Rodrigo Martino

Summary

Affiliation: Hospital de la Santa Creu i Sant Pau
Country: Spain

Publications

  1. ncbi request reprint Reduced-intensity conditioning allogeneic blood stem cell transplantation with fludarabine and oral busulfan with or without pharmacokinetically targeted busulfan dosing in patients with myeloid leukemia ineligible for conventional conditioning
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Sant Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 11:437-47. 2005
  2. ncbi request reprint Empirical antifungal therapy in patients with neutropenia and persistent or recurrent fever of unknown origin
    Rodrigo Martino
    Division of Clinical Haematology, Hospital de la Sant Creu i Sant Pau, and The Autonomous University of Barcelona, Spain
    Br J Haematol 132:138-54. 2006
  3. doi request reprint Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: a retrospective European Group for Blood and Marrow Transplantation analysis
    Johannes Schetelig
    University Hospital Carl Gustav Carus, Medizinische Klinik und Poliklinik I, Dresden, Germany
    J Clin Oncol 26:5094-100. 2008
  4. ncbi request reprint Severe infections after unrelated donor allogeneic hematopoietic stem cell transplantation in adults: comparison of cord blood transplantation with peripheral blood and bone marrow transplantation
    Rocio Parody
    Division of Clinical Hematology, Hospital Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 12:734-48. 2006
  5. ncbi request reprint Cyclophosphamide, pegylated liposomal doxorubicin (Caelyx), vincristine and prednisone (CCOP) in elderly patients with diffuse large B-cell lymphoma: results from a prospective phase II study
    Rodrigo Martino
    Servei d Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni M a Claret 167, 08025 Barcelona, Spain
    Haematologica 87:822-7. 2002
  6. ncbi request reprint Evidence for a graft-versus-leukemia effect after allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning in acute myelogenous leukemia and myelodysplastic syndromes
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni Maria Claret, 167 08025 Barcelona, Spain
    Blood 100:2243-5. 2002
  7. ncbi request reprint Respiratory virus infections in adults with hematologic malignancies: a prospective study
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain
    Clin Infect Dis 36:1-8. 2003
  8. ncbi request reprint Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in acute lymphoblastic leukemia: a feasibility study
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni Ma Claret, 167, 08025 Barcelona, Spain
    Haematologica 88:555-60. 2003
  9. ncbi request reprint Blastoschizomyces capitatus infection in patients with leukemia: report of 26 cases
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Clin Infect Dis 38:335-41. 2004
  10. ncbi request reprint Efficacy, safety and cost-effectiveness of Amphotericin B Lipid Complex (ABLC): a review of the literature
    Rodrigo Martino
    Division of Clinical Haematology, Hospital de la Santa Creu i Sant Pau, Sant Antoni Ma Claret 167, Barcelona, Spain
    Curr Med Res Opin 20:485-504. 2004

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Reduced-intensity conditioning allogeneic blood stem cell transplantation with fludarabine and oral busulfan with or without pharmacokinetically targeted busulfan dosing in patients with myeloid leukemia ineligible for conventional conditioning
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Sant Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 11:437-47. 2005
    ..In conclusion, therapeutic dose monitoring of oral Bu in a reduced-intensity conditioning setting does not seem to affect outcome, although further studies may identify very-high-risk patients who benefit from this strategy...
  2. ncbi request reprint Empirical antifungal therapy in patients with neutropenia and persistent or recurrent fever of unknown origin
    Rodrigo Martino
    Division of Clinical Haematology, Hospital de la Sant Creu i Sant Pau, and The Autonomous University of Barcelona, Spain
    Br J Haematol 132:138-54. 2006
    ....
  3. doi request reprint Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: a retrospective European Group for Blood and Marrow Transplantation analysis
    Johannes Schetelig
    University Hospital Carl Gustav Carus, Medizinische Klinik und Poliklinik I, Dresden, Germany
    J Clin Oncol 26:5094-100. 2008
    ..Although allogeneic hematopoietic stem-cell transplantation (HCT) has the potential to cure patients with advanced CLL, it is not known whether this holds true for patients with 17p-CLL...
  4. ncbi request reprint Severe infections after unrelated donor allogeneic hematopoietic stem cell transplantation in adults: comparison of cord blood transplantation with peripheral blood and bone marrow transplantation
    Rocio Parody
    Division of Clinical Hematology, Hospital Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 12:734-48. 2006
    ....
