Jesus Guinea

Summary

Affiliation: Hospital Universitario
Country: Spain

Publications

  1. ncbi request reprint Current challenges in the microbiological diagnosis of invasive aspergillosis
    Jesus Guinea
    Servicio de Microbiologia Clinica y Enfermedades Infecciosas, Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, C Dr Esquerdo, 46, 28007, Madrid, Spain
    Mycopathologia 178:403-16. 2014
  2. pmc Evaluation of MycAssay™ Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without hematological cancer
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    PLoS ONE 8:e61545. 2013
  3. ncbi request reprint Value of a single galactomannan determination (Platelia) for the diagnosis of invasive aspergillosis in non-hematological patients with clinical isolation of Aspergillus spp
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Spain
    Med Mycol 46:575-9. 2008
  4. pmc In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Antimicrob Agents Chemother 54:4012-5. 2010
  5. ncbi request reprint Empirical treatment of candidemia in intensive care units: fluconazole or broad-spectrum antifungal agents?
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    Med Mycol 47:515-20. 2009
  6. pmc Clinical isolates of Aspergillus species remain fully susceptible to voriconazole in the post-voriconazole era
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Antimicrob Agents Chemother 52:3444-6. 2008
  7. pmc In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Antimicrob Agents Chemother 52:1396-400. 2008
  8. ncbi request reprint Pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: incidence, risk factors, and outcome
    J Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    Clin Microbiol Infect 16:870-7. 2010
  9. ncbi request reprint Antifungal susceptibility, serotyping, and genotyping of clinical Cryptococcus neoformans isolates collected during 18 years in a single institution in Madrid, Spain
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Med Mycol 48:942-8. 2010
  10. pmc Rapid antifungal susceptibility determination for yeast isolates by use of Etest performed directly on blood samples from patients with fungemia
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    J Clin Microbiol 48:2205-12. 2010

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Current challenges in the microbiological diagnosis of invasive aspergillosis
    Jesus Guinea
    Servicio de Microbiologia Clinica y Enfermedades Infecciosas, Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, C Dr Esquerdo, 46, 28007, Madrid, Spain
    Mycopathologia 178:403-16. 2014
    ..In the present review, we discuss current culture-based and non-culture-based procedures for the microbiological diagnosis of invasive aspergillosis...
  2. pmc Evaluation of MycAssay™ Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without hematological cancer
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    PLoS ONE 8:e61545. 2013
    ..Sensitivity increased when multiple samples were used. Compared with fungal culture, PCR significantly reduced the time to diagnosis...
  3. ncbi request reprint Value of a single galactomannan determination (Platelia) for the diagnosis of invasive aspergillosis in non-hematological patients with clinical isolation of Aspergillus spp
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Spain
    Med Mycol 46:575-9. 2008
    ..15%/100%, and 93.55%/92.86% (p=0.001 and p<0.001), respectively. The determination of galactomannan in the sera of non-neutropenic patients could prove to be a useful microbiological finding when diagnosing invasive aspergillosis...
  4. pmc In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Antimicrob Agents Chemother 54:4012-5. 2010
    ..5, 2, and < or = 0.015 to > 16; voriconazole, 0.125, 2, and < or = 0.015 to 8; and fluconazole, 4, > 128, and < or = 0.125 to > 128. Isavuconazole showed potent activity against the isolates studied...
  5. ncbi request reprint Empirical treatment of candidemia in intensive care units: fluconazole or broad-spectrum antifungal agents?
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    Med Mycol 47:515-20. 2009
    ..In conclusion, the use of broad-spectrum antifungal agents is not justified in ICUs with a low proportion of candidemia episodes caused by fluconazole-resistant strains of Candida...
  6. pmc Clinical isolates of Aspergillus species remain fully susceptible to voriconazole in the post-voriconazole era
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Antimicrob Agents Chemother 52:3444-6. 2008
    ..Although the mean MICs of strains from the post-voriconazole period were slightly higher (0.39 versus 0.57 microg/ml; P < 0.001), all strains were susceptible to voriconazole and presented an MIC of <or=2 microg/ml...
  7. pmc In vitro antifungal activities of isavuconazole (BAL4815), voriconazole, and fluconazole against 1,007 isolates of zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium species
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Antimicrob Agents Chemother 52:1396-400. 2008
    ....
  8. ncbi request reprint Pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: incidence, risk factors, and outcome
    J Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    Clin Microbiol Infect 16:870-7. 2010
    ..07-62.92). However, we found statistically significant differences between patients with IPA (29 days; 95% CI 20.59-37.40) and patients without IPA (86 days; 95% CI 61.13-110.86) (log rank, p <0.001)...
