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Genomes and Genes | D A de LuisSummaryAffiliation: Hospital Universitario Country: Spain Publications
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Publications
Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric dietDaniel de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, C Los perales 16, Simancas 47130, Valladolid, Spain Electronic address
J Diabetes Complications 27:235-9. 2013..The C385A polymorphism of FAAH gene (rs324420C>A) has been associated with obesity. We investigate the role of this polymorphism on anthropometric and metabolic responses after an enriched monounsaturated fat hypocaloric diet...
Micronutrient status in morbidly obese women before bariatric surgeryDaniel A de Luis
Institute of Endocrinology and Nutrition, University of Valladolid Medicine School, Valladolid, Spain
Surg Obes Relat Dis 9:323-7. 2013..The aim of our work was to describe the micronutrient status in obese women before surgery at a university hospital...
[Insulin analogues: modifications in the structure, molecular and metabolic consequences]D A de Luis
Facultad de Medicina, Universidad de Valladolid, Valladolid, Espana
Semergen 39:34-40. 2013..In addition we discussed the main controversies of the use of these insulin analogues. In particular, those related with the risk of cancer and retinopathy, and their use in pregnant women...
[Relation of -55CT polymorphism of UCP3 gene with weight loss and metabolic changes after a high polyunsaturated fat diet in obese patients]D A de Luis
Centro de Investigación de Endocrinología y Nutrición Clínica, Facultad de Medicina, Hospital Rio Hortega, Universidad de Valladolid, Valladolid, Espana
Nutr Hosp 27:190-1195. 2012..Conclusion: The T allele carriers of -55CT UCP3 polymorphism exhibit no metabolic response to weight loss induced by a hypocaloric diet rich in polyunsaturated fatty acids...
[Relation of the rs9939609 gene variant in FTO with cardiovascular risk factor and serum adipokine levels in morbid obese patients]D A de Luis
Centro de Investigación de Endocrinología y Nutrición Clínica, Facultad de Medicina, Hospital Río Ortega, Universidad de Valladolid, Valladolid, Espana
Nutr Hosp 27:1184-9. 2012..Conclusion: The FTO gene polymorphism, rs9939609, was found to be associated with weight, fat mass, C reactive protein and leptin levels in morbid obese patients with A allele...
Evaluation of weight loss and adipocytokines levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs9939609 gene variantDaniel Antonio de Luis
Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Diabetes Metab Res Rev 28:663-8. 2012..Common polymorphisms of the fat mass and obesity associated gene (FTO) have been linked to obesity in some populations. One of these genetic variants (rs9939609) has been related to an increased risk of obesity...
Immunoenhanced enteral nutrition, effect on inflammatory markers in head and neck cancer patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation Hospital Rio Hortega, Spain
Eur J Clin Nutr 59:145-7. 2005..In conclusion, both formulas improved IL-6 and CRP levels. Further studies are needed to determine whether type of formula is the key in these patients or genetic background play a main role in inflammatory response...
Influence of hormonal status and oral intake on phase angle in HIV-infected menDaniel A de Luis
Institute of Endocrinology and Nutrition, Section on Endocrinology and Nutrition, Unidad de Apoyo a la Investigación, H Universitario Río Hortega, Valladolid, Spain
Nutrition 20:731-4. 2004..In the literature, this angle is the single best predictor of survival in patients with the human immunodeficiency virus (HIV). The aim of our study was to detect nutritional and biochemical parameters that influence the phase angle...
Effects of a low-fat versus a low-carbohydrate diet on adipocytokines in obese adultsD A de Luis
Institute of Endocrinology and Nutrition, Medical School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Horm Res 67:296-300. 2007..The aim of our study was to determine whether different diets would have different weight loss effects and to examine the changes in adipocytokine levels...
Resting energy expenditure and insulin resitance in obese patients, differences in women and menD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Eur Rev Med Pharmacol Sci 10:285-9. 2006..There is little research about the relation of REE and insulin resistance with gender. The aim of our work was to study gender differences in REE and insulin resistance in obese patients...
Polymorphism Ala54Thr of fatty acid-binding protein 2: Allelic frequencies and influence on cardiovascular risk factors in a multicenter study of Castilla y LeonD A de Luis
Institute of Endocrinology and Nutrition, Hospital Rio Hortega, University of Valladolid, Spain
Ann Nutr Metab 57:163-8. 2010..A transition of guanin to alanin at codon 54 of the fatty acid-binding protein 2 gene (FABP2) results in an amino acid substitution (Ala54 to Thr54). This polymorphism was associated with some cardiovascular risk factors...