  5. ncbi request reprint Cyclophosphamide, pegylated liposomal doxorubicin (Caelyx), vincristine and prednisone (CCOP) in elderly patients with diffuse large B-cell lymphoma: results from a prospective phase II study
    Rodrigo Martino
    Servei d Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni M a Claret 167, 08025 Barcelona, Spain
    Haematologica 87:822-7. 2002
    ..Anthracycline-based combination chemotherapy regimens are the standard therapy for patients with diffuse large B-cell lymphoma (DLBCL), but such regimens may be poorly tolerated in elderly patients...
  6. ncbi request reprint Evidence for a graft-versus-leukemia effect after allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning in acute myelogenous leukemia and myelodysplastic syndromes
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni Maria Claret, 167 08025 Barcelona, Spain
    Blood 100:2243-5. 2002
    ..008). These results suggest that a graft-versus-leukemia effect plays a crucial role in reducing the risk of relapse after a RIC allograft in AML and MDS...
  7. ncbi request reprint Respiratory virus infections in adults with hematologic malignancies: a prospective study
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain
    Clin Infect Dis 36:1-8. 2003
    ..For both epidemiological and therapeutic considerations, frequent screening for respiratory viruses should be incorporated into the routine diagnostic study of patients with hematologic malignancies...
  8. ncbi request reprint Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in acute lymphoblastic leukemia: a feasibility study
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni Ma Claret, 167, 08025 Barcelona, Spain
    Haematologica 88:555-60. 2003
    ..We sought to analyze the results of reduced intensity conditioning for allografts in adult patients with ALL...
  9. ncbi request reprint Blastoschizomyces capitatus infection in patients with leukemia: report of 26 cases
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Clin Infect Dis 38:335-41. 2004
    ..006). Outcome for neutropenic patients with B. capitatus infection is still poor. Rapid removal of the central venous catheter and novel antifungal therapies are recommended for treatment of this rare infection...
  10. ncbi request reprint Efficacy, safety and cost-effectiveness of Amphotericin B Lipid Complex (ABLC): a review of the literature
    Rodrigo Martino
    Division of Clinical Haematology, Hospital de la Santa Creu i Sant Pau, Sant Antoni Ma Claret 167, Barcelona, Spain
    Curr Med Res Opin 20:485-504. 2004
    ..Comparative studies suggest that ABLC is a cost-effective treatment option compared with conventional AmB or other lipid-based formulations of amphotericin B...
  11. ncbi request reprint Early detection of Toxoplasma infection by molecular monitoring of Toxoplasma gondii in peripheral blood samples after allogeneic stem cell transplantation
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Sant Creu i Sant Pau, Barcelona, Spain
    Clin Infect Dis 40:67-78. 2005
    ..Isolated case reports have shown that recipients of allogeneic hematopoietic stem cell transplants (HSCTs) who develop toxoplasmosis may have circulating Toxoplasma gondii DNA in peripheral blood before the onset of clinical symptoms...
  12. pmc Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies
    Rodrigo Martino
    Department of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, and Autonomous University of Barcelona, Spain
    Biol Blood Marrow Transplant 11:781-96. 2005
    ..In addition, human metapneumovirus should be added to the potentially serious causes of RV infections in HSCT...
  13. ncbi request reprint Efficacy and toxicity of intermediate-dose amphotericin B lipid complex as a primary or salvage treatment of fungal infections in patients with hematological malignancies
    Rodrigo Martino
    Divisions of Clinical Haematology, Hospital de la Sant Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Leuk Lymphoma 46:1429-35. 2005
    ..These data suggest that intermediate-doses of ABLC may be of similar efficacy than higher doses with less toxicity, making it a cost-effective alternative worthy of study in future trials...
  14. ncbi request reprint Invasive fungal infections in hematology: new trends
    R Martino
    Division of Clinical Hematology, Hospital de la Sant Creu i Sant Pau, Av Sant Antoni Ma Claret, 167, 08025 Barcelona, Spain
    Ann Hematol 81:233-43. 2002
    ..However, the exact place of these agents in treating different IFI will need to be found in the near future...
  15. ncbi request reprint Severe infections after allogeneic peripheral blood stem cell transplantation: a matched-pair comparison of unmanipulated and CD34+ cell-selected transplantation
    R Martino
    Servei d Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni M0 Claret, 167, 08025 Barcelona, Spain
    Haematologica 86:1075-86. 2001
    ..T-cell depletion of the graft delays immune recovery following allogeneic peripheral blood stem cell transplantation (PBSCT), but it is not clear whether it actually increases the risk of severe infections after the transplant...
  16. ncbi request reprint Bacteremia caused by Capnocytophaga species in patients with neutropenia and cancer: results of a multicenter study
    R Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Clin Infect Dis 33:E20-2. 2001
    ....
