X Leon

Summary

Affiliation: Hospital de la Santa Creu i Sant Pau
Country: Spain

Publications

  1. ncbi request reprint [Isolated lymphatic recurrences in patients with head and neck carcinomas]
    X Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Avda San Antoni Ma Claret, 167, 08025 Barcelona
    Acta Otorrinolaringol Esp 54:710-7. 2003
  2. ncbi request reprint [Selective neck dissection in patients presenting clinical node metastases]
    X Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Avda San Antoni M Claret, 167, 08025 Barcelona
    Acta Otorrinolaringol Esp 55:73-80. 2004
  3. ncbi request reprint Comparison of the Radiation Therapy Oncology Group recursive partitioning classification and Union Internationale Contre le Cancer TNM classification for patients with head and neck carcinoma
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Avda San Antoni Ma Claret, 167, 08025 Barcelona, Spain
    Head Neck 27:248-57. 2005
  4. ncbi request reprint Incidence and significance of clinically unsuspected thyroid tissue in lymph nodes found during neck dissection in head and neck carcinoma patients
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Laryngoscope 115:470-4. 2005
  5. ncbi request reprint Metachronous second primary tumours in the aerodigestive tract in patients with early stage head and neck squamous cell carcinomas
    Xavier Leon
    Department of Otolaryngology Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Eur Arch Otorhinolaryngol 262:905-9. 2005
  6. ncbi request reprint A retrospective analysis of the outcome of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck refractory to a platinum-based chemotherapy
    X Leon
    Hospital Santpau, Barcelona, Spain
    Clin Oncol (R Coll Radiol) 17:418-24. 2005
  7. ncbi request reprint Supracricoid laryngectomy as salvage surgery after failure of radiation therapy
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, 08025, Barcelona, Spain
    Eur Arch Otorhinolaryngol 264:809-14. 2007
  8. ncbi request reprint [Prevalence of tobacco and alcohol use following treatment in patients with head and neck squamous carcinoma: a cross-sectional study]
    X Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Avda San Antoni Ma Claret, 167, 08025 Barcelona
    Acta Otorrinolaringol Esp 53:764-70. 2002
  9. ncbi request reprint External validation of a risk group defined by recursive partitioning analysis in patients with head and neck carcinoma treated with surgery and postoperative radiotherapy
    Xavier Leon
    Department of Otolaryngology Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Head Neck 29:815-21. 2007
  10. doi request reprint Recurrent laryngeal squamous cell carcinoma: rTNM versus composite laryngeal recurrence staging system. Proposal for a modification of the CLRSS to improve patient classification
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Head Neck 30:939-45. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint [Isolated lymphatic recurrences in patients with head and neck carcinomas]
    X Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Avda San Antoni Ma Claret, 167, 08025 Barcelona
    Acta Otorrinolaringol Esp 54:710-7. 2003
    ..Recurrencies of lymphatic metastasis implies a poor prognosis in patients with head and neck carcinoma. The aim of our study is to analyse the results of salvage treatment after an isolated regional tumour recurrence...
  2. ncbi request reprint [Selective neck dissection in patients presenting clinical node metastases]
    X Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Avda San Antoni M Claret, 167, 08025 Barcelona
    Acta Otorrinolaringol Esp 55:73-80. 2004
    ..To evaluate the results obtained with selective neck dissection in patients with clinically positive neck nodes at diagnosis (N+)...
  3. ncbi request reprint Comparison of the Radiation Therapy Oncology Group recursive partitioning classification and Union Internationale Contre le Cancer TNM classification for patients with head and neck carcinoma
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Avda San Antoni Ma Claret, 167, 08025 Barcelona, Spain
    Head Neck 27:248-57. 2005
    ..The aim of this study was to compare the RPA and Union Internationale Contre le Cancer (UICC) TNM classification systems in patients with head and neck carcinoma treated consecutively in a single center...
  4. ncbi request reprint Incidence and significance of clinically unsuspected thyroid tissue in lymph nodes found during neck dissection in head and neck carcinoma patients
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Laryngoscope 115:470-4. 2005
    ....