Influence of lys656asn polymorphism of leptin receptor gene on surgical results of biliopancreatic diversionDaniel Antonio de Luis
Unit of Investigation and Endocrinology Department, Hospital Rio Hortega, Institute of Endocrinology and Nutrition, Medicine School, University of Valladolid, Valladolid 47130, Spain
J Gastrointest Surg 14:899-903. 2010..The purpose of the present study was to evaluate Lys656Asn polymorphism of leptin receptor gene on outcomes 1 year after biliopancreatic diversion...
Resting energy expenditure, cardiovascular risk factors and insulin resistance in obese patientsD A de Luis
Institute of Endocrinology and Nutrition, Medical School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Spain
Ann Nutr Metab 49:381-5. 2005..The aim of our study was to determine whether energy expenditure modified by increasing body mass over the wide range of body mass index (BMI) was related to insulin resistance, cardiovascular risk factors and dietary intakes...
Tissue electric properties in head and neck cancer patientsD A de Luis
Institute of Endocrinology and Nutrition, Unidad de Apoyo a la Investigación, H Universitario Río Hortega, Sv Digestive, H Valladolid, Spain
Ann Nutr Metab 50:7-10. 2006..The phase angle is easy to obtain. The aim of our study was to investigate in a case-control study the utility of phase angle and other impedance parameters in a population of male patients with head and neck cancer...
Metabolic syndrome and ALA54THR polymorphism of fatty acid-binding protein 2 in obese patientsDaniel Antonio de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Simancas 47130, Valladolid, Spain
Metabolism 60:664-8. 2011..No differences in anthropometric and biochemical parameters were detected between genotypes in the same group of MS. The finding of our study is the lack of association of the Thr54/Ala54 and Thr54/Thr54 FABP2 genotypes with MS...
[Relation between intake of omega 3 fatty acids and CD4 count in patients with HIV infection: a transversal study]D A de Luis
Sección de Endocrinología y Nutrición Clínica, Hospital del Rio Hortega, Valladolid
An Med Interna 22:323-5. 2005..These agents could develop a main role in patients with HIV infection. The aim of our study was to analyse the relation between polyunsaturated fatty acid intake and CD4 count in HIV infected patients...
Experience of 6 years with home enteral nutrition in an area of SpainD A de Luis
Secc de Endocrinologia Y Nutricion Clinica Hospital U Rio Hortega, Valladolid, Spain
Eur J Clin Nutr 60:553-7. 2006..The aim of our study was to analyze incidence and characteristics of a cohort of patients on HEN during 6 years, after our previous pilot study of 3 years...
Influence of G308A polymorphism of tumor necrosis factor-alpha gene on inflammatory markers in postsurgical head and neck cancer patients with early enteral nutritionDaniel Antonio de Luis
Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Nutrition 23:529-32. 2007..Our study evaluated the effect of G308A polymorphism of the tumor necrosis factor-alpha (TNF-alpha) gene on inflammatory markers in patients after surgery for head and neck cancer who received early enteral nutrition...
[Influence of a W3 fatty acids oral enhanced formula in clinical and biochemical parameters of head and neck cancer ambulatory patients]D A de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina y Unidad de Investigación, Hospital Rio Hortega, Valladolid
An Med Interna 25:275-8. 2008....
[Perioperatory artificial nutrition]D A de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina, Unidad de Apoyo a la Investigación, Hospital Clínico Universitario Río Hortega, Valladolid
An Med Interna 25:297-300. 2008..New research areas have been explored in this topic area, carbohydrate utility in presurgical patients and probiotic in enteral formulas...
Interaction of -55CT polymorphism of UCP3 gene with Trp64Arg polymorphism of beta3adrenoreceptor gene on insulin resistance in obese patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain RD056 0001 3RETICEF
Eur Rev Med Pharmacol Sci 16:610-6. 2012..The aim of our study was to investigate the interaction of tryptophan-to-arginine (Trp64Arg) missense mutation in the beta3 adrenoreceptor (Beta3AR) with polymorphism in the UCP3 promotor (-55C->T) on insulin resistance in obese patients...
A randomized clinical trial with two enteral diabetes-specific supplements in patients with diabetes mellitus type 2: metabolic effectsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School, University of Valladolid, Valladolid, Spain
Eur Rev Med Pharmacol Sci 12:261-6. 2008..A diabetes-specific supplement with lower fat percentage than the first improved weight and protein levels without significative metabolic effects...
A randomized clinical trial with two omega 3 fatty acid enhanced oral supplements in head and neck cancer ambulatory patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Eur Rev Med Pharmacol Sci 12:177-81. 2008..In conclusion, at dose taken, omega 3 enhanced formulas with different omega3/omega6 ratios improved serum protein concentrations in ambulatory postoperative head and neck cancer patients with good tolerance...
