Pablo Perez-Martinez

Summary

Affiliation: Hospital Universitario
Country: Spain

Publications

  1. ncbi request reprint The APOB -516C/T polymorphism is associated with differences in insulin sensitivity in healthy males during the consumption of diets with different fat content
    Pablo Perez-Martinez
    Unit of Lipids and Atherosclerosis, Hospital Universitario Reina Sofia, Avda Menendez Pidal, s n 14004, Cordoba, Spain
    Br J Nutr 97:622-7. 2007
  2. pmc Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men
    Javier Delgado-Lista
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Instituto Maimonides de Investigacion Biomedica de Cordoba IMIBIC, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos III, CordobaSpain
    J Lipid Res 51:63-73. 2010
  3. ncbi request reprint Nutrigenetics, metabolic syndrome risk and personalized nutrition
    Pablo Perez-Martinez
    Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit Avda Menendez Pidal, s n 14004 Cordoba, Spain
    Curr Vasc Pharmacol 11:946-53. 2013
  4. ncbi request reprint The chronic intake of a Mediterranean diet enriched in virgin olive oil, decreases nuclear transcription factor kappaB activation in peripheral blood mononuclear cells from healthy men
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Atherosclerosis 194:e141-6. 2007
  5. doi request reprint Consumption of diets with different type of fat influences triacylglycerols-rich lipoproteins particle number and size during the postprandial state
    P Perez-Martinez
    Reina Sofia University Hospital, Instituto Maimonides de Investigacion Biomedica Cordoba IMIBIC, University of Cordoba, Cordoba, Spain
    Nutr Metab Cardiovasc Dis 21:39-45. 2011
  6. ncbi request reprint Nutrigenetics of the postprandial lipoprotein metabolism: evidences from human intervention studies
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital Avda Menéndez Pidal, S N, 14004 Cordoba, Spain
    Curr Vasc Pharmacol 9:287-91. 2011
  7. ncbi request reprint Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population
    Pablo Perez-Martinez
    Unit of Lipids and Atherosclerosis, Hospital Universitario Reina Sofia, Avda Menendez Pidal, Cordoba, Spain
    Lipids 42:143-50. 2007
  8. ncbi request reprint Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 87:744-52. 2008
  9. ncbi request reprint [Nutrition in the age of genomics: towards a personalized diet]
    Pablo Perez-Martinez
    Hospital Universitario Reina Sofia, Unidad de Lipidos y Arteriosclerosis, Universidad de Cordoba, CIBER Fisiopatología Obesidad y Nutrición CB06 03, Instituto de Salud Carlos III, Espana
    Med Clin (Barc) 130:103-8. 2008
  10. pmc Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:391-9. 2009

Collaborators

Detail Information

Publications83

  1. ncbi request reprint The APOB -516C/T polymorphism is associated with differences in insulin sensitivity in healthy males during the consumption of diets with different fat content
    Pablo Perez-Martinez
    Unit of Lipids and Atherosclerosis, Hospital Universitario Reina Sofia, Avda Menendez Pidal, s n 14004, Cordoba, Spain
    Br J Nutr 97:622-7. 2007
    ....
  2. pmc Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men
    Javier Delgado-Lista
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Instituto Maimonides de Investigacion Biomedica de Cordoba IMIBIC, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos III, CordobaSpain
    J Lipid Res 51:63-73. 2010
    ..APOC3 -640 was associated with altered TG kinetics but not its magnitude. We have identified new associations between SNPs in the APOA1/C3/A4/A5 gene cluster and altered postprandial lipid metabolism...
  3. ncbi request reprint Nutrigenetics, metabolic syndrome risk and personalized nutrition
    Pablo Perez-Martinez
    Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit Avda Menendez Pidal, s n 14004 Cordoba, Spain
    Curr Vasc Pharmacol 11:946-53. 2013
    ..In this review we will present recent data highlighting the importance of gene-nutrient interactions in the context of MetS risk. ..
  4. ncbi request reprint The chronic intake of a Mediterranean diet enriched in virgin olive oil, decreases nuclear transcription factor kappaB activation in peripheral blood mononuclear cells from healthy men
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Atherosclerosis 194:e141-6. 2007
    ..We have examined the effect of three diets, with different fat composition, on the activation of NF-kappaB on peripheral blood mononuclear cells (PBMCs)...
