Jose Martinez-Gonzalez

Summary

Affiliation: Hospital de la Santa Creu i Sant Pau
Country: Spain

Publications

  1. pmc Decreased pre-surgical CD34+/CD144+ cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients
    Santiago Redondo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    J Cardiothorac Surg 7:2. 2012
  2. pmc Emerging therapeutic strategies to enhance HDL function
    Santiago Redondo
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Spain
    Lipids Health Dis 10:175. 2011
  3. ncbi request reprint Influence of statin use on endothelial function: from bench to clinics
    Jose Martinez-Gonzalez
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Curr Pharm Des 13:1771-86. 2007
  4. ncbi request reprint Mechanisms underlying the cardiovascular effects of COX-inhibition: benefits and risks
    Jose Martinez-Gonzalez
    Centro de Investigacion Cardiovascular, CSIC ICCC Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Curr Pharm Des 13:2215-27. 2007
  5. ncbi request reprint Bemiparin: second-generation, low-molecular-weight heparin for treatment and prophylaxis of venous thromboembolism
    Jose Martinez-Gonzalez
    Cardiovascular Research Center CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Expert Rev Cardiovasc Ther 6:793-802. 2008
  6. ncbi request reprint Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism
    Jose Martinez-Gonzalez
    Centro de Investigacion Cardiovascular, Consejo Superior de Investigaciones Científicas Institut Català de Ciències Cardiovasculars Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Nutr 138:443-8. 2008
  7. ncbi request reprint Neuron-derived orphan receptor-1 (NOR-1) modulates vascular smooth muscle cell proliferation
    Jose Martinez-Gonzalez
    Instituto de Investigación Cardiovascular de Barcelona, CSIC ICCC Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Circ Res 92:96-103. 2003
  8. ncbi request reprint Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation
    Javier Crespo
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Cardiovasc Res 67:333-41. 2005
  9. ncbi request reprint Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB
    Jordi Rius
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 24:697-702. 2004
  10. ncbi request reprint Low density lipoproteins downregulate lysyl oxidase in vascular endothelial cells and the arterial wall
    Cristina Rodriguez
    Instituto de Investigación Cardiovascular de Barcelona, CSIC ICCC Hospital de Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 22:1409-14. 2002