Relation between total homocysteine levels and beer intake in patients with diabetes mellitus Type 2Daniel Antonio de Luis
Institute of Endocrinology and Nutrition, Hospital Rio Hortega and University of Valladolid Medical School, Valladolid, Spain
Ann Nutr Metab 47:119-23. 2003..The aim of our study was to investigate the relation between macro- and micronutrient intakes and homocysteine levels in a population having diabetes type 2...
Lack of association of serum resistin levels with metabolic syndrome criteria in obese female patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid Spain
Clin Biochem 44:1280-3. 2011..As unclear data of resistin relation with metabolic syndrome has been published, we decide to investigate the association between metabolic syndrome and resistin levels in female obese subjects...
The effects of two different hypocaloric diets on glucagon-like peptide 1 in obese adults, relation with insulin response after weight lossDaniel A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
J Diabetes Complications 23:239-43. 2009..Few studies have investigated the effect of type of diets on GLP-1 concentrations. The aim of this study was to compare the effect of two diets on circulating GLP-1 levels and the relation with insulin response after weight loss...
[Antioxidant and fat intake in patients with polinic asthma]Daniel Antonio de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina, Hospital Rio Hortega, Universidad de Valladolid, Valladolid, Espana
Med Clin (Barc) 121:653-4. 2003..The aim of our work was to evaluate the dietary intake of patients with asthma...
Changes of ghrelin and leptin in response to hypocaloric diet in obese patientsDaniel Antonio de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, RD 056 0013RETICF, Valladolid, Spain
Nutrition 24:162-6. 2008..The aim of the present study was to determine whether subjects who lose significant weight experience changes in circulating ghrelin and leptin levels...
Influence of insulin resistance and adipocytokines on elevated serum alanine aminotransferase in obese patientsDaniel Antonio de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Arch Med Res 39:110-4. 2008..The aim of our study was to study the influence of insulin resistance and adipocytokines in obese patients on elevated serum alanine aminotransferase (ALT)...
Polymorphism Trp64Arg of beta 3 adrenoreceptor gene: allelic frequencies and influence on insulin resistance in a multicenter study of Castilla-LeónD A de Luis
Institute of Endocrinology and Nutrition, Medicine School, University of Valladolid, Spain
Nutr Hosp 25:299-303. 2010..The aim of our study was to investigate the influence of Trp64Arg polymorphism in the Beta3AR gene on insulin resistance in obese patients and the allelic distribution of this polymorphismin a geographic area of Spain...
Relationship among metabolic syndrome, C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistanceD A de Luis
Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
J Diabetes Complications 26:328-32. 2012..It has been demonstrated that the polymorphism 385 C/A of FAAH (fatty acid amide hydrolase) was associated with obesity and metabolic disorders...
Relationship of -55C/T polymorphism of uncoupling protein 3 (UCP3) gene with metabolic syndrome by ATP III classificationDaniel Antonio de Luis
Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, C Los perales 16, Simancas, Valladolid, Spain
J Clin Lab Anal 26:272-8. 2012..The aim of our study was to investigate the association of -55C/T polymorphism of UCP3 gene with MS...
Effects of RS9939609 gene variant in FTO gene on weight loss and cardiovascular risk factors after biliopancreatic diversion surgeryDaniel Antonio de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
J Gastrointest Surg 16:1194-8. 2012..Only two studies have investigated the effect of FTO variants on weight loss of morbid obese patients undergoing bariatric surgery with contradictory results...
Allelic frequency of G380A polymorphism of tumor necrosis factor alpha gene and relation with cardiovascular risk factors and adipocytokines in obese patientsD A de Luis
Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, University of Valladolid, Spain
Nutr Hosp 26:711-5. 2011..The aim of our study was to investigate the allelic frequency of the G308A polymorphism in the TNF alpha gene and the influence of G308A this polymorphism on cardiovascular risk factors and adipokine levels in obese patients...
Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patientsD A de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina y Unidad de Apoyo a la Investigación Hospital Río Hortega, Universidad de Valladolid, Valladolid, Espana
Nutr Hosp 26:827-33. 2011..The aim of our study was to evaluate the response of the cardiovascular risk profile in obese patients after inclusion in the diet of an ALA, FOS and inulin enriched-cookie...
Nutritional treatment for ambulatory patients with acquired immunodeficiency virus infection and previous weight loss using a formula enriched with n3 fatty acids: a randomized prospective trialD A de Luis
Institute of Endocrinology and Nutrition I E N School of Medicine, University of Valladolid, Spain
Eur Rev Med Pharmacol Sci 14:449-54. 2010..The aim of the study was to compare the progression of nutritional indicators with or without a formula enriched with n-3 fatty acids...
