Research Topics
Species | Jaime KulisevskySummaryAffiliation: Hospital de la Santa Creu i Sant Pau Country: Spain Publications
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Detail Information
Publications
Changes in artistic style and behaviour in Parkinson's disease: dopamine and creativityJaime Kulisevsky
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona, Sant Antoni Maria Claret 167, Barcelona 08025, Spain
J Neurol 256:816-9. 2009..This case suggests that changes in creativity in PD seem to be related to dopaminergic imbalance in the limbic system...- Prevalence and correlates of neuropsychiatric symptoms in Parkinson's disease without dementiaJaime Kulisevsky
Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona, Spain
Mov Disord 23:1889-96. 2008..Apathy emerged as an independent construct in PD-ND, indicating the need to address specific therapeutical approaches targeted toward this particular symptom... 
Acute effects of immediate and controlled-release levodopa on mood in Parkinson's disease: A double-blind studyJaime Kulisevsky
Movement Disorders Unit, Neurology Department, Autonomous University of Barcelona, Barcelona, Spain
Mov Disord 22:62-7. 2007..Mood changes in PD patients are related to the patient's type of motor response to oral LD and also to the kinetic profile of the LD formulation used for dopaminergic replacement...- Levodopa and executive performance in Parkinson's disease: a randomized studyBerta Pascual-Sedano
Department of Neurology Movement Disorders Unit and CIBERNED, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
J Int Neuropsychol Soc 14:832-41. 2008..A slower rise in LD levels appears to have a more favorable impact on more difficult working memory tests. These results require replication to determine their generalization... - Glucocerebrosidase mutations confer a greater risk of dementia during Parkinson's disease courseNúria Setó-Salvia
Neurology Department Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Mov Disord 27:393-9. 2012.... - PDD-Short Screen: a brief cognitive test for screening dementia in Parkinson's diseaseJavier Pagonabarraga
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain
Mov Disord 25:440-6. 2010..The PDD-SS appears as the first BST for diagnosing PDD, displays an excellent diagnostic accuracy, and takes 5 to 7 minutes to be administered... - Neuropsychological correlates of mild to severe hallucinations in Parkinson's diseaseGisela Llebaria
Movement Disorders Unit, Neurology Department, Sant Pau Hospital Sant Pau Institute of Biomedical Research, Autonomous University of Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Barcelona, Spain
Mov Disord 25:2785-91. 2010..A comprehensible continuum pattern of clinical relationships emerged among VH and cognitive functioning in PD... - Parkinson's disease-cognitive rating scale: a new cognitive scale specific for Parkinson's diseaseJavier Pagonabarraga
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona, Spain
Mov Disord 23:998-1005. 2008..Performance on the PD-CRS showed that PDD is characterized by the addition of cortical dysfunction upon a predominant and progressive fronto-subcortical impairment... - Usefulness of p300 in subjective memory complaints: a prospective studyAlexandre Gironell
Cognitive Disorders Section, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
J Clin Neurophysiol 22:279-84. 2005..9% and a specificity of 76.9%; the odds ratio was 3.75 (95% confidence interval, 1.23-11.41). Findings from the present study suggest that assessment of evoked related potentials may contribute to the early detection of DAT... - Preclinical memory profile in Alzheimer patients with and without allele APOE-epsilon4Armando Estévez-González
Department of Neurology, Santa Creu i Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain
Eur Neurol 51:199-205. 2004..We found no significant differences: memory performance was similar in both genotype groups. The presence of the APOE-epsilon4 allele does not seem to be sufficient to cause a distinctive preclinical memory phenotype in AD patients... - Cut-off score of the Mattis Dementia Rating Scale for screening dementia in Parkinson's diseaseGisela Llebaria
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona and CIBERNED Centro de Investigaciones Biomédicas en Red Enfermedades Neurodegenerativas, Barcelona, Spain
Mov Disord 23:1546-50. 2008..The MDRS has an excellent discriminant ability to diagnose dementia in PD and provides an objective measure to distinguish PD-ND from PDD... - A prospective study of delusional misidentification syndromes in Parkinson's disease with dementiaJavier Pagonabarraga
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED Barcelona, Spain
Mov Disord 23:443-8. 2008..DMS is a neuropsychiatric feature associated with PDD. Greater impairment in language and memory in PDD with DMS suggests a prominent role of the temporal cortex in the genesis of DMS in PDD... - Controlled study of decision-making and cognitive impairment in Parkinson's diseaseJavier Pagonabarraga