  9. ncbi request reprint Antifungal susceptibility, serotyping, and genotyping of clinical Cryptococcus neoformans isolates collected during 18 years in a single institution in Madrid, Spain
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Med Mycol 48:942-8. 2010
    ..4%). However, these two isolates remained very susceptible to the new triazoles (MICs ≤ 0.062 μg/ml). The remaining strains always showed MICs ≤ 8 μg/ml...
  10. pmc Rapid antifungal susceptibility determination for yeast isolates by use of Etest performed directly on blood samples from patients with fungemia
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    J Clin Microbiol 48:2205-12. 2010
    ..Etest direct is a useful tool to screen for the presence of azole-resistant and caspofungin-nonsusceptible strains...
  11. ncbi request reprint Correlation between the E test and the CLSI M-38 A microdilution method to determine the activity of amphotericin B, voriconazole, and itraconazole against clinical isolates of Aspergillus fumigatus
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    Diagn Microbiol Infect Dis 57:273-6. 2007
    ..fumigatus for itraconazole and voriconazole when the plates are read after 48 h of incubation. The use of the E test to study the activity of amphotericin B should be avoided...
  12. pmc Workload due to Aspergillus fumigatus and significance of the organism in the microbiology laboratory of a general hospital
    E Bouza
    Clinical Microbiology and Infectious Diseases Department, Servicio de Microbiologia, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    J Clin Microbiol 43:2075-9. 2005
    ..A simple score based on five easily available parameters may be of help to microbiologists and clinicians to predict the risk of IA...
  13. pmc Molecular epidemiology of Aspergillus fumigatus: an in-depth genotypic analysis of isolates involved in an outbreak of invasive aspergillosis
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    J Clin Microbiol 49:3498-503. 2011
    ..STRAf typing proved to be a valuable tool for identifying the source of invasive aspergillosis outbreaks and for studying the genotypic diversity of clinical and environmental A. fumigatus isolates...
  14. ncbi request reprint Isavuconazole: a new and promising antifungal triazole for the treatment of invasive fungal infections
    Jesus Guinea
    Servicio de Microbiologia Clinica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Maranon, C Dr Esquerdo no 46, 28007 Madrid, Spain
    Future Microbiol 3:603-15. 2008
    ..In the absence of clinical and cost data, the real possibilities of this agent as a competitor for the treatment and prevention of IFIs in the clinical setting are still unknown...
  15. pmc In vitro acquisition of secondary azole resistance in Aspergillus fumigatus isolates after prolonged exposure to itraconazole: presence of heteroresistant populations
    Pilar Escribano
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Antimicrob Agents Chemother 56:174-8. 2012
    ..In all procedures, A. fumigatus short tandem repeat (STRAf) typing was used to demonstrate that the genotype did not change before or after exposure to itraconazole...
  16. ncbi request reprint [Cardiac invasive aspergillosis in a heart transplant recipient]
    Alia Eworo
    Servicio de Microbiología Clínicay Enfermedades Infecciosas, Hospital General Universitario Gregorio Maranon, Departamento de Medicina, Universidad Complutense, Madrid, Espana
    Rev Iberoam Micol 28:134-8. 2011
    ..Solid organ transplant recipients are a population at risk of invasive aspergillosis. The lung and the central nervous system are usually affected...
  17. ncbi request reprint Mixed fungemia: incidence, risk factors, and mortality in a general hospital
    Julia Jensen
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    Clin Infect Dis 44:e109-14. 2007
    ..We describe episodes of mixed fungemia (MF), detected between 1985 and 2006, in a large teaching hospital...
  18. ncbi request reprint Does identification to species level provide sufficient evidence to confirm catheter-related fungemia caused by Candida albicans?
    Pilar Escribano
    Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Madrid
    Med Mycol 51:769-73. 2013
    ..Consequently, identification of the same species from both the catheter tip and blood could be used to confirm catheter-related candidemia...
  19. pmc Endemic genotypes of Candida albicans causing fungemia are frequent in the hospital
    Pilar Escribano
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    J Clin Microbiol 51:2118-23. 2013
    ..Some of these endemic genotypes were found in the same unit of the hospital, mainly neonatology, whereas others infected patients in different wards...