[Randomized clinical trial between nutritional counselling and commercial hypocaloric diet in weight loss in obese patients with chronic arthropathy]Daniel A de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina y Unidad de Apoyo a la Investigación, Valladolid, Espana
Med Clin (Barc) 132:735-9. 2009..The aim of our work was to evaluate in obese patients with an indication of replacement surgery for degenerative osteoarthritis, the utility of a hypocaloric diet with Optisource vs nutritional counseling...
Effect of omega-3 fatty acids on cardiovascular risk factors in patients with type 2 diabetes mellitus and hypertriglyceridemia: an open studyD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Eur Rev Med Pharmacol Sci 13:51-5. 2009..The aim of our study was to investigate the effectivity on triglyceride levels and inflammatory markers of a concentrated of n-3 fatty acids in patients with type 2 diabetes mellitus and hypertriglyceridaemia...
Relation of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) with obesity and insulin resistanceD A de Luis
Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School, University of Valladolid, Valladolid, Spain
Nutr Hosp 25:993-8. 2010..The aim of our study was to investigate the relationship of missense polymorphism (cDNA 385 C-A) of FAAH gene on obesity anthropometric parameters, cardiovascular risk factors and adipocytokines...
[Effects of a diet with products in texture modified diets in elderly ambulatory patients]D A de Luis
Sección de Endocrinología y Nutrición Clínica, Unidad de Apoyo a la Investigación, Hospital Universitario del Rio Hortega, Valladolid, Espana
Nutr Hosp 24:87-92. 2009..The main objective of our work was to evaluate the influence in elderly ambulatory patients with dysphagia of a texture modified diet ready to use on nutritional parameters and quality of life...
Roles of G1359A polymorphism of the cannabinoid receptor gene (CNR1) on weight loss and adipocytokines after a hypocaloric dietD A de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina, Universidad de Valladolid, Valladolid, Espana
Nutr Hosp 26:317-22. 2011..Intervention studies with this polymorphism have not been realized...
Lys656Asn polymorphism of leptin receptor gene and metabolic syndrome in obese patientsD A de Luis
Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, Hospital Universitario Rio Hortega, University of Valladolid, Valladolid, Spain
Eur Rev Med Pharmacol Sci 15:463-8. 2011..Alterations of the normal leptin receptor gene be involved in the development of obesity. The polymorphism on codon 656 produces a change in charge, making this change a possibility to be functional...
Resistin levels and inflammatory markers in patients with morbid obesityD A de Luis
Instituto de Endocrinología y Nutrición Clínica, Medicine School, Valladolid University, Valladolid, Spain
Nutr Hosp 25:630-4. 2010..The aim of the present study was to explore the relationship of resistin levels with inflammatory markers and anthropometric parameters in morbid obese patients...
[The effects of a low-fat versus a low carbohydrate diet in obese adults]Daniel A de Luis
Red temática de Investigación Corporativa en Envejecimiento RD056 0013, Instituto de Endocrinología y Nutrición, Facultad de Medicina, Universidad de Valladolid, Unidad de Investigacion, Hospital Río Hortera, Valladolid, Espana
Med Clin (Barc) 132:203-7. 2009..The aim of our study was to compare the effect of a high fat and a high protein diet vs a fat restricted diet on weight loss in obese patients...
[Arginine enhanced enteral nutrition, effect on blood inflammatory markers in head and neck cancer patients]Daniel Antonio de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina y Hospital Río Hortega, Valladolid, Espana
Med Clin (Barc) 132:49-52. 2009....
Influence of G308A promoter variant of tumor necrosis factor-alpha gene on insulin resistance and weight loss secondary to two hypocaloric diets: a randomized clinical trialDaniel Antonio de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Arch Med Res 40:36-41. 2009..The aim of our study was to investigate the influence of G-308A promoter variant in the TNF-alpha gene on insulin resistance and weight loss secondary to two hypocaloric diets...
The ratio of adiponectin to HOMA as an index of metabolic syndrome in obese womenDaniel Antonio de Luis
Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Ann Nutr Metab 58:301-6. 2011..The aim of our study was to investigate the role of the ratio of adiponectin concentration to homeostasis model assessment insulin resistance (HOMA-IR) as a predictor of metabolic syndrome (MS) in obese subjects...
Relation of Trp64Arg polymorphism of beta3-adrenoreceptor gene with cardiovascular risk factors in presurgical morbidly obese patientsDaniel A de Luis
Institute of Endocrinology and Nutrition, School of Medicine and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Arch Med Res 39:791-5. 2008..Genetic background of presurgical morbidly obese patients may have an influence on follow-up and outcome. A genetic variant is the Trp64Arg missense mutation in the beta3-adrenoreceptor (beta3-AR) gene...
Modulation of insulin concentrations and metabolic parameters in obese patients by -55CT polymorphism of the UCP3 gene secondary to two hypocaloric dietsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Horm Metab Res 41:62-6. 2009..In probands with both C alleles, both diets decreased insulin concentrations, blood pressure, and leptin concentrations. Weight reduction was similar with C and T alleles, independent of macronutrient distribution...