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain
Mov Disord 22:1430-5. 2007..Although impaired decision-making appears unrelated to executive dysfunction, patients with the better cognitive status appears more prone to assume risky behaviors... - Dementia risk in Parkinson disease: disentangling the role of MAPT haplotypesNúria Setó-Salvia
Memory Unit, Neurology Department, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Sant Antoni M Claret 167, 08025 Barcelona, Spain
Arch Neurol 68:359-64. 2011..Dementia in Parkinson disease (PD) causes nursing home placement, caregiver distress, higher health care burden, and increased mortality... - A double-blind crossover, placebo-controlled study of the adenosine A2A antagonist theophylline in Parkinson's diseaseJaime Kulisevsky
Movement Disorders Unit, Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, Spain
Clin Neuropharmacol 25:25-31. 2002..During this exploratory study, the effects of theophylline were not strong enough to potentiate clearly the antiparkinsonian action of levodopa or to increase ON time in patients with advanced PD... - Effects of pallidotomy and bilateral subthalamic stimulation on cognitive function in Parkinson disease. A controlled comparative studyAlexandre Gironell
Cognitive and Movement Disorders Section, Dept. of Neurology, Sant Pau Hospital Autonomous University of Barcelona, Barcelona, Catalonia, Spain
J Neurol 250:917-23. 2003..005). This controlled comparative study suggests that neither unilateral pallidotomy nor bilateral STN-DBS have global adverse cognitive consequences, but bilateral STN-DBS may cause a selective decrease in verbal fluency... - Effect of amantadine in essential tremor: a randomized, placebo-controlled trialAlexandre Gironell
Movement Disorders Unit, Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, Catalonia, Spain
Mov Disord 21:441-5. 2006..An increase in postural tremor as an adverse effect of amantadine was referred by 37.5% of patients. Results from the present trial indicate amantadine at 100 mg b.i.d. is not effective as a treatment for ET... - Semantic knowledge of famous people in mild cognitive impairment and progression to Alzheimer's diseaseArmando Estévez-González
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
Dement Geriatr Cogn Disord 17:188-95. 2004..A neuropsychological task of semantic knowledge of famous people may be useful in the early diagnosis of Alzheimer's disease... 
Pattern of regional cortical thinning associated with cognitive deterioration in Parkinson's diseaseJavier Pagonabarraga
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, Spain Universitat Autònoma de Barcelona U A B, Barcelona, Spain
PLoS ONE 8:e54980. 2013..Mild cognitive impairment in PD (PD-MCI) seems to represent a transitional state between PD-NC and PDD. Few studies have explored the structural changes that differentiate PD-NC from PD-MCI and PDD patients...- Cognitive impairment in Parkinson's disease: tools for diagnosis and assessmentJaime Kulisevsky
Movement Disorders Unit, Neurology Department, Hospital de Sant Pau, Barcelona, Spain
Mov Disord 24:1103-10. 2009.... - Tolerability and safety of ropinirole versus other dopamine agonists and levodopa in the treatment of Parkinson's disease: meta-analysis of randomized controlled trialsJaime Kulisevsky
Unit of Movement Disorders, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Drug Saf 33:147-61. 2010..Dopamine agonists have a well established role in the treatment of Parkinson's disease. The choice of a particular dopamine agonist requires assessing the benefit-risk balance of each available medication... - Facial emotion recognition impairment in patients with Parkinson's disease and isolated apathyMerce Martínez-Corral
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Sant Pau Institute of Biomedical Research IIB Sant Pau, Autonomous University of Barcelona and Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Sant Antoni M Claret 167, 08025 Barcelona, Spain
Parkinsons Dis 2010:930627. 2010..To identify specific dysfunction of limbic structures in PD, patients with isolated apathy may have therapeutic and prognostic implications... - Spectroscopic changes associated with mild cognitive impairment and dementia in Parkinson's diseaseJavier Pagonabarraga
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, Spain
Dement Geriatr Cogn Disord 34:312-8. 2012..The PD-CRS was able to capture the differential impairment of prefrontal versus temporal cortical areas... - Cognitive impairment and dementia in Parkinson's diseaseJavier Pagonabarraga
Movement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Neurobiol Dis 46:590-6. 2012.... - The Glass scale: a simple tool to determine severity in essential tremorAlexandre Gironell