  5. doi request reprint Consumption of diets with different type of fat influences triacylglycerols-rich lipoproteins particle number and size during the postprandial state
    P Perez-Martinez
    Reina Sofia University Hospital, Instituto Maimonides de Investigacion Biomedica Cordoba IMIBIC, University of Cordoba, Cordoba, Spain
    Nutr Metab Cardiovasc Dis 21:39-45. 2011
    ..In a controlled intervention study on healthy subjects, we evaluated the influence of 3 dietary interventions, with different types of fat on postprandial TRL particle size and number...
  6. ncbi request reprint Nutrigenetics of the postprandial lipoprotein metabolism: evidences from human intervention studies
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital Avda Menéndez Pidal, S N, 14004 Cordoba, Spain
    Curr Vasc Pharmacol 9:287-91. 2011
    ..Knowledge of how these and other genes influence postprandial response should increase the understanding of personalised nutrition...
  7. ncbi request reprint Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population
    Pablo Perez-Martinez
    Unit of Lipids and Atherosclerosis, Hospital Universitario Reina Sofia, Avda Menendez Pidal, Cordoba, Spain
    Lipids 42:143-50. 2007
    ..Thus, the allele variability in the -516C/T polymorphism in the APOB gene promoter may partly explain the interindividual differences in postprandial lipemic response in healthy subjects...
  8. ncbi request reprint Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 87:744-52. 2008
    ..Several perilipin (PLIN) polymorphic sites have been studied for their potential use as markers for obesity and the metabolic syndrome...
  9. ncbi request reprint [Nutrition in the age of genomics: towards a personalized diet]
    Pablo Perez-Martinez
    Hospital Universitario Reina Sofia, Unidad de Lipidos y Arteriosclerosis, Universidad de Cordoba, CIBER Fisiopatología Obesidad y Nutrición CB06 03, Instituto de Salud Carlos III, Espana
    Med Clin (Barc) 130:103-8. 2008
  10. pmc Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:391-9. 2009
    ..Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol...
  11. ncbi request reprint The -675 4G/5G polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat consumption
    P Perez-Martinez
    Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, CIBER, Fisiopatologia, Obesidad y Nutricion, Avda Menendez Pidal, s n 14004 Cordoba, Spain
    Br J Nutr 99:699-702. 2008
    ..On the other hand, carriers of the 4G allele are more likely to hyper-respond to the presence of MUFA in the diet because of a greater decrease in PAI-1 concentrations...
  12. pmc Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men
    Pablo Perez-Martinez
    Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit, University of Cordoba, CIBER Fisiopatologia de la Obesidad y Nutricion, 14004 Cordoba, Spain
    J Nutr 138:1609-14. 2008
    ..This information should help in the identification of vulnerable populations or persons who will benefit from more personalized and mechanism-based dietary recommendations...
  13. pmc ABCA1 gene variants regulate postprandial lipid metabolism in healthy men
    Javier Delgado-Lista
    Lipids and Atherosclerosis Unit, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Spain
    Arterioscler Thromb Vasc Biol 30:1051-7. 2010
    ....
  14. ncbi request reprint Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor kappaB in peripheral blood mononuclear cells from healthy men
    Cecilia Bellido
    Lipids and Arteriosclerosis Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    Am J Clin Nutr 80:1487-91. 2004
    ....
  15. ncbi request reprint Polymorphism exon 1 variant at the locus of the scavenger receptor class B type I gene: influence on plasma LDL cholesterol in healthy subjects during the consumption of diets with different fat contents
    Pablo Perez-Martinez
    Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Cordoba, Spain
    Am J Clin Nutr 77:809-13. 2003
    ..The association between polymorphisms in the scavenger receptor class B type I (SRB-I) gene and variations in basal plasma concentrations of cholesterol in humans has recently been described...
  16. doi request reprint Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects
    Pablo Perez-Martinez
    Lipid and Atherosclerosis Research Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Avda Menendez Pidal, 14004 Cordoba, Spain
    Clin Nutr 32:630-5. 2013
    ..Moreover, we analyzed the PCK1 gene expression in the adipose tissue of a subgroup of MetS subjects according to the PCK1 genetic variants...
  17. ncbi request reprint The apolipoprotein E gene promoter (-219G/T) polymorphism determines insulin sensitivity in response to dietary fat in healthy young adults
    Juan Antonio Moreno
    Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Nutr 135:2535-40. 2005
    ..In conclusion, carriers of the -219T allele are less insulin sensitive than GG individuals. Furthermore, only carriers of the -219G allele have improved IS when MUFA- or CHO-rich diets are consumed instead of a SFA-rich diet...