  5. ncbi request reprint Metachronous second primary tumours in the aerodigestive tract in patients with early stage head and neck squamous cell carcinomas
    Xavier Leon
    Department of Otolaryngology Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Eur Arch Otorhinolaryngol 262:905-9. 2005
    ..3%. Classification of the patients according to the mentioned variables allows us to focus follow-up and prevention efforts on high-risk patients...
  6. ncbi request reprint A retrospective analysis of the outcome of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck refractory to a platinum-based chemotherapy
    X Leon
    Hospital Santpau, Barcelona, Spain
    Clin Oncol (R Coll Radiol) 17:418-24. 2005
    ..In an effort to generate such data, this retrospective study analysed clinical records from 151 patients with SCCHN refractory to platinum-based chemotherapy treated between 1990 and 2000 at seven different centres around Europe...
  7. ncbi request reprint Supracricoid laryngectomy as salvage surgery after failure of radiation therapy
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, 08025, Barcelona, Spain
    Eur Arch Otorhinolaryngol 264:809-14. 2007
    ....
  8. ncbi request reprint [Prevalence of tobacco and alcohol use following treatment in patients with head and neck squamous carcinoma: a cross-sectional study]
    X Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Avda San Antoni Ma Claret, 167, 08025 Barcelona
    Acta Otorrinolaringol Esp 53:764-70. 2002
    ..To evaluate the prevalence of tobacco and alcohol use following treatment in patients with head and neck squamous cell carcinoma, and to determine factors possibly related to this use..
  9. ncbi request reprint External validation of a risk group defined by recursive partitioning analysis in patients with head and neck carcinoma treated with surgery and postoperative radiotherapy
    Xavier Leon
    Department of Otolaryngology Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Head Neck 29:815-21. 2007
    ..The objective of the present study was to carry out an external validation of this RPA-derived classification system...
  10. doi request reprint Recurrent laryngeal squamous cell carcinoma: rTNM versus composite laryngeal recurrence staging system. Proposal for a modification of the CLRSS to improve patient classification
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Head Neck 30:939-45. 2008
    ..The objective of our study was to carry out an external validation of the CLRSS, and to evaluate a modified version of the original CLRSS, that we named CLRSS-2...
  11. ncbi request reprint Can cure be achieved in patients with head and neck carcinomas? The problem of second neoplasm
    X Leon
    Department of Otolaryngology, Hospital de Sant Pau, Barcelona, Universitat Autonoma de Barcelona, Avda San Antoni Ma Claret, 167 08025 Barcelona, Spain
    Expert Rev Anticancer Ther 1:125-33. 2001
    ....
  12. ncbi request reprint [Design, maintenance, and exploitation of an oncologic database for patients with malignant tumors of the head and neck]
    X Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Barcelona
    Acta Otorrinolaringol Esp 53:185-90. 2002
    ..We present the design of the database that collects the oncological information of patients with head and neck malignant tumours diagnosed in our centre since 1984, and the needs of maintenance and possibilities of exploitation...
  13. ncbi request reprint Hypothyroidism in patients treated with total laryngectomy. A multivariate study
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Eur Arch Otorhinolaryngol 259:193-6. 2002
    ..We consider that it is important to check the thyroid function periodically in these patients to obtain early diagnosis and appropriate treatment...
  14. ncbi request reprint Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced pyriform sinus carcinoma
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Eur Arch Otorhinolaryngol 259:32-6. 2002
    ..The frequency of organ preservation for the group of 78 patients who began treatment with induction chemotherapy was 18%...
  15. doi request reprint Influence of the persistence of tobacco and alcohol use in the appearance of second neoplasm in patients with a head and neck cancer. A case-control study
    Xavier Leon
    Department of Otolaryngology Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Avda, San Antoni Ma Claret, 167, 08025 Barcelona, Spain
    Cancer Causes Control 20:645-52. 2009
    ..To evaluate the influence of persistent tobacco and alcohol use on the risk of a second metachronous neoplasm in the aerodigestive tract in head and neck squamous cell carcinoma (HNSCC) patients...