Movement Disorders Unit, Department of Neurology, Hospital de Sant Pau, Av Sant Antoni Maria Claret 167, 08025 Barcelona, Catalonia, Spain
Parkinsonism Relat Disord 16:412-4. 2010..The method for measuring disease severity in essential tremor (ET) is not consistent among neurologists in routine clinical practice... - Routine neurophysiologic tremor analysis as a diagnostic tool for essential tremor: a prospective studyAlexandre Gironell
Department of Neurology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Catalonia, Spain
J Clin Neurophysiol 21:446-50. 2004..43 (95% CI, 66.03 to 596.35). For the diagnosis of ET in patients with postural tremor, routine neurophysiologic tests have high diagnostic and predictive value that justifies its practice in movement disorders clinics... - Noradrenergic modulation of the motor response induced by long-term levodopa administration in Parkinsonian ratsVirgili Perez
Laboratori de Neuropsicofarmacologia, Institut de Recerca de l Hospital de la Santa Creu i de Sant Pau, Avgda Sant Antoni Maria Claret, 167, Barcelona 08025, Spain
J Neural Transm 116:867-74. 2009..This type of response appears to be comparable to that in the clinical setting with intermittent L-DOPA administration where no desensitization occurs once the abnormal response is established... - Motor laterality asymmetry and nonmotor symptoms in Parkinson's diseaseEsther Cubo
Neurology Department, Hospital General Yague, Burgos, Spain
Mov Disord 25:70-5. 2010..This study was designed to evaluate the predominant laterality of motor symptoms and its relationship with cognition and other NMS in idiopathic PD... - Brain apparent water diffusion coefficient magnetic resonance image during a prolonged visual auraRobert Belvís
Department of Neurology, USP Dexeus University Institute, Barcelona, Spain
Headache 50:1045-9. 2010.... - Using the WHOQOL-DIS to measure quality of life in persons with physical disabilities caused by neurodegenerative disordersRamona Lucas-Carrasco
Department of Methodology of the Behavioural Sciences, Faculty of Psychology, University of Barcelona, Barcelona, Spain
Neurodegener Dis 8:178-86. 2011..The objective of this study was to examine QoL in persons with ND... - Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screeningJordi Clarimon
Memory Unit, Alzheimer s Laboratory, and Centro de Investigación Biomédica en Red CIBERNED, Neurology Department, Sant Pau Hospital, Barcelona, Spain
Mov Disord 23:518-23. 2008.... - Apathy in Parkinson's disease: more than just executive dysfunctionSaül Martínez-Horta
1 Neurology Department, Movement Disorders Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona Barcelona, Spain
J Int Neuropsychol Soc 19:571-82. 2013..On the basis of our findings, we discuss the possible implication of added mechanisms rather than just executive dysfunction in the development of apathy in PD. (JINS, 2013, 19, 1-12.)... - Is all cognitive impairment in Parkinson's disease "mild cognitive impairment"?Saül Martínez-Horta
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Universitat Autonoma de Barcelona, Sant Antoni M Claret 167, 08025, Barcelona, Spain
J Neural Transm 118:1185-90. 2011..Thus, along with other possible biological markers, from a neuropsychological point of view, posterior-cortical defects probably represent the very syndrome of MCI in PD... - Efficacy of botulinum toxin in severe Tourette syndrome with dystonic tics involving the neckMaria Aguirregomozcorta
Neurology Department, Hospital Dr Josep Trueta, Girona, Spain
Parkinsonism Relat Disord 14:443-5. 2008.... - Diagnostic potential of acoustic startle reflex, acoustic blink reflex, and electro-oculography in progressive supranuclear palsy: a prospective studyAlexandre Gironell
Department of Neurology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Catalonia, Spain
Mov Disord 18:1273-9. 2003..The three neurophysiological tests investigated provided sensitive and specific measures with predictor value in early stages of atypical parkinsonian syndrome... - Hallucinations and sleep disturbances in Parkinson's diseaseJaime Kulisevsky
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain
Neurology 63:S28-30. 2004..In some patients, VHs may represent intrusion of REM sleep-related imagery into wakefulness. Improving REM sleep abnormalities in PD (e.g., stimulants, anticholinesterase inhibitors) is one strategy now being tested to improve VHs in PD... - Individual triptan selection in migraine attack therapyRobert Belvís
Headache Unit, Department of Neurology, USP Dexeus University Institute, Barcelona, Spain
Recent Pat CNS Drug Discov 4:70-81. 2009..We present a state-of-the-art of the triptan selection in treatment of moderate-severe migraine attacks... - Clopidogrel in secondary ischemic stroke preventionRobert Belvís
Department of Neurology, USP Dexeus University Institute, Barcelona, Spain
