Research Topics
Genomes and GenesSpecies | Enrique LermaSummaryAffiliation: Hospital de la Santa Creu i Sant Pau Country: Spain Publications
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Detail Information
Publications
Exon 20 PIK3CA mutations decreases survival in aggressive (HER-2 positive) breast carcinomasEnrique Lerma
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
Virchows Arch 453:133-9. 2008..Exon 20 PIK3CA mutations are relatively frequent in Her-2+ tumors and shorten survival, whereas neither exons 9 and 20 mutations seem related with "triple negative" breast carcinomas...
Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinomaEnrique Lerma
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
Virchows Arch 452:65-74. 2008..03) and decrease in host inflammatory response (p = 0.01). Fas-R expression by tumor cells seems unrelated to stage or lymphoid infiltrate. Tumor production of Fas-L may represent an attempt to destroy the host's lymphocytic reaction...- Immunohistochemical heterogeneity of breast carcinomas negative for estrogen receptors, progesterone receptors and Her2/neu (basal-like breast carcinomas)Enrique Lerma
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Mod Pathol 20:1200-7. 2007..001) and activated caspase-3 (P=0.089). IGF-IR could be as important as EGFR for the growth of these neoplasms. Basal cell carcinoma has at least two subtypes with distinct microscopic and immunohistochemical features... - Effectiveness of liquid-based cytology and papanicolaou tests in a low risk populationEnrique Lerma
Department of Pathology, Hospital Santa Creu i Sant Pau, Barcelona, Spain
Acta Cytol 51:399-406. 2007..Pap Test and determine whether the Hybrid Capture System II (HCII) for detection of human papillomavirus (HPV) could increase the sensitivity and effectiveness of cervical screening in a low risk population... - Low-density lipoprotein receptor-related protein 1 is associated with proliferation and invasiveness in Her-2/neu and triple-negative breast carcinomasLluis Catasus
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institut d Investigació Biomèdica IIB Sant Pau, Autonomous University of Barcelona, 08041 Barcelona, Spain
Hum Pathol 42:1581-8. 2011..046). These findings suggest a relationship between hypercholesterolemia and aggressiveness of ductal breast carcinomas... - Genetic up-regulation and overexpression of PLEKHA7 differentiates invasive lobular carcinomas from invasive ductal carcinomasBarbara Castellana
Department of Pathology, Institut de Recerca Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain
Hum Pathol 43:1902-9. 2012..The gene expression profile in ILCs and IDCs differs in several signaling pathways. Our findings suggest that overexpression of PLEKHA7 is common in ILCs and could be a molecular marker to differentiate ILCs from IDCs... - Triple negative breast carcinomas: similarities and differences with basal like carcinomasEnrique Lerma
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
Appl Immunohistochem Mol Morphol 17:483-94. 2009..Recent studies suggest that basal like carcinomas are originated from mammary stem cells... - Telomerase activity in "suspicious" thyroid cytologyEnrique Lerma
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University, Barcelona, Spain
Cancer 105:492-7. 2005..The authors studied the utility of TA detection as an ancillary tool to thyroid fine-needle aspiration (FNA) for patients with nonconclusive cytologic diagnoses... - Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide studySilvia de Sanjose
IDIBELL, Institut Català d Oncologia Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
Lancet Oncol 11:1048-56. 2010..We aimed to provide novel and comprehensive data about the worldwide genotype distribution in patients with invasive cervical cancer... - Human papillomavirus genotype distribution in cervical cancer cases in Spain. Implications for preventionLaia Alemany
IDIBELL, Institut Català d Oncologia Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
Gynecol Oncol 124:512-7. 2012..Human papillomavirus (HPV) genotype distribution in invasive cervical cancer (ICC) is critical to guide the introduction and to assess the impact of HPV prophylactic vaccines. This study aims to provide specific information for Spain... - Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: a cooperative effort?Nuria Montserrat
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, 08025 Barcelona, Spain
Hum Pathol 42:103-10. 2011.... - Radiologic evaluation of breast disorders related to pregnancy and lactationJosep M Sabate
Unit of Breast Imaging, Department of Diagnostic Radiology, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
Radiographics 27:S101-24. 2007..Knowledge of the unique entities that are specifically related to pregnancy and lactation and of their radiologic-pathologic appearances can help the radiologist make the correct diagnosis... 
