-Zúñiga
Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s n, 08916, Badalona, Barcelona, Spain
Dig Dis Sci 52:3245-50. 2007..In conclusion, IGF-I synthesis is disturbed in CHC and reflects the severity of the liver fibrosis. Combined therapy improves serum IGF-I levels. IGF-I could represent a good, noninvasive marker of liver fibrosis... - Results of a study of prolonging treatment with pegylated interferon-alpha2a plus ribavirin in HIV/HCV-coinfected patients with no early virological responseDaniel Fuster
, , Badalona, Barcelona, Spain
Antivir Ther 11:473-82. 2006..Measures to improve adherence to HCV antiviral therapy should be considered when new approaches based on extended periods of treatment are investigated... - Differences in virological response to pegylated interferon and ribavirin between hepatitis C virus (HCV)-monoinfected and HCV-HIV-coinfected patientsCristina Tural
HIV Clinical Unit, Internal Medicine Department, Fundació de la Lluita contra la SIDA, University Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Barcelona, Spain
Antivir Ther 13:1047-55. 2008..Suboptimal doses of ribavirin have been suggested to explain the diminished efficacy of pegylated interferon (PEG-IFN) plus ribavirin in hepatitis C virus (HCV)-HIV-coinfected patients... - Poor response to hepatitis C virus (HCV) therapy in HIV- and HCV-coinfected patients is not due to lower adherence to treatmentRicard Sola
Liver Section, Hospital del Mar, Institut Municipal d Investigacio Medica, Universitat Autonoma de Barcelona, 08003 Barcelona, Spain
AIDS Res Hum Retroviruses 22:393-400. 2006..In addition to improved adherence, in coinfected patients more aggressive therapeutic strategies may be necessary to achieve SVR... 
Incidence and prognosis of different types of functional renal failure in cirrhotic patients with ascitesSilvia Montoliu
Liver Unit, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
Clin Gastroenterol Hepatol 8:616-22; quiz e80. 2010..We assessed the incidence and prognosis of different types of functional renal failure in cirrhotic patients with ascites and investigated prognostic factors for these disorders...- Long-term clinical course of decompensated alcoholic cirrhosis: a prospective study of 165 patientsMarco Antonio Alvarez
Departament of Gastroenterology, Liver Unit, Hospital Universitari Germans Trias i Pujol, Spain
J Clin Gastroenterol 45:906-11. 2011.... - Natural history of patients hospitalized for management of cirrhotic ascitesRamon Planas
Liver Section, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Clin Gastroenterol Hepatol 4:1385-94. 2006..2) The probability of RA and HRS development is relatively low, but they are associated with a poor prognosis... - Effect of an induction period of pegylated interferon-α2a and ribavirin on early virological response in HIV-HCV-coinfected patients: results from the CORAL-2 studyCristina Tural
HIV Clinical Unit, Internal Medicine Department and Fundació de la Lluita contra la SIDA, University Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Barcelona, Spain
Antivir Ther 16:833-41. 2011..It is uncertain whether a 4-week induction period of pegylated interferon and ribavirin increases early virological response (EVR) in HIV-HCV-coinfected patients... - Prophylactic treatment with escitalopram of pegylated interferon alfa-2a-induced depression in hepatitis C: a 12-week, randomized, double-blind, placebo-controlled trialCrisanto Diez-Quevedo
Department of Psychiatry, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Ctra de Canyet s n, 08916 Badalona, Spain
J Clin Psychiatry 72:522-8. 2011..Antidepressants are useful for its treatment, but whether they can also be used for prevention has yet to be established... - Probability of liver cancer and survival in HCV-related or alcoholic-decompensated cirrhosis. A study of 377 patientsRicard Sola
Liver Section, Department of Gastroenterology, Hospital del Mar, Barcelona, Spain
Liver Int 26:62-72. 2006..Although chronic alcohol intake and chronic hepatitis C may progress to cirrhosis and hepatocellular carcinoma (HCC), few data are available about survival and probability of developing HCC in decompensated cirrhosis of both aetiologies... - Short communication. Baseline factors associated with haematological toxicity that leads to a dosage reduction of pegylated interferon-alpha2a and ribavirin in HIV- and HCV-coinfected patients on HCV antiviral therapyDaniel Fuster
, University Hospital Germans Trias i Pujol, , Badalona, Spain
Antivir Ther 10:841-7. 2005..CONCLUSIONS: Baseline factors allow the identification of a subset of HIV/HCV-coinfected patients who are prone to experience haematological toxicity during HCV antiviral therapy... 
