Carlos Lopez-Larrea

Summary

Affiliation: Hospital Universitario Central de Asturias
Country: Spain

Publications

  1. pmc Epigenetic modulation of the immune function: a potential target for tolerance
    Beatriz Suarez-Alvarez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Epigenetics 8:694-702. 2013
  2. pmc Molecular mechanisms involved in the aging of the T-cell immune response
    Marco Antonio Moro-García
    Immunology Department, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain
    Curr Genomics 13:589-602. 2012
  3. pmc Epigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cells
    Beatriz Suarez-Alvarez
    Histocompatibility and Transplantation Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
    PLoS ONE 5:e10192. 2010
  4. pmc NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system
    Rebeca Alonso-Arias
    Histocompatibility Unit, Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
    Age (Dordr) 33:591-605. 2011
  5. doi Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo 33006, Spain
    BMC Med 12:34. 2014
  6. ncbi NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp
    Esther Serrano-Pertierra
    1 Hospital Universitario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Spain
    J Leukoc Biol 95:487-95. 2014
  7. ncbi Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population
    A Lopez-Vazquez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Hum Immunol 66:285-9. 2005
  8. pmc Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection
    J R Vidal-Castineira
    Hospital Universitario Central de Asturias, Spain
    J Virol 84:475-81. 2010
  9. ncbi The role of HLA-B27 polymorphism and molecular mimicry in spondylarthropathy
    C Lopez-Larrea
    Immunology Dept, Hospital Central Asturias, Oviedo, Spain
    Mol Med Today 4:540-9. 1998
  10. ncbi Association of ankylosing spondylitis with HLA-B*1403 in a West African population
    Carlos Lopez-Larrea
    Department of Immunology, Hospital Central de Asturias, Julian Claveria, Oviedo 33006, Spain
    Arthritis Rheum 46:2968-71. 2002

Collaborators

Detail Information

Publications73

  1. pmc Epigenetic modulation of the immune function: a potential target for tolerance
    Beatriz Suarez-Alvarez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Epigenetics 8:694-702. 2013
    ..Here, we describe recent discoveries concerning the epigenetic regulation of the immune system, and how this knowledge could be translated to the field of transplantation. ..
  2. pmc Molecular mechanisms involved in the aging of the T-cell immune response
    Marco Antonio Moro-García
    Immunology Department, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain
    Curr Genomics 13:589-602. 2012
    ..In summary, owing to a lifetime of exposure to and proliferation against a variety of pathogens, highly differentiated T-cells suffer molecular modifications that alter their cellular homeostasis mechanisms...
  3. pmc Epigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cells
    Beatriz Suarez-Alvarez
    Histocompatibility and Transplantation Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
    PLoS ONE 5:e10192. 2010
    ..hESCs have exhibited low immunogenicity due to low levels of Mayor Histocompatibility Complex (MHC) class-I and absence of MHC class-II expression. Nevertheless, the mechanisms regulating MHC expression in hESCs had not been explored...
  4. pmc NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system
    Rebeca Alonso-Arias
    Histocompatibility Unit, Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
    Age (Dordr) 33:591-605. 2011
    ..In conclusion, CD4+ NKG2D+ represent a subset of highly differentiated T cells which characterizes the senescence of the immune system...
  5. doi Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo 33006, Spain
    BMC Med 12:34. 2014
    ..The aim of this study was to investigate anti-MICA antibody formation in patients with celiac disease and its association with other autoimmune processes...
  6. ncbi NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp
    Esther Serrano-Pertierra
    1 Hospital Universitario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Spain
    J Leukoc Biol 95:487-95. 2014
    ..Thus, our findings reveal new differences in the signaling pathways between CD28- and NKG2D-mediated costimulation in the regulation of cell chemotaxis in human CD8(+) T cells. ..
  7. ncbi Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population
    A Lopez-Vazquez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Hum Immunol 66:285-9. 2005
    ..00003; OR = 10.11). The presence of the inhibitory allele KIR3DL1 in combination with the HLA-B*57s alleles that contain the Bw4-I80 epitope, has a highly protective effect against progression to AIDS in Zambian patients...