  18. ncbi request reprint A single nucleotide polymorphism of the apolipoprotein A-V gene -1131T>C modulates postprandial lipoprotein metabolism
    Rafael Moreno
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    Atherosclerosis 189:163-8. 2006
    ..The modifications observed in postprandial lipoprotein metabolism in subjects with the apoA-V -1131T>C polymorphism could be involved in the increased fasting plasma TG concentrations previously described in carriers of the C allele...
  19. ncbi request reprint The APOB -516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Avda Menendez Pidal, s n 14004 Cordoba, Spain
    Nutr Metab Cardiovasc Dis 17:224-9. 2007
    ..In conclusion, our data suggest that the APOB -516C/T polymorphism has no effect on the lipid profile after changes in dietary fat intake in a healthy population...
  20. doi request reprint Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism
    Antonio Garcia-Rios
    Department of Medicine, Universidad de Cordoba, Cordoba, Spain
    Atherosclerosis 218:416-22. 2011
    ..To investigate whether seven common single nucleotide polymorphisms (SNPs) at the lipoprotein lipase (LPL) locus interact with total plasma fatty acids to modulate plasma lipid metabolism in metabolic syndrome (MetS) patients...
  21. ncbi request reprint The effect of dietary fat on LDL size is influenced by apolipoprotein E genotype in healthy subjects
    Juan Antonio Moreno
    Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Nutr 134:2517-22. 2004
    ..043). In conclusion, a Mediterranean diet, high in MUFA-fat increases LDL particle size compared with a CHO diet, and this effect is dependent of apoE genotypes...
  22. ncbi request reprint Influence of the -514C/T polymorphism in the promoter of the hepatic lipase gene on postprandial lipoprotein metabolism
    Purificacion Gomez
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Avda Menendez Pidal, s n 14004 Cordoba, Spain
    Atherosclerosis 174:73-9. 2004
    ..04) when compared to subjects homozygous for the C allele. Our data suggest that the T allele of the -514C/T polymorphism in the promoter region of the hepatic lipase gene is associated with a lower postprandial lipemic response...
  23. pmc Postprandial antioxidant gene expression is modified by Mediterranean diet supplemented with coenzyme Q(10) in elderly men and women
    Elena M Yubero-Serrano
    Lipids and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba and CIBER Fisiopatologia Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos III, Cordoba, Spain
    Age (Dordr) 35:159-70. 2013
    ....
  24. doi request reprint Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function
    Javier Delgado-Lista
    Lipids and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital, University of Cordoba and CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III 14004, Cordoba, Spain
    Clin Nutr 30:234-8. 2011
    ..Our aim was to determine if two single nucleotide polymorphisms (SNPs) located in NOS3 (E298D and i19342) interfere with microvascular endothelial function (MEF) and/or oxidative stress during the postprandial state...
  25. doi request reprint The insulin sensitivity response is determined by the interaction between the G972R polymorphism of the insulin receptor substrate 1 gene and dietary fat
    Carmen Marin
    Lipids and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Hospital Universitario Reina Sofía Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Cordoba, Spain
    Mol Nutr Food Res 55:328-35. 2011
    ..Furthermore, we examined whether the presence of this single nucleotide polymorphism (SNP; GR or GG) interacts with dietary fat to modulate insulin sensitivity...
  26. ncbi request reprint The -514 C/T polymorphism in the hepatic lipase gene promoter is associated with insulin sensitivity in a healthy young population
    Purificacion Gomez
    Unit of Lipids and Arteriosclerosis, Hospital Universitario Reina Sofia, 14004 Cordoba, Spain
    J Mol Endocrinol 34:331-8. 2005
    ..In summary, our results show an improvement in insulin sensitivity in men with the -514T allele of the HL promoter polymorphism, when MUFA and carbohydrates are consumed instead of SFA fat...
  27. ncbi request reprint Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population
    Rafael Moreno-Luna
    Unit of Lipids and Atherosclerosis, Hospital Universitario Reina Sofia, Avda Menendez Pidal, Cordoba, Spain
    J Clin Endocrinol Metab 92:2280-5. 2007
    ..1259T>C) in the APOA5 gene define three common haplotypes (APOA5*1, APOA5*2, and APOA5*3) in Caucasian individuals. Our aim was to determine whether these haplotypes could modulate the postprandial response in young healthy males...