Baseline prediction of combination therapy outcome in hepatitis C virus 1b infected patients by discriminant analysis using viral and host factorsVerónica Saludes
Microbiology Service, Fundació Institut d Investigació en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
PLoS ONE 5:e14132. 2010..We aimed to identify pre-treatment clinical and virological parameters associated with treatment failure, as well as to assess whether therapy outcome could be predicted at baseline...- Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic ratsVicente Lorenzo-Zúñiga
Departments of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Hepatology 37:551-7. 2003..Oral conjugated bile acids may be useful in preventing bacterial translocation, endotoxemia, and spontaneous bacterial perotonitis in cirrhotic patients... - Hepatitis C virus sequences from different patients confirm the existence and transmissibility of subtype 2q, a rare subtype circulating in the metropolitan area of Barcelona, SpainElisa Martro
Microbiology Service, Health Sciences Research Institute of Germans Trias i Pujol Foundation, Germans Trias i Pujol Hospital, Autonoma University of Barcelona, Badalona, Spain
J Med Virol 83:820-6. 2011.... - Role of viral kinetics under HCV therapy in HIV/HCV-coinfected patientsAngel Luis Ballesteros
HIV Clinical Unit, Hospital Universitari Germans Trias i Pujol, , Barcelona, Spain
J Antimicrob Chemother 55:824-7. 2005.... - Rat CCl(4)-induced cirrhosis plus total portal vein ligation: a new model for the study of hyperammonaemia and brain oedemaMireia Miquel
Germans Trias i Pujol Health Science Research Institute, Badalona, Spain
Liver Int 30:979-87. 2010..Animal models used to study hyperammonaemic disorders related to chronic liver disease are unsatisfactory. These animals only develop hyperammonaemia and brain oedema when fed with diets supplemented with amonium acetate... - Rifaximin, but not growth factor 1, reduces brain edema in cirrhotic ratsGemma Odena
Hepatology Unit, Department of Gastroenterology, Germans Trias i Pujol Health Science Research Institute, 08916 Badalona, Spain
World J Gastroenterol 18:2084-91. 2012..To compare rifaximin and insulin-like growth factor (IGF)-1 treatment of hyperammonemia and brain edema in cirrhotic rats with portal occlusion... - Evolutionary dynamics of the E1-E2 viral populations during combination therapy in non-responder patients chronically infected with hepatitis C virus subtype 1bVerónica Saludes
Microbiology Service, Fundació Institut d Investigació en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
Infect Genet Evol 13:1-10. 2013..In conclusion, although diverse evolutionary patterns with no apparent common adaptive changes were observed during therapy, treatment failure was characterised by a decline in genetic diversity... - Effect of the administration of fermentable and non-fermentable dietary fibre on intestinal bacterial translocation in ascitic cirrhotic ratsRamon Bartolí
Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s n, 08916, Badalona, Catalonia, Spain
Clin Nutr 26:383-7. 2007..Both fermentable and non-fermentable fibre avoided intestinal bacterial translocation (IBT) in animal models of gut starvation and critical illness... - Evaluation of a new assay in comparison with reverse hybridization and sequencing methods for hepatitis C virus genotyping targeting both 5' noncoding and nonstructural 5b genomic regionsElisa Martro
Microbiology Department, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet, s n 08916 Badalona, Spain
J Clin Microbiol 46:192-7. 2008.... - A prospective study of lymphocyte subpopulations and regulatory T cells in patients with chronic hepatitis C virus infection developing interferon-induced thyroiditisBerta Soldevila
Department of Medicine, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
Clin Endocrinol (Oxf) 75:535-43. 2011..The aim of this study was to assess different peripheral blood lymphocyte subpopulations, mainly CD4(+) CD25(+) CD127low/-FoxP3(+) regulatory T cells (Tregs), in patients with chronic hepatitis C virus (HCV) infection who developed IIT... - Spironolactone alone or in combination with furosemide in the treatment of moderate ascites in nonazotemic cirrhosis. A randomized comparative study of efficacy and safetyJustiniano Santos
Department of Gastroenterology, Hospital Universitari Germans Tri;as i Pujol, Carretera del Canyet, s/n, 08916, Badalona, Spain
J Hepatol 39:187-92. 2003..Since spironolactone alone requires less dose adjustment, it would be more suitable for treating ascites on an outpatient basis... - Combining steroids with enteral nutrition: a better therapeutic strategy for severe alcoholic hepatitis? Results of a pilot studyMarco A Alvarez
Department of Gastroenterology, University Hospital Germans Trias i Pujol, Badalona, Catalonia, Spain