Recent Pat Cardiovasc Drug Discov 3:119-25. 2008..We review the reported evidence on the efficacy of clopidogrel in the secondary prevention of ischemic stroke... - Adenosine A2A-receptor antagonism and pathophysiology of Parkinson's disease and drug-induced movement disordersJaime Kulisevsky
Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Institute of Biomedical Research Barcelona, Spain
Eur Neurol 67:4-11. 2012..Understanding the role of A(2A)-receptor antagonism in the pathophysiology of Parkinson's disease and DIMD has therapeutic implications... - Repetitive transcranial magnetic stimulation for the treatment of depression. Systematic review and meta-analysisJose Luis R Martin
Iberoamerican Cochrane Centre, Hospital de la Santa Crue i Sant Pau, Barcelona, Spain
Br J Psychiatry 182:480-91. 2003..Repetitive transcranial magnetic stimulation (rTMS) may be useful in the treatment of depression but results from trials have been inconclusive to date... - Penetrance of FMR1 premutation associated pathologies in fragile X syndrome familiesLaia Rodriguez-Revenga
CIBER de Enfermedades Raras, Barcelona, Spain
Eur J Hum Genet 17:1359-62. 2009..6, 15.9 and 24.4%, respectively. The knowledge of this data might be useful for accurate genetic counselling as well as for a better characterization of the clinical phenotypes of FMR1 premutation carriers... - Diagnosis and management of essential tremor and dystonic tremorAlexandre Gironell
Movement Disorders Unit, Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, Catalonia and Ciberned Centro de Enfermedades Neurodegenerativas en Red, Spain
Ther Adv Neurol Disord 2:215-22. 2009..Treatment of dystonic tremor matches the treatment of dystonia. In cases of symptomatic dystonic tremor similar to ET, therapeutic strategies would be the same as for ET... - Treatment of Parkinson's disease in SpainFrancisco Grandas
Servicio de Neurologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain
Mov Disord 18:87-9. 2003.... - Rivastigmine for dementia associated with Parkinson's diseaseMurat Emre
Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
N Engl J Med 351:2509-18. 2004..Cholinergic deficits are prominent in patients who have dementia associated with Parkinson's disease. We investigated the effects of the dual cholinesterase inhibitor rivastigmine in such patients... - Rey verbal learning test is a useful tool for differential diagnosis in the preclinical phase of Alzheimer's disease: comparison with mild cognitive impairment and normal agingArmando Estévez-González
Department of Psychiatry and Clinical Psychobiology University of Barcelona, Spain
Int J Geriatr Psychiatry 18:1021-8. 2003..To confirm that performance in verbal learning and memory test (Rey's Auditory Verbal Learning Test-RAVLT) is a helpful early neuropsychological marker of dementia of Alzheimer's type (DAT)... - Modulation of the motor response to dopaminergic drugs in a parkinsonian model of combined dopaminergic and noradrenergic degenerationVirgili Perez
Laboratori de Neuropsicofarmacologia, Institut de Recerca de l Hospital de la Santa Creu i de Sant Pau, Avgda St Antoni M a Claret, 167, 08025 Barcelona, Spain
Eur J Pharmacol 576:83-90. 2007..These findings suggest that additional noradrenergic denervation selectively decreases the motor threshold to l-DOPA treatment without modifying the magnitude or the pattern of the motor response to adenosinergic antagonism... - Beneficial effect of donepezil on sensorimotor function after strokeMarcelo L Berthier
Department of Medicine, University of Malaga School of Medicine, Spain
Am J Phys Med Rehabil 82:725-9. 2003..It was concluded that donepezil HCl may be an effective treatment for improving sensorimotor function in chronic stroke patients. Randomized controlled trials are required to support these preliminary findings... - Pergolide: multiple-dose pharmacokinetics in patients with mild to moderate Parkinson diseaseClaire Thalamas
Clinical Investigation Center, Department of Clinical Pharmacology, University Hospital, Toulouse, France
Clin Neuropharmacol 28:120-5. 2005..This prolonged half-life is of particular interest, given the current hypothesis that more continuous dopaminergic receptor stimulation may reduce motor complications in patients with Parkinson disease... - Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing planChristopher G Goetz
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Mov Disord 22:41-7. 2007.... - "Prodromic" tremor: prevalence and clinical correlatesAlexandre Gironell
Mov Disord 22:1203-4. 2007 - Transcranial magnetic stimulation of the cerebellum in essential tremor: a controlled studyAlexandre Gironell
Servei de Neurologia, Hospital de Sant Pau, Av Sant Antoni Ma Claret 167, 08025 Barcelona, Catalonia, Spain
Arch Neurol 59:413-7. 2002.... - Effects of internal globus pallidus stimulation on motor cortex excitabilityAlexander Gironell
Neurology 58:669-70; author reply 670. 2002