  28. ncbi request reprint A polymorphism exon 1 variant at the locus of the scavenger receptor class B type I (SCARB1) gene is associated with differences in insulin sensitivity in healthy people during the consumption of an olive oil-rich diet
    Pablo Perez-Martinez
    Units of Lipids and Artherosclerosis, Hospital Universitario Reina Sofia, Avenida Menendez Pidal, sin número 14004 Cordoba, Spain
    J Clin Endocrinol Metab 90:2297-300. 2005
    ..Our aim was to determine whether the presence of an exon 1 (G-->A) polymorphism at the SCARB1 gene modifies the insulin sensitivity to dietary fat...
  29. pmc Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study
    Elena María Yubero-Serrano
    Lipids and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos III, Spain
    Exp Mol Med 45:e28. 2013
    ....
  30. ncbi request reprint Apolipoprotein E gene promoter -219G->T polymorphism increases LDL-cholesterol concentrations and susceptibility to oxidation in response to a diet rich in saturated fat
    Juan Antonio Moreno
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    Am J Clin Nutr 80:1404-9. 2004
    ..The apolipoprotein E (APOE) gene promoter polymorphism (-219G-->T) has been associated with increased risk of myocardial infarction, premature coronary artery disease, and decreased plasma apolipoprotein E concentrations...
  31. doi request reprint A variant near the melanocortin-4 receptor gene regulates postprandial lipid metabolism in a healthy Caucasian population
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Cordoba, Spain
    Br J Nutr 106:468-71. 2011
    ..These results suggest that the rs12970134 polymorphism near the MC4R gene region may partly explain the inter-individual differences in postprandial lipoprotein response in healthy subjects...
  32. ncbi request reprint The Mediterranean and CHO diets decrease VCAM-1 and E-selectin expression induced by modified low-density lipoprotein in HUVECs
    Cecilia Bellido
    Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofia, Avda Menendez Pidal, s n 14004 Cordoba, Spain
    Nutr Metab Cardiovasc Dis 16:524-30. 2006
    ....
  33. pmc Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women
    Elena M Yubero-Serrano
    Lipids and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba and CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Age (Dordr) 33:579-90. 2011
    ....
  34. doi request reprint APOA1 and APOA4 gene polymorphisms influence the effects of dietary fat on LDL particle size and oxidation in healthy young adults
    Purificacion Gomez
    Lipids and Atherosclerosis Research Unit, Instituto Maimónides para la Investigación Biomédica de Córdoba IMIBIC, Department of Medicine, Reina Sofia University Hospital, University of Cordoba, CIBER Fisiopatologia de la Obesidad y Nutricion, Cordoba, Spain
    J Nutr 140:773-8. 2010
    ..No differences in LDL oxidation were found in this analysis. Our study supports the concept that SNP in APOA1and APOA4 genes influences atherogenic characteristics of LDL particles in response to diet...
  35. doi request reprint Pre-exercise intake of different carbohydrates modifies ischemic reactive hyperemia after a session of anaerobic, but not after aerobic exercise
    Juan M Fernandez
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Cordoba, CIBER Physiopathology of the Obesity and Nutrition CIBEROBN, and Andalusian Center of Sports Medicine, Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Cordoba, Spain
    J Strength Cond Res 24:1623-32. 2010
    ..These results suggest that the addition of fructose to a single G supplement ingested before a glycolitic exercise can modify the glucoregulation and increases ischemic reactive hyperemia...
  36. doi request reprint Postprandial oxidative stress is modified by dietary fat: evidence from a human intervention study
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Hospital Universitario Reina Sofía Universidad de Córdoba and Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, 14004 Cordoba, Spain
    Clin Sci (Lond) 119:251-61. 2010
    ..These findings suggest that the postprandial state is important for understanding the possible cardioprotective effects associated with mono-unsaturated dietary fat, particularly in subjects with the MetS...
  37. doi request reprint A monounsaturated fatty acid-rich diet reduces macrophage uptake of plasma oxidised low-density lipoprotein in healthy young men
    Juan Antonio Moreno
    Ciber Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Br J Nutr 100:569-75. 2008
    ..Our data suggest that a MUFA-rich diet may have favourable effects on cardiovascular risk since it prevents the oxidative modifications of LDL and reduces macrophage uptake of plasma oxLDL...
  38. ncbi request reprint Chronic dietary fat intake modifies the postprandial response of hemostatic markers to a single fatty test meal
    Javier Delgado-Lista
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Cordoba, and Ciber Fisiopatología Obesidad y Nutrición Instituto de Salud Carlos III, Spain
    Am J Clin Nutr 87:317-22. 2008
    ..Hemostasis is the result of a complex equilibrium between coagulation and fibrinolysis, and the influence of different dietary models on this equilibrium is not entirely known...