  17. ncbi request reprint Toxoplasmosis after hematopoietic stem cell transplantation
    R Martino
    Servei d Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Clin Infect Dis 31:1188-95. 2000
    ..Toxoplasmosis after HSCT is a severe infection with a high mortality rate even when diagnosed soon after HSCT, and PCR may help establish the diagnosis earlier...
  18. ncbi request reprint Allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning: results of a prospective multicentre study
    R Martino
    Servicio de Hematología Clínica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Br J Haematol 115:653-9. 2001
    ..In conclusion, RIC regimens lead to low early toxicity after allografting, with stable donor haematopoietic engraftment, with an apparent low risk of acute GVHD. Chronic GVHD, however, develops in a significant proportion of patients...
  19. ncbi request reprint Intensive salvage chemotherapy for primary refractory or first relapsed adult acute lymphoblastic leukemia: results of a prospective trial
    R Martino
    Servei d Hematologia Clinica, Hospital de Sant Pau, Av Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Haematologica 84:505-10. 1999
    ..In this protocol, chemotherapy was to be followed by an allogeneic or autologous stem cell transplant (SCT) within three months from CR...
  20. ncbi request reprint Allogeneic peripheral blood stem cell transplantation with CD34+-cell selection and delayed T-cell add-back in adults. Results of a single center pilot study
    R Martino
    Servei d Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni M feminine Claret, 167, 08025 Barcelona, Spain
    Haematologica 85:1165-71. 2000
    ..e., age >= 45 years)...
  21. ncbi request reprint Bacteremia by gram-negative bacilli in patients with hematologic malignancies. Comparison of the clinical presentation and outcome of infections by enterobacteria and non-glucose-fermenting gram-negative bacilli
    R Martino
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Acta Haematol 102:7-11. 1999
    ..aeruginosa) and the new NGFGNB in adults with hematologic malignancies...
  22. ncbi request reprint Amphotericin B lipid complex at 3 mg/kg/day for treatment of invasive fungal infections in adults with haematological malignancies
    R Martino
    Division of Clinical Haematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Antimicrob Chemother 44:569-72. 1999
    ..These data suggest that lower doses of ABLC may be equally effective but less toxic than higher doses. However, a controlled study is required to confirm these observations...
  23. ncbi request reprint Bacteraemia caused by non-glucose-fermenting gram-negative bacilli and Aeromonas species in patients with haematological malignancies and solid tumours
    R Martino
    Servei d Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Eur J Clin Microbiol Infect Dis 19:320-3. 2000
    ..The most important predictors of catheter-related bacteraemia and its outcome were polymicrobial infection, the presence of pneumonia or septic syndrome and the species involved...
  24. ncbi request reprint Invasive fungal infections after allogeneic peripheral blood stem cell transplantation: incidence and risk factors in 395 patients
    Rodrigo Martino
    Division of Clinical Hematology, Hospital de la Sant Creu i Sant Pau, Barcelona, Spain
    Br J Haematol 116:475-82. 2002
    ..Prophylactic strategies for these infections should thus take into account these risk factors...
  25. doi request reprint Early and late neurological complications after reduced-intensity conditioning allogeneic stem cell transplantation
    Pere Barba
    Hematology Department and Stem Cell Transplantation Program, Hospital de Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Biol Blood Marrow Transplant 15:1439-46. 2009
    ..05). In conclusion, our study showed that NC are observed after allo-RIC and have diverse features. NC affecting the CNS have earlier onset and worse outcome than those involving the PNS...
  26. doi request reprint Study of kidney function impairment after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation. A single-center experience
    José Luis Piñana
    Clinical Hematology and Hematopoietic Transplantation Division, Autonomous University of Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 15:21-9. 2009
    ..05). ARF is a frequent complication in patients after Allo-RIC, and it has a negative impact on outcome. Identification of ARF risk factors could help to avoid exposure to nephrotoxic drugs during the follow-up in patients at high risk...
  27. ncbi request reprint Sustained remissions of high-risk acute myeloid leukemia and myelodysplastic syndrome after reduced-intensity conditioning allogeneic hematopoietic transplantation: chronic graft-versus-host disease is the strongest factor improving survival
    David Valcarcel
    Hospital de la Santa Creu i Sant Pau, Universitat Autonoma Barcelona, Barcelona, Spain
    J Clin Oncol 26:577-84. 2008
    ....
  28. doi request reprint Impact of hyperferritinemia on the outcome of reduced-intensity conditioning allogeneic hematopoietic cell transplantation for lymphoid malignancies
    Pere Barba
    Hematology Departments of Hospital Universitari Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 19:597-601. 2013
    ..Our results indicate that high ferritin levels at HCT are associated with an adverse outcome after allo-RIC in patients with lymphoid malignancies...
