Jorge Manzanares

Summary

Affiliation: Hospital Universitario
Country: Spain

Publications

  1. ncbi request reprint Differences in basal cannabinoid CB1 receptor function in selective brain areas and vulnerability to voluntary alcohol consumption in Fawn Hooded and Wistar rats
    Sergio Ortiz
    Servicio de Psiquiatria, Edificio Materno Infantil, 6 Planta, 613 A, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, E 28041 Madrid, Spain
    Alcohol Alcohol 39:297-302. 2004
  2. ncbi request reprint Interactions between cannabinoid and opioid receptor systems in the mediation of ethanol effects
    Jorge Manzanares
    Edificio Materno Infantil, Planta 6, 613 A, Hospital Universitario 12 de Octubre, Avda Cordoba s n, 28041 Madrid, Spain
    Alcohol Alcohol 40:25-34. 2005
  3. ncbi request reprint Time course of opioid and cannabinoid gene transcription alterations induced by repeated administration with fluoxetine in the rat brain
    Jose M Oliva
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
    Neuropharmacology 49:618-26. 2005
  4. ncbi request reprint Spontaneous cannabinoid withdrawal produces a differential time-related responsiveness in cannabinoid CB1 receptor gene expression in the mouse brain
    Jose M Oliva
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
    J Psychopharmacol 18:59-65. 2004
  5. ncbi request reprint Chronic ethanol consumption regulates cannabinoid CB1 receptor gene expression in selected regions of rat brain
    Sergio Ortiz
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
    Alcohol Alcohol 39:88-92. 2004
  6. ncbi request reprint Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice
    Leyre Urigüen
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
    Eur J Neurosci 22:2106-10. 2005
  7. ncbi request reprint Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice
    Jose M Oliva
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
    J Neurochem 85:94-104. 2003
  8. ncbi request reprint Naltrexone improves outcome of a controlled drinking program
    Gabriel Rubio
    Unidad de Conductas Adictivas, Servicio de Psiquiatria, Pabellon de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
    J Subst Abuse Treat 23:361-6. 2002
  9. ncbi request reprint Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors
    Leyre Urigüen
    Servicio de Psiquiatría y Unidad de Investigación, Pabellon de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda Cordoba s n, 28041 Madrid, Spain
    Neuropharmacology 46:966-73. 2004
  10. ncbi request reprint Role of endocannabinoid system in mental diseases
    Jorge Manzanares
    Servicio de Psiquiatría y Unidad de Investigación, Hospital 12 de Octubre, Edificio Materno Infantil, Planta 6a, 613 A, Avenida de Córdoba s n 28041 Madrid, Spain
    Neurotox Res 6:213-24. 2004

Collaborators

  • Gabriel Rubio
  • Francisco López-Muñoz
  • R Maldonado
  • Basalingappa Hungund
  • Javier Fernandez-Ruiz
  • Jose M Oliva
  • Sergio Ortiz
  • Tomas Palomo
  • Sandra Pérez-Rial
  • Leyre Urigüen
  • K Yaragudri Vinod
  • Antonio Fontanellas
  • Mercedes Delgado
  • Catherine Ledent
  • José A Fuentes
  • Javier Corchero
  • Fernando Berrendero
  • Isabel Lastres-Becker
  • Elena Sanguino
  • Ratnakumar Yalamanchili
  • Miguel A Pozo
  • Maria Luz López-Rodriguez
  • María García-Bravo
  • José María Oliva
  • Anne G Caicoya
  • Virginia Greciano
  • Rafael Enriquez de Salamanca
  • Manuel Mendez
  • Ana Maria Buzaleh
  • Alcira Batlle
  • Bellinda Benhamú
  • María Soledad Fernández-Alfonso
  • Henrik H Hansen
  • Alberto Pérez-Rosado
  • Rosario de Miguel
  • Jose A Ramos