ASPN and GJB2 Are Implicated in the Mechanisms of Invasion of Ductal Breast CarcinomasBarbara Castellana
1 Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
J Cancer 3:175-83. 2012..The association of GJB2 protein expression with invasion was confirmed by qRT-PCR in mouse tumors (P < 0.05).Conclusions: The upregulation of ASPN and GJB2 may play important roles in local invasion of breast ductal carcinomas...- PTEN promoter methylation in sporadic thyroid carcinomasFrancisco Alvarez-Nuñez
Laboratory of Experimental Endocrinology, Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Thyroid 16:17-23. 2006..001). These results show a high frequency of PTEN promoter hypermethylation, especially in follicular tumors, suggesting its possible role in thyroid tumorigenesis... - Telomerase activity in thyroid fine needle aspiratesJosefina Mora
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University, Barcelona, Spain
Acta Cytol 48:818-24. 2004..Further studies are needed to confirm whether TA detection could contribute to identifying neoplasms when FNAs are inconclusive for malignancy and in cases of scanty material... - Cytologic diagnosis of ocular melanocytoma: a case reportFrancesca Saro
Cytopathology Section, Department of Pathology, Hospital de la Santa Creu i Sant Pau, Spain
Acta Cytol 52:87-90. 2008..Pigmented lesions of the eye represent a challenging field from both clinical and pathologic approaches. The importance of a correct diagnosis in this case is enhanced by the delicate structures involved and their difficult accessibility... - Expression profiles associated with aggressive behavior in Merkel cell carcinomaMaria Teresa Fernandez-Figueras
Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
Mod Pathol 20:90-101. 2007..These findings may be helpful in predicting the clinical course of Merkel cell carcinoma and are potentially useful for the development of targeted therapies... - Alterations of the p16/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosusEnrique Lerma
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
Hum Pathol 33:1120-5. 2002.... - Corneal transplantations from donors with cancerAntonio Lopez-Navidad
Department of Organ and Tissue Procurement for Transplantation and Tissue Bank, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Transplantation 83:1345-50. 2007..Such acceptance is based on the fact that the cornea is an avascular tissue and metastatic dissemination is extremely unlikely... - Lupus panniculitis involving the breastJosep M Sabate
Unity of Breast Imaging, Department of Diagnostic Radiology, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Sant Antoni M Claret 167, 08025, Barcelona, Spain
Eur Radiol 16:53-6. 2006..Differential diagnosis with carcinoma and fat necrosis and the value of core biopsy are discussed... - Comparative findings of lymphocytic thyroiditis and thyroid lymphomaEnrique Lerma
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University, Barcelona, Spain
Acta Cytol 47:575-80. 2003..To compare the cytologic features of histologically proven lymphocytic (Hashimoto's) thyroiditis (Hashimoto's thyroitidis) and primary thyroid lymphomas (TL)... - Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markersJose Palacios
Breast and Gynaecological Cancer Laboratory, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
Breast Cancer Res Treat 90:5-14. 2005.... - Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX familiesEmiliano Honrado
Department of Human Genetics, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, Madrid, Spain
Mod Pathol 20:1298-306. 2007..In addition we have defined a subset of them that have somatic inactivation of the BRCA1 gene... - Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumorsEmiliano Honrado
, 3 28029 Madrid, Spain
J Clin Oncol 23:7503-11. 2005..CONCLUSION: Our results suggest that BRCA2 tumors demonstrate more cytoplasmic and less nuclear RAD51 staining, and increased CHEK2 staining. This pattern may distinguish BRCA2 from familial non-BRCA1/2 tumors... - [BRCA1 and BRCA2 mutations in patients with familial breast cancer]Pascual Bolufer
Laboratorio de Biologia Molecular, Departamento de Biopatología Médica, Escuela de Enfermeria, Hospital Universitario La Fe, Valencia, Spain
Med Clin (Barc) 124:10-2. 2005..The present study reports the mutations found in 48 families of the Valencian Community studied in the University Hospital La Fe of Valencia (Spain)... - Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriersJose Palacios
Laboratory of Breast and Gynecological Cancer, Immunohistological Unit, Centro Nacional de Investigaciones Oncologicas, 28029 Madrid, Spain
Clin Cancer Res 9:3606-14. 2003..Therefore, it is of major importance to define the morphological, immunohistochemical, and molecular features of this group of tumors to improve genetic testing and also gain further insight into the biological characteristics of tumors...