  29. ncbi request reprint Low-dose amphotericin B lipid complex vs. conventional amphotericin B for empirical antifungal therapy of neutropenic fever in patients with hematologic malignancies--a randomized, controlled trial
    Maricel Subirá
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Av Sant Antoni Ma Claret 167, 08025 Barcelona, Spain
    Eur J Haematol 72:342-7. 2004
    ..Amphotericin B lipid complex (ABLC) has been investigated for this indication due to its low toxicity profile. The recommended dose of ABLC is 5 mg/kg/d, which is five to seven times higher than the recommended dose of c-AmB...
  30. doi request reprint Degree of mucositis and duration of neutropenia are the major risk factors for early post-transplant febrile neutropenia and severe bacterial infections after reduced-intensity conditioning
    Luca Facchini
    Hematology Department of the Hospital de la Santa Creu I Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur J Haematol 88:46-51. 2012
    ..We analyzed the risk factors (RFs) for the development of FN and SBI in the first 100d post-transplant in 195 consecutive adult recipients of a reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-allo)...
  31. doi request reprint The effect of in vivo T cell depletion with alemtuzumab on reduced-intensity allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia
    Julio Delgado
    Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Biol Blood Marrow Transplant 14:1288-97. 2008
    ..629, P=.361, P=.735, and P=0.112, respectively). In conclusion, both methods of GVHD prophylaxis were equivalent in terms of survival. The administration of alemtuzumab led to reduced cGVHD, possibly improving quality of life...
  32. doi request reprint Comparison of two pretransplant predictive models and a flexible HCT-CI using different cut off points to determine low-, intermediate-, and high-risk groups: the flexible HCT-CI Is the best predictor of NRM and OS in a population of patients undergoing a
    Pere Barba
    Hematology and Stem Cell Transplantation Division Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 16:413-20. 2010
    ..In conclusion, our single-center study suggests that the flexible HCT-CI is a good predictor of 2-year NRM and survival after an allo-RIC...
  33. ncbi request reprint Reduced-intensity conditioning regimen preserves thymic function in the early period after hematopoietic stem cell transplantation
    Monica Jimenez
    Department of Hematology, Institute of Hematology and Oncology, Institut d Investigacions Biomediques August Pi i Sunyer, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Exp Hematol 33:1240-8. 2005
    ..To compare T-cell reconstitution in two groups of patients submitted to allogeneic stem cell transplantation (SCT): those receiving reduced-intensity conditioning (RIC, n = 24) and those receiving myeloablative conditioning (MA, n = 27)...
  34. ncbi request reprint Strategies to reduce transplant-related mortality after allogeneic stem cell transplantation in elderly patients: Comparison of reduced-intensity conditioning and unmanipulated peripheral blood stem cells vs a myeloablative regimen and CD34+ cell selectio
    Carmen Canals
    Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Exp Hematol 31:1039-43. 2003
    ..The aim of this study was to compare two approaches used to reduce transplant-related mortality (TRM) after allogeneic peripheral blood stem cell transplantation (allo-PBSCT) in elderly patients...
  35. pmc Reduced intensity conditioning HLA identical sibling donor allogeneic stem cell transplantation for patients with follicular lymphoma: long-term follow-up from two prospective multicenter trials
    José Luis Piñana
    Division of Clinical Hematology, Hospital de la Santa Creu i, Sant Pau St Antoni M Claret 167 Barcelona 08021, Spain
    Haematologica 95:1176-82. 2010
    ....
  36. ncbi request reprint CD34+-enriched-CD19+-depleted autologous peripheral blood stem cell transplantation for chronic lymphoproliferative disorders: high purging efficiency but increased risk of severe infections
    Albert Altes
    Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Exp Hematol 30:824-30. 2002
    ..The main objective of this work was to decrease the incidence of relapse after autologous stem cell transplantation with a "double purging" procedure...
  37. ncbi request reprint Encouraging results with inolimomab (anti-IL-2 receptor) as treatment for refractory acute graft-versus-host disease
    José Luis Piñana
    Division of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 12:1135-41. 2006
    ....
  38. doi request reprint Updated experience with inolimomab as treatment for corticosteroid-refractory acute graft-versus-host disease
    Irene García-Cadenas
    Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Biol Blood Marrow Transplant 19:435-9. 2013
    ..These data highlight the need to investigate new rescue treatments with sustained effect and the importance of reporting long-term outcomes in GVHD studies...