  8. pmc Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection
    J R Vidal-Castineira
    Hospital Universitario Central de Asturias, Spain
    J Virol 84:475-81. 2010
    ..However, the KIR2DL3/KIR2DL3-HLA-C1C1 genotype clearly correlated with a satisfactory response to treatment, defined by the clearance of HCV RNA...
  9. ncbi The role of HLA-B27 polymorphism and molecular mimicry in spondylarthropathy
    C Lopez-Larrea
    Immunology Dept, Hospital Central Asturias, Oviedo, Spain
    Mol Med Today 4:540-9. 1998
    ..The experimental studies reviewed here have greatly increased our knowledge of the structure, function and disease association of HLA-B27...
  10. ncbi Association of ankylosing spondylitis with HLA-B*1403 in a West African population
    Carlos Lopez-Larrea
    Department of Immunology, Hospital Central de Asturias, Julian Claveria, Oviedo 33006, Spain
    Arthritis Rheum 46:2968-71. 2002
    ..To investigate the contribution of HLA class I alleles in the susceptibility to primary ankylosing spondylitis (AS) in West African patients living in Togo...
  11. doi Advances in translational transplant immunology
    Carlos Lopez-Larrea
    Immunology, Histocompatibility Unit, Hospital Universitario Central de Asturias, Oviedo, Spain
    Transplantation 88:S1-7. 2009
    ..Detection of a potential or existing immune response to tissue grafts is an important first step in improving the survival of heart, liver, and kidney transplant patients...
  12. pmc Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations
    Carlos Lopez-Larrea
    Histocompatibility and Transplantation Unit, Hospital Universtario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Asturias, Spain
    Arthritis Res Ther 8:R101. 2006
    ..The susceptibility to AS could be determined by the overall balance of activating and inhibitory composite KIR-HLA genotypes...
  13. ncbi MICA rather than MICB, TNFA, or HLA-DRB1 is associated with susceptibility to psoriatic arthritis
    Segundo Gonzalez
    University of Oviedo, and Department of Immunology, Hospital Central de Asturias, Spain
    J Rheumatol 29:973-8. 2002
    ....
  14. ncbi Patients with psoriatic arthritis may show differences in their clinical and genetic profiles depending on their age at psoriasis onset
    Ruben Queiro
    Hospital Universitario Central de Asturias, Oviedo, Spain
    Clin Exp Rheumatol 30:476-80. 2012
    ..The aim of the present paper is to analyse whether the age of psoriasis onset may have an impact on the clinical and genetic characteristics in a cohort of PsA patients...
  15. doi Association of the KIR3DS1*013 and KIR3DL1*004 alleles with susceptibility to ankylosing spondylitis
    Roberto Díaz-Peña
    Hospital Universitario Central de Asturias, 33006 Oviedo, Spain
    Arthritis Rheum 62:1000-6. 2010
    ..The aim of this study was to analyze the possible contribution of the KIR3DL1 and KIR3DS1 alleles, in addition to HLA-B27, in the susceptibility to ankylosing spondylitis (AS) in a population of individuals from Spain...
  16. doi Activating KIR genes are associated with ankylosing spondylitis in Asian populations
    Roberto Díaz-Peña
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Hum Immunol 69:437-42. 2008
    ..005 and p(c) < 0.05 in the Chinese and Thai populations, respectively), whereas 3DL1/3DS1 demonstrated an increased frequency in AS (p(c) < 0.005 in the Chinese population and p(c) < 0.05 in the Thai population)...
  17. ncbi Extended human leukocyte antigen haplotype EH18.1 influences progression to hepatocellular carcinoma in patients with hepatitis C virus infection
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Central de Asturias, Oviedo, Spain
    J Infect Dis 189:957-63. 2004
    ..01). In conclusion, HLA-DR11 seems to be protective against the development of severe forms of infection, and the DR3/MICA-A4/B18 haplotype may be an important factor in the progression to the most severe HCV-infection status...