Ala54Thr polymorphism of fatty acid binding protein 2, role on insulin resistance and cardiovascular risk factors in presurgical morbid obesity patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, RD056 00013 RETICEF, Valladolid, Spain
Obes Surg 19:1691-6. 2009..A transition G to A at codon 54 of fatty acid binding protein 2 (FABP2) results in an amino acid substitution (ala 54 to Thr 54). This polymorphism was associated with insulin resistance in some populations...
Circulating adipocytokines in morbid obese patients, relation with cardiovascular risk factors and anthropometric parametersD A de Luis
Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School, University of Valladolid, Valladolid, Spain
Nutr Hosp 26:91-6. 2011..The aim of the present study was to explore the relation of circulating adipocytokines with cardiovascular risk and anthropometric parameters in morbid obese patients...
High dose of arginine enhanced enteral nutrition in postsurgical head and neck cancer patients. A randomized clinical trialD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, Valladolid, Spain
Eur Rev Med Pharmacol Sci 13:279-83. 2009..The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using a higher dose of arginine (20 g per day) could improve nutritional variables...
Relation of phase angle tertiles with blood adipocytokines levels, insulin resistance and cardiovascular risk factors in obese women patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School, Hospital Rio Hortega, Valladolid, Spain
Eur Rev Med Pharmacol Sci 14:521-6. 2010..The aim of our study was to evaluate the association of adipocytokines levels and classical cardiovascular risk factors with tertiles of phase angle in obese women...
Interaction between tumor necrosis factor-α gene -308G/A promoter and leptin receptor gene Lys656Asn single-nucleotide polymorphisms: effect on serum leptin concentrationsD A de Luis
Institute of Endocrinology and Nutrition, School of Medicine and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, C Los perales 16, Simancas, Spain
Ann Nutr Metab 57:89-94. 2010....
Relation of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naïve diabetes obese patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, RD 056 0013 RETICEF, University of Valladolid, C Los perales 16, Simancas 47130, Valladolid, Spain
Diabetes Res Clin Pract 89:110-4. 2010..The aim of the present study was to explore the relationship of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naïve diabetic patients...
G 1359A polymorphism of the cannabinoid receptor gene (CNR1) and clinical results of biliopancreatic diversionD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Eur Rev Med Pharmacol Sci 14:197-201. 2010..We decide to investigate the role of the polymorphism (G1359A) of the cannabinoid (CB)1 receptor gene on clinical outcomes 1 year after biliopancreatic diversion in morbidly obese patients...
Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on insulin resistance and adipocytokines in patients with diabetes mellitus type 2D A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Eur Rev Med Pharmacol Sci 14:89-95. 2010..A transition G to A at codon 54 of FABP2 results in an amino acid substitution (ala 54 to Thr 54). This polymorphism could be associated with insulin resistance and adipocytokines in patients with diabetes mellitus type 2...
Effects of olmesartan vs irbesartan on metabolic parameters and visfatin in hypertensive obese womenD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega RD 056 0013 RETICEF, University of Valladolid, Valladolid, Spain
Eur Rev Med Pharmacol Sci 14:759-63. 2010..Angiotensin II regulates the production of adipokines. The objective was to study the effect of treatment with irbesartan versus olmesartan in obese hypertensive women...
[Randomized clinical trial with a inulin enriched cookie on risk cardiovascular factor in obese patients]D A de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina, Universidad de Valladolid, Simancas, Valladolid, Espana
Nutr Hosp 25:53-9. 2010..Inulin is a prebiotic with potential benefit in cardiovascular risk factors. The aim of our work is to evaluate in obese patients the effect of a inulin enriched cookie on cardiovascular risk factors...
Resistin levels in morbid obese patients following the biliopancreatic diversion surgeryD A de Luis
Center of Investigation of Endocrinology and Nutrition, Medicine School, Unit of Investigation, Surgical Department, and Endocrinology Department, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Horm Metab Res 43:205-8. 2011..68, p < 0.01) and fat mass (r = 0.65, p < 0.05). Resistin concentrations did not change after massive weight loss with biliopancreatic diversion in morbid obese patients without diabetes mellitus...
Lack of effect of a moderate hypocaloric diet on visfatin levels in morbid obese patients: relationship with insulin resistanceD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Eur Rev Med Pharmacol Sci 14:1031-6. 2010..The insulin-mimetic adipocytokine visfatin has been related to obesity. The aim of this study was to examine whether weight loss could change visfatin concentrations in morbidly obese patients and its relationship with insulin resistance...