Eur J Gastroenterol Hepatol 16:1375-80. 2004..We report a pilot study of combined treatment with TEN and a shorter course of steroids in patients with severe alcoholic hepatitis... - Mitochondrial effects of a 24-week course of pegylated-interferon plus ribavirin in asymptomatic HCV/HIV co-infected patients on long-term treatment with didanosine, stavudine or bothAngel Luis Ballesteros
HIV Clinical Unit, Hospital Universitari Germans Trias i Pujol, , Barcelona, Spain
Antivir Ther 9:969-77. 2004..These findings could suggest that additional triggers are required to achieve a critical threshold in the degree of mitochondrial damage needed for symptoms to develop... - High-definition colonoscopy and risk factors for recurrence of advanced adenomas in patients with a personal history of polypsVicente Lorenzo-Zúñiga
Department of Gastroenterology, Endoscopy Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona
Eur J Gastroenterol Hepatol 23:425-30. 2011.... - [Treatment of hepatitis B virus infection: present and future]Ramon Planas
Unidad de Hepatologia, Servicio de Aparato Digestivo, CIBERehd, Universidad Autonoma de Barcelona, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
Gastroenterol Hepatol 31:349-55. 2008..And finally, the duration and modification of the treatment based on the answer to itself. The objective of this article is a practical revision of the present management of the infection by the HVB... - Enterococcus gallinarum bacteriascites in a patient with active tuberculosis and HCV cirrhosisMarco A Alvarez
Am J Gastroenterol 97:2681-2. 2002 - Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosisCristina Ripoll
Veterans Affairs CT Healthcare System, Yale University School of Medicine, West Haven, Connecticut 06516, USA
Gastroenterology 133:481-8. 2007.... - Beta-blockers to prevent gastroesophageal varices in patients with cirrhosisRoberto J Groszmann
Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
N Engl J Med 353:2254-61. 2005..ClinicalTrials.gov number, NCT00006398.).. - Hospital admission is a relevant source of hepatitis C virus acquisition in SpainEva Martinez-Bauer
Liver Unit, Hospital Clinic de Barcelona, IDIBAPS, Ciber de Enfermedades Hepaticas y Digestivas, CIBERehd, Spain
J Hepatol 48:20-7. 2008..The aim of this study was to investigate the current relevance of nosocomial HCV infection... - The management of ascites in cirrhosis: report on the consensus conference of the International Ascites ClubKevin P Moore
Centre for Hepatology, Royal Free and University College Medical School, UCL, London, United Kingdom
Hepatology 38:258-66. 2003..Liver transplantation should be considered for all ascitic patients, and this should preferably be performed prior to the development of renal dysfunction to prevent further compromise of their prognosis... - [Risk of transmission of HIV or hepatitis B or C viruses from an infected physician. Preventive measures]Miquel Bruguera
, , Barcelona,
Med Clin (Barc) 129:309-13. 2007 - Advanced liver fibrosis in HIV/HCV-coinfected patients on antiretroviral therapyDaniel Fuster
HIV Clinical Unit Department, University Hospital Germans Trias i Pujol, , 08916 Badalona, Barcelona, Spain
AIDS Res Hum Retroviruses 20:1293-7. 2004..HIV infection is associated with advanced liver fibrosis. HIV/HCV-coinfected individuals on HAART are at risk of developing end-stage liver disease despite virological success and immunological reconstitution... - Platelet count is not a predictor of the presence or development of gastroesophageal varices in cirrhosisAmir A Qamar
Brigham and Women s Hospital, Boston, MA 02446, USA
Hepatology 47:153-9. 2008..Patients with mild portal hypertension whose PLT remains greater than 100,000 have significantly less risk of GEV. Although HVPG correlates somewhat with PLT, changes in PLT cannot be used as a surrogate for HVPG changes... - Daily norfloxacin is more effective than weekly rufloxacin in prevention of spontaneous bacterial peritonitis recurrenceTilman M Bauer
Liver Unit, IMD, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
Dig Dis Sci 47:1356-61. 2002..The development of quinolone-resistant E. coli in feces may be an important problem in patients on long-term quinolone prophylaxis... - Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trialJosep M Llovet
Liver Unit, Digestive Disease Institute, , University of Barcelona, Barcelona, Spain
Lancet 359:1734-9. 2002..45 [95% CI 0.25-0.81], p=0.02). INTERPRETATION: Chemoembolisation improved survival of stringently selected patients with unresectable hepatocellular carcinoma... - Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trialAntoni Mas
Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
J Hepatol 38:51-8. 2003..The efficacy and safety of rifaximin in comparison with lactitol in the treatment of acute hepatic encephalopathy was assessed in a prospective randomized, double-blind, double-dummy, controlled trial...