  18. ncbi High variability of HLA-B27 alleles in ankylosing spondylitis and related spondyloarthropathies in the population of northern Spain
    Segundo Gonzalez
    Functional Biology Department S G, University of Oviedo, Oviedo, Spain
    Hum Immunol 63:673-6. 2002
    ..B*2713 was identified in a healthy control family. B*2713 has not been reported to be represented in either ethnic group. Thus, this population shows higher levels of B27 diversity than other Caucasian groups...
  19. ncbi MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patients
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Central de Asturias, C Celestino Villamil, 33 006 Oviedo, Spain
    Immunogenetics 53:989-91. 2002
    ..002). No other MICA allele was found to be significantly increased in the groups under study. The presence of MICA-A5.1 in atypical CD DQ2-negative patients may indicate a possible role of this allele in the development of CD...
  20. ncbi MICB typing by PCR amplification with sequence specific primers
    Segundo Gonzalez
    Department of Functional Biology, University of Oviedo, Julián Clavería sn, 33006 Oviedo, Spain
    Immunogenetics 54:850-5. 2003
    ..Thus, the linkage disequilibrium with MICA and HLA-B suggests that MICB is a potential candidate for those diseases classically associated with HLA class I alleles...
  21. ncbi MHC class I chain-related gene A transmembrane polymorphism modulates the extension of ulcerative colitis
    Juan Luis Fdez-Morera
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Hum Immunol 64:816-22. 2003
    ..These results are in agreement with other studies that suggest a similar role of such alleles in other diseases, such as insulin-dependent diabetes mellitus and celiac disease...
  22. doi KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients
    Beatriz Tavira
    Genetica Molecular, Hospital Universitario Central de Asturias, Spain
    Clin Transplant 25:E284-91. 2011
    ..Other KCNQ1 variants were not associated with NODAT in our patients. Our work supported a role for KCNQ1 gene variants as determinants of the risk of developing NODAT among Tac-treated patients...
  23. doi CD127(low) expression in CD4+CD25(high) T cells as immune biomarker of renal function in transplant patients
    Rebeca Alonso-Arias
    Histocompatibility Unit, Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
    Transplantation 88:S85-93. 2009
    ..CD25 is a promising marker of activation. Recent descriptions of CD127 expression as a discriminating factor between regulatory and activated T cells suggest its potential utility...
  24. doi Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus
    Beatriz Tavira
    Genetica Molecular, Hospital Universitario Central de Asturias, Oviedo, Spain
    Mol Genet Metab 105:525-7. 2012
    ..E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association...
  25. ncbi Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    J Infect Dis 192:162-5. 2005
    ..Moreover, these associations were not independent of each other--the KIR3DS1/Bw4I80 genotype clearly was also more frequent in HCV carriers (odds ratio, 24.22)...
  26. ncbi Post-transplant soluble MICA and MICA antibodies predict subsequent heart graft outcome
    Beatriz Suarez-Alvarez
    Histocompatibility and Transplantation Unit, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain
    Transpl Immunol 17:43-6. 2006
    ..Further research is needed to clarify the role of sMICA in allograft acceptance. Post-transplant evaluation of humoral immune response to MICA and the measure of sMICA in patient's sera may provide a good predictor of AR...
  27. ncbi TNF-alpha -308A promoter polymorphism is associated with enhanced TNF-alpha production and inflammatory activity in Crohn's patients with fistulizing disease
    Segundo Gonzalez
    Department of Functional Biology, University of Oviedo, Oviedo, Spain
    Am J Gastroenterol 98:1101-6. 2003
    ..The aim of this study was to investigate the effect of TNF-alpha promoter polymorphism at -308 on the susceptibility and phenotypic expression of fistulizing CD...
  28. ncbi Influence of HLA-B*5703 and HLA-B*1403 on susceptibility to spondyloarthropathies in the Zambian population
    Roberto Díaz-Peña
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    J Rheumatol 35:2236-40. 2008
    ....
