Research Topics
Genomes and Genes | Jose Martinez-GonzalezSummaryAffiliation: Hospital de la Santa Creu i Sant Pau Country: Spain Publications
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Detail Information
Publications
Decreased pre-surgical CD34+/CD144+ cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patientsSantiago Redondo
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
J Cardiothorac Surg 7:2. 2012..EPCs may play a pivotal role in vascular grafting. However, the EPC depletion in coronary artery bypass grafting (CABG) patients has not been compared to coronary artery disease-free valvular replacement patients with aortic stenosis...- Emerging therapeutic strategies to enhance HDL functionSantiago Redondo
Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Spain
Lipids Health Dis 10:175. 2011..In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD... 
Mechanisms underlying the cardiovascular effects of COX-inhibition: benefits and risksJose Martinez-Gonzalez
Centro de Investigacion Cardiovascular, CSIC ICCC Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Curr Pharm Des 13:2215-27. 2007....- Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanismJose Martinez-Gonzalez
Centro de Investigacion Cardiovascular, Consejo Superior de Investigaciones Científicas Institut Català de Ciències Cardiovasculars Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
J Nutr 138:443-8. 2008..Oleanolic acid could be regarded as a bioactive molecule that may contribute to the beneficial effects of the Mediterranean diet... - Influence of statin use on endothelial function: from bench to clinicsJose Martinez-Gonzalez
Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Curr Pharm Des 13:1771-86. 2007.... 
Bemiparin: second-generation, low-molecular-weight heparin for treatment and prophylaxis of venous thromboembolismJose Martinez-Gonzalez
Cardiovascular Research Center CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
Expert Rev Cardiovasc Ther 6:793-802. 2008..In the near future, information from ongoing clinical trials could be key to establishing the potential of bemiparin in different clinical settings...- Neuron-derived orphan receptor-1 (NOR-1) modulates vascular smooth muscle cell proliferationJose Martinez-Gonzalez
Instituto de Investigación Cardiovascular de Barcelona, CSIC ICCC Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Circ Res 92:96-103. 2003..These results show that NOR-1 modulates VSMC proliferation, and suggest that this transcription factor may play a role in both spontaneous and accelerated atherosclerosis... - Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREBJordi Rius
Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Arterioscler Thromb Vasc Biol 24:697-702. 2004..Our aim was to analyze whether NOR-1 is involved in LDL-induced mitogenic effects in VSMC... - Low density lipoproteins downregulate lysyl oxidase in vascular endothelial cells and the arterial wallCristina Rodriguez
Instituto de Investigación Cardiovascular de Barcelona, CSIC ICCC Hospital de Sant Pau, Barcelona, Spain
Arterioscler Thromb Vasc Biol 22:1409-14. 2002..Hypercholesterolemia induces endothelial dysfunction, a hallmark of the atherosclerotic process, modulating the expression of key genes in vascular endothelial cells... - Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatinMaria Gonzalez-Diez
Centro de Investigacion Cardiovascular, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
Thromb Haemost 100:119-26. 2008..Strategies aimed to therapeutically modulate S1P or S1P receptors could be useful to improve cardiovascular protection... - Lysyl oxidase and endothelial dysfunction: mechanisms of lysyl oxidase down-regulation by pro-inflammatory cytokinesJavier F Alcudia
Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, c Antoni Ma Claret 167, 08025 Barcelona, Spain
Front Biosci 13:2721-7. 2008..LOX rises as a promising target gene for the development of therapeutic strategies in the treatment of cardiovascular diseases... - Vascular effects of thrombin: involvement of NOR-1 in thrombin-induced mitogenic stimulus in vascular cellsLluis Martorell
Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, c Antoni Ma Claret 167, 08025 Barcelona, Spain
Front Biosci 13:2909-15. 2008..NOR-1 knockdown reduces DNA synthesis and EC re-growth in an in vitro model of wound repair. NOR-1 could be regarded as a new target to prevent endothelial effects triggered by thrombin and other mitogens... - NOR-1 is involved in VEGF-induced endothelial cell growthJordi Rius
Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, Barcelona 8025, Spain
Atherosclerosis 184:276-82. 2006..These results indicate that NOR-1 could be a key transcription factor regulating endothelial cell growth induced by VEGF... - Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDLJose Martinez-Gonzalez