  39. pmc Allogeneic stem cell transplantation after reduced intensity conditioning in patients with relapsed or refractory Hodgkin's lymphoma. Results of the HDR-ALLO study - a prospective clinical trial by the Grupo Español de Linfomas/Trasplante de Médula Osea (
    Anna Sureda
    Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Haematologica 97:310-7. 2012
    ..We investigated the potential role of allogeneic stem cell transplantation in this setting...
  40. ncbi request reprint Early clinical impact of iron overload in stem cell transplantation. A prospective study
    Albert Altes
    Department of Haematology, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Ann Hematol 86:443-7. 2007
    ..In conclusion, iron burden seems to influence the appearance of toxic-infectious complications during the first 3 months after transplant in AUTO-transplanted patients...
  41. doi request reprint Predicting survival in adults with invasive aspergillosis during therapy for hematological malignancies or after hematopoietic stem cell transplantation: Single-center analysis and validation of the Seattle, French, and Strasbourg prognostic indexes
    Rocio Parody
    Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Am J Hematol 84:571-8. 2009
    ..01]. In addition, we validated the French and Seattle prognostic indexes for allo-HSCT recipients and the Strasbourg model for all hematological patients with IA...
  42. ncbi request reprint Air-leak syndromes in hematopoietic stem cell transplant recipients with chronic GVHD: high-resolution CT findings
    Tomas Franquet
    Department of Radiology, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Thorac Imaging 22:335-40. 2007
    ....
  43. ncbi request reprint Low transplant related mortality in older patients with hematologic malignancies undergoing autologous stem cell transplantation
    Luis Villela
    Servei d Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Antoni Maria i Claret 167, 08025 Barcelona, Spain
    Haematologica 88:300-5. 2003
    ..We evaluated the results of ASCT in a group of 49 patients >= 60 years of age [32 males, median age 63 years (range, 60 to 71)] autografted in our institution from January 1995 to December 2001...
  44. ncbi request reprint Kinetics of recovery of dendritic cell subsets after reduced-intensity conditioning allogeneic stem cell transplantation and clinical outcome
    Carme Talarn
    Institute of Hematology and Oncology, Department of Hematology, H Clínic, Barcelona, Spain
    Haematologica 92:1655-63. 2007
    ..We studied the clinical relevance of early reconstitution of DC after reduced-intensity conditioning allo-SCT (allo-RIC)...
  45. ncbi request reprint Thin-section CT findings in hematopoietic stem cell transplantation recipients with respiratory virus pneumonia
    Tomas Franquet
    Department of Radiology, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Avda Sant Antoni Ma Claret 167, 08025 Barcelona, Spain
    AJR Am J Roentgenol 187:1085-90. 2006
    ..The purpose of this study was to use serial thin-section CT scans to assess the incidence of respiratory viral infection and lung abnormalities in a large patient population at high risk of pulmonary complications...
  46. doi request reprint Pretransplantation liver function impacts on the outcome of allogeneic hematopoietic stem cell transplantation: a study of 455 patients
    Pere Barba
    Hematology Departments of Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona and Universitat Autònoma de Barcelona, Mas Casanovas 90, Barcelona, Spain
    Biol Blood Marrow Transplant 17:1653-61. 2011
    ..In conclusion, hepatic dysfunction before allo-SCT is frequent and has an impact on transplantation outcomes. The best indicator of liver dysfunction still has to be determined...
  47. doi request reprint Pulmonary function testing prior to reduced intensity conditioning allogeneic stem cell transplantation in an unselected patient cohort predicts posttransplantation pulmonary complications and outcome
    José Luis Piñana
    Hematology and Stem Cell Transplantation Division, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Am J Hematol 87:9-14. 2012
    ..8, 95% CI. 0.98-3.6, P = 0.06 and HR 1.7, 95% CI. 1.1-2.6, P = 0.008). This study emphasizes the valuable role of PFTs in identifying patients at risk for PPC, NRM, and lower OS in the Allo-RIC setting...
  48. doi request reprint Valganciclovir as pre-emptive therapy for cytomegalovirus infection in allogeneic haematopoietic stem cell transplant recipients
    Isabel Ruiz-Camps
    Hospital Universitari Vall d Hebron, Barcelona, Spain
    Antivir Ther 16:951-7. 2011
    ....
  49. doi request reprint Allogeneic stem cell transplantation after reduced-intensity conditioning for acute myeloid leukaemia: impact of chronic graft-versus-host disease
    David Valcarcel
    Division of Clinical Hematology, Hospital de la Sant Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Curr Opin Oncol 21:S35-7. 2009
    ..For this purpose, an adequate identification of high-risk patients, close monitoring of minimal residual disease after the procedure, and the use of antineoplastic drugs or immunotherapy may be of help...