  20. ncbi request reprint Comparison of Sensititre YeastOne with the NCCLS M38-A microdilution method to determine the activity of amphotericin B, voriconazole, and itraconazole against clinical isolates of Aspergillus fumigatus
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, 28007 Madrid, Spain
    Diagn Microbiol Infect Dis 56:53-5. 2006
    ..7%, 98.3%, 98.2%), and voriconazole (92.8%, 98.3%, 98.9%). Sensititre YeastOne is a suitable alternative for the determination of the MICs of itraconazole and voriconazole against A. fumigatus when results are read at 48 h of incubation...
  21. pmc Impact of zygomycosis on microbiology workload: a survey study in Spain
    Marta Torres-Narbona
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    J Clin Microbiol 45:2051-3. 2007
    ..Less than 8% of the patients who harbored zygomycete isolates had zygomycosis. The incidence of zygomycosis (6 cases) was 0.43 cases/1,000,000 inhabitants and 0.62 cases/100,000 hospital admissions...
  22. pmc Aspergillus fumigatus strains with mutations in the cyp51A gene do not always show phenotypic resistance to itraconazole, voriconazole, or posaconazole
    Pilar Escribano
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, C Dr Esquerdo, 46, 28007 Madrid, Spain
    Antimicrob Agents Chemother 55:2460-2. 2011
    ..We found 14 different mutations in nine isolates at codons different from G54, M220, G138, G448, and L98. We report new mutations at positions 165, 262, 479, and 497 (silent). The role of these mutations should be analyzed...
  23. ncbi request reprint Infectious and non-infectious neurologic complications in heart transplant recipients
    Patricia Munoz
    Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    Medicine (Baltimore) 89:166-75. 2010
    ..5% of HT recipients. Non-infectious causes clearly predominated, but infections still accounted for 32% of the episodes. New monoclonal induction therapies have contributed to diminished CNS opportunistic infections in our program...
  24. pmc Is azole resistance in Aspergillus fumigatus a problem in Spain?
    Pilar Escribano
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Antimicrob Agents Chemother 57:2815-20. 2013
    ..Only 1 of the 6 A. fumigatus isolates in which the cyp51A gene was sequenced had a mutation at position G448. The proportion of patients infected by azole-resistant A. fumigatus isolates was low...
  25. ncbi request reprint Prostatic aspergillosis in a heart transplant recipient: case report and review
    Maricela Valerio
    Department of Clinical Microbiology Infectious Diseases, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Heart Lung Transplant 28:638-46. 2009
    ..Urine culture can be negative and treatment should include long-term systemic anti-fungal therapy and, in most cases, prostatectomy...
  26. ncbi request reprint Evaluation of Czapeck agar and Sabouraud dextrose agar for the culture of airborne Aspergillus conidia
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, University of Madrid, 28007 Madrid, Spain
    Diagn Microbiol Infect Dis 53:333-4. 2005
    ..Both media were equally suitable. Czapeck agar should be used in institutions interested only in Aspergillus surveys, and Sabouraud agar should be used in those institutions interested in all sorts of filamentous fungi...
  27. ncbi request reprint Post-surgical invasive aspergillosis: an uncommon and under-appreciated entity
    Julia Jensen
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    J Infect 60:162-7. 2010
    ..Post-surgical invasive aspergillosis (PSIA) is an unusual and underestimated complication of surgery. It may occur after colonization of surgical sites by airborne Aspergillus conidia during surgery, or in the immediate postoperative...
  28. ncbi request reprint Effect of protein binding on the activity of voriconazole alone or combined with anidulafungin against Aspergillus spp. using a time-kill methodology
    Fabio Cafini
    Microbiology Department, School of Medicine, Universidad Complutense, Madrid, Spain
    Rev Esp Quimioter 25:47-55. 2012
    ....
  29. ncbi request reprint Treatment of invasive fungal infections in immunocompromised and transplant patients: AmBiLoad trial and other new data
    Patricia Munoz
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Spain
    Int J Antimicrob Agents 32:S125-31. 2008
    ..The use of inhaled L-AmB has shown promising results for use as antifungal prophylaxis in high-risk patients...
  30. pmc In vitro activities of amphotericin B, caspofungin, itraconazole, posaconazole, and voriconazole against 45 clinical isolates of zygomycetes: comparison of CLSI M38-A, Sensititre YeastOne, and the Etest
    Marta Torres-Narbona
    Servicio de Microbiologia Clinica, Hospital Universitario Gregorio Maranon, Dr Esquerdo 46, 28007 Madrid, Spain
    Antimicrob Agents Chemother 51:1126-9. 2007
    ..The most active drug was posaconazole, followed by amphotericin B and itraconazole. The correlation of the Etest and Sensititre with CLSI M38-A was moderate for posaconazole but poor for the others...