Centro de Investigacion Cardiovascular, CSIC ICCC Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
Atherosclerosis 174:305-13. 2004..The potential contribution of HDL to vascular homeostasis, via increases in PGI(2) synthesis, could be enhanced by HMG-CoA reductase inhibitors... - Thrombin and protease-activated receptors (PARs) in atherothrombosisLluis Martorell
Centro de Investigacion Cardiovascular, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
Thromb Haemost 99:305-15. 2008..In this paper we review cellular responses triggered by thrombin and their implication in vascular pathophysiology... - Fibulin-5 is up-regulated by hypoxia in endothelial cells through a hypoxia-inducible factor-1 (HIF-1α)-dependent mechanismAnna Guadall
Centro de Investigacion Cardiovascular, Consejo Superior de Investigaciones Científicas Institut Català de Ciències Cardiovasculars, Sant Pau, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
J Biol Chem 286:7093-103. 2011.... - Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseasesCristina Rodriguez
Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Antoni Ma Claret 167, 08025 Barcelona, Spain
Cardiovasc Res 79:7-13. 2008..This review addresses the experimental evidence related to the role of LOX in vascular disorders and the potential benefits of controlling its expression and function... - C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expressionMarta M Turu
Department of Neurology, University Hospital of Bellvitge, Fundacio IDIBELL, Barcelona, Spain
BMC Cell Biol 9:47. 2008..Although CRP is known to induce a pro-inflammatory phenotype in endothelial cells (EC) a direct role on modulation of angiogenesis has not been established... - Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cellsAnna Guadall
Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, cBarcelona, Spain
Front Biosci (Elite Ed) 3:955-67. 2011..Thus, our data support a role of Smad signaling and ROS in the up-regulation of LOX by hypoxia in endothelial cells... - Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growthMarta Garcia-Ramírez
Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Arterioscler Thromb Vasc Biol 25:2398-403. 2005..We analyzed SOX18 expression in human coronary atherosclerotic lesions and investigated its potential function in vascular cells... - Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuliMercedes Camacho
Angiology, Vascular Biology, and Inflammation Laboratory, Institute of Biomedical Research IIB Sant Pau, Barcelona, Spain
J Lipid Res 52:720-31. 2011..These data suggest that PGIS upregulation is part of the adaptive response of vascular cells to hypoxic stress and could play a role in counteracting the deleterious effect of inflammatory stimuli... - Endogenous expression of C-reactive protein is increased in active (ulcerated noncomplicated) human carotid artery plaquesJerzy Krupinski
Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
Stroke 37:1200-4. 2006..Our aim was to analyze the presence of CRP in human advanced carotid artery plaques with differential anatomo-pathological characteristics and to assess local expression of CRP and other proinflammatory genes in these lesions... - Trans-10,cis-12-CLA dysregulate lipid and glucose metabolism and induce hepatic NR4A receptorsMaria A Navarro
Centro de Investigacion Cardiovascular, Hospital de la Santa Creu i Sant Pau, c Antoni Ma Claret 167, 08025 Barcelona, Spain
Front Biosci (Elite Ed) 2:87-97. 2010..These results suggest that t10,c12-CLA promote dysregulation of lipid and glucose metabolism, at least in part, by an isomer-specific modulation of hepatic expression of NR4A receptors... - Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclinCristina Rodriguez
Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Thromb Haemost 101:665-73. 2009.... - Imidazolineoxyl N-oxide induces COX-2 in endothelial cells: role of free radicalsMercedes Camacho
Laboratory of Angiology, Vascular Biology and Inflammation, Institute of Biomedical Research II B Sant Pau, Barcelona, Spain
Front Biosci (Elite Ed) 4:2654-69. 2012..Additional effects other than a direct NO scavenging activity may confer therapeutic advantages to cPTIO as compared with NO-synthase inhibitors for the treatment of systemic inflammation-associated vascular hyporeactivity... - Retinoic acid induces PGI synthase expression in human endothelial cellsMercedes Camacho
Angiology, Vascular Biology, and Inflammation Laboratory of the Institute of Research, Hospital Santa Creu i Sant Pau, Barcelona, Spain
J Lipid Res 49:1707-14. 2008..These results reinforce the concept that RA could be beneficial for patients with cardiovascular risk... - Carotid plaque, stroke pathogenesis, and CRP: treatment of ischemic strokeJerzy Krupinski
Department of Neurology, Stroke Unit, Hospital Universitari de Bellvitge, Feixa Llarga s n 08907 L Hospitalet de Llobregat, Barcelona, Spain