  50. ncbi request reprint Membrane PKC-beta 2 protein expression predicts for poor response to chemotherapy and survival in patients with diffuse large B-cell lymphoma
    Inigo Espinosa
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Universidad Autonoma de Barcelona, Barcelona, Spain
    Ann Hematol 85:597-603. 2006
    ..4, P=0.011). Our results suggest that membrane expression of PKC-beta 2 protein on DLBCL predicts for poor survival, especially in patients with low IPI...
  51. pmc Impact of the intensity of the pretransplantation conditioning regimen in patients with prior invasive aspergillosis undergoing allogeneic hematopoietic stem cell transplantation: A retrospective survey of the Infectious Diseases Working Party of the Euro
    Rodrigo Martino
    Hematology Department of Sant Pau Hospital, Autonomous University of Barcelona, Spain
    Blood 108:2928-36. 2006
    ..001]). These findings may help in the interpretation and design of future studies on secondary prophylaxis of IA after an allo-HSCT...
  52. ncbi request reprint High-dose infusional ifosfamide, etoposide plus methylprednisolone followed by dexamethasone, high-dose ara-C and cisplatinum and autologous stem cell transplantation for refractory or relapsed aggressive non-Hodgkin's lymphoma
    Antonio Salar
    Department of Clinical Hematology from Hospital del Mar, Hospital de la Santa Cruz y San Pablo, Hospital Germans Trias i Pujol, Hospital Clinic, Barcelona, Spain
    Haematologica 87:1028-35. 2002
    ..A salvage program including infusional high-dose ifosfamide plus etoposide (IFOVM) was evaluated in patients with refractory or relapsed aggressive non-Hodgkin's lymphoma...
  53. ncbi request reprint Reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and acute myelogenous leukemia
    David Valcarcel
    Division of Clinical Hematology, Hospital de la Sant Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Curr Opin Oncol 19:660-6. 2007
    ..The aim of this article is to summarize the outcome in recent studies of patients with acute myelogenous leukemia/myelodysplastic syndromes after reduced intensity conditioning for allogeneic stem cell transplantation...
  54. ncbi request reprint International and Italian prognostic indices in follicular lymphoma
    Granada Perea
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Haematologica 88:700-4. 2003
    ..The Italian Lymphoma Intergroup (ILI) created a new prognostic index specific for FL. The aim of this study was to compare which of these two indices is more useful when applied to a large group of FL patients...
  55. ncbi request reprint Invasive pulmonary aspergillosis in patients with hematologic malignancies: survival and prognostic factors
    Maricel Subirá
    Servei d Hematologia Clinica, Hospital de la Santa Creu i Sant Pau, Av S A M Claret 167, 08025 Barcelona, Spain
    Haematologica 87:528-34. 2002
    ..In this retrospective study we have reviewed all consecutive cases of IPA diagnosed in adult patients with hematologic malignancies in our center from 1995 to 2000 to determine survival and prognostic factors...
  56. ncbi request reprint Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA-identical sibling donors in myelodysplastic syndromes
    Rodrigo Martino
    Division of Clinical Hematology, Hopital de la Sant Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Blood 108:836-46. 2006
    ....
  57. ncbi request reprint Impact of ABO incompatibility on allogeneic peripheral blood progenitor cell transplantation after reduced intensity conditioning
    Carmen Canals
    Blood Bank, Hospital de Sant Pau, Barcelona, Spain
    Transfusion 44:1603-11. 2004
    ..Data on these events after reduced intensity conditioning (RIC) regimens are limited, but recent studies have suggested a higher transplant-related mortality (TRM) and morbidity in this setting...
  58. pmc Long-Term Results of Fludarabine/Melphalan as a Reduced-Intensity Conditioning Regimen in Mantle Cell Lymphoma: The GELTAMO Experience
    Jorge Gayoso Cruz
    Servicio de Hematologia, Hospital Santa Creu i Sant Pau, Barcelona, Spain
    Ther Adv Hematol 2:5-10. 2011
    ..We herein report the long-term results of an allogeneic reduced-intensity conditioning (allo-RIC) protocol used in 21 consecutive patients (16 males, median age 56 years, 71% in complete remission) diagnosed with mantle cell lymphoma (MCL)...
  59. doi request reprint Beta2-microglobulin is a better predictor of treatment-free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate
    Julio Delgado
    Department of Haematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Br J Haematol 145:801-5. 2009
    ..In all survival models, B2M did not attain independent significance unless GFR-B2M was eliminated from the analysis. In conclusion, GFR-B2M is a better predictor of TFS than unadjusted B2M in CLL patients...