G1359A polymorphism of the cannabinoid receptor gene (CNR1) and insulin resistance in patients with diabetes mellitus type 2D A de Luis
Institute of Endocrinology and Nutrition, Medicine School, University of Valladolid, Simancas, Valladolid, Spain
Nutr Hosp 25:34-8. 2010..A silent intragenic biallelic polymorphism (1359 G/A) (rs1049353) of the CB1 gene resulting in the substitution of the G to A at nucleotide position 1359 in codon 435 (Thr), was reported as a common polymorphism in Caucasian populations...
Influence of G1359A polymorphism of the cannabinoid receptor gene on anthropometric parameters and insulin resistance in women with obesityDaniel Antonio de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Simancas 47130, Valladolid, Spain
Metabolism 60:272-6. 2011....
[G1359A polymorphism of the cannabinoid receptor gene (CNR1) on anthropometric parameters and cardiovascular risk factors in patients with morbid obesity]D A de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina, Universidad de Valladolid, Valladolid, Espana
Nutr Hosp 24:688-92. 2009..The aim of our study was to investigate the influence of this polymorphism of CB1 receptor gene on obesity anthropometric parameters, cardiovascular risk factors and adipocytokines in morbid obese patients...
Relation of -55CT polymorphism of uncoupling protein 3 gene with fat mass and insulin resistance in morbidly obese patientsDaniel Antonio de Luis Roman
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, 47130 Valladolid, Spain
Metabolism 59:608-12. 2010..3 +/- 26.1 vs 30.5 +/- 32.5 ng/mL, P < .05). In conclusion, mutant-type group of -55CC UCP3 gene patients had higher weight, fat mass, and insulin resistance than wild-type group...
Relation of G1359A polymorphism of the cannabinoid receptor (CB1) gene with metabolic syndrome by ATP III classificationD A de Luis
Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Simancas, Valladolid, Spain
Diabetes Metab Res Rev 27:506-11. 2011..A polymorphism (1359 G/A) of the cannabinoid type-1 receptor gene was reported as a common polymorphism in Caucasian populations. Some metabolic disorders are related to this polymorphism...
Relation of resistin levels with cardiovascular risk factors and insulin resistance in non-diabetes obese patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, RD 056 0013 RETICEF, University of Valladolid, C Los perales 16, Simancas 47130, Valladolid, Spain
Diabetes Res Clin Pract 84:174-8. 2009..The aim of the present study was to explore the relationship of resistin levels with these above mentioned factors...
Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2D A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Diabetes Res Clin Pract 81:e9-e11. 2008..Mutant type patient (39%) (Lys656/Asn656 or Asn656/Asn656) group had higher fat mass, HOMA, CRP and leptin than wild type. Adiponectin levels were lower in mutant type group than wild type (61%) (Lys656/Lys656)...
Dietary intake in patients with asthma: a case control studyDaniel Antonio de Luis
Institute of Endocrinology and Nutrition, Medical School, and Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Nutrition 21:320-4. 2005..This case-controlled study investigated differences in dietary intake between a population with and without asthma...
[Home enteral nutrition: analysis of efficiency in a Health District]D De Luis Roman
Sección de Endocrinología y Nutrición Clínica Hospital del Río Hortega Valladolid Instituto de Endocrinología y Nutrición Clínica Facultad de Medicina Valladolid Spain
Rev Clin Esp 203:317-20. 2003..The objective of our study was to carry out a direct costs analysis of household enteral nutrition using both the biochemical and nutritional monitoring values of the nutritional state as a point of reference...
[Adapted basic feeding and dysphagia]D De Luis Roman
Sección de Endocrinología y Nutrición Clínica Hospital del Río Hortega Valladolid Spain
Rev Clin Esp 203:384-5. 2003
Clinical and biochemical characteristics of patients with home enteral nutrition in an area of SpainD A de Luis
Seccione de Endocrinologia y Nutricion Clinica Hospital u Rio Hortega, Valladolid, Spain
Eur J Clin Nutr 57:612-5. 2003..The aim of our study was to analyze incidence, clinical and biochemical characteristics of a cohort of patients on home enteral nutrition (HEN)...
Influence of insulin resistance in obese patients on elevated serum alanine aminotransferaseD A de Luis
Institute of Endocrinology and Nutrition, Medicine School, University of Valladolid, Spain
Eur Rev Med Pharmacol Sci 11:21-5. 2007..Insulin resistance has been associated with fat liver and non-alcoholic fatty liver disease. The aim of our study was to study the influence of insulin resistance in obese patients on elevated serum alanine aminotransferase...
Pravastatin in hyperlipidemia secondary to HIV protease inhibitors without response to fenofibrate: a brief preliminary reportDaniel A de Luis
Unit of Investigation, , Valladolid, Spain
Nutrition 19:903-4. 2003
Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2D A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C Los perales 16 URB Las Aceñas, Simancas 47130, Valladolid, Spain
J Diabetes Complications 19:42-6. 2005..We also analyzed the relationship between tHcy and the body composition of these patients and other cardiovascular risk factors...
