Albert Lecube

Summary

Affiliation: Hospital Universitari Vall d'Hebron
Country: Spain

Publications

  1. pmc Diabetes is the main factor accounting for hypomagnesemia in obese subjects
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Diabetes and Metabolism Research Unit, Endocrinology Department, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 7:e30599. 2012
  2. doi Proteomic analysis of cerebrospinal fluid from obese women with idiopathic intracranial hypertension: a new approach for identifying new candidates in the pathogenesis of obesity
    A Lecube
    Department of Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca i Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neuroendocrinol 24:944-52. 2012
  3. doi TNF-α system and lung function impairment in obesity
    A Lecube
    Endocrinology Department, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Cytokine 54:121-4. 2011
  4. doi Insulin resistance is related to impaired lung function in morbidly obese women: a case-control study
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Diabetes Metab Res Rev 26:639-45. 2010
  5. doi Type 2 diabetes impairs pulmonary function in morbidly obese women: a case-control study
    A Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron, 119 129, 08035 Barcelona, Spain
    Diabetologia 53:1210-6. 2010
  6. doi Asymptomatic sleep-disordered breathing in premenopausal women awaiting bariatric surgery
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Obes Surg 20:454-61. 2010
  7. ncbi Glucose abnormalities in non-alcoholic fatty liver disease and chronic hepatitis C virus infection: the role of iron overload
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Metab Res Rev 25:403-10. 2009
  8. pmc Diabetes is an independent risk factor for severe nocturnal hypoxemia in obese patients. A case-control study
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    PLoS ONE 4:e4692. 2009
  9. doi Factors accounting for high ferritin levels in obesity
    A Lecube
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Int J Obes (Lond) 32:1665-9. 2008
  10. ncbi Iron deficiency in obese postmenopausal women
    Albert Lecube
    Obesity Research Unit, Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Obesity (Silver Spring) 14:1724-30. 2006