  60. ncbi request reprint Human metapneumovirus infection in hematopoietic stem cell transplant recipients: high-resolution computed tomography findings
    Tomas Franquet
    Department of Radiology, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Comput Assist Tomogr 29:223-7. 2005
    ..To review the high-resolution computed tomography (CT) findings in hematopoietic stem cell transplant (HCT) recipients who had proven human metapneumovirus (HMPV) pneumonia...
  61. doi request reprint Acquired bullous dermatosis associated with IgA multiple myeloma: a case report
    Maria A Barnadas
    Department of Dermatology, Hospital Sta Creu i St Pau, Barcelona, Spain
    J Cutan Pathol 37:1174-7. 2010
    ....
  62. doi request reprint Hematopoietic transplantation for acute myeloid leukemia with internal tandem duplication of FLT3 gene (FLT3/ITD)
    Salut Brunet
    Hematology Service, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Curr Opin Oncol 25:195-204. 2013
    ..Optimal postremission therapy for these high-risk molecular cases is not well established; as the prognosis is adverse hematopoietic cell transplantation (HCT), mainly allogeneic HCT (allo-HCT), is the most widely accepted strategy...
  63. doi request reprint Molecular diagnosis of bloodstream infections with a new dual-priming oligonucleotide-based multiplex PCR assay
    Lucrecia Carrara
    1Servicio de Microbiología, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain
    J Med Microbiol 62:1673-9. 2013
    ..We concluded that the MST shows a high specificity but changes in design are needed to increase bacteraemia detection. For viability in clinical laboratories, technical improvements are also required to further automate the process. ..
  64. ncbi request reprint Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey
    Dan Engelhard
    Department of Pediatrics, Hadassah University Hospital and Hebrew University Hadassah Medical School, Ein Karem, Jerusalem, Israel
    Br J Haematol 117:444-50. 2002
    ..The high IPI mortality rate, both early and late post-transplantation, requires preventive approaches, mainly effective immunization...
  65. ncbi request reprint Prospective trial of chemotherapy and donor leukocyte infusions for relapse of advanced myeloid malignancies after allogeneic stem-cell transplantation
    John E Levine
    University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 20:405-12. 2002
    ..A chemotherapy strategy was used to debulk disease before administration of granulocyte colony-stimulating factor (G-CSF)-primed DLIs...
  66. ncbi request reprint Impact of CD34+ cell dose on the outcome of patients undergoing reduced-intensity-conditioning allogeneic peripheral blood stem cell transplantation
    Jose A Perez-Simon
    Department of Hematology, Hospital Clinico Universitario, Salamanca, Spain
    Blood 102:1108-13. 2003
    ....
  67. ncbi request reprint Chronic but not acute graft-versus-host disease improves outcome in multiple myeloma patients after non-myeloablative allogeneic transplantation
    Jose A Perez-Simon
    Hospital Clinico Universitario, Salamanca, Spain
    Br J Haematol 121:104-8. 2003
    ..04). The present study suggests that graft-versus-myeloma effect is the main weapon for disease control after NMT in MM patients and the efficacy of this immune effect depends on tumour burden before transplant...
  68. ncbi request reprint Nonmyeloablative transplantation with or without alemtuzumab: comparison between 2 prospective studies in patients with lymphoproliferative disorders
    Jose A Perez-Simon
    Department of Hematology, Hospital Universitairo de Salamanca, Paseo de San Vicente s n, 37007 Salamanca, Spain
    Blood 100:3121-7. 2002
    ..Patients receiving alemtuzumab often required DLIs to achieve similar tumor control but the incidence of GVHD was not significantly increased after DLI...
  69. ncbi request reprint Toxoplasmosis following allogeneic hematopoietic stem cell transplantation
    Rodrigo Martino
    Bone Marrow Transplant 31:617-8; author reply 619. 2003
  70. pmc Impact of posttransplantation G-CSF on outcomes of allogeneic hematopoietic stem cell transplantation
    Hanna J Khoury
    Center for International Blood and Marrow Transplant Research CIBMTR, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    Blood 107:1712-6. 2006
    ..In conclusion, results of this study found no long-term benefit or disadvantage of giving G-CSF after transplantation to promote hematopoietic recovery...
  71. ncbi request reprint Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-)
    Dolores Caballero
    Hospital Clinico Universitario de Salamanca, Spain
    Clin Cancer Res 11:7757-63. 2005
    ..To evaluate the efficacy of reduced intensity conditioning (RIC) allogeneic transplant in 30 patients with poor-prognosis chronic lymphocytic leukemia (CLL) and/or high-risk molecular/cytogenetic characteristics...