[Homocysteine in patients with diabetes mellitus]Daniel de Luis
Unidad de Apoyo a la Investigación Servicio de Endocrinología y Nutrición Hospital Universitario Río Hortega Instituto de Endocrinología y Nutrición Facultad de Medicina Valladolid España
Med Clin (Barc) 122:27-32. 2004..Nevertheless, it is necesary to perform more prospective and intervention studies to clarify the independent risk of homocysteine and thus assay alternative treatments...
[Utility of dehydrated products in texture modified diets in elderly ambulatory patients]Daniel de Luis
Sección de Endocrinología y Nutrición Clínica, Unidad de Apoyo a la Investigación, Hospital Universitario del Rio Hortega, Valladolid, Espana
Med Clin (Barc) 127:374-5. 2006..The main objective of our work was to evaluate the influence in elderly ambulatory patients with dysphagia of a texture modified diet with dehydrated nutritional products on nutritional parameters and quality of life...
Leptin receptor Lys656Asn polymorphism is associated with decreased leptin response and weight loss secondary to a lifestyle modification in obese patientsDaniel de Luis Roman
Institute of Endocrinology and Nutrition, School of Medicine and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Arch Med Res 37:854-9. 2006....
Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patientsD A de Luis
Medicine School and Unit of Investigation, Institute of Endocrinology and Nutrition, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Eur J Clin Nutr 61:200-4. 2007....
Nutritional assessment: predictive variables at hospital admission related with length of stayDaniel A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Ann Nutr Metab 50:394-8. 2006..The aim of our study was to detect nutritional parameters, which could have an influence on length of stay in hospitalized patients...
Influence of ALA54THR polymorphism of fatty acid binding protein 2 on lifestyle modification response in obese subjectsD A de Luis
Institute of Endocrinology and Nutrition, Medical School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Ann Nutr Metab 50:354-60. 2006..The aim of our study was to investigate the influence of Thr54 polymorphism in the FABP2 protein on the response to a lifestyle modification (Mediterranean hypocaloric diet and exercise) in obese patients...
[Maple syrup disease: a rare entity that we must know. Review of its dietetic management]D A de Luis Román
Unidad de Apoyo a la Investigación, Instituto de Endocrinología y Nutrición, Facultad de Medicina, Hospital Rio Hortega, Valladolid
An Med Interna 22:493-7. 2005..Dietetic support is the second treatment, with a minimum energy intake and controlling blood levels of aminoacids. Modified dietetic formulas is a main device to treat these patients...
Quality of life and dietary intake in elderly patients with dysphagiaDaniel A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, Valladolid, Spain
Nutrition 22:584. 2006
Early clinical and surgical results of biliopancreatic diversionD A de Luis
Institute of Endocrinology and Nutrition, Medical School Unit of Investigation, Surgical Department, Hospital Rio Hortega, University of Valladolid, 47130 Valladolid, Spain
Obes Surg 15:799-802. 2005..Scopinaro biliopancreatic diversion (BPD) for morbid obesity results in significant longterm weight loss and reduction or resolution of obesity-associated co-morbidities. The aim of our work was to describe the early results after BPD...
Nutritional status in head and neck cancer patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega
Eur Rev Med Pharmacol Sci 11:239-43. 2007..Patients suffering from cancer of head and neck are at risk of nutritional depletion. The aim of our study was to investigate the role of type, location and stage of tumors in nutritional status...
[Hypothyroidism: clinical and economical implications in a health area]D De Luis Roman
Unidad de Endocrinología y Nutrición Clínica, Unidad de Apoyo a la Investigación, Hospital del Rio Hortega, Instituto de Endocrinología y Nutrición, Facultad de Medicina, Valladolid
An Med Interna 20:127-33. 2003..To analyze the clinical, biochemical and epidemiological characteristics in patients with hypothyroidism, substitutive dose and annual direct costs, in a health area...
[Usefulness of oral nutritional supplements]D De Luis Roman
Sección de Endocrinología y Nutrición Clínica Hospital del Río Hortega Valladolid Spain
Rev Clin Esp 202:602-3. 2002
Influence of ALA54THR polymorphism of fatty acid-binding protein 2 on obesity and cardiovascular risk factorsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Horm Metab Res 39:830-4. 2007..Further studies are needed to explain the role of this polymorphism in different populations...