Collaborators

Detail Information

Publications43

  1. pmc Decreased pre-surgical CD34+/CD144+ cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients
    Santiago Redondo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    J Cardiothorac Surg 7:2. 2012
    ..EPCs may play a pivotal role in vascular grafting. However, the EPC depletion in coronary artery bypass grafting (CABG) patients has not been compared to coronary artery disease-free valvular replacement patients with aortic stenosis...
  2. pmc Emerging therapeutic strategies to enhance HDL function
    Santiago Redondo
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Spain
    Lipids Health Dis 10:175. 2011
    ..In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD...
  3. ncbi request reprint Influence of statin use on endothelial function: from bench to clinics
    Jose Martinez-Gonzalez
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Curr Pharm Des 13:1771-86. 2007
    ....
  4. ncbi request reprint Mechanisms underlying the cardiovascular effects of COX-inhibition: benefits and risks
    Jose Martinez-Gonzalez
    Centro de Investigacion Cardiovascular, CSIC ICCC Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Curr Pharm Des 13:2215-27. 2007
    ....
  5. ncbi request reprint Bemiparin: second-generation, low-molecular-weight heparin for treatment and prophylaxis of venous thromboembolism
    Jose Martinez-Gonzalez
    Cardiovascular Research Center CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Expert Rev Cardiovasc Ther 6:793-802. 2008
    ..In the near future, information from ongoing clinical trials could be key to establishing the potential of bemiparin in different clinical settings...
  6. ncbi request reprint Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism
    Jose Martinez-Gonzalez
    Centro de Investigacion Cardiovascular, Consejo Superior de Investigaciones Científicas Institut Català de Ciències Cardiovasculars Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Nutr 138:443-8. 2008
    ..Oleanolic acid could be regarded as a bioactive molecule that may contribute to the beneficial effects of the Mediterranean diet...
  7. ncbi request reprint Neuron-derived orphan receptor-1 (NOR-1) modulates vascular smooth muscle cell proliferation
    Jose Martinez-Gonzalez
    Instituto de Investigación Cardiovascular de Barcelona, CSIC ICCC Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Circ Res 92:96-103. 2003
    ..These results show that NOR-1 modulates VSMC proliferation, and suggest that this transcription factor may play a role in both spontaneous and accelerated atherosclerosis...
  8. ncbi request reprint Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation
    Javier Crespo
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Cardiovasc Res 67:333-41. 2005
    ..Our aim was to investigate whether neuron-derived orphan receptor-1 (NOR-1), an early gene induced by low density lipoproteins (LDL) in vascular smooth muscle cells (VSMC), is regulated by statins...
  9. ncbi request reprint Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB
    Jordi Rius
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 24:697-702. 2004
    ..Our aim was to analyze whether NOR-1 is involved in LDL-induced mitogenic effects in VSMC...
  10. ncbi request reprint Low density lipoproteins downregulate lysyl oxidase in vascular endothelial cells and the arterial wall
    Cristina Rodriguez
    Instituto de Investigación Cardiovascular de Barcelona, CSIC ICCC Hospital de Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 22:1409-14. 2002
    ..Hypercholesterolemia induces endothelial dysfunction, a hallmark of the atherosclerotic process, modulating the expression of key genes in vascular endothelial cells...
  11. ncbi request reprint Vascular effects of thrombin: involvement of NOR-1 in thrombin-induced mitogenic stimulus in vascular cells
    Lluis Martorell
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, c Antoni Ma Claret 167, 08025 Barcelona, Spain
    Front Biosci 13:2909-15. 2008
    ..NOR-1 knockdown reduces DNA synthesis and EC re-growth in an in vitro model of wound repair. NOR-1 could be regarded as a new target to prevent endothelial effects triggered by thrombin and other mitogens...
  12. ncbi request reprint Lysyl oxidase and endothelial dysfunction: mechanisms of lysyl oxidase down-regulation by pro-inflammatory cytokines
    Javier F Alcudia
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, c Antoni Ma Claret 167, 08025 Barcelona, Spain
    Front Biosci 13:2721-7. 2008
    ..LOX rises as a promising target gene for the development of therapeutic strategies in the treatment of cardiovascular diseases...
  13. doi request reprint Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin
    Maria Gonzalez-Diez
    Centro de Investigacion Cardiovascular, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Thromb Haemost 100:119-26. 2008
    ..Strategies aimed to therapeutically modulate S1P or S1P receptors could be useful to improve cardiovascular protection...
  14. ncbi request reprint NOR-1 is involved in VEGF-induced endothelial cell growth
    Jordi Rius
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, Barcelona 8025, Spain
    Atherosclerosis 184:276-82. 2006
    ..These results indicate that NOR-1 could be a key transcription factor regulating endothelial cell growth induced by VEGF...
  15. ncbi request reprint Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDL
    Jose Martinez-Gonzalez
    Centro de Investigacion Cardiovascular, CSIC ICCC Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Atherosclerosis 174:305-13. 2004
    ..The potential contribution of HDL to vascular homeostasis, via increases in PGI(2) synthesis, could be enhanced by HMG-CoA reductase inhibitors...
  16. pmc Fibulin-5 is up-regulated by hypoxia in endothelial cells through a hypoxia-inducible factor-1 (HIF-1α)-dependent mechanism