  72. pmc A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections
    John V Williams
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2581, USA
    J Infect Dis 192:1061-5. 2005
    ..Nine patients with hMPV developed LRI; 3 of these patients died. hMPV is a common cause of respiratory infections in adults with hematologic malignancies, with associated morbidity and mortality...
  73. ncbi request reprint [Allogeneic transplantation of peripheral blood hematopoietic stem-cells with low intensity conditioning for the treatment of a metastatic clear cell carcinoma. Preliminary results after two years of follow-up]
    Jose Pablo Maroto
    Servicio de Oncología M6dica, Servicio de Hematologia, Barcelona, Espana
    Arch Esp Urol 59:44-8. 2006
    ....
  74. ncbi request reprint Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia
    Carol Moreno
    Department of Hematology, Institute of Hematology and Oncology, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Spain
    J Clin Oncol 23:3433-8. 2005
    ..To investigate whether allogeneic stem-cell transplantation (allo-SCT) may overcome the negative impact of unmutated VH genes in the outcome of patients with chronic lymphocytic leukemia (CLL)...
  75. ncbi request reprint Influence of the intensity of the conditioning regimen on the characteristics of acute and chronic graft-versus-host disease after allogeneic transplantation
    Jose A Perez-Simon
    Servicio de Hematlogía, Hospital Clinico Universitario, Salamanca, Spain
    Br J Haematol 130:394-403. 2005
    ....
  76. ncbi request reprint Relapse to prior autograft and chronic graft-versus-host disease are the strongest prognostic factors for outcome of melphalan/fludarabine-based dose-reduced allogeneic stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Germany
    Biol Blood Marrow Transplant 10:698-708. 2004
    ....
  77. ncbi request reprint Myeloablative allogeneic hematopoietic stem cell transplantation in patients who experience relapse after autologous stem cell transplantation for lymphoma: a report of the International Bone Marrow Transplant Registry
    Cesar O Freytes
    University of Texas Health Science Center, Mail Code 7880, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Blood 104:3797-803. 2004
    ..Most likely to benefit are patients who have HLA-matched sibling donors, are in remission, and have good performance status...
  78. doi request reprint Risk factors for breakthrough invasive fungal infection during secondary prophylaxis
    Oliver A Cornely
    Klinik I fur Innere Medizin, Klinikum der Universität Köln, 50924 Köln, Germany
    J Antimicrob Chemother 61:939-46. 2008
    ..This study determines risk factors for recurrent IFI in leukaemia patients...
  79. ncbi request reprint Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma
    Koen Van Besien
    Lymphoma Working Committee, International Bone Marrow Transplant Registry Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    Blood 102:3521-9. 2003
    ..We did not detect a correlation between graft-versus-host disease (GVHD) and recurrence. Finally, outcomes of transplantation for follicular lymphoma show improvement over the past decade...
  80. ncbi request reprint Prognostic factors for survival in patients with advanced renal cell carcinoma undergoing nonmyeloablative allogeneic stem cell transplantation
    Jacopo Peccatori
    Hematology Bone Marrow Transplant Unit, Istituto Scientifico H San Raffaele, Milano, Italy
    Cancer 104:2099-103. 2005
    ..The objective of this study was to identify prognostic factors for predicting survival in patients with advanced renal cell carcinoma (RCC) who had undergone an allogeneic stem cell transplantation after failure on immunotherapy...
  81. ncbi request reprint Decreased treatment failure in recipients of HLA-identical bone marrow or peripheral blood stem cell transplants with high CD34 cell doses
    Olle Ringden
    Division of Clinical Immunology F79, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Br J Haematol 121:874-85. 2003
    ..34, P = 0.003), lower risk of relapse (RR = 0.62, P = 0.029) and treatment failure (RR = 0.74, P = 0.03). We conclude that higher CD34 cell doses decrease treatment failure in recipients of HLA-identical sibling BM and PBSC transplants...
  82. doi request reprint Reduced-intensity conditioning allogeneic transplantation from unrelated donors: evaluation of mycophenolate mofetil plus cyclosporin A as graft-versus-host disease prophylaxis
    Jose A Perez-Simon
    Servicio de Hematologia, Hospital Clinico Universitario de Salamanca, Salamanca, Spain
    Biol Blood Marrow Transplant 14:664-71. 2008
    ..Regarding GVHD, this combination allowed to control aGVHD but lead to a high incidence of cGVHD, so that newer strategies are required, especially in trying to decrease gastrointestinal involvement...