Collaborators

Detail Information

Publications38

  1. pmc Diabetes is the main factor accounting for hypomagnesemia in obese subjects
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Diabetes and Metabolism Research Unit, Endocrinology Department, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 7:e30599. 2012
    ..Type 2 diabetes (T2DM) and obesity are associated with magnesium deficiency. We aimed to determine whether the presence of type 2 diabetes and the degree of metabolic control are related to low serum magnesium levels in obese individuals...
  2. doi Proteomic analysis of cerebrospinal fluid from obese women with idiopathic intracranial hypertension: a new approach for identifying new candidates in the pathogenesis of obesity
    A Lecube
    Department of Endocrinology, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca i Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neuroendocrinol 24:944-52. 2012
    ..Further studies aiming to investigating the precise role of these proteins in the pathogenesis of obesity and their potential therapeutic implications are needed...
  3. doi TNF-α system and lung function impairment in obesity
    A Lecube
    Endocrinology Department, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Cytokine 54:121-4. 2011
    ..Therefore, studies addressed to evaluating the potential beneficial effect of anti-TNF-α agents on pulmonary function tests in obese subjects seem warranted...
  4. doi Insulin resistance is related to impaired lung function in morbidly obese women: a case-control study
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Diabetes Metab Res Rev 26:639-45. 2010
    ..The aim of the study is to determine whether obese patients with insulin resistance without diabetes have reduced pulmonary function in comparison with non-diabetic obese subjects without insulin resistance...
  5. doi Type 2 diabetes impairs pulmonary function in morbidly obese women: a case-control study
    A Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron, 119 129, 08035 Barcelona, Spain
    Diabetologia 53:1210-6. 2010
    ..To determine whether the presence of type 2 diabetes and the degree of metabolic control are related to reduced pulmonary function in obese individuals...
  6. doi Asymptomatic sleep-disordered breathing in premenopausal women awaiting bariatric surgery
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Obes Surg 20:454-61. 2010
    ..To evaluate the prevalence and characteristics of sleep apnea-hypopnea syndrome (SAHS) and obesity hypoventilation syndrome (OHS) in morbidly obese pre-menopausal women included in a program of bariatric surgery...
  7. ncbi Glucose abnormalities in non-alcoholic fatty liver disease and chronic hepatitis C virus infection: the role of iron overload
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Metab Res Rev 25:403-10. 2009
    ..Therefore, glucose abnormalities, and specially type 2 diabetes, should be taken into account when evaluating serum ferritin levels in patients with HCV infection...
  8. pmc Diabetes is an independent risk factor for severe nocturnal hypoxemia in obese patients. A case-control study
    Albert Lecube
    CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salud Carlos III ISCIII, Diabetes and Metabolism Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    PLoS ONE 4:e4692. 2009
    ..The aim of this cross-sectional case-control study was to evaluate whether obese patients with T2DM are more prone to severe SAHS than obese non-diabetic subjects...
  9. doi Factors accounting for high ferritin levels in obesity
    A Lecube
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Int J Obes (Lond) 32:1665-9. 2008
    ..Ferritin is a widely used marker of iron status. A relationship between iron stores, obesity and metabolic syndrome (METs) has been proposed...
  10. ncbi Iron deficiency in obese postmenopausal women
    Albert Lecube
    Obesity Research Unit, Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Obesity (Silver Spring) 14:1724-30. 2006
    ..This study evaluates whether the iron deficiency suggested in children and adolescents with overweight is also present with increasing age...
  11. doi Lipoprotein lipase expression in livers of morbidly obese patients could be responsible for liver steatosis
    Eva Pardina
    Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Diagonal 645, 08028, Barcelona, Spain
    Obes Surg 19:608-16. 2009
    ..Most patients with morbid obesity develop non-alcoholic fatty liver disease (NAFLD). The origins of lipid deposition in the liver and the effects of bariatric surgery in the obese with NAFLD are controversial...
  12. ncbi The relationships between IGF-1 and CRP, NO, leptin, and adiponectin during weight loss in the morbidly obese
    Eva Pardina
    Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Barcelona, Spain
    Obes Surg 20:623-32. 2010
    ....
  13. doi Alterations in the common pathway of coagulation during weight loss induced by gastric bypass in severely obese patients
    Eva Pardina
    Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Barcelona, Spain
    Obesity (Silver Spring) 20:1048-56. 2012
    ..Gastric bypass surgery leads to a normalization of the hematological profile and a decrease in PAI-1 levels, which entails a decrease of risk for thromboembolism in severely obese...
  14. doi Only C-reactive protein, but not TNF-α or IL6, reflects the improvement in inflammation after bariatric surgery
    Eva Pardina
    Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Diagonal 643, 08028, Barcelona, Spain
    Obes Surg 22:131-9. 2012
    ..We wanted to study the CRP in plasma and tissue in morbidly obese patients before and after surgery and relate it with the expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in tissues...
  15. ncbi Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance
    David M Selva
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Clin Endocrinol Metab 94:4499-507. 2009
    ..Zinc-alpha2 glycoprotein (ZAG) has been proposed as a new candidate in the pathogenesis of obesity, but most of the information stems from studies performed in rodents and in vitro assays...
  16. ncbi Diabetes is the main factor accounting for the high ferritin levels detected in chronic hepatitis C virus infection
    Albert Lecube
    Diabetes Research Unit, Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Diabetes Care 27:2669-75. 2004
    ..The aim of this study was to investigate the contribution of diabetes to the high ferritin levels observed in HCV-infected patients with chronic hepatitis...
  17. ncbi Intravitreous leptin concentrations in patients with proliferative diabetic retinopathy
    Cristina Hernandez
    Diabetes Research Unit, Hospital General Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Retina 24:30-5. 2004
    ..The aim of the present study was to investigate the source of intravitreal leptin and to determine whether it is related to PDR activity...
  18. ncbi Deficit of somatostatin-like immunoreactivity in the vitreous fluid of diabetic patients: possible role in the development of proliferative diabetic retinopathy
    Rafael Simo
    Diabetes Unit, Division of Endocrinology, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 25:2282-6. 2002
    ..To evaluate the vitreous levels of somatostatin-like immunoreactivity (SLI) in patients with proliferative diabetic retinopathy (PDR)...
  19. ncbi High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury
    Albert Lecube
    Diabetes Research Unit, Division of Endocrinology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 27:1171-5. 2004
    ....
  20. ncbi Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection
    Rafael Simo
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 29:2462-6. 2006
    ..The main aim of this study was to compare the incidence of glucose abnormalities (diabetes plus impaired fasting glucose) between HCV-infected patients with or without sustained virological response (SVR) after antiviral therapy...
  21. doi Molecular Mechanism of TNFα-Induced Down-Regulation of SHBG Expression
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Passeig Vall d Hebron 119 129, Barcelona, Spain
    Mol Endocrinol 26:438-46. 2012
    ..We conclude that sustained exposition to elevated levels of TNFα decreases SHBG production by reducing hepatic HNF-4α levels via NF-κB activation in HepG2 cells...
  22. ncbi Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case-control study
    Albert Lecube
    Diabetes Research Unit Endocrinology Division, Institut de Recerca, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 29:1096-101. 2006
    ..The purpose of this study was to explore the initial pathogenic mechanisms of diabetes associated with hepatitis C virus (HCV) infection...
  23. ncbi Glucose abnormalities in patients with hepatitis C virus infection: Epidemiology and pathogenesis
    Albert Lecube
    Division of Endocrinology, Diabetes Research Unit, Institut de Recerca, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Diabetes Care 29:1140-9. 2006
  24. ncbi Glucose abnormalities are an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C
    Albert Lecube
    Diabetes Research Unit, Endocrinology Division, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Am J Gastroenterol 102:2189-95. 2007
    ..This study investigated whether glucose abnormalities (impaired fasting glucose and type 2 diabetes) influence the response to antiviral therapy with interferon plus ribavirin in patients with chronic hepatitis C...
  25. ncbi Adiponectin Upregulates SHBG Production: Molecular Mechanisms and Potential Implications
    Rafael Simo
    Diabetes and Metabolism Research Unit R S, C S L, C H, D M S, Vall d Hebron Institut de Recerca, 08035 Barcelona, Universitat Autonoma de Barcelona, 08193 Barcelona, Centro de Investigación Biomédica en Red, 28029 Madrid, Spain Endocrinology and Nutrition Unit A L, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain Endocrine, Metabolic and Bariatric Unit J M F, General Surgery Department, Hospital Universitari Vall d Hebron, 08035 Barcelona, Spain
    Endocrinology 155:2820-30. 2014
    ..Our results suggest for the first time that adiponectin increases SHBG production by activating AMPK, which reduces hepatic lipid content and increases HNF-4α levels. ..
  26. doi Internet of things and bariatric surgery follow-up: Comparative study of standard and IoT follow-up
    Ramon Vilallonga
    Endocrine, metabolic and bariatric Unit, General Surgery Department, University Hospital Vall d Hebron, Universitat Autà noma de Barcelona, Center of Excellence for the EAC BC, Barcelona, Spain
    Minim Invasive Ther Allied Technol 22:304-11. 2013
    ..Follow-up of obese patient is difficult. There is no literature related to patient follow-up that incorporates the concept of Internet of Things (IoT), use of WiFi, Internet, or portable devices for this purpose...
  27. doi Bariatric surgery outcomes in a European Centre of Excellence (CoE)