    Anna Guadall
    Centro de Investigacion Cardiovascular, Consejo Superior de Investigaciones Científicas Institut Català de Ciències Cardiovasculars, Sant Pau, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    J Biol Chem 286:7093-103. 2011
    ....
  17. doi request reprint Over-expression of neuron-derived orphan receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury
    Ricardo Rodríguez-Calvo
    Centro de Investigacion Cardiovascular, CSIC ICCC, IIB Sant Pau, Barcelona, Spain
    Hum Mol Genet 22:1949-59. 2013
    ..36-fold induction, P < 0.01). Our in vivo data support a role for NOR-1 in VSMC proliferation and vascular remodelling. This NOR-1 transgenic mouse could be a useful model to study fibroproliferative vascular diseases...
  18. ncbi request reprint Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases
    Cristina Rodriguez
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Antoni Ma Claret 167, 08025 Barcelona, Spain
    Cardiovasc Res 79:7-13. 2008
    ..This review addresses the experimental evidence related to the role of LOX in vascular disorders and the potential benefits of controlling its expression and function...
  19. ncbi request reprint Differential intracellular trafficking of von Willebrand factor (vWF) and vWF propeptide in porcine endothelial cells lacking Weibel-Palade bodies and in human endothelial cells
    Teresita Royo
    Instituto de Investigación Cardiovascular de Barcelona, CSIC ICCC Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Maria Claret 167, Spain
    Atherosclerosis 167:55-63. 2003
    ..Our results confirm that PAEC express very low levels of vWF mRNA and indicate that in these cells, that do not have WPB, vWF and vWFpp have divergent intracellular trafficking pathways...
  20. doi request reprint Thrombin and protease-activated receptors (PARs) in atherothrombosis
    Lluis Martorell
    Centro de Investigacion Cardiovascular, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Thromb Haemost 99:305-15. 2008
    ..In this paper we review cellular responses triggered by thrombin and their implication in vascular pathophysiology...
  21. pmc C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression
    Marta M Turu
    Department of Neurology, University Hospital of Bellvitge, Fundacio IDIBELL, Barcelona, Spain
    BMC Cell Biol 9:47. 2008
    ..Although CRP is known to induce a pro-inflammatory phenotype in endothelial cells (EC) a direct role on modulation of angiogenesis has not been established...
  22. pmc Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli
    Mercedes Camacho
    Angiology, Vascular Biology, and Inflammation Laboratory, Institute of Biomedical Research IIB Sant Pau, Barcelona, Spain
    J Lipid Res 52:720-31. 2011
    ..These data suggest that PGIS upregulation is part of the adaptive response of vascular cells to hypoxic stress and could play a role in counteracting the deleterious effect of inflammatory stimuli...
  23. ncbi request reprint Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cells
    Anna Guadall
    Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, cBarcelona, Spain
    Front Biosci (Elite Ed) 3:955-67. 2011
    ..Thus, our data support a role of Smad signaling and ROS in the up-regulation of LOX by hypoxia in endothelial cells...
  24. ncbi request reprint Endogenous expression of C-reactive protein is increased in active (ulcerated noncomplicated) human carotid artery plaques
    Jerzy Krupinski
    Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
    Stroke 37:1200-4. 2006
    ..Our aim was to analyze the presence of CRP in human advanced carotid artery plaques with differential anatomo-pathological characteristics and to assess local expression of CRP and other proinflammatory genes in these lesions...
  25. pmc Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm
    Mercedes Camacho
    Angiology, Vascular Biology, and Inflammation Laboratory, Institute of Biomedical Research II B Sant Pau, Barcelona, Spain
    J Lipid Res 54:3506-15. 2013
    ..We provide new data concerning mPGES-1 expression in human AAA. Our findings suggest the potential relevance of the COX-2/mPGES-1/EP-4 axis in the AAA-associated hypervascularization. ..
  26. ncbi request reprint Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth
    Marta Garcia-Ramírez
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 25:2398-403. 2005
    ..We analyzed SOX18 expression in human coronary atherosclerotic lesions and investigated its potential function in vascular cells...
  27. ncbi request reprint Trans-10,cis-12-CLA dysregulate lipid and glucose metabolism and induce hepatic NR4A receptors
    Maria A Navarro
    Centro de Investigacion Cardiovascular, Hospital de la Santa Creu i Sant Pau, c Antoni Ma Claret 167, 08025 Barcelona, Spain
    Front Biosci (Elite Ed) 2:87-97. 2010
    ..These results suggest that t10,c12-CLA promote dysregulation of lipid and glucose metabolism, at least in part, by an isomer-specific modulation of hepatic expression of NR4A receptors...
  28. ncbi request reprint High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells
    Berta Raposo
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Atherosclerosis 177:1-8. 2004
    ..Downregulation of lysyl oxidase (LOX), an enzyme involved in extracellular matrix maturation, impairs the endothelial barrier function and could be involved in homocysteine (HC)-induced endothelial dysfunction...
  29. ncbi request reprint Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin
    Cristina Rodriguez
    Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Thromb Haemost 101:665-73. 2009
    ....
  30. ncbi request reprint Imidazolineoxyl N-oxide induces COX-2 in endothelial cells: role of free radicals
    Mercedes Camacho
    Laboratory of Angiology, Vascular Biology and Inflammation, Institute of Biomedical Research II B Sant Pau, Barcelona, Spain