  31. ncbi request reprint Invasive pulmonary aspergillosis in heart transplant recipients: two radiologic patterns with a different prognosis
    Patricia Munoz
    Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, and Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain Centros de Investigación Biomédica en Red Enfermedades Respiratorias CIBERES CB06 06 0058, Madrid, Spain Electronic address
    J Heart Lung Transplant 33:1034-40. 2014
    ..Computed tomography (CT) findings can be used to classify invasive pulmonary aspergillosis (IPA) in 2 patterns: airway-invasive (AIR) or angioinvasive (ANG)...
  32. ncbi request reprint Is biofilm production a predictor of catheter-related candidemia?
    María Guembe
    Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañon, Madrid, Spain
    Med Mycol 52:407-10. 2014
    ..Also, we demonstrated that there was no difference in the mortality of candidemia patients infected by biofilm-forming isolates and those in which the infection is caused by nonbiofilm-forming species...
  33. ncbi request reprint Invasive aspergillosis among heart transplant recipients: a 24-year perspective
    Patricia Munoz
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Madrid Department of Medicine, Facultad de Medicina, Universidad Complutense, Madrid CIBER de Enfermedades Respiratorias CIBERES CD06 06 0058, Palma de Mallorca Red Española para la Investigación en Patología Infecciosa RD06 0008 1025, Madrid Electronic address
    J Heart Lung Transplant 33:278-88. 2014
    ..Despite the severity of the disease in this population, few recent series with secular trends have addressed the problem...
  34. ncbi request reprint Is it feasible to diagnose catheter-related candidemia without catheter withdrawal?
    Ana Fernández-Cruz
    Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain
    Med Mycol 52:491-7. 2014
    ..Classic tests to assess CR-BSI caused by bacteria cannot be reliably used to diagnose CRC. Combinations of tests could be useful, but more and larger studies are required. ..
  35. pmc Comparison between the EUCAST procedure and the Etest for determination of the susceptibility of Candida species isolates to micafungin
    Laura Judith Marcos-Zambrano
    Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Antimicrob Agents Chemother 57:5767-70. 2013
    ..False susceptibility was seen only for Candida krusei (10%), and false resistance was observed in 6% of the isolates, ranging from 2.6% (C. glabrata) to 13% (C. albicans). ..
  36. pmc Evolution of the antimicrobial resistance of Staphylococcus spp. in Spain: five nationwide prevalence studies, 1986 to 2002
    Oscar Cuevas
    Servicio de Microbiología Clínica y E Infecciosas, Hospital General Universitario Gregorio Maranon, Dr Esquerdo 46, 28007 Madrid, Spain
    Antimicrob Agents Chemother 48:4240-5. 2004
    ....
  37. pmc Rapid detection and identification of Aspergillus from lower respiratory tract specimens by use of a combined probe-high-resolution melting analysis
    Maria Alonso
    Servicio de Microbiologia y Enfermedades Infecciosas, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Clin Microbiol 50:3238-43. 2012
    ..With culture as the gold standard, our assay shows 100% sensitivity and specificity and constitutes an efficient alternative for identification of Aspergillus in lower respiratory tract samples...
  38. ncbi request reprint Relapsing Rhodococcus equi infection in a heart transplant recipient successfully treated with long-term linezolid
    Patricia Munoz
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, 28007 Madrid, Spain
    Diagn Microbiol Infect Dis 60:197-9. 2008
    ..This is the 1st R. equi infection to be cured with linezolid in a heart transplant recipient...
  39. ncbi request reprint Potential role of Candida albicans germ tube antibody in the diagnosis of deep-seated candidemia
    M Carmen Martínez-Jiménez
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid
    Med Mycol 52:270-5. 2014
    ..Prospective studies are needed to determine the clinical implications of this finding and its potential use in defining the optimal duration of therapy. ..
  40. ncbi request reprint Mixed bloodstream infections involving bacteria and Candida spp
    Emilio Bouza
    Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
    J Antimicrob Chemother 68:1881-8. 2013
    ..This study examines trends in BSI episodes caused by bacteria and Candida spp. (mixed-BSI) in a large teaching hospital...