  16. ncbi request reprint Results of salvage surgery for local or regional recurrence after larynx preservation with induction chemotherapy and radiotherapy
    X Leon
    Department of Otorhinolaryngology, Hospital de la Santa Creu i Sant Pau, Avda San Antoni M a Claret, 167, Universitat Autonoma de Barcelona, 08025 Barcelona, Spain
    Head Neck 23:733-8. 2001
    ..The aim of this study was to review the results of such salvage surgery in this group of patients...
  17. ncbi request reprint Selective dissection of levels II-III with intraoperative control of the upper and middle jugular nodes: a therapeutic option for the N0 neck
    X Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Avda San Antoni Ma Claret, 167, Barcelona, Spain 08025
    Head Neck 23:441-6. 2001
    ..When intraoperative analysis was positive, dissection of levels IV and V was completed...
  18. ncbi request reprint Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced laryngeal carcinoma
    Xavier Leon
    Department of Otolaryngology, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur Arch Otorhinolaryngol 262:93-8. 2005
    ..In a multivariate study, only the response after induction chemotherapy was significantly related to organ preservation...
  19. ncbi request reprint Treatment of neck nodes after induction chemotherapy in patients with primary advanced tumours
    X Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Eur Arch Otorhinolaryngol 257:521-5. 2000
    ....
  20. ncbi request reprint Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy
    C Orus
    Servei d ORL, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Eur Arch Otorhinolaryngol 257:512-6. 2000
    ....
  21. ncbi request reprint [Treatment for the early stages (T1-T2NO) of squamous cell carcinoma of the mobile tongue]
    J R Gras
    Servicio ORL, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma, Barcelona
    Acta Otorrinolaringol Esp 54:443-8. 2003
    ..The aim of this study is to define the best local treatment in patients with squamous cell carcinoma of mobile tongue in the early stages (I-II) and to establish the best election for neck management...
  22. ncbi request reprint [Treatment of T1N0 glottis carcinoma with radiotherapy. Results at our center and review of the literature]
    X Leon
    Servicio de Otorrinolaringologia, Hospital de la Santa Creu i Sant Pau, Avda, San Antoni Ma, Claret, 167, 08025 Barcelona
    Acta Otorrinolaringol Esp 54:39-47. 2003
    ..To evaluate the results of radiotherapy in the treatment of patients with T1N0 glottic squamous cell carcinoma...
  23. ncbi request reprint [CEA and Cyfra 21.1 study pre-treatment in 252 patients with head and neck carcinomas]
    M Costey
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Barcelona
    Acta Otorrinolaringol Esp 55:338-42. 2004
    ..As in most malignant tumors, the earlier the diagnosis, is made the longer the survivalis. Several molecules, including CEA and Cyfra 21.1, have been evaluated in an attempt to improve diagnosis and follow-up...
  24. doi request reprint Salvage surgery after locoregional failure in head and neck carcinoma patients treated with chemoradiotherapy
    E Esteller
    Otorhinolaryngology Department, Hospital General de Catalunya, San Cugat Del Valles, Barcelona, Spain
    Eur Arch Otorhinolaryngol 268:295-301. 2011
    ..In conclusion, salvage surgery after CCRT involves extensive resections, requiring reconstruction techniques with regional or microanastomosed free flaps in most cases, achieving acceptable outcomes...
  25. doi request reprint Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer
    Miguel Angel Pavon
    Grup d Oncogenesi i Antitumorals, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine CIBER and Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Int J Cancer 123:1068-79. 2008
    ....
  26. ncbi request reprint [Consequences of the bilateral vagus nerve section at a cervical level]
    X Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Avda San Antoni M Claret, 167, 08025 Barcelona
    Acta Otorrinolaringol Esp 54:157-60. 2003
    ....
  27. doi request reprint Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma
    M Á Pavón
    Grup d Oncogenesi i Antitumorals, Institut d Investigacions Biomèdiques Sant Pau, Barcelona, Spain
    Carcinogenesis 33:1707-16. 2012
    ..Independent prospective studies would be necessary to assess if the proposed survival signature could help to guide clinical management of HNSCC...
  28. ncbi request reprint [Results of an organ conservation protocol in patients with locally advanced laryngeal tumours]
    Xavier Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Barcelona, Espana
    Acta Otorrinolaringol Esp 60:176-85. 2009
    ..One of them is induction chemotherapy, which allows modulation of the second manoeuvre according to the degree of response achieved. This study presents the results of a large series of patients treated according to this protocol...