Modulation of adipocytokines response and weight loss secondary to a hypocaloric diet in obese patients by -55CT polymorphism of UCP3 geneD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain RD 056 0013
Horm Metab Res 40:214-8. 2008..Patients with -55CC genotype have a significant decrease in leptin, interleukin 6, BMI, weight, fat mass, systolic blood pressure, LDL cholesterol, waist circumference, waist-to-hip ratio weight, fat mass, and systolic blood pressure...
Influence of Lys656Asn polymorphism of leptin receptor gene on leptin response secondary to two hypocaloric diets: a randomized clinical trialD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, RD056 0013 Valladolid, Spain
Ann Nutr Metab 52:209-14. 2008..Human obesity is characterized by high levels of leptin, and it has been suggested that obese patients may be leptin-resistant...
Effect of a hypocaloric diet on serum visfatin in obese non-diabetic patientsDaniel A de Luis
Institute of Endocrinology and Nutrition, University of Valladolid, and Clinical Nutrition Research Unit RD056 0013, Hospital Rio Hortega, Valladolid, Spain
Nutrition 24:517-21. 2008..The aim of this study was to examine whether weight reduction could change visfatin serum concentrations in obese patients...
Influence of G308A polymorphism of tumor necrosis factor alpha gene on surgical results of biliopancreatic diversionD A de Luis
Unit of Investigation, Surgical Department, Hospital Rio Hortega, Institute of Endocrinology and Nutrition, Medicine School, University of Valladolid, Simancas 47130, Valladolid, Spain
Obes Surg 20:221-5. 2010..The purpose of the present study was to evaluate G308A polymorphism of the tumor necrosis factor (TNF) alpha gene on outcomes 1 year after biliopancreatic diversion...
[Use of lyophilized products in texture modified diets at a hospital]D A de Luis
Unidad de Apoyo a la Investigación, Sección de Endocrinología y Nutrición Clínica, Hospital Universitario del Rio Hortega, Valladolid
Nutr Hosp 17:240-3. 2002..The objective of our study is to compare the acceptance of texture modifies courses against conventional courses...
[Relation among micronutrient intakes with CD4 count in HIV infected patients]D A de Luis
Sección de Endocrinología y Nutrición Clínica, Unidad de Apoyo a la Investigación, Hospital Rio Hortega, Valladolid
Nutr Hosp 17:285-9. 2002..Several studies have shown an association between disease progression and micronutrient status. The aim of our study was to assess the correlation between micronutrients intakes and immune status in HIV infected patients...
Lack of association of -55CT polymorphism of UCP3 gene with fat distribution in obese patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Ann Nutr Metab 51:374-8. 2007..The aim of our study was to investigate the influence of -55CT polymorphism of UCP3 gene on fat distribution and classical cardiovascular risk factors in obese patients...
[Influence of omega 3 fatty acid dietary intake on asthma]D A de Luis
Instituto de Endocrinología y Nutrición, Facultad de Medicina, Unidad de Apoyo a la Investigación, Hospital Universitario Rio Hortega, Valladolid, Espana
Rev Clin Esp 207:24-5. 2007..Perhaps, the influence of polyunsaturated fatty acid intake could be due to the ratio w-6/w-3 and no to the total amount of w3 intake. A general recommendation is a dietary intake of fish three times each week, one of them fat fish...
Light symptoms following a high-dose intentional L-thyroxine ingestion treated with cholestyramineD A de Luis
Institute of Endocrinology and Nutrition, Medical School, Hospital Rio Hortega, University of Valladolid, Spain
Horm Res 57:61-3. 2002..This case illustrates the potential utility of cholestyramine to treat L-thyroxine intoxications...
Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on weight loss and insulin levels secondary to two hypocaloric diets: a randomized clinical trialD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Diabetes Res Clin Pract 82:113-8. 2008..The aim of our study was to investigate the influence of this polymorphism on weight loss and metabolic changes secondary to two hypocaloric diets...
Influence of visfatin on histopathological changes of non-alcoholic fatty liver diseaseR Aller
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, C Los perales 16, 47130, Simancas, Valladolid, Spain
Dig Dis Sci 54:1772-7. 2009..Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. The aim of the present study was to explore the relation of visfatin with underlying histopathological changes of NAFLD patients...
Effect of c-reactive protein and interleukins blood levels in postsurgery arginine-enhanced enteral nutrition in head and neck cancer patientsD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, Valladolid, Spain
Eur J Clin Nutr 57:96-9. 2003..The aim of our study was to evaluate the effect of enteral nutrition supplemented with arginine on c-reactive protein (CRP), interleukin 6 (IL-6) and tumour necrosis factor (TNFalpha) in surgical head and neck cancer patients...
Prediction equation of resting energy expenditure in an adult Spanish population of obese adult populationD A de Luis
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
Ann Nutr Metab 50:193-6. 2006..WHO equation developed in normal weight individuals provided the closest values. The two new equations (male and female equations) developed in our study had a good accuracy...