  29. ncbi Transcriptional regulation of MICA and MICB: a novel polymorphism in MICB promoter alters transcriptional regulation by Sp1
    Sandra Rodriguez-Rodero
    Unidad de Histocompatibilidad y Transplantes, Hospital Universitario Central de Asturias Oviedo, Oviedo, Spain
    Eur J Immunol 37:1938-53. 2007
    ....
  30. pmc Clinical differences between men and women with psoriatic arthritis: relevance of the analysis of genes and polymorphisms in the major histocompatibility complex region and of the age at onset of psoriasis
    Ruben Queiro
    Rheumatology Department, Hospital Universitario Central de Asturias, C Celestino Villamil S N, Oviedo, 33006 Asturias, Spain
    Clin Dev Immunol 2013:482691. 2013
    ..Our results point to the need to include patient's age at the onset of psoriasis and gender as key stratification elements in future studies of genetic associations in PsA...
  31. ncbi The allele MICB 0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence
    Jesus Martinez-Borra
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Hum Immunol 68:705-7. 2007
    ..This new exon contains a premature stop codon and therefore the transcript does not produce a functional protein...
  32. ncbi HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma
    Eugenia Lauret
    Department of Gastroenterology, Hospital Central de Asturias, Spain
    Am J Gastroenterol 97:1016-21. 2002
    ..The aim of this study was to investigate the association between HFE gene mutations (C282Y, H63D) and hepatocellular carcinoma in patients with alcoholic and virus-related cirrhosis...
  33. doi A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis
    Roberto Díaz-Peña
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Ann Rheum Dis 71:714-7. 2012
    ..To identify genomic variants in the 19q13 chromosome region associated with ankylosing spondylitis (AS) in human leucocyte antigen (HLA)-B27-positive populations...
  34. doi Identification of epitopes and immunodominant regions on the MICA protein defined by alloantibodies from kidney transplant patients
    Beatriz Suarez-Alvarez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Transplantation 88:S68-77. 2009
    ....
  35. pmc Relationship between functional ability in older people, immune system status, and intensity of response to CMV
    Marco Antonio Moro-García
    Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
    Age (Dordr) 34:479-95. 2012
    ..In summary, we concluded that the functional decline of elderly individuals was clearly associated with the aging of their immune system, and the intensity of the response to CMV...
  36. doi A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-transplanted patients
    Beatriz Tavira
    Molecular Genetics Laboratory of Medicine, Hospital Universitario Central de Asturias HUCA, Oviedo, Spain
    Pharmacogenet Genomics 23:445-8. 2013
    ..P227>T) in one patient. We concluded that CYP3A5*3 and CYP3A4*1B were the main determinants of the Tac dose-adjusted blood concentration in our cohort of renal-transplanted patients. ..
  37. ncbi High serum tumor necrosis factor-alpha levels are associated with lack of response to infliximab in fistulizing Crohn's disease
    Jesus Martinez-Borra
    Department of Immunology and Gastroenterology, Hospital Central de Asturias, Oviedo, Spain
    Am J Gastroenterol 97:2350-6. 2002
    ..We investigated the effect of infliximab on circulating cytokines and acute phase proteins in patients with fistulas to determine the clinical response to anti-TNF-alpha...
  38. ncbi Comparison of six human anti-transglutaminase ELISA-tests in the diagnosis of celiac disease in the Saharawi population
    Eloy Fernández
    Biochemistry Service, Hospital de Cabuenes, Gijon, Asturias, Spain
    World J Gastroenterol 11:3762-6. 2005
    ..Celiac disease (CD) is an enteropathic disorder very prevalent in Saharawi people. Our aim was to investigate the diagnostic accuracy of six human tissue transglutaminase (tTG) based ELISA tests in Saharawi CD patients...
  39. ncbi The amino acid at position 97 is involved in folding and surface expression of HLA-B27
    M A Blanco-Gelaz
    Department of Immunology, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain
    Int Immunol 18:211-20. 2006
    ..Future work must therefore aim to clarify the functional connection between the unfolded protein response pathway in response to the accumulation of HLA-B27 in the ER. This mutant could be useful as a model for the misfolding of HLA-B27...
