Research Topics
Species | Jorge ManzanaresSummaryAffiliation: Hospital Universitario Country: Spain Publications
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Detail Information
Publications
Differences in basal cannabinoid CB1 receptor function in selective brain areas and vulnerability to voluntary alcohol consumption in Fawn Hooded and Wistar ratsSergio Ortiz
Servicio de Psiquiatria, Edificio Materno Infantil, 6 Planta, 613 A, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, E 28041 Madrid, Spain
Alcohol Alcohol 39:297-302. 2004..To specify the functional activity of cannabinoid CB1 receptor in alcohol-preferring Fawn Hooded and alcohol nonpreferring Wistar rats under naïve conditions...- Interactions between cannabinoid and opioid receptor systems in the mediation of ethanol effectsJorge Manzanares
Edificio Materno Infantil, Planta 6, 613 A, Hospital Universitario 12 de Octubre, Avda Cordoba s n, 28041 Madrid, Spain
Alcohol Alcohol 40:25-34. 2005..In this paper, we review the role of opioid and cannabinoid receptor systems, their vulnerability to alcohol intake and the development of dependence, and the targeting of these systems in the treatment of alcoholism... - Time course of opioid and cannabinoid gene transcription alterations induced by repeated administration with fluoxetine in the rat brainJose M Oliva
Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
Neuropharmacology 49:618-26. 2005.... - Spontaneous cannabinoid withdrawal produces a differential time-related responsiveness in cannabinoid CB1 receptor gene expression in the mouse brainJose M Oliva
Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
J Psychopharmacol 18:59-65. 2004..These findings further suggest a time and regional differential role for cannabinoid receptors in short- and long-term neuroadaptations that occur after exposure to cannabis derivatives... - Chronic ethanol consumption regulates cannabinoid CB1 receptor gene expression in selected regions of rat brainSergio Ortiz
, Hospital Universitario 12 de Octubre, Madrid, Spain
Alcohol Alcohol 39:88-92. 2004..Furthermore, these findings suggest that cannabinoid CB(1) receptor may be considered as a new pharmacological target for treating ethanol dependence... - Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout miceLeyre Urigüen
Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
Eur J Neurosci 22:2106-10. 2005.... - Behavioural and gene transcription alterations induced by spontaneous cannabinoid withdrawal in miceJose M Oliva
Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
J Neurochem 85:94-104. 2003..This 'syndrome' includes behavioural, hormonal and gene transcription alterations that seems to be part of the regulation of neuronal plasticity induced by spontaneous cannabinoid withdrawal... - Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptorsLeyre Urigüen
Servicio de Psiquiatría y Unidad de Investigación, Pabellon de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda Cordoba s n, 28041 Madrid, Spain
Neuropharmacology 46:966-73. 2004..They suggest that alterations in the functional activity of the CB(1) receptor may be related to the emergence of anxiety disorders, and may affect treatment with anxiolytics... - Naltrexone improves outcome of a controlled drinking programGabriel Rubio
Unidad de Conductas Adictivas, Servicio de Psiquiatria, Pabellon de Medicina Comunitaria, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
J Subst Abuse Treat 23:361-6. 2002..The results of this study suggest a role for naltrexone in controlled drinking programs... - Role of endocannabinoid system in mental diseasesJorge Manzanares
Servicio de Psiquiatría y Unidad de Investigación, Hospital 12 de Octubre, Edificio Materno Infantil, Planta 6a, 613 A, Avenida de Córdoba s n 28041 Madrid, Spain
Neurotox Res 6:213-24. 2004..This review attempts to link current understanding of the basic neurobiology of the endocannabinoid system to novel opportunities for therapeutic intervention and its effects on the central nervous system... 
Modulation of impulsivity by topiramate: implications for the treatment of alcohol dependenceGabriel Rubio
Dual Diagnoses Unit, Department of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain
J Clin Psychopharmacol 29:584-9. 2009..The results of this study indicate that TP reduces drinking and that the mechanisms underlying this effect may involve, at least in part, modulation of the behavioral inhibition paradigm...- Effects of repeated administration with CP-55,940, a cannabinoid CB1 receptor agonist on the metabolism of the hepatic hemeAntonio Fontanellas
Research Center, Hospital Universitario 12 de Octubre, Madrid, Spain
Int J Biochem Cell Biol 37:1620-5. 2005..Our findings indicate that CP-55,940 and its metabolites do not behave as porphyrinogenic drugs and may potentially be safe for treating pain in patients with acute porphyrias... - Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanolK Yaragudri Vinod
Division of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, USA
J Neurochem 104:233-43. 2008..Treatment with drugs that decrease AEA tone might prove useful in reducing excessive ethanol consumption... - Gene transcription alterations associated with decrease of ethanol intake induced by naltrexone in the brain of Wistar ratsJose M Oliva
Institute of Physiological Chemistry and Pathobiochemistry, School of Medicine, Johannes Gutemberg University of Mainz, Mainz, Germany
Neuropsychopharmacology 32:1358-69. 2007..These results point to a role for the mu-opioid receptor, TH, PENK, CRF, CB1-R, and 5-HTT genes in specific brain regions in the modulation of neuroadaptative mechanisms associated to the decrease of ethanol intake induced by naltrexone... - Cannabinoid/opioid crosstalk in the central nervous systemJavier Corchero
, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain
Crit Rev Neurobiol 16:159-72. 2004.... - Naltrexone for alcohol dependenceGabriel Rubio
N Engl J Med 346:1329-31; author reply 1329-31. 2002 - Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptorsMercedes Delgado
, Instituto Pluridisciplinar, Avda. Juan XXIII, 1, 28040 Madrid, Spain
Eur J Pharmacol 511:9-19. 2005..Taken together, these results suggest that CSP-2503 is a new 5-HT1 receptor agonist with 5-HT2A and 5-HT3)receptor antagonist activities that might be useful in a number of conditions associated with anxiety... - Time dependent alterations on tyrosine hydroxylase, opioid and cannabinoid CB1 receptor gene expressions after acute ethanol administration in the rat brainJose M Oliva
Section of Molecular Neuropharmacology and Centre for Behavioral Phenotyping, Department of Physiology and Pharmacology, Karolinska Institute, S 171 77 Stockholm, Sweden
Eur Neuropsychopharmacol 18:373-82. 2008.... - Use of cocaine by heavy drinkers increases vulnerability to developing alcohol dependence: a 4-year follow-up studyGabriel Rubio
Alcoholism Research Program, Mental Health Center of Retiro, Madrid, Spain
J Clin Psychiatry 69:563-70. 2008..This study examined the influence of cocaine use and the role of impulsivity in the development of DSM-IV alcohol dependence in nondependent drinkers in a 4-year follow-up study... - Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's diseaseIsabel Lastres-Becker
, Facultad de Medicina, Universidad Complutense, 28040-Madrid, Spain
Synapse 44:23-35. 2002..These observations might be relevant to the treatment of hyperkinetic symptoms in HD, a human disorder with unsatisfactory symptomatic treatment for most patients...