    Jose Manuel Fort
    Endocrine, metabolic and bariatric Unit, General Surgery Department, Hospital Universitari de la Vall d Hebron, Center of Excellence for the EAC BC, Passeig de la Vall d Hebron, 119 129, 08035 Barcelona, Spain
    Obes Surg 23:1324-32. 2013
    ..Mortality rate was 2, 0.85, 0.47 and 0 % in the four periods. Teams that are just at the beginning of their experience in bariatric surgery in order to avoid complications and deal with better long-term results. ..
  28. ncbi Bariatric surgery in morbidly obese patients improves the atherogenic qualitative properties of the plasma lipoproteins
    Josep Julve
    Institut d Investigació Biomèdica de l Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain CIBER de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Barcelona, Spain Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    Atherosclerosis 234:200-5. 2014
    ..The purpose of this study was to evaluate the effect of weight loss induced in morbidly obese subjects by Roux-en-Y gastric bypass bariatric surgery on the atherogenic features of their plasma lipoproteins...
  29. ncbi Free insulin growth factor-I and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy
    Rafael Simo
    Division of Endocrinology, Diabetes Research Unit, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Am J Ophthalmol 134:376-82. 2002
    ..To investigate the relationship between insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in the vitreous fluid of diabetic patients with proliferative diabetic retinopathy (PDR)...
  30. ncbi Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content
    Eva Pardina
    Department of Biochemistry and Molecular Biology, University of Barcelona, Diagonal 645, 08028, Barcelona, Spain
    Obes Surg 19:894-904. 2009
    ..The types and sources of lipid deposition in the liver of most patients with morbid obesity, as well as the effects of bariatric surgery, are discussed...
  31. pmc Potential role of tumor necrosis factor-α in downregulating sex hormone-binding globulin
    Rafael Simo
    Diabetes and Metabolism Research Unit, Vall d Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas ISCIII, Barcelona, Spain
    Diabetes 61:372-82. 2012
    ..Our results suggest that TNF-α plays an important role downregulating SHBG in chronic low-grade inflammatory diseases such as obesity and type 2 diabetes...
  32. pmc Endoscopic Management of Drain Inclusion in the Gastric Pouch after Gastrojejunal Leakage after Laparoscopic Roux-en-Y Gastric Bypass for the Treatment of Morbid Obesity (LRYGBP)
    Ramon Vilallonga
    Endocrine and Metabolic Unit, General Surgery Department, Universitary Hospital Vall d Hebron, Passeig de la Vall d Hebron, 119 129, 08035 Barcelona, Spain
    Diagn Ther Endosc 2010:891345. 2010
    ..If so, endoscopy is indicated for diagnostic accuracy. Under endoscopy vision, the drain is gently removed from the gastric reservoir leading to sudden and complete resolution of the fistula...
  33. doi Weight-related quality of life in Spanish obese subjects suitable for bariatric surgery is lower than in their North American counterparts: a case-control study
    Assumpta Caixàs
    S Endocrinología y Nutrición, Corporació Sanitaria Univ Parc Taulí, Institut de Recerca Parc Taulí UAB, C Parc Taulí s n, 08208, Sabadell, Barcelona, Spain
    Obes Surg 23:509-14. 2013
    ..Obesity impairs quality of life, but the perception of the impairment could be different from one country to another. The purpose was to compare weight-related quality of life (QOL) between cohorts from Spain and North America...
  34. ncbi Effects of hypolipidemic treatment on serum markers of vascular inflammation in dyslipidemic men
    Cristina Hernandez
    Endocrinology Division, Hospital General Vall d Hebron, Barcelona, Spain
    Med Sci Monit 9:CR114-9. 2003
    ..The purpose of our study was to assess the effect of hypolipidemiant drugs on serum markers of vascular inflammation (E-Selectin, VCAM-1 and MCP-1) in dyslipidemic men without cardiovascular disease...
  35. doi Psychometric evaluation of the IWQOL-Lite (Spanish version) when applied to a sample of obese patients awaiting bariatric surgery
    Ana Andres
    Department of Methodology for the Behavioural Sciences, University of Barcelona, Passeig Vall d Hebron 171, 08035 Barcelona, Spain
    Obes Surg 22:802-9. 2012
    ....
  36. pmc Phagocytic activity is impaired in type 2 diabetes mellitus and increases after metabolic improvement
    Albert Lecube
    Diabetes and Metabolism Research Unit, CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Vall d Hebron Institut de Recerca, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 6:e23366. 2011
    ....
  37. ncbi V804M RET mutation and familial medullary thyroid carcinoma: report of a large family with expression of the disease only in the homozygous gene carriers
    Albert Lecube
    Department of Endocrinology, Hospital Vall d Hebron, Barcelona, Spain
    Surgery 131:509-14. 2002
    ..We describe a large kindred with not only heterozygous but also homozygous members with the V804M mutation. This is, to our knowledge, the first report of a homozygous RET mutation...
  38. pmc Management of patients with hernia or incisional hernia undergoing surgery for morbid obesity
    Ramon Vilallonga
    General Surgery Department, Universitary Hospital Vall d Hebron, Passeig de la Vall d Hebron, 119 129, 08035 Barcelona, Spain
    J Obes 2011:860942. 2011
    ....