  40. ncbi The predictive value of soluble major histocompatibility complex class I chain-related molecule A (MICA) levels on heart allograft rejection
    Beatriz Suarez-Alvarez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Transplantation 82:354-61. 2006
    ..Shedding of sMICA by tumor cells downregulates NKG2D-mediated antitumor immunity. The aim of this investigation was to study the possible involvement of sMICA in the allograft acceptance after heart transplantation (HTX)...
  41. doi Fine mapping of a major histocompatibility complex in ankylosing spondylitis: association of the HLA-DPA1 and HLA-DPB1 regions
    Roberto Díaz-Peña
    Hospital Universitario Central de Asturias, Oviedo, Spain
    Arthritis Rheum 63:3305-12. 2011
    ..To investigate the potential association of major histocompatibility complex (MHC) markers other than HLA-B27 with ankylosing spondylitis (AS)...
  42. ncbi MHC class I region plays a role in the development of diverse clinical forms of celiac disease in a Saharawi population
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Am J Gastroenterol 99:662-7. 2004
    ..The aim of this study was to investigate the association of MHC genes in the development of celiac disease (CD) and its diverse clinical forms in a Saharawi population...
  43. ncbi The region of 150 kb telometic to HLA-C is associated with psoriasis in the Jewish population
    Jesus Martinez-Borra
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    J Invest Dermatol 125:928-32. 2005
    ..3-4.5, p(c) = 0.004), however, were associated with the disease. These results suggest that a major psoriasis susceptibility gene is likely to be located within a region of 150 kb telomeric to HLA-C and centromeric to the CDSN gene...
  44. ncbi Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor
    Alejandro Lopez-Soto
    Departamento de Biologia Funcional, Facultad de Medicina, Instituto Universitario de Oncologia del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain
    J Biol Chem 281:30419-30. 2006
    ..Finally, the definition of ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells...
  45. ncbi Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy
    Eliecer Coto
    Genética Molecular Red de Investigación Renal REDINREN Fundación Renal, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain
    Biochem Biophys Res Commun 397:576-9. 2010
    ..Our data suggests that the variation in CYP3A5, CYP3A4, and CYP21A2 did not contribute to the risk for hypertension in pregnancy in our population...
  46. ncbi Diversity of Killer Cell Immunoglobulin-Like Receptor (KIR) Genotypes and KIR2DL2/3 Variants in HCV Treatment Outcome
    Jose Ramon Vidal-Castiñeira
    Immunology Service, Hospital Universitario Central de Asturias, Oviedo, Spain
    PLoS ONE 9:e99426. 2014
    ..The study of KIR receptors may be a powerful tool for predicting the combined treatment response in patients with chronic HCV infection in association with the determination of IFNL3 polymorphism. ..
  47. doi CD8dim and NKG2D expression defines related subsets of CD4+ T cells in HIV-infected patients with worse prognostic factors
    Rebeca Alonso-Arias
    Histocompatibility Unit, Immunology Department Hospital Universitario Central de Asturias, Oviedo, Spain
    J Acquir Immune Defic Syndr 51:390-8. 2009
    ..Their common ontogenic origin and oligoclonality, possibly due to repeated encounters with the same antigen, could result in a limitation of the repertoire of responder cells and in a worse prognosis of HIV infection...
  48. doi Genetic study confirms association of HLA-DPA1(∗)01:03 subtype with ankylosing spondylitis in HLA-B27-positive populations
    Roberto Díaz-Peña
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Hum Immunol 74:764-7. 2013
    ..05). We also found association of the HLA-DPA1(∗)01:03 allele with AS (P<0.05). This is the first study that confirms the association of HLA markers and haplotypes around HLA-DPA1 and HLA-DPB1 with AS...
  49. doi The NKG2D receptor: sensing stressed cells
    Carlos Lopez-Larrea
    Department of Immunology, Histocompatibility Unit, Hospital Universitario Central de Asturias, Julian Claveria Street, 33006 Oviedo, Spain
    Trends Mol Med 14:179-89. 2008
    ....