  39. pmc Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism
    Javier Delgado-Lista
    Lipids and Atherosclerosis Unit, Instituto Maimonides de Investigacion Biomedica de Cordoba Hospital Universitario Reina Sofia Universidad de Cordoba and CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, 14004 Cordoba, Spain
    J Clin Endocrinol Metab 96:E816-20. 2011
    ..Fatty meals cause transient hypertriglyceridemia and are considered to be proinflammatory, but the extent of these responses shows high interindividual susceptibility...
  40. ncbi request reprint Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men
    Toshiko Tanaka
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1402-8. 2007
    ..These data suggest that PPARalpha variants may modulate the risk of cardiovascular disease by influencing both fasting and postprandial lipid concentrations...
  41. ncbi request reprint Olive oil and haemostasis: platelet function, thrombogenesis and fibrinolysis
    Javier Delgado-Lista
    Lipids and Atherosclerosis Unit, Instituto Maimonides de Investigación Biomédica de Córdoba Hospital Universitario Reina Sofía Universidad de Córdoba, Ciber Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Curr Pharm Des 17:778-85. 2011
    ..In this article we will review the current evidences that relate olive oil with the haemostatic system...
  42. ncbi request reprint The influence of the apolipoprotein E gene promoter (-219G/ T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males
    Juan Antonio Moreno
    Lipids and Atherosclerosis Research Unit, Hospital Reina Sofía University, Cordoba, Spain
    J Lipid Res 44:2059-64. 2003
    ..05). In conclusion, the -219G/T polymorphism may influence TRL metabolism during the postprandial period, thus prolonging postprandial lipemia in subjects with the TT genotype...
  43. doi request reprint The effect of apoE genotype and sex on ApoE plasma concentration is determined by dietary fat in healthy subjects
    Juan Antonio Moreno
    Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, Avda Menendez Pidal, s n 14004, Cordoba, Spain
    Br J Nutr 101:1745-52. 2009
    ..Sex and apoE genotype determine ApoE plasma levels; however, this effect is dependent on dietary fat...
  44. doi request reprint Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men
    Yolanda Jimenez-Gomez
    The Lipids and Arteriosclerosis Unit, Reina Sofia University Hospital, University of Cordoba, CIBER de Fisiopatologia de la Obesidad y Nutricion CIBEROBN, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Atherosclerosis 204:e70-6. 2009
    ..Inflammation is crucial in all stages of atherosclerosis, and few studies have investigated the effect of dietary fat on markers of inflammation related to this disease during the postprandial period...
  45. ncbi request reprint Effects of the human apolipoprotein A-I promoter G-A mutation on postprandial lipoprotein metabolism
    Carmen Marin
    Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Cordoba, Spain
    Am J Clin Nutr 76:319-25. 2002
    ..We previously showed that the G-A mutation 5' to the apolipoprotein (apo) A-I gene was significantly associated with the LDL-cholesterol response to diet...
  46. ncbi request reprint Scavenger receptor class B type I (SCARB1) c.1119C>T polymorphism affects postprandial triglyceride metabolism in men
    Toshiko Tanaka
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Nutr 137:578-82. 2007
    ..923) or total TG (Pgeno x time = 0.529) did not differ by genotype. These results suggest that the c.1119C>T polymorphism is associated with a lower postprandial TG response in the smaller, partially catabolized lipoprotein fraction...
  47. ncbi request reprint A MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in insulin-resistant subjects
    Juan A Paniagua
    Lipids and Atherosclerosis Research Unit, University Hospital Reina Sofia, Cordoba, Spain
    J Am Coll Nutr 26:434-44. 2007
    ..To study the effects of three weight-maintenance diets with different macronutrient composition on carbohydrate, lipid metabolism, insulin and incretin levels in insulin-resistant subjects...
  48. ncbi request reprint Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients
    Juan Ruano
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Am J Clin Nutr 86:341-6. 2007
    ..Oxidative stress associated with postprandial lipemia contributes to endothelial dysfunction, which shifts hemostasis to a more thrombogenic state...
  49. doi request reprint Dietary fat modifies the postprandial inflammatory state in subjects with metabolic syndrome: the LIPGENE study
    Cristina Cruz-Teno
    Lipids and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba and CIBER Fisiopatologia Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos III, Cordoba, Spain
    Mol Nutr Food Res 56:854-65. 2012
    ..Our aim was to investigate whether the inflammatory state associated to metabolic syndrome (MetS) patients is affected by diets with different fat quality and quantity...