  29. ncbi request reprint [Organ preservation in laryngeal and hypopharyngeal cancer]
    Miquel Quer
    Servicio de Otorrinolaringología y Patología Cérvico Facial Hospital de la Santa Creu i de Sant Pau Universitat Autònoma de Barcelona Barcelona España
    Acta Otorrinolaringol Esp 58:476-82. 2007
    ..With so many options and in view of the lack of a global agreement, more multidisciplinary clinical research is still needed in order to define the best strategy for each patient...
  30. ncbi request reprint [Larynx transplant: a therapeutic option for the 21st century? Literature review]
    Xavier Leon
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Barcelona, Spain
    Acta Otorrinolaringol Esp 59:127-38. 2008
    ..This review of the literature aims to update the compendium of knowledge about this procedure and to explore the prospects of larynx transplantation as a viable therapeutic option...
  31. ncbi request reprint [Glottic immobility: retrospective study of 229 cases]
    X Leon
    Servicio ORL, Hospital de la Santa Creu i Sant Pau, Avda San Antoni M Claret, 167, 08025 Barcelona
    Acta Otorrinolaringol Esp 52:486-92. 2001
    ....
  32. ncbi request reprint [Assessment of the prognostic capacity improvement of the 5th edition of the TNM in patients with nasopharyngeal carcinoma]
    M P Venegas
    Servicio de Otorrinolaringologia, Hospital de Sant Pau, Barcelona
    Acta Otorrinolaringol Esp 54:512-7. 2003
    ..Evaluate the changes included in the 5th edition of the TNM classification in patients with nasopharyngeal carcinoma...
  33. ncbi request reprint Second primary tumors in head and neck cancer patients
    Xavier Leon
    Department of Otolaryngology, Hospital de Santa Creu i Sant Pau, Barcelona, Spain
    Acta Otolaryngol 122:765-78. 2002
  34. doi request reprint Prostaglandin E(2) pathway in head and neck squamous cell carcinoma
    Mercedes Camacho
    Laboratory of Angiology, Vascular Biology and Inflammation, Institute of Research, Hospital Santa Creu i Sant Pau, Barcelona, Spain
    Head Neck 30:1175-81. 2008
    ..Prostaglandin E(2) (PGE(2)) is involved in malignant growth. The objective was to study the PGE(2) pathway in head and neck squamous cell carcinoma (HNSCC) patients...
  35. ncbi request reprint The effect of waiting time on local control and survival in head and neck carcinoma patients treated with radiotherapy
    Xavier Leon
    Department of Otolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Avda San Antoni Ma Claret, 167, 08025 Barcelona, Spain
    Radiother Oncol 66:277-81. 2003
    ..To determine the influence of waiting time for radiotherapy on local control and survival in a cohort of patients with head and neck carcinoma of different locations and stages treated with radiotherapy...
  36. doi request reprint Parotidectomies in benign parotid tumours: "Sant Pau" surgical extension classification
    Miquel Quer
    Servicio de ORL y Patología Cervicofacial, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Espana
    Acta Otorrinolaringol Esp 61:1-5. 2010
    ..In an effort to improve this situation, we created a classification system to define the areas removed. We started using this classification in July, 2006, and this article reviews its applicability and usefulness...
  37. ncbi request reprint Is the external laryngeal nerve an exclusively motor nerve? The cricothyroid connection branch
    Eva Maranillo
    Unit of Anatomy and Embryology, School of Medicine, Autonomous University of Barcelona, Cerdanyola del Valles 08193, Barcelona, Spain
    Laryngoscope 113:525-9. 2003
    ..To obtain an accurate morphological description of the nerve that provides communication between the external laryngeal nerve and the recurrent laryngeal nerve in a large sample of human larynges...
  38. ncbi request reprint Variability of the nerve supply patterns of the human posterior cricoarytenoid muscle
    Eva Maranillo
    Unit of Anatomy and Embryology, School of Medicine, Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain
    Laryngoscope 113:602-6. 2003
    ..The goal of the present study was to establish an accurate morphological description of the posterior cricoarytenoid muscle nerve supply in a large sample of human larynges...