    Front Biosci (Elite Ed) 4:2654-69. 2012
    ..Additional effects other than a direct NO scavenging activity may confer therapeutic advantages to cPTIO as compared with NO-synthase inhibitors for the treatment of systemic inflammation-associated vascular hyporeactivity...
  31. doi request reprint Retinoic acid induces PGI synthase expression in human endothelial cells
    Mercedes Camacho
    Angiology, Vascular Biology, and Inflammation Laboratory of the Institute of Research, Hospital Santa Creu i Sant Pau, Barcelona, Spain
    J Lipid Res 49:1707-14. 2008
    ..These results reinforce the concept that RA could be beneficial for patients with cardiovascular risk...
  32. ncbi request reprint Carotid plaque, stroke pathogenesis, and CRP: treatment of ischemic stroke
    Jerzy Krupinski
    Department of Neurology, Stroke Unit, Hospital Universitari de Bellvitge, Feixa Llarga s n 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Curr Cardiol Rep 10:25-30. 2008
    ..Whether a reduction of CRP levels could be beneficial to stroke patients remains to be clarified. More studies are needed before CRP becomes a routine part of the evaluation of stroke patients...
  33. doi request reprint CCL20 is increased in hypercholesterolemic subjects and is upregulated by LDL in vascular smooth muscle cells: role of NF-κB
    Olivier Calvayrac
    Centro de Investigacion Cardiovascular, Consejo Superior de Investigaciones Cientificas, Institut Català de Ciencies Cardiovasculars, Instituto de Investigaciones Biomédicas Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 31:2733-41. 2011
    ..Our aim was to analyze the regulation of CC Chemokine ligand 20 (CCL20) by LDL in human vascular smooth muscle cells (VSMC)...
  34. pmc The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxia
    Lluis Martorell
    Cardiovascular Research Center CSIC ICCC, Hospital de la Santa Creu i Sant Pau, C Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Mol Cell Biol 29:5828-42. 2009
    ..Therefore, NOR-1 is a downstream effector of HIF-1 signaling involved in the survival response of endothelial cells to hypoxia...
  35. ncbi request reprint The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells
    Jose Martinez-Gonzalez
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, Barcelona, Spain
    Cardiovasc Res 65:609-18. 2005
    ..In this review, we discuss our present knowledge on the role of this subfamily of NRs in vascular cell function...
  36. ncbi request reprint Blood-borne tissue factor activity predicts major cerebrovascular events in patients undergoing carotid endarterectomy: results from a 1-year follow-up study
    Jerzy Krupinski
    Department of Neurology, University Hospital of Bellvitge, Fundacio IDIBELL, Barcelona, Spain
    Cerebrovasc Dis 25:32-9. 2008
    ..The aim of this study was to assess whether the expression of TF in carotid plaques from patients undergoing carotid endarterectomy (CEA) or/and blood-borne ('circulating') TF activity could predict future vascular complications...
  37. ncbi request reprint [Neovascularization in human coronary arteries with lesions of different severity]
    Josep O Juan-Babot
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Espana
    Rev Esp Cardiol 56:978-86. 2003
    ..The aim of this study was to quantify neovessels in human coronary arteries with atherosclerotic lesions of different severity and analyze their relationship with inflammatory cell and plasma product infiltrates...
  38. doi request reprint Modulation of endothelium and endothelial progenitor cell function by low-density lipoproteins: implication for vascular repair, angiogenesis and vasculogenesis
    Cristina Rodriguez
    Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Pathobiology 76:11-22. 2009
    ..This review is focused on the central role of the cholesterol pathway in the biology of the endothelium and EPCs...
  39. doi request reprint Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors
    Cristina Rodriguez
    Centro de Investigacion Cardiovascular, Antoni M Claret 167, Barcelona 08025, Spain
    Cardiovasc Res 83:595-603. 2009
    ..Our aim was to analyse whether statins could normalize LOX expression impaired by proatherogenic risk factors...
  40. doi request reprint New challenges for a second-generation low-molecular-weight heparin: focus on bemiparin
    Jose Martinez-Gonzalez
    Cardiovascular Research Center CSIC ICCC, Hospital de la Santa Creu i Sant Pau Pabellón no 11, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    Expert Rev Cardiovasc Ther 8:625-34. 2010
    ..Finally, the pharmacokinetics of two oral bemiparin formulations are currently being analyzed in a Phase I trial...
  41. ncbi request reprint Lysyl oxidase as a potential therapeutic target
    Cristina Rodriguez
    Centro de Investigacion Cardiovascular CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Drug News Perspect 21:218-24. 2008
    ..Here we review clinical and experimental evidence that supports a role for LOX in the pathophysiology of those processes and point out LOX as a potential therapeutic target...
  42. ncbi request reprint Human coronary smooth muscle cells internalize versican-modified LDL through LDL receptor-related protein and LDL receptors
    Vicenta Llorente-Cortes
    Cardiovascular Research Center, IIBB CSIC, Institut de Recerca del Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 22:387-93. 2002
    ..These results suggest that versican-LDL induces CE accumulation in human VSMCs by the LDL receptor (monomeric particles) and LDL receptor-related protein (fused LDL)...
  43. ncbi request reprint [Endothelium and vascular protection: an update]
    Lina Badimon
    Centro de Investigacion Cardiovascular, IIBB CSIC Institut de Recerca del Hospital Santa Creu i Sant Pau, Barcelona, Spain
    Rev Esp Cardiol 55:17-26. 2002
    ....