  50. pmc Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects
    Francisco M Gutierrez-Mariscal
    Lipid and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba, Spain
    Age (Dordr) 34:389-403. 2012
    ..05). In conclusion, Med+CoQ diet improves oxidative DNA damage in elderly subjects and reduces processes of cellular oxidation. Our results suggest a starting point for the prevention of oxidative processes associated with aging...
  51. doi request reprint A Period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome
    Antonio Garcia-Rios
    Lipid and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba Reina Sofia University Hospital University of Cordoba, and Centro de Investigación Biomédica en Red en Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Spain
    J Nutr 142:1213-8. 2012
    ..The understanding of these gene-nutrient interactions could help to provide a better knowledge of the pathogenesis in MetS...
  52. pmc Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome
    Pablo Perez-Martinez
    Lipid and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos III, Cordoba, Spain
    PLoS ONE 6:e20555. 2011
    ..Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been of considerable interest, due to their potential to reduce metabolic syndrome (MetS) risk...
  53. doi request reprint Dietary fat differentially influences regulatory endothelial function during the postprandial state in patients with metabolic syndrome: from the LIPGENE study
    Pablo Perez-Martinez
    Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit, Instituto Maimonides de Investigacion Biomedica de Cordoba, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion CB06 03 Instituto Salud Carlos III, Spain
    Atherosclerosis 209:533-8. 2010
    ....
  54. ncbi request reprint Olive oil and the haemostatic system
    Jose Lopez-Miranda
    Lipid and Arteriosclerosis Unit, Department of Internal Medicine, Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
    Mol Nutr Food Res 51:1249-59. 2007
    ....
  55. ncbi request reprint Olive oil and haemostasis: a review on its healthy effects
    Francisco Perez-Jimenez
    Lipids and Atherosclerosis Unit, Reina Sofia University Hospital, University of Cordoba, Spain
    Public Health Nutr 9:1083-8. 2006
    ..Despite the high complexity of its nutrients composition, olive oil emerges as its principal food, since it provides the higher percentage of energy and a lot of bioactive compounds...
  56. doi request reprint Expression of proinflammatory, proatherogenic genes is reduced by the Mediterranean diet in elderly people
    Antonio Camargo
    Lipids and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, CIBER Fisiopatologia de la Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos III, Cordoba, Spain
    Br J Nutr 108:500-8. 2012
    ..These findings may be partly responsible for the lower CVD risk found in populations with a high adherence to the Med Diet...
  57. doi request reprint Nutrigenetics of the lipoprotein metabolism
    Antonio Garcia-Rios
    Lipids and Atherosclerosis Research Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos, Cordoba, Spain
    Mol Nutr Food Res 56:171-83. 2012
    ..This review discusses some of the evidence in which candidate SNPs can affect the key players of lipid metabolism and how their phenotypic manifestations can be modified by dietary intake...
  58. doi request reprint Mediterranean diet supplemented with coenzyme Q10 modifies the expression of proinflammatory and endoplasmic reticulum stress-related genes in elderly men and women
    Elena M Yubero-Serrano
    Lipids and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
    J Gerontol A Biol Sci Med Sci 67:3-10. 2012
    ..Our results support the anti-inflammatory effect of Med diet and that exogenous CoQ supplementation in synergy with a Med diet modulates the inflammatory response and endoplasmic reticulum stress...
  59. pmc Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil
    Antonio Camargo
    IMIBIC Instituto Maimonides de Investigacion Biomedica de Cordoba, Reina Sofia University Hospital, University of Cordoba, Spain
    BMC Genomics 11:253. 2010
    ..To achieve this goal, we aimed at identifying expression changes in genes which could be mediated by virgin olive oil phenol compounds in the human...
  60. ncbi request reprint Factor VII polymorphisms influence the plasma response to diets with different fat content, in a healthy Caucasian population
    Rafael Angel Fernandez de la Puebla
    Reina Sofia University Hospital, Lipids and Atherosclerosis Research Unit, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Cordoba, Spain
    Mol Nutr Food Res 51:618-24. 2007
    ..To determine the influence of the factor VII gene polymorphisms, R353Q and 5'F7, on factor VII Ag plasma levels after the consumption of diets with different fat contents...