  50. ncbi BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility
    Adolfo Quiñones-Lombraña
    Department of Functional Biology, University of Oviedo, IUOPA, Oviedo, Spain
    J Rheumatol 35:741-4. 2008
    ..To analyze whether the polymorphisms -22 (G/C) and -348 (C/T) of the BAT1 gene are associated with susceptibility to rheumatoid arthritis (RA)...
  51. ncbi Frequent participation in high volume exercise throughout life is associated with a more differentiated adaptive immune response
    Marco Antonio Moro-García
    Immunology Department, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain
    Brain Behav Immun 39:61-74. 2014
    ..In conclusion, high volume exercise throughout life appears to be associated with increased levels of biomarkers that are associated with an aging immune system, which are partially reduced with physiological aging. ..
  52. pmc DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8+ T and NK cells
    Alba Fernández-Sánchez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Epigenetics 8:66-78. 2013
    ..These findings suggest that differential NKG2D expression in the different cell subsets is regulated by epigenetic mechanisms and that its modulation by epigenetic treatments might provide a new strategy for treating several pathologies...
  53. doi IL-15 preferentially enhances functional properties and antigen-specific responses of CD4+CD28(null) compared to CD4+CD28+ T cells
    Rebeca Alonso-Arias
    Department of Immunology, Hospital Universitario Central de Asturias, c Julian Claveria s n, Oviedo, Spain
    Aging Cell 10:844-52. 2011
    ..IL-15 could play a role enhancing the effector response of CD4+CD28(null) T cells against their specific chronic antigens...
  54. doi A predictive model of treatment outcome in patients with chronic HCV infection using IL28B and PD-1 genotyping
    Jose Ramon Vidal-Castiñeira
    Immunology Service, Hospital Universitario Central de Asturias, Oviedo, Spain
    J Hepatol 56:1230-8. 2012
    ..The aim of this study was to analyse the effect of several single nucleotide polymorphisms of PD-1 gene and several previously associated factors (IL28B and KIR receptors) on treatment responses...
  55. doi Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes
    Beatriz Tavira
    Genetica Molecular, Hospital Universitario Central de Asturias, Oviedo, Spain
    Clin Chem Lab Med 49:825-33. 2011
    ..Our aim was to define the effect of DNA variants at 16 drug metabolising enzymes on Tac dose in patients with kidney transplants...
  56. ncbi Immunosenescence and inflammation characterize chronic heart failure patients with more advanced disease
    Marco Antonio Moro-García
    Immunology Department, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain
    Int J Cardiol 174:590-9. 2014
    ..We hypothesized that patients with CHF may develop immunosenescence due to inflammation and that this may be associated with a worse stage of the disease...
  57. pmc Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects
    Marco Antonio Moro-García
    Immunology Department, Hospital Universitario Central de Asturias, 33006, Oviedo, Spain
    Age (Dordr) 35:1311-26. 2013
    ..bulgaricus 8481 could favor the maintenance of an adequate immune response, mainly by slowing the aging of the T cell subpopulations and increasing the number of immature T cells which are potential responders to new antigens...
  58. doi Soluble MHC class I chain-related protein B serum levels correlate with disease activity in relapsing-remitting multiple sclerosis
    Juan Luis Fernandez-Morera
    Unidad de Histocompatibilidad y Transplantes, Hospital Universitario Central de Asturias, Oviedo, Spain
    Hum Immunol 69:235-40. 2008
    ..Elevated soluble MICB levels exist in serum of multiple sclerosis patients related with disease activity. This may contribute to the modulation of immune response activity during relapses...
  59. pmc HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis
    Ruben Queiro
    Rheumatology Service, Hospital Universitario Central de Asturias HUCA, C Celestino Villamil S N, 33006, Oviedo, Spain
    Arthritis Res Ther 8:R185. 2006
    ..HLA-C alleles may modulate some aspects of the clinical expression of PsA, but these findings need confirmation...
  60. doi NKG2D ligands: key targets of the immune response
    Segundo Gonzalez
    Department of Functional Biology, University of Oviedo, IUOPA, Oviedo 33006, Spain
    Trends Immunol 29:397-403. 2008
    ..In this review, we analyse the recent advances in understanding the regulation of NKG2D ligand expression and their therapeutic implications...