  41. ncbi request reprint Outdoor environmental levels of Aspergillus spp. conidia over a wide geographical area
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    Med Mycol 44:349-56. 2006
    ..Changes in atmospheric parameters influenced the levels in air. None of the water samples were positive. Counts of Aspergillus spp. spores were always under 85 c.f.u./m3. Public water does not seem to contain Aspergillus spores...
  42. ncbi request reprint New antifungal agents for the treatment of candidaemia
    Patricia Munoz
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Int J Antimicrob Agents 36:S63-9. 2010
    ..Early microbiological information and medical education may contribute to better use of these important drugs. We review the characteristics of the new antifungals used for the treatment of candidaemia...
  43. ncbi request reprint Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals?
    Alfonso Pérez-Parra
    Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain
    Intensive Care Med 35:707-12. 2009
    ..To assess the influence of antifungal therapy on the outcome of non-candidemic adult patients with central vascular catheter (CVC) tips colonized by Candida species...
  44. pmc Antifungal resistance to fluconazole and echinocandins is not emerging in yeast isolates causing fungemia in a Spanish tertiary care center
    Laura Judith Marcos-Zambrano
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
    Antimicrob Agents Chemother 58:4565-72. 2014
    ..Resistance mainly affected non-Candida yeasts. The rate of resistance to fluconazole and echinocandins did not change considerably during the study period. ..
  45. ncbi request reprint Micafungin is more active against Candida albicans biofilms with high metabolic activity
    Laura Judith Marcos-Zambrano
    Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
    J Antimicrob Chemother 69:2984-7. 2014
    ..The metabolic activity of C. albicans biofilms is strain-dependent, and cell wall formation is thought to be more prominent in biofilms showing high metabolic activity...
  46. ncbi request reprint Production of biofilm by Candida and non-Candida spp. isolates causing fungemia: Comparison of biomass production and metabolic activity and development of cut-off points
    Laura Judith Marcos-Zambrano
    Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
    Int J Med Microbiol 304:1192-8. 2014
    ..17). The overall categorical agreement between the procedures was 43.7%, which increased to >50% for C. albicans and C. parapsilosis. XTT and crystal violet are complementary procedures for the study of biofilm production. ..
  47. ncbi request reprint [Use of molecular typing tools for the study of hospital outbreaks of candidemia]
    Laura Judith Marcos-Zambrano
    Servicio de Microbiologia Clinica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Maranon, Madrid, España Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Espana
    Rev Iberoam Micol 31:97-103. 2014
    ..The role of genotyping Candida isolates causing candidemia for the study of nosocomial outbreaks of candidemia is reviewed, as well as the patients more commonly affected by epidemic strains...
  48. ncbi request reprint [Guidelines for the treatment of invasive fungal disease by Aspergillus spp. and other fungi issued by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC). 2011 Update]
    Jesus Fortun
    Servicio de Enfermedades Infecciosas, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Enferm Infecc Microbiol Clin 29:435-54. 2011
    ..Specific recommendations on the prevention of fungal infections in these patients are included...
  49. pmc Molecular identification and antifungal susceptibility of yeast isolates causing fungemia collected in a population-based study in Spain in 2010 and 2011
    Jesus Guinea
    Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense de Madrid, Madrid, Spain
    Antimicrob Agents Chemother 58:1529-37. 2014
    ..The decrease in the susceptibility to fluconazole in Spanish isolates should be closely monitored in future studies. ..
  50. ncbi request reprint Extra-abdominal infections due to Gemella species
    Juan M García-Lechuz
    Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Int J Infect Dis 6:78-82. 2002
    ..To understand the role of Gemella species as a pathogen causing extra-abdominal infections in the Hospital General Universitario Gregorio Marañón...
  51. pmc Antifungal susceptibility of 596 Aspergillus fumigatus strains isolated from outdoor air, hospital air, and clinical samples: analysis by site of isolation
    J Guinea
    Servicio de Microbiologia, Hospital Universitario Gregorio Maranon, Calle Doctor Esquerdo, 46, 28007 Madrid, Spain
    Antimicrob Agents Chemother 49:3495-7. 2005
    ..We did not find differences among the susceptibilities by site of isolation...
  52. ncbi request reprint Nosocomial invasive aspergillosis in a heart transplant patient acquired during a break in the HEPA air filtration system
    P Munoz
    Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Doctor Esquerdo 46, 28007 Madrid, Spain
    Transpl Infect Dis 6:50-4. 2004
    ..A high overload of Aspergillus spores in the intensive care unit room led this patient to acquire IA. Identical environmental and patient isolates allowed our hypothesis to be confirmed and a very precise incubation time to be estimated...