  61. doi request reprint Postprandial changes in the proteome are modulated by dietary fat in patients with metabolic syndrome
    Antonio Camargo
    Lipids and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba and CIBER Fisiopatologia Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos III 14004, Cordoba, Spain
    J Nutr Biochem 24:318-24. 2013
    ..Moreover, the addition of long-chain n-3 PUFA to an HPUFA meal may improve insulin signaling and exerts an anti-inflammatory effect when compared to an HPUFA meal...
  62. pmc Mediterranean diet reduces senescence-associated stress in endothelial cells
    Carmen Marin
    Lipids and Atherosclerosis Unit, Cordoba, Spain
    Age (Dordr) 34:1309-16. 2012
    ..Dietary fat modulates the oxidative stress in human endothelial cells. MedDiet protects these cells from oxidative stress, prevents cellular senescence and reduces cellular apoptosis...
  63. ncbi request reprint [Effect of the Mediterranean diet on fasting concentrations of activated factor VII in healthy persons]
    Purificacion Gomez
    Unidad de Lipidos y Arteriosclerosis, Servicio de Medicina Intern, Hospital Universitario Reina Sofia, Cordoba, Spain
    Rev Esp Cardiol 58:285-9. 2005
    ..Our objective was to determine the effect of a Mediterranean diet on plasma levels of activated factor VII in comparison to a low-fat diet and a diet rich in saturated fat...
  64. doi request reprint Postprandial inflammatory response in adipose tissue of patients with metabolic syndrome after the intake of different dietary models
    Maria E Meneses
    Lipids and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital, University of Cordoba and CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain
    Mol Nutr Food Res 55:1759-70. 2011
    ..Our aim was to determine whether the specific quality and quantity of dietary fat produce differential postprandial inflammatory responses in adipose tissue from metabolic syndrome (MetS) patients...
  65. ncbi request reprint Postprandial lipoprotein metabolism, genes and risk of cardiovascular disease
    Jose Lopez-Miranda
    Lipid and Arteriosclerosis Unit, Department of Internal Medicine, Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
    Curr Opin Lipidol 17:132-8. 2006
    ....
  66. ncbi request reprint The influence of lipoprotein lipase gene variation on postprandial lipoprotein metabolism
    Jose Lopez-Miranda
    Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Avda Menendez Pidal, s n 14004 Cordoba, Spain
    J Clin Endocrinol Metab 89:4721-8. 2004
    ..The modifications observed in postprandial lipoprotein metabolism in young normolipemic males with LPL polymorphism could be involved in the lower risk of coronary artery disease associated with the H1X447 genotype...
  67. ncbi request reprint The influence of olive oil on human health: not a question of fat alone
    Francisco Perez-Jimenez
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, University of Cordoba, CIBER Fisiopatología Obesidad y Nutrición CB06 03, Instituto de Salud Carlos III, Spain
    Mol Nutr Food Res 51:1199-208. 2007
    ....
  68. doi request reprint Lipid metabolism after an oral fat test meal is affected by age-associated features of metabolic syndrome, but not by age
    Ana I Perez-Caballero
    Lipids and Atherosclerosis Unit, Department of Medicine, IMIBIC, Hospital Universitario Reina Sofia, Universidad de Cordoba, Cordoba, Spain
    Atherosclerosis 226:258-62. 2013
    ..Age has been defined as a regulating factor of the extent of postprandial lipemia, but its independence of other age-associated phenotypic features, such as metabolic syndrome, has not been fully elucidated...
  69. pmc Effects of rs7903146 variation in the Tcf7l2 gene in the lipid metabolism of three different populations
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Unit, IMIBIC Hospital Universitario Reina Sofía Universidad de Córdoba, Cordoba, Spain
    PLoS ONE 7:e43390. 2012
    ..To date, there is little information about the additional impact of this single nucleotide polymorphism (SNP) beyond glucose metabolism...
  70. doi request reprint Insulin receptor substrate-2 gene variants in subjects with metabolic syndrome: association with plasma monounsaturated and n-3 polyunsaturated fatty acid levels and insulin resistance
    Pablo Perez-Martinez
    Lipid and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos, Cordoba, Spain
    Mol Nutr Food Res 56:309-15. 2012
    ..To examine whether the genetic variability at the IRS-2 gene locus was associated with the degree of insulin resistance and plasma fatty acid levels in metabolic syndrome (MetS) subjects...
  71. doi request reprint Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium
    Carmen Marin
    Lipids and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
    Am J Clin Nutr 93:267-74. 2011
    ..Endothelial progenitor cells may contribute to the maintenance of the endothelium by replacing injured mature endothelial cells...