Curr Cardiol Rep 10:25-30. 2008..Whether a reduction of CRP levels could be beneficial to stroke patients remains to be clarified. More studies are needed before CRP becomes a routine part of the evaluation of stroke patients... - The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cellsJose Martinez-Gonzalez
Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, Barcelona, Spain
Cardiovasc Res 65:609-18. 2005..In this review, we discuss our present knowledge on the role of this subfamily of NRs in vascular cell function... - CCL20 is increased in hypercholesterolemic subjects and is upregulated by LDL in vascular smooth muscle cells: role of NF-κBOlivier Calvayrac
Centro de Investigacion Cardiovascular, Consejo Superior de Investigaciones Cientificas, Institut Català de Ciencies Cardiovasculars, Instituto de Investigaciones Biomédicas Sant Pau, Barcelona, Spain
Arterioscler Thromb Vasc Biol 31:2733-41. 2011..Our aim was to analyze the regulation of CC Chemokine ligand 20 (CCL20) by LDL in human vascular smooth muscle cells (VSMC)... - Blood-borne tissue factor activity predicts major cerebrovascular events in patients undergoing carotid endarterectomy: results from a 1-year follow-up studyJerzy Krupinski
Department of Neurology, University Hospital of Bellvitge, Fundacio IDIBELL, Barcelona, Spain
Cerebrovasc Dis 25:32-9. 2008..The aim of this study was to assess whether the expression of TF in carotid plaques from patients undergoing carotid endarterectomy (CEA) or/and blood-borne ('circulating') TF activity could predict future vascular complications... - The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxiaLluis Martorell
Cardiovascular Research Center CSIC ICCC, Hospital de la Santa Creu i Sant Pau, C Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
Mol Cell Biol 29:5828-42. 2009..Therefore, NOR-1 is a downstream effector of HIF-1 signaling involved in the survival response of endothelial cells to hypoxia... - Human coronary smooth muscle cells internalize versican-modified LDL through LDL receptor-related protein and LDL receptorsVicenta Llorente-Cortes
Cardiovascular Research Center, IIBB CSIC, Institut de Recerca del Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Arterioscler Thromb Vasc Biol 22:387-93. 2002..These results suggest that versican-LDL induces CE accumulation in human VSMCs by the LDL receptor (monomeric particles) and LDL receptor-related protein (fused LDL)... - New challenges for a second-generation low-molecular-weight heparin: focus on bemiparinJose Martinez-Gonzalez
Cardiovascular Research Center CSIC ICCC, Hospital de la Santa Creu i Sant Pau Pabellón no 11, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
Expert Rev Cardiovasc Ther 8:625-34. 2010..Finally, the pharmacokinetics of two oral bemiparin formulations are currently being analyzed in a Phase I trial... - Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factorsCristina Rodriguez
Centro de Investigacion Cardiovascular, Antoni M Claret 167, Barcelona 08025, Spain
Cardiovasc Res 83:595-603. 2009..Our aim was to analyse whether statins could normalize LOX expression impaired by proatherogenic risk factors... - Modulation of endothelium and endothelial progenitor cell function by low-density lipoproteins: implication for vascular repair, angiogenesis and vasculogenesisCristina Rodriguez
Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Pathobiology 76:11-22. 2009..This review is focused on the central role of the cholesterol pathway in the biology of the endothelium and EPCs... - Lysyl oxidase as a potential therapeutic targetCristina Rodriguez
Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Drug News Perspect 21:218-24. 2008..Here we review clinical and experimental evidence that supports a role for LOX in the pathophysiology of those processes and point out LOX as a potential therapeutic target... - [Endothelium and vascular protection: an update]Lina Badimon
Centro de Investigacion Cardiovascular, IIBB CSIC Institut de Recerca del Hospital Santa Creu i Sant Pau, Barcelona, Spain
Rev Esp Cardiol 55:17-26. 2002.... - High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cellsBerta Raposo
, CSIC/ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Atherosclerosis 177:1-8. 2004..This effect was dependent on a mechanism involving both an inhibition of LOX activity and a reduction of LOX expression... - Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activationJavier Crespo
, CSIC/ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret # 167, 08025 Barcelona, Spain
Cardiovasc Res 67:333-41. 2005..CONCLUSIONS: NOR-1 is a target for simvastatin in the vascular wall. We identified NOR-1 and CREB as key transcription factors mediating the effect of statins on VSMC proliferation through a mechanism dependent on RhoA/ROCK...