Detail Information

Publications20

  1. ncbi request reprint Differences in basal cannabinoid CB1 receptor function in selective brain areas and vulnerability to voluntary alcohol consumption in Fawn Hooded and Wistar rats
    Sergio Ortiz
    Servicio de Psiquiatria, Edificio Materno Infantil, 6 Planta, 613 A, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, E 28041 Madrid, Spain
    Alcohol Alcohol 39:297-302. 2004
    ..To specify the functional activity of cannabinoid CB1 receptor in alcohol-preferring Fawn Hooded and alcohol nonpreferring Wistar rats under naïve conditions...
  2. ncbi request reprint Interactions between cannabinoid and opioid receptor systems in the mediation of ethanol effects
    Jorge Manzanares
    Edificio Materno Infantil, Planta 6, 613 A, Hospital Universitario 12 de Octubre, Avda Cordoba s n, 28041 Madrid, Spain
    Alcohol Alcohol 40:25-34. 2005
    ..In this paper, we review the role of opioid and cannabinoid receptor systems, their vulnerability to alcohol intake and the development of dependence, and the targeting of these systems in the treatment of alcoholism...
  3. ncbi request reprint Time course of opioid and cannabinoid gene transcription alterations induced by repeated administration with fluoxetine in the rat brain
    Jose M Oliva
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
    Neuropharmacology 49:618-26. 2005
    ....
  4. ncbi request reprint Spontaneous cannabinoid withdrawal produces a differential time-related responsiveness in cannabinoid CB1 receptor gene expression in the mouse brain
    Jose M Oliva
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
    J Psychopharmacol 18:59-65. 2004
    ..These findings further suggest a time and regional differential role for cannabinoid receptors in short- and long-term neuroadaptations that occur after exposure to cannabis derivatives...
  5. ncbi request reprint Chronic ethanol consumption regulates cannabinoid CB1 receptor gene expression in selected regions of rat brain
    Sergio Ortiz
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
    Alcohol Alcohol 39:88-92. 2004
    ..The aim of this study was to examine the effects of chronic ethanol consumption in cannabinoid CB(1) receptor gene expression in Wistar rats...
  6. ncbi request reprint Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice
    Leyre Urigüen
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
    Eur J Neurosci 22:2106-10. 2005
    ....
  7. ncbi request reprint Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in mice
    Jose M Oliva
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
    J Neurochem 85:94-104. 2003
    ..This 'syndrome' includes behavioural, hormonal and gene transcription alterations that seems to be part of the regulation of neuronal plasticity induced by spontaneous cannabinoid withdrawal...
  8. ncbi request reprint Naltrexone improves outcome of a controlled drinking program
    Gabriel Rubio
    Unidad de Conductas Adictivas, Servicio de Psiquiatria, Pabellon de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
    J Subst Abuse Treat 23:361-6. 2002
    ..The results of this study suggest a role for naltrexone in controlled drinking programs...
  9. ncbi request reprint Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors
    Leyre Urigüen
    Servicio de Psiquiatría y Unidad de Investigación, Pabellon de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda Cordoba s n, 28041 Madrid, Spain
    Neuropharmacology 46:966-73. 2004
    ..They suggest that alterations in the functional activity of the CB(1) receptor may be related to the emergence of anxiety disorders, and may affect treatment with anxiolytics...
  10. ncbi request reprint Role of endocannabinoid system in mental diseases
    Jorge Manzanares
    Servicio de Psiquiatría y Unidad de Investigación, Hospital 12 de Octubre, Edificio Materno Infantil, Planta 6a, 613 A, Avenida de Córdoba s n 28041 Madrid, Spain
    Neurotox Res 6:213-24. 2004
    ..This review attempts to link current understanding of the basic neurobiology of the endocannabinoid system to novel opportunities for therapeutic intervention and its effects on the central nervous system...
  11. doi request reprint Modulation of impulsivity by topiramate: implications for the treatment of alcohol dependence
    Gabriel Rubio
    Dual Diagnoses Unit, Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
    J Clin Psychopharmacol 29:584-9. 2009
    ..The results of this study indicate that TP reduces drinking and that the mechanisms underlying this effect may involve, at least in part, modulation of the behavioral inhibition paradigm...
  12. ncbi request reprint Effects of repeated administration with CP-55,940, a cannabinoid CB1 receptor agonist on the metabolism of the hepatic heme
    Antonio Fontanellas
    Research Center, Hospital Universitario 12 de Octubre, Madrid, Spain
    Int J Biochem Cell Biol 37:1620-5. 2005
    ..Our findings indicate that CP-55,940 and its metabolites do not behave as porphyrinogenic drugs and may potentially be safe for treating pain in patients with acute porphyrias...
  13. ncbi request reprint Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol
    K Yaragudri Vinod
    Division of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, USA
    J Neurochem 104:233-43. 2008
    ..Treatment with drugs that decrease AEA tone might prove useful in reducing excessive ethanol consumption...
  14. ncbi request reprint Gene transcription alterations associated with decrease of ethanol intake induced by naltrexone in the brain of Wistar rats
    Jose M Oliva
    Institute of Physiological Chemistry and Pathobiochemistry, School of Medicine, Johannes Gutemberg University of Mainz, Mainz, Germany
    Neuropsychopharmacology 32:1358-69. 2007
    ..These results point to a role for the mu-opioid receptor, TH, PENK, CRF, CB1-R, and 5-HTT genes in specific brain regions in the modulation of neuroadaptative mechanisms associated to the decrease of ethanol intake induced by naltrexone...
  15. ncbi request reprint Cannabinoid/opioid crosstalk in the central nervous system
    Javier Corchero
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain
    Crit Rev Neurobiol 16:159-72. 2004
    ....
  16. ncbi request reprint Naltrexone for alcohol dependence
    Gabriel Rubio
    N Engl J Med 346:1329-31; author reply 1329-31. 2002
  17. ncbi request reprint Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors
    Mercedes Delgado
    Unidad de Cartografía Cerebral, Instituto Pluridisciplinar, Avda Juan XXIII, 1, 28040 Madrid, Spain
    Eur J Pharmacol 511:9-19. 2005
    ..Taken together, these results suggest that CSP-2503 is a new 5-HT1 receptor agonist with 5-HT2A and 5-HT3)receptor antagonist activities that might be useful in a number of conditions associated with anxiety...
  18. ncbi request reprint Time dependent alterations on tyrosine hydroxylase, opioid and cannabinoid CB1 receptor gene expressions after acute ethanol administration in the rat brain
    Jose M Oliva
    Section of Molecular Neuropharmacology and Centre for Behavioral Phenotyping, Department of Physiology and Pharmacology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Eur Neuropsychopharmacol 18:373-82. 2008
    ....
  19. ncbi request reprint Use of cocaine by heavy drinkers increases vulnerability to developing alcohol dependence: a 4-year follow-up study
    Gabriel Rubio
    Alcoholism Research Program, Mental Health Center of Retiro, Madrid, Spain
    J Clin Psychiatry 69:563-70. 2008
    ..This study examined the influence of cocaine use and the role of impulsivity in the development of DSM-IV alcohol dependence in nondependent drinkers in a 4-year follow-up study...
  20. ncbi request reprint Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease
    Isabel Lastres-Becker
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Synapse 44:23-35. 2002
    ..These observations might be relevant to the treatment of hyperkinetic symptoms in HD, a human disorder with unsatisfactory symptomatic treatment for most patients...