  72. ncbi request reprint Dietary fat, genes and insulin sensitivity
    Jose Lopez-Miranda
    Lipid and Arteriosclerosis Unit, Department of Internal Medicine, Reina Sofia University Hospital, Avda Menendez Pidal, S N, 14004, Cordova, Spain
    J Mol Med (Berl) 85:213-26. 2007
    ....
  73. pmc The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs
    Jian Shen
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 49:1839-45. 2008
    ..This phenomenon could be responsible for the observed association of this genetic variant with cardiovascular disease risk...
  74. doi request reprint Metabolic syndrome: evidences for a personalized nutrition
    Pablo Perez-Martinez
    Lipid and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion CIBEROBN, Instituto de Salud Carlos III, Spain
    Mol Nutr Food Res 56:67-76. 2012
    ..that influence insulin resistance in subjects with metabolic syndrome...
  75. ncbi request reprint The apo A-I gene promoter region polymorphism determines the severity of hyperlipidemia after heart transplantation
    Angel González-Amieva
    Unidad de Lipidos y Arteriosclerosis, Departamento de Medicina Interna, Hospital Universitario Reina Sofia, Cordoba, Spain
    Clin Transplant 17:56-62. 2003
    ..To study whether the Apolipoprotein A-I (apo A-I) promoter region gene polymorphism produces changes in the lipid profile of heart transplant recipients...
  76. ncbi request reprint Mediterranean diet rich in olive oil and obesity, metabolic syndrome and diabetes mellitus
    Pablo Perez-Martinez
    Lipid and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Curr Pharm Des 17:769-77. 2011
    ....
  77. doi request reprint Calpain-10 interacts with plasma saturated fatty acid concentrations to influence insulin resistance in individuals with the metabolic syndrome
    Pablo Perez-Martinez
    Lipid and Atherosclerosis Unit, IMIBIC Reina Sofia University Hospital University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Cordoba, Spain
    Am J Clin Nutr 93:1136-41. 2011
    ..Fatty acids are key metabolic regulators that may interact with genetic factors and influence glucose metabolism...
  78. ncbi request reprint An apolipoprotein A-II polymorphism (-265T/C, rs5082) regulates postprandial response to a saturated fat overload in healthy men
    Javier Delgado-Lista
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    J Nutr 137:2024-8. 2007
    ..This finding may partially explain the role of Apo A-II in lipid metabolism and can identify a population with a decreased risk of cardiovascular disease, as corresponds to the lower level of postprandial hypertriglyceridemia...
  79. doi request reprint Update on genetics of postprandial lipemia
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Research Unit, Instituto Maimonides de Investigacion Biomedica de Cordoba Hospital Universitario Reina Sofia Universidad de Cordoba and CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Atheroscler Suppl 11:39-43. 2010
    ..Increased knowledge of how these and other genes influence postprandial response should increase the understanding of personalised nutrition...
  80. doi request reprint Fructose modifies the hormonal response and modulates lipid metabolism during aerobic exercise after glucose supplementation
    Juan M Fernandez
    Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, CIBER Fisiopatologia de la Obesidad y Nutricion, 14004 Cordoba, Spain
    Clin Sci (Lond) 116:137-45. 2009
    ..05) compared with after the ingestion of Glu alone. In conclusion, hormonal and lipid alterations are provoked during aerobic exercise and recovery by the addition of a dose of fructose to the pre-exercise ingestion of glucose...
  81. ncbi request reprint Phenolic content of virgin olive oil improves ischemic reactive hyperemia in hypercholesterolemic patients
    Juan Ruano
    Department of Medicine, University of Cordoba, Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    J Am Coll Cardiol 46:1864-8. 2005
    ..The goal of this study was to evaluate the effects of the phenolic content of virgin olive oil on endothelial reactivity...
  82. doi request reprint Influence of genetic factors in the modulation of postprandial lipemia
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, J M US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atheroscler Suppl 9:49-55. 2008
    ..This review presents the current evidence linking a number of candidate genes to the modulation of postprandial lipid metabolism...
  83. doi request reprint n-3 PUFA and lipotoxicity
    Pablo Perez-Martinez
    Lipids and Atherosclerosis Research Unit, Instituto Maimonides de Investigacion Biomedica IMIBIC, Reina Sofia University Hospital, University of Cordoba, Ciber Fisiopatologia Obesidad y Nutricion CB06 03 Instituto Salud Carlos III, Spain
    Biochim Biophys Acta 1801:362-6. 2010
    ..Further human studies are needed to test the evidence and elucidate the mechanisms involved in this process...