  61. pmc DNA methylation dynamics in blood after hematopoietic cell transplant
    Ramon M Rodriguez
    Cancer Epigenetics Laboratory, Instituto Universitario de Oncologia del Principado de Asturias, HUCA, Universidad de Oviedo, Oviedo, Spain
    PLoS ONE 8:e56931. 2013
    ....
  62. doi DNA methylation: a promising landscape for immune system-related diseases
    Beatriz Suarez-Alvarez
    Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
    Trends Genet 28:506-14. 2012
    ....
  63. doi Immunology and the challenge of transplantation
    Rebeca Alonso Arias
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Adv Exp Med Biol 741:27-43. 2012
    ..In this chapter we will describe fundamental aspects of the MHC system, as well as, specifically, its involvement in the allogenic response of the immune system against organ transplants...
  64. doi Endoplasmic reticulum stress signals in defined human embryonic stem cell lines and culture conditions
    Miguel Angel Blanco-Gelaz
    Histocompatibility and Transplantation Unit, Hospital Universitario Central de Asturias, 33006, Oviedo, Spain
    Stem Cell Rev 6:462-72. 2010
    ..The early differentiation status defined could progress into a more differentiated state, and may be influenced by culture conditions...
  65. doi Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation
    Esther Serrano-Pertierra
    Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
    Eur J Immunol 42:2142-51. 2012
    ..Therefore, our results provide a new mechanism that may contribute to the immune response or evasion in tumors...
  66. doi The emergence of the major histocompatilibility complex
    Jesus Martinez-Borra
    Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
    Adv Exp Med Biol 738:277-89. 2012
    ..The study of how the MHC appeared during evolution and how it is organized in different species can help us clarify what features are essential in their participation in self-nonself recognition...
  67. doi Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding
    Leticia Huergo-Zapico
    Functional Biology Department Instituto Universitario Oncologico del Principado de Asturias IUOPA, Universidad de Oviedo, Oviedo, Spain
    Cancer Immunol Immunother 61:1201-10. 2012
    ..In conclusion, these results uncover a molecular mechanism which regulates MICA protein shedding and immune evasion in CLL...
  68. doi Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H
    María Palacín
    Genetica Molecular, Hospital Universitario Central de Asturias, Oviedo, Spain
    Mitochondrion 11:176-81. 2011
    ..Our work supported a role for the mtDNA variation in the risk for atherosclerosis and ischemic associated events, likely due to differences in mitochondrial function and reactive oxygen production between the different haplogroups...
  69. doi Autophagy and self-defense
    Jesus Martinez-Borra
    Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
    Adv Exp Med Biol 738:169-84. 2012
    ....
  70. ncbi KIR genes and their role in spondyloarthropathies
    Roberto Díaz-Peña
    Hospital Universitario Central de Asturias, Oviedo, Spain
    Adv Exp Med Biol 649:286-99. 2009
    ..Furthermore, some of these have been associated with certain SpA, such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA)...
  71. doi Mobilization and homing of hematopoietic stem cells
    Beatriz Suarez-Alvarez
    Department of Immunology, Asturias Central University Hospital, Oviedo, Spain
    Adv Exp Med Biol 741:152-70. 2012
    ..Novel agents (AMD3100, stem cell factor, GROßT.) are being developed to enhance the mobilization to modify the signaling into the niche and boost the stem cell harvest, increasing the number of HSCs available for the transplant...
  72. doi The origin of the bacterial immune response
    Jesus Martinez-Borra
    Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
    Adv Exp Med Biol 738:1-13. 2012
    ..In this chapter, we review the bacterial strategies that hinder the phage infection as well as the counter-defense mechanisms developed...
  73. doi Immune systems evolution
    Ramon M Rodriguez
    Cancer Epigenetics Laboratory, Instituto Universitario de Oncologia del Principado de Asturias IUOPA, HUCA, Universidad de Oviedo, Oviedo, Spain
    Adv Exp Med Biol 739:237-51. 2012
    ....